CYMBALTA Reviews (DULOXETINE)

Average Rating: 2.7 (2745 Ratings)

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 ANTIDEPRESSANTS

 Type: Rx Drug

  

CYMBALTA  (DULOXETINE):  Duloxetine is used to treat depression and anxiety. In addition, duloxetine is used to help relieve nerve pain (peripheral neuropathy) in people with diabetes or ongoing pain due to medical conditions such as arthritis, chronic back pain, or fibromyalgia (a condition that causes widespread pain). Duloxetine may improve your mood, sleep, appetite, and energy level, and decrease nervousness. It can also decrease pain due to certain medical conditions. Duloxetine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). This medication works by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in the brain.   FDA Approval Date: 2004-08-03 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on CYMBALTA: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR CYMBALTACOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 5  Severe depression mild nausea, insomnia, lack of concentration. Compared to the horrible darkness of deep depression, this medication and even with the side effects is a lifesaver. I am able to get out of bed and function. I am no longer angry and I have been able to do things around that house that only a few months ago seemed hopeless. I still have to push myself every day to not go back to bed but I know Cymbalta has made a very significant difference and I will not stop taking it any time soon. One other comment- this is a very potent drug. I have read postings where people state they are taking it for mild pain or stress....this strikes me as odd. why does a M.D. prescribe this for anything other than severe depression? I would advise people not to take it for anything else - it is a very potent drug. Any side effects for me are better than the blackness of depression. F 42 2 months
1/2/2008
 5  Pain/Anxiety/Depression Excessive Yawning & Sleeplessness (at 1st) - Weight Loss - Constipation/Diarrhea - Vivid Dreams - Food doesn't have much taste AMAZING!!! I didn't know i could ever feel so good again. Just days after starting the medicine, I could tell a difference in my anxiety & patience levels. However, i considered getting off due to excessive yawning & sleeplessness. After reading this website, i decided to try to work through those side effects. I'm SOOO glad I did. I am happier than I have been in a long time. I spent a lot of time in prayer over taking any type of antidepressant - i'm grateful God made people smart enough to make such a drug, and had my dr prescribe it. I use to go to the bathroom 15-20 times a day because of anxiety - now i can go an hour or more without having to go. I feel like i actually have my life back! Try to work through any side effects you are having (3-4 wks) it will be well worth it - besides i was more afraid of the side effects for coming off. Good luck F 35 10 weeks
1/2/2008
 4  Head Injury related depression The medication works well for me but a warning to all! Do not ever stop taking the medication! I was not able to afford it and stopped taking it and the results were DISASTER! I was not warned of the severe side effects (the Pharmacy label said...Headaches and tingling in the hands and feet..No big deal right?) Well, I did not know the WITHDRAWL would turn in to my falling asleep at the well and then totaling my car(lucky I was the only that got hurt.) I lost my license, my car and had to slowly get back on the medication. I though I had a stroke. But no it was withdrawl from this medication and then it caused an overdose on my other medication (Trazadone)since they were not both in my system working together. So, this medicine can work well but do not ever stop it because the headaches are bad and your speech turns in to salad then if you do not know this is what is happening and you drive then DEATH could be a side effect! F 37 2 years
1/2/2008
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 3  depression got bad again was on 30 mg. paxil for 5 years and told to go right to cymbalta next day. moderate nausea for a short time the first night on 30 mg; the nausea woke me up but continued to sleep through it. mild nausea lasted about one hour the second day. since then no problems. not sure if it's helping as i still feel depressed and having anxiety, but it's only been two weeks. 30 mg. the 1st week and 60 mg. the 2nd. F 38 14 days
1/2/2008
 4  joint pain None noticed Prescribed for pain in the ankle which included stiffness, constant ache with shooting pains (like a toothache. Cymbalta provided relief within a few days. F 49 1 years
1/1/2008
 2  Depression, Anxiety Apathy, weight gain, confusion, brain fog/zaps, TERRIBLE WITHDRAWL, no sex drive/response, sleeplessness 60 mg...May have helped anxiety & depression at first when I needed the help, but now 2 years later my life is different and I cannot get off this drug. The feelings of chemical & withdrawl makes depression seem a better alternative. The person perscribing it didn't describe it properly. If I had any idea how bad the withdrawl would be, I never would have taken this. It's not even known if birth defects can result, but it seems likely due to tests on animals...I feel my personality comes from the cybalta now, not me. I am very concerned about having a baby when I am still on this. I tried to get off of it over the summer and couldn't sleep, was a raging lunatic, couldn't work, couldn't drive, just wanted to cry or scream.. F 33 2 years
1/1/2008
 3  depression, anxiety Very vivid dreams (not nightmares); teeth clenching; sleepy all the time and I can sleep hours and hours if I let myself; increase in blood pressure; weight gain of 10+ pounds over a period of months; night sweats (extreme -- I wake up with sheets and hair and pjs soaking wet, in the middle of winter, and then I am freezing!). After awhile, good (intended) effects started to wear off. I do think this drug helped me for awhile, but after several months I don't feel it is really helping anymore. I've tried lots of different antidepressants and at least in the short term, this one helped the most. I'm now tapering off (at 90 mg dosage, now down to 30 after 2 weeks) as I don't feel I'm getting benefits anymore and am tired of the side effects (even though overall they really aren't severe). I haven't had any bad effects going off except mild migraines every couple of days. I'm ready to find out what I am like when not taking anything -- I have had so many over the last 3 1/2 years. I might try a naturopathic route. Thanks for everyone's input and info; it does help to know I'm not just imagining things! F 40 8 months
12/31/2007
 5  pain and depression because of it constipation taken care of with proper diet sleep disorders I have tken numerus medications and therapies before but none has helped me this much F 50 4 months
12/29/2007
 5  Bipolar Dissorder Good concertation You have to take them every 4 hours. M 24 4 months
12/28/2007
 1  depression vivid dreams, nightmares, night sweats,loss of libido and ability to orgasm, constipation, occational brain zaps, weight loss then a ton of weight gain. This was a miracle drug for the first few months,then it stopped working. Side effects stayed and now that I'm trying to slowly withdraw from it they have gotten worse and new ones have started, especially dizziness and irritibility and lack of energy. From what I've been reading it sounds like I have a long horrible road ahead of me. Lily had to have known about how absolutley grim the withdrawals were. F 32 11 months
12/28/2007
 2  Neuropathic Pain, depression Significant weight gain; 15 pounds in 4 weeks. Muscle cramps, fluid retention, increase blood pressure I know this is a great drug and others get similar effects combining Lyrica with an SSRI, or Gabapentin (Neurontin) with an SSRI antidepressant. Certainly the fluid retention and weight gain are unacceptable, but with an increase in my blood pressure without having hypertension was a deal breaker for me. F 44 3 months
12/27/2007
 4  Depression, Anxiety, Fibromyalgia Cymbalta makes it very hard to cry and somewhat descreases my libido. Otherwise, I'm a fan. When I was on Lexapro, I wanted to peel off my skin for 3 months from the crawling jitters, couldn't sleep, and was terribly anxious. Cymbalta does more good than harm. F 23 2 years
12/26/2007
 1  depression weight gain 26 pounds in 3 months. I went from a healthy 115 lbs to 141 pounds practically overnight. I don't have the money to buy a new wardrobe, I spent it all trying to find a decent anti-depressant. 5 months
12/24/2007
 2  Major Depression Extreme Fatigue, Nausea, Upset Stomach Cymbalta has made me feel so incredibly tired. No matter how many naps I take I still feel exhausted. If I miss a dose then I feel so nauseous that it makes it hard for me to function. I switched from Lexapro but after cymbalta, Lexapro seems like it was doing a much better job with hardly any side effects. F 19 6 weeks
12/23/2007
 4  mood disorder/epilepsy Major weight gain (20+ lbs). Night sweats. Hot flashes. I still really like this medicine even though I have gone from a 4-6 pant size to a 8-10 in the last year. Before that, I was having to work out like a fiend to keep the weight off. That being said, I turn into a sane, fairly personable person with it. I was having major "rages" for insignificant reasons, and, with it, I'm not an angry person at all. And I like myself so much more when I take it. My husband and children like me more, too. F 38 4 days
12/21/2007
 3  lDepression, peripheral neuropathy No energy, short term memory loss very bad, aggression (like PMS but I past that age), still have problem with pain in my feet I was on Effexor prior to this for about 2 years and I liked that anti-depressant but my doctor wanted to see if Cymbalta would help me with the neuropathy pain. F 58 90 days
12/18/2007
 1  Anxiety Dry mouth, extreme insomnia, nausea, dizziness I took my first and last pill (30mg) last night... Past 24 hours have been hellacious! I've never felt so bad in my whole life F 24
12/18/2007
 4  depression/migraine HOrrible migraines but i have had migraines since early childhood,This medicine just caused more frequency and higher degree of pain with headaches,Best medicine for depression that i had ever taken and worked instantly I must say that i felt the happiest i had ever felt in my life except for the extreme migraines,Due to the frequency of the migraines i discontinued cymbalta ,wish i could go back on it.I did suffer some withdrawl depressive symptoms after stopping the medicines but felt better in about two weeks F 36 60 days
12/17/2007
 4  Peripheral Neuropathy Insomnia, sweaty hands/feet, decreased appetite=weight loss,dilated pupils. Side effects have lessened over time. Neuropathy symptoms improved; however, they still break-thru from time to time (although much less severe than without the Cymbalta). I also have lupus and this drug seems to help with the extreme fatigue I have felt for the past 4 years. Have lost about 10 lbs thus far. The benefits greatly outweight the side effects for me. The first two nights I took the medication, I experienced total insomnia; therefore, physician has me take Cymbalta in morning & Trazadone @bedtime. This combo works well for me. F 35 3 months
12/15/2007
 3  depression Day 2 of using it: slightly queasy, a bit light headed, a bit of jaw clenching. Day 2 of using it: mood swings, seems to magnify emotions either way, not the best for me. M 52 2 days
12/14/2007

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