CYMBALTA Reviews (DULOXETINE)

Average Rating: 2.7 (2744 Ratings)

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 ANTIDEPRESSANTS

 Type: Rx Drug

  

CYMBALTA  (DULOXETINE):  Duloxetine is used to treat depression and anxiety. In addition, duloxetine is used to help relieve nerve pain (peripheral neuropathy) in people with diabetes or ongoing pain due to medical conditions such as arthritis, chronic back pain, or fibromyalgia (a condition that causes widespread pain). Duloxetine may improve your mood, sleep, appetite, and energy level, and decrease nervousness. It can also decrease pain due to certain medical conditions. Duloxetine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). This medication works by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in the brain.   FDA Approval Date: 2004-08-03 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on CYMBALTA: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR CYMBALTACOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 3  Depression, Anxiety Hair loss, Weight Gain, Severe tiredness / exhaustion At first this medication worked really well for depression and anxiety. Then I gained 20 pounds, had insatiable sugar cravings and I increasingly overslept. The tiredness is what is finally compelling me to get off this medication (although the weight gain is also contributing to this). I can't stand to sleep any more. I have spent most of the past year in bed. I am sleeping away my thirties. The sleeping and the weight gain are making me more depressed then I already was. Also I feel emotionally flat on Cymbalta. I haven't cried in over a year. I don't think I could if I wanted to. In short, I really needed this medication when I started taking it. Now that I've stabilized the side effects outweigh any benefits. F 32 1 years
60 MG 1X day
8/9/2010
 1  Pain Slept continually night and day for 4 days. 2 hrs after taking Cymbalta I started to tremble and shake. 4 days was not enough to see any pain moderation and no drug is worth being giving up life and being confined to bed. F 63 4 days
30mg 1X day
8/9/2010
Email
 2  depersonalization and depression Sleep disturbances (both insomnia and drowsiness). Feeling medicated and numb. More of that good old sexual dysfuntion and complete loss of libido! I tried this medication hoping it would be effective since I had good results for a time on Effexor (which of course is also an SNRI). Unfortunately it wasn't a good fit for me at all. More side effects than with any other antidepressant (and I've been on a slew of them). M 42 6 weeks
60 1X day
8/6/2010
 3  major depression, severe anxiety So far I feel kind of high and it seems like I can feel my brain if that makes sense. I am not sleepy at all - I feel wide awake. I have some nausea and loss of appetite. I was very surprised to feel so much from the very first dose. I am glad to feel anything because that means I dont have to wait 30 days for it to do what it is supposed to do. I am only on day 3 but went looking for feedback on what other people feel taking this medicine. It looks like it affects everyone differently from what I'm reading here. I'm hoping to experience the 'weight loss' side effect. Not liking the sound of constipation or hair loss though. I'm glad to know what to look for based on everyone's experiences blogged here. I have been on SSRI's before but never an SNRI. I think this medicine is making it easier to concentrate. F 34 3 days
30 1X day
8/5/2010
 2  Mild anxiety I'd say it had a mild effect on my anxiety; thoughts still mostly there, but butterflies not. MANY mild side effects: 1) Libido actually increased a bit, probably due to lower anxiety about things, though orgasms more elusive. Didn't bother me too much; usually had one "the next time" 2) Constipation, controllable with Fibercon. 3) Insomnia, despite taking first in AM. 4) Slightly blurred distance vision 4) Pretty sure my thinking isn't quite as reliable 5) Weight gain already. Given all the above, for only marginal benefit, I'm stopping. M 46 3 months
60 1X day
8/2/2010
 2  Back pain and sciatica Major anxiety, shaking, very tense (especially neck muscles), a little nausea M 49 7 days
30 mg 1X day
8/2/2010
 2  Mastecomy Pain Syndrome, Neuropathy Horrible Sweating, Memory Loss, Confusion, Loss of Libido, 10# Weight Gain Cymbalta has helped my pain. It has also helped me get to the point of being in a better mood, having energy and being able to exercise. This has been huge for me. If only they could develop these pain drugs without the horrible side effects. I am now at the point of having to decide to stay with it or try to go off of it because the side effects I listed are wearing me down. I just don't want that terrible pain back. F 51 8 months
20mg 1XD 1X day
8/2/2010
 5  depression ocd little tired, slow weight Gain. I was on concerta for ADD when a counselor recommended Cymbalta. This med has really helped with my mood swings, my anxiety, and every other negative aspect of my personality. I am a little concerned about the weight gain but it may be due to the discontinuance of the Concerta. M 43 15 days
60 mg 1X day
8/1/2010
 4  Bipolar Depression Jaw clenching, I was hospitalized at Four Winds for three weeks for depression. They put me on cymbalta. It has definitely helped tremendously with depression. I am grateful for this medication. M 20 3 months
60 mg 1X day
8/1/2010
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 1  depression 35 lb weight gain, stomach upset almost since day one of taking it, no sex drive, blurred vision, dizziness, etc. Decided to stop taking cymbalta and the withdrawals are HORRIBLE! I will never take this drug again and I will tell everyone who will listen to me not to take it. It is truly evil!! F 52 2 years
60mg 1X day
8/1/2010
 5  Neuralgia, Myofascial Pain Syndrome nausea Cymbalta is a wonder drug for me. I feel so much better on it, happier, able to do activities I'd given up on. The only side effect was nausea, but that was mitigated when I changed to taking it at night. I was on nortriptyline before which only took care of the shingles post herpetic neuralgia, but didn't touch the sacroiliac joints nerve pain that came up after a 3 level lumbar fusion, both are permanent nerve damage. The Cymbalta took care of both excruciating types of nerve pain. I also have myofascial fascial pain syndrome with trigger points in all major muscle groups. The Cymbalta hasn't touched the major trigger point problems but it has resolved the smaller triggerpoints and fascial pain such as on my ribs and chest. I still have the bad dry mouth that we thought was from the nortriptyline. But with the dry eyes and skin dryness, we are beginning to think that's sjogren's syndrome. F 56 5 months
30 1X day
7/31/2010
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 1  depression i feel high, my vision is blurred, i can't think or concentrate, i am always sleepy, but can't really sleep, dilated pupils, glassy eyes, diarrhea but sandy looking, sudden heat and pins on my back and head when I'm nervous. i bad taste in my mouth, dry mouth, constantly drinking though, and finally i have absolutly no appetite, even when i do eat it tastes like chemicals. this has been horrible! i wake up at all times in the night and then i can't get back to bed and then i wake up really early take a shower and then suddenly tired so i have to go back to sleep, and even after that sleep i have to take another one later in the day. the sleeping has been a vicious cycle. so i stopped taking this medication as of today, and i am so happy that i will not have to experience this any more. F 19 5 days
20 mg 1X day
7/31/2010
 2  depression/anxiety sadness,nauseau M 38 3 months
60 1X day
7/29/2010
 5  depression and pain from accident no bad ones, this was wonderful, except for cost I had to go off Cymbalta due to the expense. I have been off for 2 weeks and still have weepy, angry moments and the pain has returned. I hope I will be able to get help from something cheaper. F 63 3 years
60 1X day
7/28/2010
 1  I wasn't. I don't take drugs I don't see why all these healthy young people are on these dangerous drugs. Do you believe all the TV pitches about drugs? Are you that dumb? Being a little depressed or "down" is part of life. Find distractions, excercise, visit friends, do anything, but stay away from drugs. They will make you worse, not better. Our country is over prescribed on useless meds. Break away! Think for yourself!! Don't just pop a pill and think it will make things better. Sucks big time, but so do other drugs. F 67 0 days
0 1X day
7/28/2010
 2  anxiety nausea,weight loss, sweating regularly (like hot flashes, but more frequent and uncomfortable), inability to have an orgasm It was given to me to help with chronic back pain and anxiety. I do not like the feelings I am having. Feel a little zombie like, sweating (I normally did not) and do like the sexual side effects. F 54 3 weeks
30/then 60 1X day
7/25/2010
 1  depression/fibro loss of interest in everything, NO libido, WEIGHT GAIN(even though they say only 1% of people gain weight. If I forget to take, I get "brain zaps". I am tired of feeling like a fat zombie, no emotions either way, I am in the process of "withdrawing" from the medicine. I have read and have been told I will feel much better in a few weeks and like a "New" person F 44 3 years
60 1X day
7/20/2010
 4   Dizziness, lethargy, zero libido, nausea, massive weight gain, memory loss and impairment. Whilst this drug helped me to begin with I feel that the longer I am on it the worse I am becoming in regards to my memory, lethargy, libido and now anger is also becoming an issue. I have gained some serious weight with this medication and this is leading to deeper depression and embarrassment, I would not advise this medication as a long term solution but rather a short term helper. F 35 15 months
60mg 1X day
7/19/2010
Email
 4  anxiety/moderate long term depressi Headache and slightly hungover feeling if I forget to take it. Took zoloft for 10 years, when that stopped working, I tried Lexapro and then Effexor. Neither of which made a dent in my depression. Cymbalta slowly pulled me out of the darkness and I've developed a sex drive for the first time in 15 years. I am so very thankful that it works for me and believe that if you are on the edge of giving up, it is definitely worth trying. F 37 1 years
100 1X day
7/19/2010
Email
 4  Moderate Depression, Severe Anxiety Night sweats, constipation, taking longer to climax during sexual intercourse I am glad that I started Cymbalta before I came to this site. I have only been on Cymbalta for 10 days but I am already starting to feel so much better...I've gone years and years being depressed, sometimes severe sometimes moderately. The disheartening thing is that the people who are most likely to post on sites like this are the few that have had bad side effects. However, remember that everyone is different and out of ALL those taking this medication only 20-30% end up with severe side effects if any at all. Every person physiologically is different and processes meds such as Cymbalta differently. There is a balance...there are many who are taking this medication and have not had any side effects at all and even the ones that have, it has been worth the side effects. I am hoping that my experience with this med continues and that it gets more effective as time goes on. M 32 10 days
60 1X day
7/18/2010

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