CYMBALTA Reviews (DULOXETINE)

Average Rating: 2.7 (2744 Ratings)

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 ANTIDEPRESSANTS

 Type: Rx Drug

  

CYMBALTA  (DULOXETINE):  Duloxetine is used to treat depression and anxiety. In addition, duloxetine is used to help relieve nerve pain (peripheral neuropathy) in people with diabetes or ongoing pain due to medical conditions such as arthritis, chronic back pain, or fibromyalgia (a condition that causes widespread pain). Duloxetine may improve your mood, sleep, appetite, and energy level, and decrease nervousness. It can also decrease pain due to certain medical conditions. Duloxetine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). This medication works by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in the brain.   FDA Approval Date: 2004-08-03 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on CYMBALTA: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR CYMBALTACOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 1  Depression This is the worst drug I have ever taken. Lost interest in everything. More depressed,weight gain,ringing in my ears. DO NOT TAKE THIS DRUG! Very hard to get off of. M 42 2 years
12/13/2007
 3  Depression Anxiety Constipation (cured with metamucil), longer to reach orgasm, nausea gone after the first three days. Overall so far better tolerated than other drug I dont feel like I am doped up or in a daze the first few days I did but it went away. My anxiety has decreased not much of a change in depression but it has just been two weeks at 30 mgs. I will post again in two weeks M 30 14 days
12/12/2007
 4  Depression Insomnia the first few days, stomach upset (also went away), a little bit of that "I drank too much coffee" feeling. Delayed orgasm (actually a good thing for me...). Can't drink alcohol without feeling a little sick (which is also probably a good thing for me... I'll probably lose weight just from not drinking.) I've been taking this for about two weeks now, and so far so good. I think the key is taking a very small dosage. I actually opened up the 60mg tabs, and just dip my finger into the beads and take about 10-15 of them (probably about 10mg). It works great. Sex drive is back, orgasm is delayed and better, no noticable weight gain/loss, but it has made me enjoy excercise again. Eliminated my anxiety issues when talking to people, and I am new person at work. Actually optimistic about my future! It has helped me deal with ADD symptoms also. I have been taking for a short time, and I am worried about withdrawals, but so far so good. I took 60mg the first day and that was a BAD IDEA... couldn't sleep, jittery, upset stomach, etc. My advice would be to start with a very, very low dose and work your way up. Just thought I would post a positive about this drug, because it is working for me. M 25 14 days
12/10/2007
 4  Fibromyalgia Sweating ("menopausal" type burning sensation & sweats), dizziness, fatigue, sleeplessness/restlessness. After taking the pill I get very dizzy and fatigued. This is followed by the burning sensation/sweats, and lastly sleeplessness. Noticed a dramatic change in my "normal" day-to-day pains the first 24 hours. As my dosage increased to 60mgs the dizziness and sweating increased. It is better to take this drug when you get home from work. As far as my bad days, the flare-ups, it didn't take those pains away. Also helped the anxiety and depression I began to suffer with since the Fibromyalgia. I am still trying to find a good time of day to take this drug. I just started taking this drug a few weeks ago, so it might begin to affect my flare-ups, but for now I still feel the flareup pain. F 27 3 weeks
12/10/2007
 2  Neuropathy uncontrolled shaking, brain zaps, short-term memory loss, the worst though was feeling detached. Jekyll and Hyde effect. I could rationalized why I shouldn't do things, but I could not control my impulses.. Which typically meant cutting myself. I have never had esteem issues or contiplated suicide. However on this drug, I became obsessed with it. Make sure you are watched carefully when ramping up on this drug. It completely changed my personality for the worse. However, many people have benefited from the drug, including my own brother. So body chemistries vary. JUST MAKE SURE YOU HAVE SOMEONE WATCHING YOU and you are following up with your doctor F 35 2 months
12/10/2007
 4  Nerve pain/Post-Infectious IBS First week, very sleepy, loss of appetite. Since then great until last six months. Trouble sleeping, weight gain, jaw clenching/teeth grinding, sensitive to alcohol(heart pounding, headaches) afternoon fatigue. I was given Cymbalta 2 years ago to treat symptoms from a mild parasite infection(giardia)that was undiagnosed for a long time. It caused IBS and a lot of nerve damage/pain through my stomach and intestines. After 5 years, it was the only thing that worked. I was like new in a week. In the past six months I've started feeling odd and having weird side-effects. I started on 20mg a day six months ago after being on 30mg for a year and a half. I'm considering splitting the pills into 10mg a day after the first of the year to see if it's time that I can go off of it. F 32 2 years
12/9/2007
 1  anxiety Irritability, unstable moods, anger, dreams of murders, blood and gore. Feelings of withdrawl before the next dose. Drug made me feel very unstable emotionally. although it stopped some of the jitteryness. the mood swings were horrible F 40 3 months
12/6/2007
 5  Depression ,Anxiety,ADD None I've been on about every SSRI available over the last 11 years with Zolft and Wellbutrin being my favorites until I started taking Cymbalta a week ago. So Far I really haven't had an real side effects to speak of. I'll update this post in the future if their are any changes. M 59 8 days
12/5/2007
 3  anxiety, depression, perimenopause Nausea and stomach cramping the first couple of days; was somewhat better if I ate small amounts of food frequently. It also made me very hungry when I first started it and whenever I increased dosage. I have found Cymbalta to be helpful in reducing my anxiety, but not as effective for my chronic depression. Before, I was starting to drink a glass or 2 of wine at night to reduce my anxiety. Now I don't feel any need to drink to reduce anxiety anymore. As for depression, I took prozac years ago, and found that much more effective in eliminating my depression. But Prozac also raised the threshold on other feelings, which I didn't like. Cymbalta seems to have a lower threshold in terms of blocking feelings. So I still get the good feelings, which I like, but unfortunately I also still get the depression. For perimenopause, at first it seemed to help reduce the emotional over-reacting. But it seems less effective in doing so lately. F 48 4 months
12/5/2007
 1  L4-5-6 Fusion C 3-4 herniation fibr Had none to mild side effects on 30 mgs. Started taking 60 mgs a week ago and have had horrible side efffects. Can not urinate without major concentration, extreme dry moouth to the point of taking a drink to chew up food, no taste buds, burning mouth, cold sores, blurred vision, light trails, stuffed ears, severe constipation, dizziness, mood swings, feeling like a space cadet, very anxious. Did not notice any symptoms on 30 mgs, but moving up to 60 mgs i have had a ton of side effects. I know its only been a week but I stopped taking the drug yesterday. I have problems, I dont feel like waiting it out. I am not depressed, but this drug made me weepy and moody. F 34 21 days
12/5/2007
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 3  Major Depression None yet! Haven't started... I have to say, after reading this site's and others about Cymbalta, I'm a bit freaked out in switching from Zoloft. BUT... I gotta say this... I would like to know what other medications those who have some of the horror stories here are on. I'm no doctor, but it seems like there are some combinations that would explain much of the issues above. Also, it seems as though this drug isn't a great treatment for anything other than depression/axiety. I know Lilly wants to get the old market penetration, but GEEZ... don't use a shovel when you need a screwdriver! If I have any of the issues I've read here, you bet I'll be back to let you know... M 43 0 days
12/3/2007
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 5  Severe, Recurrent Depression Weight Gain Switched to Cymbalta from Effexor XR & now I have energy, spirit, and just feel GOOD. I also take Wellbutrin & Adderall to supplement. F 26 2 years
12/2/2007
 1  Major Depressive Disorder dizziness, nausea, vomiting Please note- I only took this for one day, so not long enough to have any real effect from it. About two hours of taking the first dose I was dizzy, nauseous, and then throwing up. For the rest of that day I felt kind of tired and a little "out of it". My doctor said not to even try it for a second day. I think this med works very well for some people, but just use with caution if you are typically sensitive to medications F 28 1 days
12/2/2007
 1  undiagnosed nervous system problems palpitations and adrenal fatigue This drug should be pulled off the market. I was beginning to wonder if this drug was draining my adrenals. So I went on-line and began to read patient comments about the drug. It seems that what some people are referring to as "withdrawal symptoms," are really symptoms of adrenal fatigue and in the more severe cases adrenal exhaustion. Instead of just trying to "wean" off the drug, I would highly recommend contacting someone who knows how to treat adrenal fatigue. One such person is Dr. Wilson. He is an N.D. who practices in Arizona. He has a great Website. Just google adrenal fatigue. He has also written a book called, "Adrenal Fatigue the 21st century stress syndrome." Dr. Wilson also has a master's degree in pharmacology. Good Luck to all of you. F 36 3 months
12/1/2007
 4  Depression, anxiety A little sleepy at first, then dosage was increased from 30mg to 60 mg after the first week & I felt better. Loss of appetite, weight loss, a bit of a headache about an hour after taking it. This med has really helped me. I'm able to focus and this is one of the only anti-depressant meds that doesn't make me feel zoned out and spacey. (I've taken Wellbutrin, Lexapro and Paxil in the past with mexed results.) If you can deal with the initial side effects, which seem to subside, this drug is worth it. That's just my opinion. Good luck, everyone. F 39 30 days
11/29/2007
 5   at the end, although i'm not 100 percent sure that this is because of the cymbalta and not the depakote or seroquel, VERY erratic behavior, perhaps what was the start of my first mixed bipolar episode. either way, my depression was killed. i cannot overemphasize how elated i feel to have no depression since it was sooo incredibly deep. i had previously tried effexor XR, wellbutrin, lexapro, and celexa to NO AVAIL whatsoever. cymbalta kicks tail. M 20 9 months
11/27/2007
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 1  "bi polar/depression" OUCH - melt down not to mention the "feeling" like you need to piss all of the time before you pop this little critter in your mouth - do your homework!!! weight gain, sexual disfunction, sleeplessness, tired, depressed. The worst part is when you decide to kick this drug to the curb - you will need to rally your crew up - because you are going to need them. Suicidal - freak out - PAIN in the BRAIN. Advice is to up your cell phone minutes and txt messages because you are going to need to keep in serious touch. You will feel like writing a "step 9 type" suicide note to everyone you ever crossed paths with when you decide to get off of cymbalta F 35 9 months
11/27/2007
 1  irritability/depression Terrible smelly gas, sudden diarrea, nausea, very spacey, yet sort of wired at the same time. Headache upon stopping, all from ONE DAY! I am an extremely hearty person. Never get nauseous, not even when pregnant. I have never ever had this many reactions to a drug and I thought it was scary!! Last night, two days after I took ONLY ONE PILL of cymbalta, I had the worst nightmares I have ever had. SO real and so freaky and twisted I cant even talk about it. I have felt so groggy and had all this from only one dose. Needless to say, I did not take another pill, and will probably not try any other medicine either, not worth it! F 37 1 days
11/27/2007
 1  Depression Acute Urinary Retention following a dosage increase F 22 2 years
11/27/2007
 4  Depression, Anxiety Loose stools, gas, some fatigue soon after dose. If I miss a dose-irritability with long and vivid dreams. This medication definitely stabilizes me, but I'm concerned by how quickly my mood goes out of control with brain zaps when I go even 36 hours without a dose. Withdrawal is much worse than the condition I'm treating! M 38 1 years
11/26/2007

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