CYMBALTA Reviews (DULOXETINE)

Average Rating: 2.7 (2745 Ratings)

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 ANTIDEPRESSANTS

 Type: Rx Drug

  

CYMBALTA  (DULOXETINE):  Duloxetine is used to treat depression and anxiety. In addition, duloxetine is used to help relieve nerve pain (peripheral neuropathy) in people with diabetes or ongoing pain due to medical conditions such as arthritis, chronic back pain, or fibromyalgia (a condition that causes widespread pain). Duloxetine may improve your mood, sleep, appetite, and energy level, and decrease nervousness. It can also decrease pain due to certain medical conditions. Duloxetine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). This medication works by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in the brain.   FDA Approval Date: 2004-08-03 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on CYMBALTA: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR CYMBALTACOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 4  Depression and anxiety Initial headache, nausea, went away after approximately 1.5 weeks. I was on lexapro on and off for several years with paxil (20mg) before that (20mg of lexapro at the highest and 5mg right now before I switched to Cymbalta). Lexapro did not help with depression. Actually, Paxil was the BEST for anxiety but the side effects were not worth it for me - extreme fatigue and weight gain. Lexpro had less weight gain but gradually I experienced more and more fatigue until I would lay around all the time and not want to do anything (which helped augment my depression ...). Anyhow I'm on 30 mg of Cymbalta now and find I have ENERGY! Without any trouble sleeping. But I'm a bit anxious during the day - more so than I was on 5mg of lexapro. So I take 1/2 mg of lorazepam on the jittery days. Talking to my dr about mixing back in some lexapro for the anxiety. But I think all around Cymbalta is the best for depression. And other than not helping the anxiety as much as lexapro, I have no side effects after 2 weeks. F 26 2 weeks
7/24/2008
 2  Depression Excessive sweating, trouble sleeping, rash F 45 2 years
7/22/2008
 5  Anxiety For the first few weeks I had constipation, sweating and dry mouth I happen to be a Psych NP and have terrible anxiety, have been on Lexapro for years, but had terrible fatigue. After the initial side effects weaned off, I have had tons of energy, it has been easier to loss weight, I have had a major increase in sex drive and my anxiety symptoms are practically non-existent. I would suggest anyone who reads this to understand that everyone's body works different with medication and although these blogs provide some comfort in knowing others are going through what you are experiencing, know that everyone's experience is a little different and the main goal is weighing the benefits from the negative side effects and together with your health care provider decide what is working for you! F 27 3 months
7/21/2008
 1  antidepressant Extreme side effects: violent shakes, seizures, fireworks in the brain feeling, feels like your losing your mind, sensitive to light, sound even touch, vomitting, lost in the "unknown realm", restless, not able to sleep.....THE WORST DRUG EVER MADE. WORSE THEN COMING OFF OF HEROIN. CYMBALTA SHOULD BE MADE ILLEGAL F 56 2 months
7/21/2008
 1  pmdd Lethargic, unable to function and wanted to sleep all the time. M 47
7/20/2008
 1  depression horrible nausea; diarreah; tingling in arms, hands, & fingers; hot flashes; rapid heart rate; dry mouth; cloudy head; sweaty; dizzines; insomnia I only took this for one day. I took it in the ,morning and suffered all day long. I was not able to fall asleep until 5am the NEXT day. I felt as if I had used cocaine. Yuck. Horible experience. I will not take this another day. I have been on Wellbutrin before and never had any of these side effects. F 32 1 days
7/20/2008
 2  Depression fatigue, sleepiness, trouble concentrating, foggy thinking (all at 60 mg dose). No side effects at 30 mg but that dose didn't help my depression much. Not very effective at depression for me. I've been switched to Wellbutrin. Depression got worse when I was tapering off Cymbalta. M 40 6 months
7/19/2008
 3  Fibromyalgia, Anxiety, Depression Catatonic, no emotion. Severe palpitations and irregular heartbeat. Stopped taking it and two weeks later still irregular. Seeking cardiovascular treatment. It DID help combat fatigue. I was able to function physically like a normal human being again for the first time in years, but I had no emotion whatsoever. F 37 7 days
7/16/2008
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 3  borderline pers. , fibromyalgia severe constipation for over a week, teeth grinding, immediate weight loss and loss of appetite I loved the weight loss, but stopped taking this because of the horrible constipation. It DID help with my anxiety/depression however immensely and with my fibromyalgia. I may go back on it because the other choices don't seem so great. F 29 5 months
7/15/2008
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 3  Depression and migraines Nausea,tingling sensation,insomnia I have epilepsy and have been suffering from migraines for years. The medicine helps great with depression the first week or two I was really really nausea but after that it got better. I accidently missed a day and woke up the next morning and felt like I was having a heart attack I was so shaky I couldn't even put in my contacts so def. don't miss a dose. I'm on 60mg and thinking about going down to 30mg for the summer I think it's giving me too much energy I work 8 hours a day and go to school full time...and I'm not tired? Other than some insomnia this drug is MUCH better than Prozac and any other depressant i'd rather be awake then knocked out for 8 hours at a time on any other anti depressant! F 20 3 months
7/13/2008
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 3  depression, anxiety I take 120 mg/day. If I don't take it I start withdrawl on day 3. it is awful. I start getting waves of pressure in my head, am unable to think and get very crabby with my kids. I also get lightening bolts of numbness across my lips (best way to describe it). I also feel like everything is unreal and I have to really work at behaving normally. I have also gained weight. I still feel depressed and anxious so I'm not sure if it is helping much. I've tried almost all other antidepressants and frankly I don't know if any of them worked. I don't know if I could survive total withdrawl from this med. Be very careful about your decision to take this drug. Really think about it. I'm glad to read that it has helped some people. Just do'nt let your prescritpion run out. F 42 10 months
7/8/2008
 2  depression tense muscles, lack of appetite, general apathy, lack of enjoyment of life in general. the reviews seem to point to Cymbalta being one of the more problematic depression meds. M 49 40 days
7/8/2008
 5  bipolar/anxiety/depression 60 mg at bedtime. Thankfully no sexual side effects, no weight gain, some teeth grinding which I wouldn't have even mentioned or thought was from this med, but saw someone else listed it too. I take this along with 100mg lamictal for bipolar /depression/anxiety. I am very pleased with that med combination. I started at 30mg, but 60mg works better. My doctor suggested taking it at nite to subdue any feeling of tiredness. I feel clear and alert for the most part. I have a more positive attitude towards life. I am not constantly worrying and the "mouse on the wheel in my brain" seems to have slowed down a bit. It is difficult to compare yourself to others when you read these because we are all different, but if you are not happy with what you are taking, I would suggest giving it a try. I may never feel like a "normal" person, but I am very content right now. F 41 9 months
7/5/2008
 1  anxiety seating, weight gain, fatigue F 57 6 days
7/1/2008
 2  depression / anxiety Prickling feeling in arms, hands, legs. Flush. I just took my first 30mg does of Cymbalta about an hour ago after my doc gave me some samples. Should have read these posts first. So concerned by the overwheliming negative comments on both this site and others on the web relating to Cymbalta use. I have mild depression/anxiety and have been on either Lexapro or Prozac for a number of years. This drug does not appear to be worth the troubles. Just hope the one 30mg dose does not result in the harsh reported withdrawals. Prozac was difficult enough to get off of. M 32 1 days
6/30/2008
 1  depression While I was on it, in the beginning, I wanted to drink alcohol like a fish and I am not really a drinker. It made me more depressed. No orgasms, Bah!! No weight gain, really. This drug is not for everyone. I understand if you really have an imbalance and need it, but for a crutch for short term depression I would seriously not reccomend it. I was on 60 mg for 6 months. I am on day 8 of cold turkey withdrawl and I feel this stuff is poison. I have researched the withdrawl symtoms to no end, and it seems to be a common theme. I had no problem coming off of celexa or wellbutrin, but this cr*p is the devil. Think twice before taking it and do your homework to make sure this is for you. DO NOT TAKE MY ADVICE LIGHTLY. F 33 6 months
6/30/2008
 5  back pain and depression Sweating,night sweats and crazy dreams I feel that this medication helped me tremendously as I have had depression for 50 years, I am a new and happy lady. F 65 15 months
6/22/2008
 5  Migraines, mild anxiety, Nausea the fist day, and after doubleing doses. Extreme drowsiness1-2hours after taking it. climax more difficult, waking up after 6 hours of sleep, constipation 1st 3 weeks-better with fiber foods, weight loss forst 3 weeks-appetite back to normal after that. Increased threshhold for pain(good thing) Week 1 improvement, after 3rd week felt great. No more migraines, except self induced(too much wine), anxiety still not completely gone but sooo much better. I have motivation again and more self confidence. I feel like I'm back to the old me....before i had any problems-emotional and migraines. I recommend trying it for migraines- it has changed my life. i was having 3-4 migraines a week, now none/very rare. F 30 7 weeks
6/19/2008
 3  Depression loss of appetite, weight loss, nausea (subsided after a few days) I switched off of Prozac after being on that for around 2 years or so. I was hit with a lot of side effects of Cymbalta. My psychiatrist wants to now switch me to Zoloft. The loss of appetite and weight loss was one of the main side effects I had, I am already underweight, and losing weight isn't good for me F 18
6/16/2008
 4  Major Depressive Disorder Mildly increased heart rate,increased muscle stiffness I have been taking 90mg for about a month after taking 150mg Effexor for years. I stopped the Effexor because I felt I had developed a tolerance to it and did not want to increase the dose. I felt better within a couple of days and stepped down the Effexor over a two week period. If you are considering taking this drug, please do not be scared off by the negative comments. Each person is different and may have other issues that don't apply to your situation. The best patient is one that is informed, aware, and communicates with their doctor. Cymbalta may not be right for you but don't stop trying to find one that is. I am sleeping better, have more energy and decreased appetite. I have not had any bowel issues or nausea. I have not had any nightmares, maybe even decreased dreaming which is okay because it gives my mind a chance to switch off. Check this, or any drug, on WebMD as you may find less biased information. F 50 1 months
6/14/2008

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