CYMBALTA Reviews (DULOXETINE)

Average Rating: 2.7 (2745 Ratings)

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 ANTIDEPRESSANTS

 Type: Rx Drug

  

CYMBALTA  (DULOXETINE):  Duloxetine is used to treat depression and anxiety. In addition, duloxetine is used to help relieve nerve pain (peripheral neuropathy) in people with diabetes or ongoing pain due to medical conditions such as arthritis, chronic back pain, or fibromyalgia (a condition that causes widespread pain). Duloxetine may improve your mood, sleep, appetite, and energy level, and decrease nervousness. It can also decrease pain due to certain medical conditions. Duloxetine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). This medication works by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in the brain.   FDA Approval Date: 2004-08-03 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on CYMBALTA: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR CYMBALTACOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 2  severe depression no real side effects to start with,but slowly they are creeping in. frequent bowel motions,lack of libido(major)tired, not interested in life,increase in weight.sleeps alot. my husband is on this drug, im getting him off it asap. he's not interested in anything or anyone.he's put on weight, no interested in sex, sits on his chair and watches tv then falls asleep,very grumpy, his depression has stsrted to return. M 49 9 months
60mg 1X day
3/10/2010
 1  Panic Anxiety Terrible nausea along with stomach cramps. I feel as if I have a stomach virus but the symptoms came on within 4 hours of my first pill. Afraid to take another one and think I'll forget this drug. I barely slept last night from the fever like hallucinations I had along with terrible indigestion/heartburn. Not a nice experience. M 41 1 days
30 3X day
3/10/2010
 4  depression/anxiety less appetite It seems to stabalize my moods. Not many neg.side affects. I'm glad I am on it. F 27 6 months
60MG 1X day
3/7/2010
 3  ibs, anxiety, depression A bit anxious after first dose. Then some diarrhea the next morning, which upset me because I already have IBS to begin with. But it subsided to more or less back to my "normal" ibs symptom. Then some nausea, dizziness, and blurred vision, but nothing terrible. These effects were mild but I could feel them. If I skip a day the side effects seem to lessen. Both my primary and GI docs want me to try this to relieve my anxiety and depression brought on by 2 plus years of ibs symptoms that will not go away, the worst of which is chronic abdominal pain. They told me it is good for both pain and depression/anxiety. So far no change in the ibs pain. I do notice a lower anxiety level, but I can't deal with the abdo. pain, I hope this helps. I wanted to post because I saw that someone asked about 20 mg. doses -YES, they DO make it in 20 mg. Ask your doctor to start you on this lower dose if you are sensitive to side effects. F 40 7 days
20 mg 1X day
3/5/2010
 3  Anxiety nausea, slight headache and sweating. I understand this is just the first day. I wasn't sure I could deal with the nausea but it seems to be getting better as the day goes by. I have noticed a great deal of alertness with me throughout the day and full of energy hopefully this will continue. I will respond back after a few more days. VERY worried about Weight Gain! M 39 1 days
30 1X day
3/5/2010
 1  Depression dry mouth, insomnia/vivid dreaming, anxiety, confusion, dramatic negative mood change ending in suicidal thoughts. I was diagnosed with depression almost 40 years ago and have been periodically treated for it with limited success. Following a truly horrific crash, my former psychiatrist (a horror story in its own right) prescribed Cymbalta after a series of other anti-depressants in combination with various anti-psychotics failed to make a dent in the depression.

About two weeks after starting the drug, my mood took a sharp turn for the worse. I became rapidly and progressively more anxious, confused and depressed. My idiot doctor told me to ride it out and those symptoms would go away, and her idiot patient believed her. Instead, about two weeks after I started to go downhill I wound up voluntarily committing myself for three days because I became suicidal.

The psychiatrist at the hospital stopped the drug and about a week later my mood began to improve somewhat, but it took about six months for me to get back to where I was, which wasn't all that great, before I took the drug.

Everyone's experience is different, but that was mine. I hate the stuff.

M 55 30 days
60 mg 1X day
3/5/2010
 1  Fibromyalgia, Depression I was extremely nauseated and debilitated and had had similar reaction to gabapentin-something else they put me on. I'm not going through that again. I read so many negative comments on this website that one day is enough to know-forget it. I've been detoxing my body and now also see a naturapath. We weren't made to have all of these chemicals in our bodies. It is amazing when you get rid of this stuff, how reduced pain can be. I never expect to be pain free but am trying to change my life to pace differently and not have to be "Superwoman" any longer. Medications can poison you and many of you sound as if this did just that. I'm not going through that again. Thanks to all of you for helping me make the decision to stop before I really got going. F 56 1 days
1X day
3/5/2010
 3  For depression and fibromyalgia Insomnia, constipation, weird dreams, loss of appetite, absolutely no libido, did not even like to be touched by my boyfriend. I was taking Celexa 20 mg daily for depression, which was working for me. Doctor wwitched to Cymbalta to help with my fibro which was causing me alot of pain. I found Cymbalta definitely helped my fibro pain. The first few days of taking it, I felt okay. But it definitely messed with my sleep. I woke up every night at 2:00 am, and couldn't go back to sleep for 2 hours. I did not suffer from insomnia previously. This side effect did not change for me throughout the month of being on this. Also had no libido whatsoever from day one, cymbalta killed it. Didn't have this problem on celexa. After the second week of taking this, I then went from feeling happy, to feeling zombie-like. Like I was in a mental fog, and felt out of it. I got angry at the slightest thing, which is not normal for me. While this drug did help my fibromyalgia, it did not help my depression. Also gave me really weird, scary dreams every night. I'm going back to Celexa, and dealing with my fibromyalgia a different way other than a pill. F 28 1 months
30 mg 1X day
3/3/2010
 2  nerve damage after spine surgery Intense nausea, yawning, complete loss of appetite, weight loss, unable to sleep at all F 38 7 days
20mg 2X day
3/3/2010
 1  Depression/chronic pain First-time-ever migraines, nausea, vomiting. 1.7.10: 20mg, 1.27.10: 30mg, 2.18.10: 50mg, 2.23.10: 60 mg. No help for mental or physical pain. Side effects began 3 days ago. Symptoms start like clockwork 2 hrs after taking med. Have to break up capsules now to wean myself off of this gradually to avoid withdrawal symptoms. Doc won't respond to my phonecalls about this development. F 55 55 days
60 mg. 1X day
3/2/2010
 4  Severe Depression, sadness, pain Immediately gave relief of peace, loss of depression, no more sadness, and overall terrible body pain disappeared. I felt happy for the first time in more years than I could remember. But I am so tired, all I want to do with my spare time is sleep and Now I am suffering severe anxiety daily as never before that I try to treat with Clonozpam. I am worried that the anxiety attacks will cause me to do something totally illogical and dangerous to myself. Don't know what to do, Don't want the depression or to have someone else step in to act "on my best interest" but need to resolve anxiety issues. No trouble sleeping; had been on Ambien CR whiich had topped working, but now I sleep all the time. Is there a smaller dose than 30 mg that might lower the anxiety and sleepiness? F 58 20 days
30 mg 1X day
3/1/2010
 2  chronic depression and back pain Was like a zombie, sick to my stomach, heart racing, and then major difficulting urinating. Was taken off. On the plus side it did take away 100% of the chronic back pain from my accident but the side effects were not a good trade off. M 53 4 days
30 1X day
3/1/2010
 4  anxiety and depression Like most drugs of this type, there are side effects when first starting such as insomnia, tired feeling, sweating, and these can be bothersome. Believe me they do go away after a week and it is definatly worth hanging in there. I was on this med for 2 years and foolishly decided to stop. Without noticing, I fell back into a major depression. See additional comments. I just restarted Cymbalta after being off of it for 6 months. I started using 60mg per day almost 2 years ago for anxiety and slight depression. Wow I had no idea how well it was helping me until I stopped taking it. Within a month, I went into a severe depression. I tried starting Cymbalta again, but developed annoying side effects. I tried 6 other SSRIs and had the same trouble. I thought I was going crazy. My Dr could not figure it out. He knows me and was shocked that I had become so severly depressed and intolorant to everything. I had always taken Xanax as needed for Panic, and even Xanax stopped working. Anyway, Dr prescribed Lyrica which is rather new for depression, and although it slowly helped, I developed a rash from it even at a low dose. He next tried Lamictal, and after tapering up for over a month, at 150mg per day I was feeling slightly motivated to leave the house, but the med made me short tempered, nasty, did not help anxiety and the crazy side effects like acne, weight gain, mouth sores etc. were not worth the benefit. The worst part of Lamictal was how manic it made me. I think Lamictal is probably great for Bi-Polar disorder, but I am not bi-polar. Anyway, Out of desperation, I decided to force myself to deal with the side effects of starting the Cymbalta again. The first night was hell not sleeping, stomach ache, dizzyness blah blah. I am so happy to report that after a couple of days telling myself, Just deal with it, I am starting to feel great again M 41 5 days
30 mg 1X day
2/28/2010
 2  neuropathy Insomnia, depersonalization, weight gain, lack of activity. Very hard to get off of. Brain zaps, crying, nausea, etc. F 52 11 months
20 MG 2X day
2/27/2010
 4  anxiety initially had dry mouth (could be due to combo of cymbalta and voltaren), headaches, racing heart. All have subsided. feel cymbalta has really helped lessen my anxiety with few lasting side effects. When things bother me now, I'm more able to bounce back to a positive outlook. Feel more like my old self. F 39 2 months
60mg 1X day
2/26/2010
 1  bi-polar/anxiety extreme vertigo/dizziness, headaches, brain "shocks", extreme fatigue, unmotivated, dull thought process cymbalta worked great while on it, but missing even one dose is where the problems begin. i have been off cymbalta for 7 days now and i regret ever going on it. i worked with my doc to ween off, yet i still have not been able to function as a mother or wife. the vertigo/dizziness is unrelenting! i still can not drive a car or even stand too fast. if i move wrong my body "zaps". i believe most of you know what i mean. i have began crying for no reason. the only good news from stopping cymbalta is i have motivation to get going, too bad i physically can not do much but lay on the couch, wishing i could do dishes without falling over. unless you plan on using cymbalta for the rest of your life, stay away from it! F 29 1.5 years
60mg 1X day
2/24/2010
 5  Nerve Pain, Mild Depression Flu Like Symptoms first 2 days of taking medication It has worked wonders for me, I had become depressed because of severe pain due to back injuries from a car accident. Not only did it help with the depression but it got rid of my back pain. I have been able to start working out again, and my grades have improved because I feel motivated again. F 21 2 weeks
60 1X day
2/23/2010
 5  depression Flu-like symptoms when starting A MIRACLE for me because my eating disorder behaviors have disappeared. I am now eating like a normal person and am losing weight without following any "plan," just eating when I'm hungry. I never want to be without this drug. F 49 35 days
60 mg 1X day
2/22/2010
 1  Depression Fatigue, Dizziness, Laziness, Lack of motivation, "Brain shocks" I can't say that I truly ever felt a significant change from the time I started taking Cymbalta to this day. The drug has been nothing but an inconvenience for me. I'm an extremely active individual, and thought process at my job is critical throughout the work week. By missing one dose of this medication, you sacrifice an entire day's worth of work, as you're completely paralyzed from thinking critically. If that doesn't deter you from taking the drug, tag on the inability to perform sexually. This, along with lack of motivation to take on any responsibility whatsoever are the reasons I've decided to come off the drug. I blindly listened to my doctor without researching the consequences. Unless you are SEVERELY depressed, I would advise you to refrain from being prescribed to this medication. Turn to God and your loved ones for support in coping with depression, not a pill!!! M 24 1 years
60 MG 1X day
2/22/2010
 4  neurotic pain and depression not sleeping fatigue blurry vision my mind not so sharp I had 2 memory losses which I never had before. tomorrow is my doctors appointment,so will know more F 78 3 months
60 mg 1X day
2/21/2010

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