CYMBALTA Reviews (DULOXETINE)

Average Rating: 2.7 (2745 Ratings)

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 ANTIDEPRESSANTS

 Type: Rx Drug

  

CYMBALTA  (DULOXETINE):  Duloxetine is used to treat depression and anxiety. In addition, duloxetine is used to help relieve nerve pain (peripheral neuropathy) in people with diabetes or ongoing pain due to medical conditions such as arthritis, chronic back pain, or fibromyalgia (a condition that causes widespread pain). Duloxetine may improve your mood, sleep, appetite, and energy level, and decrease nervousness. It can also decrease pain due to certain medical conditions. Duloxetine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). This medication works by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in the brain.   FDA Approval Date: 2004-08-03 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on CYMBALTA: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR CYMBALTACOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 1  neuropathic pain depression headache nausea body chills stomach ache diarrhea sweating extreme tiredness anxiety and zombie like does more damage to body than good should not be on the market. F 59 2 weeks
60mg
11/3/2018
 1  Depression, pain. Worse depression, contemplating suicide,body muscle and bone aches, Terrible F 63 24 days
20
11/2/2018
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 1  Depression Didn’t improve depression. Insomnia & constpation I never knew a drug could be so horrible when discontinuing. The side effects are almost unbearable! Insomnia, night sweats, horrible brain zaps, no concentration, memory issues, severe mood swings. This was after slowly weaning off. I will suffer through withdrawal, because I want this drug out of my body. F 61 4 months
60 mg
10/6/2018
Email
 1  Chronic Depression PTSD Sick, felt poisoned, flu like symptoms, in bed all day Horrible for me. I literally felt like I was taking poison even told my spouse this every day. I tried to cut down to 30 mg. Side effects were terrible. Still have side effects. I had taken a Genetic test and it showed I am highly likely to have a severe negative reaction to this medication. Doc took me off and started Wellbutrin. I cant say if the wellbutrin is working. I feel like Cymbalta is still in my system. I'll never ever take it again. Horrible for me and now withdrawals are even worse. F 51 6 months
60mg
9/27/2018
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 2  panic, GAD Constant nausea every single day. Constant sweating. Slight euphoria at times, but went away quickly. Dizziness once drug wore off. Drug worked for a few hours and then pooped out. Unhappy dreams, woke up unhappy. Felt scared of random stuff like the wind of all things!!! All side effects went away when I tapered off. F 33 3 weeks
20 1X day
9/1/2018
 4  Binge eating Low sex drive, rapid cycling, decreased appetite F 21 2 months
30mg
8/9/2018
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 1  Anxiety Tiredness, fatigue, constipation, sweating, nightmares, decreased libido and sexual functioning. Horrible med. Stopped taking it due to side effects. Experienced withdrawals for weeks including brain zaps, nausea, headaches, fatigue. F 35 6 years
60mg
8/2/2018
 1  Anxiety Fatigue, tiredness, lethargy I gradually reduced my dose of Cymbalta from 60, 30, then 15mg. At 15mg I experienced the worst withdrawal symptoms including, nausea, vomiting, diarrhea, massive headaches, fatigue, dizziness, hot flashes, and sweating. It felt like my brain was in a vice. My doctors who prescribed this drug over the past several years never once warned me about it. Do not take this drug unless you plan on being on it forever. Also, while on it I experienced constant tiredness, fatigue and slept 12 hours per day and still was tired. F 35 900 days
60 mg 1X day
7/25/2018
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 3  Major Depression Excessive sweating, cold sweats at night, withdrawal if not taken at the same exact time daily, severe nausea, weight loss, vomiting, and my depression was never 100% better. It helped better than any other antidepressants but there was still lingering depression. Withdrawal while weaning off is absolutely terrible. Unable to live a normal life and complete normal daily activities such as going to work, cleaning up, taking care of myself, etc. during withdrawal. Terrible drug. I would not recommend this to my worst enemy. The bad side effects greatly outweigh the good from my experience. I was young and naive and told that this medication would help and that it did help so I continued to take it daily until I realized that if I forgot to take it or if i take it late it would make me physically and mentally sick. My liver enzymes (ALT AND AST) were consistently elevated to abnormal levels because of the drug. Withdrawal is terrible. Hopefully I can get through this and wean off successfully. F 24 10 years
90 mg 1X day
7/13/2018
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 3  Fibromyalgia Urinary problems; severe sweating upon minimal exertion, like standing in rainstorm of sweat dripping off hair; bowel impactions Suspect future discoveries for long term use consequences. F 72 5 years
30 mg
6/15/2018
 3  Depression Backpain Nausea and insomnia. Rapid heart rate on occasion Very hesitant to start this medication due to all the bad reviews. Been on it for 5 weeks. Morning nausea still an issue, have lost 6kg. Insomnia the major problem. Dr reluctant to order any sedation so have gone the herbal route which don't work. Hope this issue eases up because I'm so tired. I try going back to bed to rest during the day but rarely catch up on sleep F 56 5 weeks
60mg 1X day
6/14/2018
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 1  Depression fibromyalgia Drug from hell..it will eventually turn on you F 61 8 days
60 mg 1X day
6/14/2018
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 1  Bipolar Intense GI issues, Chronic severe abdominal pain,chronic severe skin thinning, acute unexplained bruises, chronic severe bruxism, chronic nightmares,acute migraines, chronic pain in joints/muscles I've never had before, Severe cognitive decline, severe serotonin syndrome, chronic heart issues, chronic blood pressure issues, chronic severe suicidal ideation, chronic disorientation, chronic vertigo, chronic severe dehydration, chronic dental destruction, chronic severe fatigue, chronic severe insomnia, chronic severe raging, chronic severe depression, chronic severe anxiety, chronic severe PTSD, chronic severe borderline personality disorder, chronic severe bipolar disorder, chronic severe apathy, chronic severe despondency, chronic balance issues, chronic exacerbation of IBS-C, exacerbation of OAB, tremendous difficulty urinating, tremendous difficulty voiding, cannot void regularly naturally, blood in stool, chronic bleeder, chronic nausea, chronic fever, chronic paranoia, decreased vi PURE POISON!!! I'm suffering severe life-threatening side effects also suffered severe withdrawal effects when taken off cold turkey. VERY allergic, VERY addicted (only ever taken as prescribed). It is killing me; I can feel my body shutting down; slowly but surely. Just a matter of time. I have zero life quality, zero life purpose, 85-90% homebound, can't do basic self-care, can't do 99% personal business, and on and on and on. F 54 1 years
30 mg 1X day
6/14/2018
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 5  Depression None Saved my life. I am very grateful for this drug, nothing else worked M 61 10 years
50 mg 1X day
5/30/2018
 1  Sciatica & depression Nausea, Dizzy, Chills, headache, insomnia, total body fatigue, flu like symptoms, confused, couldn't think straight. I called my Dr. & told him I was extremely sick & his response was to stop taking it. For 3 days after I stopped I felt flu like symptoms with chills. Never again! F 51 1 days
30mg
5/27/2018
 1  Depression and chronic back pain Horrible hot flashes, memory issues, emotion less, can't ever cry, brain Zaps (those are the worst). Weight gain I never felt full. Loss of interest in sex This drug and its generic version should be removed from the market. There is no safe way to wean yourself off. I'm trying to very slowly and my concentration is shot. You have to count the tiny beads. Ive gone from 20 to 10 mg and then I'll drop to 5 mg and praying I can get through this. F 54 9 years
20 1X day
5/1/2018
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 3  Sciatica from herniated disc Dizziness, feeling high like when on ecstasy, sweating, delayed orgasm, involuntarily waking up mornings at 7:00AM with crazy noises in my brain Doc prescribed it to my sciatica coming from a herniated disc. Was on Lyrica before but it only helped a bit. Worked very good against the pain, I felt almost nothing the second day on, but suddenly I started feeling high and "light" like when on ecstasy, sometimes I wouldn't even feel my legs properly. Would wake up every morning at 7AM (regardless of when I went to sleep) with a zap on my brain and some crazy music playing in it. Works really good for the nerve pain, but the side effects weren't worth it.I felt "unnatural", always numb. M 21 5 days
60mg 1X day
4/22/2018
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 1  Depression / desth My husband before Cymbalta was a smart / strong man who became distorted , weak, nervous , anxious man .. It tore my family apart .. He could not sleep as the dr also gave him Ambien which made things worse .. He had numb feet and they were always freezing , nitemares , doing thing that he would not normally do in previous years .. Cymbalta and Ambien took this mans life and in turn took mine and my family’s , we were married 3.5 years and his mind got so bad he took his own life ! All at the hands of big pharma who didn’t kno who he was . No help except a pill and that is one sad thing to control ones life . M 48 16 months
30/60 MG
4/6/2018
 1  Neuropathy Most of what everyone else has said, anxiety, anxiousness, difficulty urinating, blood in urine, all over body weakness, especially back and upper body, blurry vision, headache, nausea, insomnia, bizarre dreams when I slept, tremor, cough, excessive yawning, no sex drive, no emotions. Didn't work for me for pain, although it does for some, the side effects outweigh its effectiveness. Wouldn't recommend this to anyone. Please don't use antipsychotics if you don't have to. It takes forever to get them out of your system M 54 25 days
60 1X day
3/28/2018
Email
 5  Nerve pain, depression Nothing really noticeable for me. As far as I'm concerned it saved me! I feel like me again! Helped with my pain and depression F 1 years
90 mg
3/19/2018

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