CYMBALTA Reviews (DULOXETINE)

Average Rating: 2.7 (2745 Ratings)

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 ANTIDEPRESSANTS

 Type: Rx Drug

  

CYMBALTA  (DULOXETINE):  Duloxetine is used to treat depression and anxiety. In addition, duloxetine is used to help relieve nerve pain (peripheral neuropathy) in people with diabetes or ongoing pain due to medical conditions such as arthritis, chronic back pain, or fibromyalgia (a condition that causes widespread pain). Duloxetine may improve your mood, sleep, appetite, and energy level, and decrease nervousness. It can also decrease pain due to certain medical conditions. Duloxetine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). This medication works by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in the brain.   FDA Approval Date: 2004-08-03 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on CYMBALTA: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR CYMBALTACOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 3  Depression and ms pain I've experience horrible nightmares that I wake up screaming from. I wake up several time during the night soaked in sweat. I did not know these were side effects of CYMbalta until I came to this site and read other people's experiences. Thank you! I had told my doctor about the sweating and he told me ghat was not a side effect of this medication. I have Fibromyalgia and ms and my dose was just increased to help with pain! It really hasn't done that so far, only made it impossible for me to get a good nights rest. I'm exhausted all the time. This doesn't help either of my conditions! F 47 1 years
120 mg 1X day
6/29/2011
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 1  Fibromyalgia Miracle drug at first, weight gain, dry mouth were acceptable for years. Knocked out about 60% of fibro pain. Thoughts of suicide and night terrors began and worsened in the last year. into 3rd week of withdrawal and it keeps getting worse. Suicide (good thing I don't own a gun), uncontrollable outbursts, sleeping all the time or can't sleep, HORRIBLE nightmares, paranoia, complete meltdowns, head pain, irritable bowl, stomach pain, hot or freezing, sweating F 61 6 years
60 1X day
6/29/2011
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 1  Depression, Anxiety, Stress, Pain Everyone imaginable. Loss of appetite, metal taste in mouth, weightloss, headache, disoriented. Worst medication to date for me. I couldn't believe the side effects and how harsh they were. I felt horrible, my mouth tasted like metal and I could not sleep for days. I was hoping it would eventually go away so I continued to take it and after the 6th day of the same intense side effects I finally had to just chunk them in the trash. Was wondering if anyone else had this bad of effects but that they did go away after a certain amount of time. I have been on wellbutrin before and the side effects were bad but did wear off after about a mont M 33 6 days
30 mg 1X day
6/27/2011
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 1  Depression, Anxiety, Stress, Pain Everyone imaginable. Loss of appetite, metal taste in mouth, weightloss, headache, disoriented. Worst medication to date for me. I couldn't believe the side effects and how harsh they were. I felt horrible, my mouth tasted like metal and I could not sleep for days. I was hoping it would eventually go away so I continued to take it and after the 6th day of the same intense side effects I finally had to just chunk them in the trash. Was wondering if anyone else had this bad of effects but that they did go away after a certain amount of time. I have been on wellbutrin before and the side effects were bad but did wear off after about a mont F 33 6 days
30 mg 1X day
6/27/2011
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 1  Lower back pain and arthritis I was great when I first started taking it, about a month later I lost my sex drive completely. Then about the 3rd month I was having my menstral cycle almost every day the 3rd and 4rth month I had maybe 3-4days I didn't have it, month 5th and 6th, had 2 days that I did not have it. My OBGYN said was cymbalt I had seen my doctor around the 3rd month because of my sexual drive got lost we went down to 30mgs. This is the ending of the 6th month I have stopped it cold turkey per dr since I was on the 30mgs, I am currently having Vertigo so bad that antivertigo medication is not helping went to the hospital this weekend cause i'm working on 6 days of vertigo, I can barely walk straight let alone drive. How long do i have to deal with this withdrawl? oh yeah i have lapse in memory, 30lb weight gain, swelling of both legs, and horrible leg cramps all night too. Since stopping the meds i have been a horrible mess with VERTIGO,crying and mood swings, not to mention wanting to kill myself on a I was at my wit's end with pain, Cymbalta seemed to be the wonder drug. I don't know the proper way of coming off this drug it appears from all the post there is none. At this point i'm going to loose my job because of this I have a 23 mile commute one way, and for the safety of myself and other's i can not drive with this VERTIGO i can barely sit up at times. F 37 6 months
60/30 1X day
6/27/2011
 2  Fibromyalgia Loss of appitite, sleep problems I am taking the highest dose of Cymbalta and I find it helps a bit. It sometimes keeps the pain to a slow moderate roar. This is the last medicine that I can take for Fibro. I have no appitite and have sleep problems. F 40 5 months
120 1X day
6/19/2011
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 1  Pain Management Psychotic break Combined with Lyrica - Baker Acted - horrible!!!! F 51 25 days
30 1X day
6/19/2011
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 3  Fibromyalgia increase in appetite, sleep 16 to 18 hrs day, Helps pain immensely, but I'm zonked out most of the day and when I'm up I'm eating like a hog. F 65 40 days
60mg 1X day
6/15/2011
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 1  Depression Was on 60 mg which gave me panic attacks and nightmares. Went down to 30 mg. Started crying every day and feeling suicidal. In the process of withdrawing from this medication which is INCAPACITATING. Diarrhea, stomach ache, dizziness, shortness of breath, extreme fatigue, headache, brain zaps, you name it, I have it. Dr. then gives me Prozac to combat withdrawal which is only working to the point where I can get out of the house now, I'm not bedridden like I was last week. Don't take this drug it's POISON. F 37 90 days
30 mg 1X day
6/7/2011
 1  Chronic migraine, depression Loss of motivation, loss of energy, sleeping all the time. Weight gain - probably about 20 or 30 lbs. Not helpful for depression. The withdrawal from Cymbalta (even with a very slow taper which included opening the capsules and splitting the dose, as recommended in a 2009 FDA report) was awful and incapacitating. It took 3 months to get off of it, and those months were awful. Severe nausea, vomiting, dry heaves, sweating, regular headache every day, severe muscle cramps and pain, NIGHT TERRORS and HYPNAGOGIC HALLUCINATIONS, liver pain, severe itching and tingling, "pins and needles." The FDA report states that doctors are not properly informed (or misinformed) by Lilly about the proper tapering process, and the side effects of tapering off of this medication. My doctor thought I was nuts, but there are many online forums dedicated to support for patients coming off of Cymbalta. THIS SHOULD NOT BE NECESSARY and LILLY should INFORM DOCTORS of the DANGERS of the WITHDRAWAL from this medication. After going through similar experiences from Effexor, I will NEVER take another SNRI; I will stick with the SSRIs. F 28 2 years
60 mg 1X day
6/2/2011
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 2  (drug resistant) major depression Constipation was the worst side effect, as it has been on most SSRIs. Some dry mouth, weight gain and sugar cravings, extreme tiredness, lethargy, excessive need for sleep. Memory loss and poor word retrieval. Not effective for extreme anxiety, but definitely takes the edge off. In all fairness it can be hard to determine which effects are directly related to the drug, and which are due to your own chemistry. I took this drug both alone (for 2 years) and in combination with other meds (such as welbutrin). I ranged from 60g/day to 120/day over 4 years. I was at a place where I was borderline functional, and didn't want to mess with that regardless of still having major depression. But I think I can do better so I'm making the switch to an MAOI (not for everyone) and withdrawing from cymbalta. Withdrawal is NOT fun, so taper off over a few weeks and prepare for a week or two of utter uselessness. F 32 4 years
60 1X day
6/1/2011
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 4  anxiety, depression, nerve pain constipation, high blood pressure when angry people need to work through the first few days F 41 3 months
60 1X day
5/26/2011
 3  fibromyalgia and severe depression. HORRIBLE weight gain.i have gained AT LEAST 25 pounds in the last year(15 in the last few months).i went from a size 4 to an 11! the weight is all in my belly and thighs.constipation,a marked change in the ability to orgasm,as well as the intensity,lower sex drive and feeling emotionally "disconnected".i took myself off of it once but within 2 days of not taking it i was in the fetal position sobbing,as well as frequent outbursts of "rage".the medicine DOES help my depression.it works better than any other rx med. i have tried,but the weight gain is proving to be too much.i was taking it twice a day,but reduced it to once a day,thinking that may help with the side effects,but it has not helped. personally,i think the benefits outweigh the side effects.i think every drug affects everyone's body differently.this caused weight gain with me,but may not with someone else.just like with any other drug on the market,it will affect each person as an individual and when you take any type of man made drug,there are ALWAYS side effects.one word:marijuana.God's natural cymbalta.it truly is a miracle drug.i am not pro-drug,but i am pro-natural,especially when it works.good luck,all! :) F 41 5 years
30 1X day
5/25/2011
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 1  Irritable Bowel Syndrome/Anxiety At the beginning, shoulder pain. Bowel changes. Constipation and then horrible diarrhea. Increase in flatulence. Over time, increased need to urinate, with flow greatly DEcreased except in the morning when it is extreme flow with extreme urgency. "Fog" feeling, definate change in short-term memory. Disconnected feeling. WEIGHT GAIN!!! Not immediate, but around month 4, was like overnight, gained 10 pounds. No change in diet, other than maybe a DECREASE with an INCREASE in physical activity. Midsection focused gain. Extreme lethargy, at points, like to the point of narcolepsy almost. Trying to wean myself off now. In the beginnigng, I think it worked GREAT! Definate change in anxiety, in a good way. I noticed a plateau-ing if not a decrease in effectiveness with an increase in side effects. An odd thing, when I first went on, I had intense right shoulder pain (I have a rotator cuff problem). As I just went down to half dosage 5 days ago, today (day 5), that intense shoulder pain is back. Feels like a pre-cursor to frozen shoulder (which I've had before). Had a BIG weight gain, 10 pounds in like 2 weeks. It literally appeared nearly overnight, and all focused on the midsection. The fatigue in the last month or two has been intense. I definately noticed a change over time, and the longer I stay on it, the worse I seem to be feeling side effects-wise. I'd rather live on Immodium than deal with this so I'm trying to wean off. I wouldn't recommend this drug to anyone. I don't think enough research has been done on it. I did also see an increase in blood pressure. I'm concerned what else it's doing to my body. F 42 5 months
50 1X day
5/23/2011
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 4  depression and neuropathy Tired most of the time, no sex drive. Very recently I've begun to experience joint pain, muscle aches, mostly in my arms. Like a weakness. My life situation has changed for the better and I don't feel I need an antidepressant. I plan on contacting my doctor in order to get off the drug. I pray I don't experience anywhere near the side effects I've been reading about on this website. THAT scares the hell out of me. Wished I'd have been told of this prior to taking this drug. I had the vivid dreams, dizziness and nausea in the beginning as my body adjusted to the dosage. It has been GREAT for my depression and helpful but not as great for my neuropathy. F 54 2 years
60 mg 2X day
5/20/2011
 1  Severe depression Loss of appetite, constipation, tiredness, loss of emotional capabilities aka zombie, general numbness, lack of sexual interest when I finally stopped taking this stuff after losing five years of my life to it, I now have joint pain that makes it difficult to do anything. I am very frustrated that this stuff has permanent consequences in joint pain which I have never experienced before. M 42 5 years
60 1X day
5/18/2011
 1  pain, neuropothy, etc No appetite(did not eat for foir days) vivid nightmares, no pain relief, anxiety, irritability, severe diarreaha I was only on cymbalta for 30 days.my side effects were so severe I insitisted on discontinuing it. It also counteracted with my migraine meds (maxalt) which could have caused coma/death. upon discontinuing it, I experienced major withdrawl symptoms which were never explained to me. Brain "zaps"- which feel like being electrocuted in yuor brain, and can shoot through your limbs. Even worse irritability. Crying spasms. (I have taken antidepressants in the past and NEVER gone through anythong like this!) And after 4 days I was hospitalized for a major asthma attack,. Had asthma since childhood but NEVER had to go to the ER before. Even they told me cymbalta was evil poison. I would not suggest this med to anyone who has remaining choices. I understand many here are suffering from extreme depression, but do not take this until all other options have been exhauseted. This stuff is poison.it also raises your blood pressure. Be careful. F 32 30 days
30 mg 1X day
5/17/2011
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 4  Depression The highest I can take is 30 MG. It is helping better than other antidepressants. I think it makes a difference because of the time-released capsule; I have never had a time-release antidepressant or any time release drug. It is working reasonably well, but underlying depression is always there. I recommend this drug F 70 10 months
30 MG 1X day
5/16/2011
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 3  headache/depression lack of appetite, probable constipation and diverticulitis attack FELT great on this medication, depression lifted quickly and headaches gone in 3 days. However the longer I took it the more hyper I got until I was unable to sleep and felt like I drank 20 cups of coffee. Had to stop due to inability to sleep, severe constipation. Tried much lower doses but became hyper almost immediately upon starting med F 51 1 months
25mg 1X day
5/16/2011
 1  depression loss of tenderness and empathy for others. Talked alot more, connected deeply alot less. Got alot done, lost alot of contact with people I loved. Emotional depth gone (the good and the bad). F 37 3 years
2X day
5/16/2011

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