CYMBALTA Reviews (DULOXETINE)

Average Rating: 2.7 (2745 Ratings)

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 ANTIDEPRESSANTS

 Type: Rx Drug

  

CYMBALTA  (DULOXETINE):  Duloxetine is used to treat depression and anxiety. In addition, duloxetine is used to help relieve nerve pain (peripheral neuropathy) in people with diabetes or ongoing pain due to medical conditions such as arthritis, chronic back pain, or fibromyalgia (a condition that causes widespread pain). Duloxetine may improve your mood, sleep, appetite, and energy level, and decrease nervousness. It can also decrease pain due to certain medical conditions. Duloxetine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). This medication works by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in the brain.   FDA Approval Date: 2004-08-03 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on CYMBALTA: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR CYMBALTACOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 5  depression. I have constipation and a pain in the stomach. I take the tablets with food to help my stomach. I get blurred vision and very often feel that I must go to sleep. Having said that, I have no doubt that I would have commited suicide if I had not had these tablets. I had been on various different things previously , all different dosage etc, none of them really helped until I had this drug. I developed 'extra' side effects when I first started taking a 60mg dosage once a day, I saw my psychiatrist and was told that the problems had developed as my body was getting used to the drug (after about a year) and so it was not so effective. I have been fine since - with side effects listed - on the big 120 dose. F 37 2 years
120mg 1X day
4/6/2011
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 3  Depression Oversleep, flat, unemotional feeling. No weight difference. A few nausea spells initially with vomiting. After initial side effects, not much I don't know how to feel about this drug. It is my first anti-depressent. I started taking it for a month and I felt great; but i needed to sleep way too much. I went off it, and felt fine for a while, but then hit a low as I had never had before. I am back on it now, and it seems to be working in a sense. But I don't feel much of anything at all. Cognitively better, sleeping too much can be a problem. Tough to gauge. M 20 4 months
60 1X day
4/5/2011
 1  fibromyalgia/depression/anxiety was not effective at all. Worst withdrawal I've ever experienced. Patient beware and informed; read about other patient experiences. Doctor was clueless and oblivious to severe withdrawal. Has made me think long and hard about going on anti-depressants again. I've tried many. When I started it, I thought any drug was worth trying for Fibromyalgia with all it's horrible symptoms. Not anymore! F 48 8 months
60 1X day
4/5/2011
 4  depression When I started cymbalta I was a new woman. My boyfriend was very much impressed at my new attitude. I used to walk for 1/2 hour on lunch and found it really helped my lower back pain. However it does have sexual side effects. If living without orgasm is ok with you, then no worry. But in a sexual relationship it can be quite frustrating... and I mean FRUSTRATING. But with a opening up and open to add some fun toys, all can be well. I have not seen any weight gain. or loss :( oh well. Dont let the t.v. commercials with their long list of side effects scare ya off. Its a very good antidepressant. WARNING...DO NOT STOP TAKING WITHOUT CONSULTING YOUR CAREGIVER FIRST. I suffered every mood swing possible. Even consulting a pharmicist inregards to my mood swings, he had not know of it...so please consult your m.d. and good luck F 49 3 years
20-30mg 1X day
4/4/2011
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 1  RA Fogging, Shaking legs arms and hands. Feeling of lonleness for no reason. scared one minute fine the next. zombie like, extremely tired! This is the strangest drug i have ever taken. It takes away all the pain compeltley, too bad it makes you stupid!!! im on it right now and dont even know if i am spelling correctly. I feel like they need to do some more reascearch on it, because if you ask me IT IS DANEROUS, ANYTHING THAT HAS TO POWER TO TAKE OVER YOUR MIND , BODY, AND YOUR PERSONAILTY IN THE WAY THIS DOES (A BAD WAY) IS PIOSION!!!!!!!!!!!!!!! F*CK CYMBALTA!!!! F 21 4 days
30 MG 1X day
4/2/2011
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 3  major depressive disorder night sweats, lack of libido, ringing in ears ,increased appetite, insomnia, headaches, racing heart, blurred vision I must admit that in the beginning cymbalta actually helped regardless of the side effects , BUT I was at rock bottom with no way out but up.I finally felt tired of playing the "empty my pockets for pharma" game and approximately 2 weeks ago I quit cold turkey. I hope the withdrawals do not destroy my marriage or my job. I would NEVER recommend this product BECAUSE of the extreme effects of withdrawal. Its been a nasty ride & its not letting up. I'm glad this Rx was & is helpful to some, but I actually would have quit it long ago if it weren't for the wicked withdrawals. Time for me to just suck it up & move on. F 43 4 years
60 1X day
4/1/2011
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 3  Anxiety, Depression Within first 2 weeks - nausea, bad gag reflex and loss of appetite, 15 pound weight loss within 1 1/2 months. Within 6 months - little or not anxiety, no depression, the drug worked wonderfully. 6 months to 1 1/2 years: depression came back, feeling unmotivated and lazy, rapid weight gain of 30 pounds, insomnia, feeling foggy At first this worked wonders and it appears it worked well for others, besides the nausea my anxiety was practically gone. This coming from a person who had 2-3 anxiety attacks a day. I lost about 15 pounds in a month, i believe this is due to the loss of appetite and nausea. After about 6 months is when the underlying side affects started to appear - weight gain, (about 30 lbs, not including the 15 pounds i had lost and gained back) distended stomach, sweating constantly, cravings for alcohol, laziness (i wasn't tired, just didn't feel like doing anything) and getting lost in thoughts for long periods of time. I started having trouble focusing on one thing. I had to play solitare and watch my fav shows at the same time or else i'd feel restless. Now that I am trying to wean myself off, i am having trouble sleeping, headaches, extreme fatigue, and I'm even slurring my speech. I gave it a 3 because it helped me when I needed it. I am in a better place and in a great relationship and I don't want this drug in my body anymore. The side effects are what bother me now, not anxiety. I want to feel like "me" again without the drugs. F 30 1.5 years
60 1X day
3/30/2011
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 1  Psoriatic Arthritis, Fibromyalgia fatigue, headaches, memory problems, weird dreams, decreased appetite, weight gain, high blood pressure, loss of motivation, zoning for hours, confusion, mood swings, feeling unsteady, dizziness, always feel "lost." Careless feeling, and anti-social, personality change, light headed, co-dependent upon Cymbalta. Yes, this does work for my muscular and joint pain. But, consequently I'm losing my mind in the process. I am weening off Cymbalta now. I informed my Doctor again, this time I decided to take my family in with me to tell him how different I am now. NOW he listened to me. (Pharmaceutical kick backs!!!) I also called Cymbalta's 1-800-545-5979, I spoke with a women about my side effects. All she could explain to me was, studies done on Cymbalta. I was frustrurated with her lack of interest or information given! So, here I am. I believe Cymbalta is dangerous. F 25 2 years
30MG 1X day
3/28/2011
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 4  Treatment resistant depression A little dry mouth, headache but nothing that lasted more than 3 months. This med has worked great for me. I occasionally still have a bad day or two but that's normal for everyone. Recently, it started pooping out (depression/anxiety has come back) and I'm bummed. I also take 150 mg Lamictal to augment. Dr. has added Lexapro and will post on that after a month or so. I M 37 3 years
60 1X day
3/24/2011
 2  Anxiety Nasuea if I ate nothing After taking cymbalta for a couple of months I noticed that my urge to drink increased rapidly and dangerously. Also when I drink I black out and become violent. I do not remember where I have been, and find myself almost to have a second identity. I believe that Cymbalta is a dangerous drug. F 29 9 months
60 mg 1X day
3/24/2011
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 1  depression and associated pain constant constipation with no relief from stool softeners, laxatives, or enemas. Weaned off to 30mg for one week then stopped totally. I experienced strong vertigo, pain in my joints, severe nausea, legs jerking at night, heavy brain fog, constant dizziness for two weeks. Now, three weeks later, still have legs jerking at night and some dizziness. I feel I took a serious poison. They "don't know" how it works to block pain. However it works to block mild pains, it must be very serious and strong since the withdrawal is severe, intense, long lasting, and affects the entire body. My doctor never warned me about the withdrawal effects. NEVER TAKE THIS POISON. F 44 2 months
60mg 1X day
3/24/2011
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 3  GAD feeling of Brain racing, dizziness, decreased appetite, insomnia Have not had need to take xanax since starting F 49 5 days
30mg 1X day
3/23/2011
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 5  depression I have had muscle aches, especially in my arms. However it is the best that I have ever had for my depression, I don't feel like I'm in a fog, I lost my youngest son 3 years ago and if I had not been on my Cymbalta I don't know how I would have made it. M 45 4 years
60mg 1X day
3/21/2011
 5  Depression I love Cymbalta. No negative sexual side effects, no brain zaps - but I consistently take it. Definately not weight gain.. not sure on a decrease. Yes - you may have difficulty sleeping, I take Trazadone but have for years. I did a rapid decline on my cymbalta because I lost my insurance. I was on 60s and did a few days of 30's and quite. I didn't have bad withdrawal... I didn't think but about a week later I started having severe pain on my right back side. A few days later I was in the hospital with bilateral pulmonary emboli. I am a low risk person (no smoking, low weight, am on birth control) but I definately believe that my PEs were a result of the rapid decline in Cymbalta. I did have a body rash (Malasezia) and other symptoms of my body experiencing a pH or general shift. I also had a pleural effusion and was hospitalized for over a day. It was very very difficult to get my pain under control - they had me maxed out on narcotics. It was determined that the withdrawal of Cymbalta was giving me additional muscle spasms/tinges and I went back on 30 mg of Cymbalta to help with my level 12 pain - and it worked... Weird but true. F 39 3 years
60 1X day
3/20/2011
 1  Bipolar mania None but could have exasperated the symptoms from the two other drugs I was taking during that time. Used for around a month and a half in conjunction with Geodon and Saphris. Didn't seem to do nothing for me so my doctor pulled me off the drug. I believe the dosage is correct. M 26 40 days
30 1X day
3/20/2011
 3  pain from DDD Inability to recognize insulin reaction; symptoms similar to hyperglycemia- dry mouth, thirst, nausea, lack of appetite; forgetfulness. Seemed to help pain better than any other med I've tried, even the half cap (15mg) I started with seemed to make a difference. Afraid to take it now, as I realized that it masks the symptoms I need to be aware of as a diabetic on insulin AND I forgot to take am meds and nighttime insulin yesterday. Forgetfulness is too dangerous for type one diabetes and for my vocation. Hoping not to have any withdrawal. Trying dry-needling by a PT for pain. F 48 2 weeks
60 1X day
3/19/2011
 2  Bipolar - mania At first really helped with my "lowest-lows" but then the brain zaps, ruminating thoughts, loss of sex drive, gained 15 lbs and I excercise and eat well religiously, high blood pressure, heavy sweating, zone out sometimes. Weirdest side effect-- The insatiable desire to drink alcohol! I've been a social drinker 3-4 a week, but then I started drinking everynight. I would drink an entire 750 ml of wine and get up the next morning and go to work with a slight headache and then think of it all day. I went to every other day for about 10 days and then stopped taking it about 5 days ago. Still can't sleep, racing thoughts, horrible dizziness/brain zaps, bloating (holding water) heavy sweating. But have stopped drinking completly and blodd pressure is going down. Hope the weight comes off soon. I think my bi polar ad Cymbalta don't mix. Tried prozac and lexapro too. No more anti-depressants for me. I'll stick to the lamictal... M 37 2 years
60 mg 1X day
3/17/2011
 2   M 56 3 days
1X day
3/15/2011
 4  Depression and anxiety Hot flush on whole body. Unable to sleep. Dry mouth. Shaky legs, feels like weak. Cymbalta makes me feel good. I never tried other AD. The worst is the hot flush I get when I took it before I sleep. After a few hours, I will be awoke by the hot flush in my body. I don't sweat. Just inside my body. My doc ask me to change it to morning and everything is fine now. I realize if I had hot flush, I just need to sweat it out by doing some excerise. M 30 1 months
30 MG 1X day
3/13/2011
 4  depression and anxiety jaw clenching. Nausea. Loss of appetite. The first two days, heightened anxiety. I am sad/scared to see so many negative reports! So far, this drug has helped me. Within a couple hours of taking it, I felt a bit better. The first two days I felt a bit more anxious, my brain was racing like crazy...but my mood was vastly improved. I got really nauseous the first day...I actually dry heaved...but I have a prescription for Zofran and that seems to really help.I have basically no appetite, but I am ok with that as my depression caused me to gain 50 lbs which I am trying to lose. The jaw clenching is beyond annoying though...I feel like I need to walk around with my mouth wide open to avoid doing it...hoping that will go away. But I do feel better, more energy,feeling hopeful about life for the first time in a long time. For the record...seeing so many negative comments initially scared the hell out of me...I would never say that a drug was poison and no one should take it...everyones body is different and your doctor prescribed you something because he/she felt that the benefits would outweigh the side effects. All ADs take time to get used to...all drugs have side effects. I would hate for someone to second guess their doctor because of something they read online. If you don't trust your doctor, then you probably need to see a new one. F 29 5 days
30mg 1X day
3/12/2011
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