CYMBALTA Reviews (DULOXETINE)

Average Rating: 2.7 (2745 Ratings)

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 ANTIDEPRESSANTS

 Type: Rx Drug

  

CYMBALTA  (DULOXETINE):  Duloxetine is used to treat depression and anxiety. In addition, duloxetine is used to help relieve nerve pain (peripheral neuropathy) in people with diabetes or ongoing pain due to medical conditions such as arthritis, chronic back pain, or fibromyalgia (a condition that causes widespread pain). Duloxetine may improve your mood, sleep, appetite, and energy level, and decrease nervousness. It can also decrease pain due to certain medical conditions. Duloxetine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). This medication works by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in the brain.   FDA Approval Date: 2004-08-03 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on CYMBALTA: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR CYMBALTACOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 1  Neurocardiogenic Syncope, Depressio Premature ejaculation, loss of sex drive, restless leg, zombie effect, sleepiness, loss of conscience, apathy, some kind of daltonism as I started seeing thing in other colors, lack of interest at work, home, family, entertainment. A total failure. I'm taking the 30mg pill and I have tried to quit twice... a horrible ordeal. The first time I stayed clean for one week (I couldn't get up of bed at the end); the second time I only lasted 2 days. READ the side effects and the withdrawal symptoms. Best of luck to those trying to quit. M 34 1 years
7/30/2007
 5  DEPRESSION & IBS NAUSEA, MILD VOMITING, SWEATING, DIZZINESS, FATIGUE, WEIGHT-GAIN, INSOMNIA ALL THESE WENT AWAY AFTER 3-4 DAYS I WAS IN A MILD DEPRESSION FOR 20 YEARS! I HAVE A NERVOUS STOMACH THE ONLY THING THAT HELPED ME LIVE NORMALLY WAS SMOKING MARIJUANA. I HAVE BEEN PRESCRIBED PAXIL, (MADE ME FEEL INSANE!!) & WELLBUTRIN SR (DID NOT DO A THING) I WAS PRESCRIBED 30MG CYMBALTA 1 MONTH AGO & IT HAS CHANGED MY LIFE!!! ( I WAS IN A MAJOR DEPRESSION, SELF-MEDICATING WITH BOOZE & COKE) -IM BEING HONEST. -ANYWAYS I HAVENT HAD A DRINK OR A LINE IN 32 DAYS!! MY OBSESSION TO USE COCAINE IS GONE!!!!! THIS IS INCREDIBLE! I FEEL SO GOOD. I SWITCHED TO THE 60 MG DOSE 2 DAYS AGO & THE BEGINNING UNPLEASNT SIDE EFFECTS ARE RETURNING AGAIN, SMOKING POT REALLY HELPS WITH THE NAUSEA. I FELT THE 30MG DOSE LEVELLING OUT AT A PLATEAU ABOUT 2 WEEKS AGO. I WANTED TO SEE IF THE 60MG DOSE WOULD FILL THAT VOID IN MY HEAD. I THINK IT WILL DO THE TRICK. I LOVE CYMBALTA, IT HAS TAKEN AWAY THE VOICES & FEARS IN MY HEAD WHEN I WAKE UP & ALSO MY CONSTIPATION & DIAHREA IS DECREASED BY ABOUT 75%. THIS MAKE MY M 35 32 days
7/29/2007
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 3  depression WEIGHT GAIN of 40lbs so far..talk about being depressed. Tried to stop cold, but after 4 days of not taking the meds I started vomitting and severe headaches..In the beginning I would get extremely tired, then dr added Welbrutrin 300mg with the Cymbalta 120mg for a "pick me up" this worked in the beginning, but eventually wears off and right back to being tired. I did notice an increase at night in my hunger/cravings. I really liked the results I had in the beginning, except for being tired. My PCP would not prescribed this med for me because her brother is a psych dr in Canada and was not approved for use in Canada. I am having a hard time dealing with the 40lbs of weight I have gained which is making me even more depressed than prior to starting the meds. I am going to follow up with my dr and see if I can try another med or stop so that I can get this weight off. I think maybe my body is used to it because I am having severe sucidal thought again and bouts of uncontrolable crying/panic attacks. Unable to deal with situations, feeling of numbness all over. F 35 2 years
7/29/2007
 2  depression, anxiety sleepiness, lack of motivation. Basically, it pooped out on me after about 6 months. Dr has added Wellbutrin to see if that will help. F 35 1 years
7/29/2007
 5  headaches sweating increases....at times....pin pricking hot feeling sometimes during the first two months...small vision problems at first...it really slows up orgasisms....when i want to have sex and a orgasism i just take half a capasule the night before otherwise it's all for the woman...you have to test it to see what your level is presribed as a remedy for headaches.... i don't know if depression caused the headaches or vice-versa but no more headaches and i'm much happier, not as gripey, don't hang on to things like i used to....i let things go.....this stuff is a real life saver...i didn't realize how i let things bother me...you just have to force yourself to get through the side effects.....it's worth it...... 57 7 months
7/26/2007
 4  back pain Sleepiness & yhanning. Debilitating muscle spasms in back. not possitive that spasms are from cymabalta but it does decrease sodium levels which inccreases the need for mor pottasium and lack of potassium cause muscle spasms.... F 39 6 weeks
7/26/2007
 5  Severe Depression absolutely none I had been crying non stop for about a month. Although I was on Zoloft, it was no longer working for me. My doctor prescribed Cymbalta and I had IMMEDIATE results. I woke up the next morning, ready to face the world, refreshed, and smiling. It's been 6 months, and I still have no side effects and feel better than I have in years. I never even transferred up to the 60 mg pills that they suggest. The 30 mg pills work just great for me. I'm a believer! F 48 6 months
7/25/2007
 3  depression nausea, indigestion, gas, belching, heartburn, constipation, acid reflux, stomach ache. Very good for depression, very rough on the stomach. I don't think I'll be able to continue because of the effect on my digestive system. I've been taking Gas X and Mylanta, which helps somewhat, but not enough. It figures that I would finally find a medication that works for me but makes me fart and constantly feel like I need to throw-up. F 52 7 weeks
7/24/2007
 3  anxiety, depression extreme dry mouth, to the point where I constantly felt as if something was stuck in my throat which would in turn cause me to have an anxiety/panic attack, decreased appetite, severe insomnia Cybalta definitely helped with my depression but the side effects really took a toll on me after only a week. I had barely slept and had lost over 6 pounds within the first week because just the thought of food would make me sick to my stomach. I was constantly drinking water and had to have a bottle by my side at all times, it was just incredibly uncomfortable. F 20 3 weeks
7/24/2007
 2  Depresion Ninguno de consideracion No ha mejorado mi depresion M 35 3 months
7/21/2007
 1  pain from int..cysti. & depression Sleeping most of the 24 hours of a day. Lack of motivation. "psychedellic quality" dreams. intense sweating & hot flashes and chills (no matter what the external temperature). I have felt more depressed, especially in the last 3 months, because of the endless sleepiness & yawning. Doing nothing but sleeping was scaring me and depressing me more & more. B4 Cymb. my depressn was mild, pain from interstitial cystitis was the worst problem. Read that Cymbalta helped with physical pain as well as depressn, asked my doctor to let me try it. I did not read my pharm. info sheet, & neither the M.D. nor pharmacist said "don't stop cold turkey." Doctor thought my sleepiness might be due to not getting any restful sleep at night and put me on Ambien. Without telling my doctor I had stopped taking the Cymbalta about a week or so before I started the Ambien. He did tell me to stop taking my Amitriptyline (which I only took at night at the small dose of 12.5 mg for pain relief.) The first day after taking the Ambien I got extremely nauseous and weak (thought it was the Ambien at first), then happened to read up on Cymbalta & w/d symptoms, and F 67 8 months
7/21/2007
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 3  Depression/Anxiety Headaches, extreme nausea, jaw clenching I have only been on Cymbalta for 2days but I am having really bad headaches in the back of my head that I have never had before. I have to concentrate on not clenching my jaw and the nausea is almost unbearable. I do not notice a difference in my moods or anxiety. Having said all this it has only been 2days. I want to at least wait out the 1st month to see if it'll get better. Anything has to be better than Lexapro. F 26 2 days
7/20/2007
 1  Anxiety; Mild Depression Difficulty Urinating; Very Tired and Listless All Day After Taking Dose; Nausea; No Taste For Food; General Apathy I was on this pill at 30mg a day for 7 days before the Dr. told me to take 60mg a day. I could hardly eat, and just sat on the couch everyday staring at the tv. It made my anxiety worse and I was quicker to anger than usual. I found that I just did not care about anyone or anything anymore. I would not reccommend this drug to anyone with anxiety issues, as it was not a very big help. F 30 11 days
7/18/2007
 4  depression yawning, teeth grinding (not just at night),incredibly vivid dreams (I feel like years have gone by at a frenetic pace each night)delayed or absent orgasm, intense cravings for sweets in evenings I am taking several drugs right now and I cannot separate the side effects. I am taking Requip for RLS and have read a lot of info about the increase in compulsive/addictive behaviors with Requip. I have gained 20 pounds since starting Cymbalta 3 months ago, this is in addition to the 40 pounds I've put on since starting Requip over a year ago. I can't isolate which one of the drugs is causing this. Food seems to take on a persona and calls to me. :) I have taken Trazodone for over a year to help me sleep, and I also take allergy meds that can cause drowsiness(Zyrtec and Singulair). Is anyone else on this particular combination of drugs? I would like to know if anyone has had similar symptoms. I feel better on Cymbalta. Wellbutrin just wasn't doing the trick anymore. I feel light-hearted, better able to deal with stressful situations, and other have commented that my mood seems much improved. The sexual side effects are difficult to deal with, but not enough to stop taking the F 36 3 months
7/17/2007
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 3  depression insomnia,drastic weight GAIN,low energy Im having to go off of it due to my weight gain F 43 4 months
7/16/2007
 1  Depression/Anxiety N/A I am reading everyone's comments here on askapatient.com about their experiences with Cymbalta and now I am almost scared to take it. I went to the doctor today for the first time to discuss my on going anxiety issue and depression, mostly about the anxiety though. I was nervous as a hen and I tried to explain that it has gotten to the point where I can't even carry on a discussion without someone feeling like I am "attacking" them. I always have that feeling in my chest like right before you are going on a roller coaster like just scared it is constant. I sweat, I turn red in the face, my heart races. So he gave me some cymbalta samples 30mg for 1 week then 60 mg for another week. I have never been on this type of medication before and I already suffer from nausea. I play piano and I am left handed. I also smoke pot but I don't drink alcohol. F 20 0 days
7/16/2007
 1  Depression Cymbalta only work for short period of time (months). After nearly a year, I started to feel very very weak and easily tired. My doctor and I decided to stop taking it. The withdrawal side effects especially brain flashes or brain zap was VERY PAINFUL even though I tapered off the medication . I would NOT recommend taking this medication. The withdrawal side effects is worse than the starting side effects. I felt like a drug addict that could not function without the medication. F 33 1.5 years
7/16/2007
 4  depression, obsessive thought some fatigue, some brief episodes of heart fibrulation, decreased sex drive, slightly less appetite. I'm pretty happy with this drug. My depression has lifted a lot and the obsessive thinking about my breakup has diminished greatly. I'm feeling much more muyself. I would say my feelings are slightly muted, but in the normal range. M 51 60 days
7/15/2007
 3  anxiety, migraines, back pain dizziness, headache, increased sweating, vivid dreams, jaw clenching, freezing cold after I went from 30mg to 60mg, can't sleep at night for more than 2 hours, helped with the back pain for the first 2 weeks on 30mg then the pain came back moved up to 60mg for 2 weeks and had more headaches and lack of sleep This is the only medicine I took for 1 month. This worked GREAT for the first 2 weeks at 30mg, then it just stopped working, moved up to 60mg for 2 weeks and felt worse, can't deal with the lack of sleep since I have 2 small children to take care of. Going through withdrawals for 2 days, very dizzy, headache, feel cold then hot, angry (which isn't normal for me). :~( M 30 1 months
7/15/2007
 4  Major depression tiredness and sleepiness at first that went away but I am unable to have an orgasm but can ejaculate I would like to stay on this as it is helpful but won't stay on it due to the sexual side effects, if you are a male and have been on it and the sexual side effects have gone away please let me know how long it took M 38 1 months
7/12/2007
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