CYMBALTA Reviews (DULOXETINE)

Average Rating: 2.7 (2745 Ratings)

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 ANTIDEPRESSANTS

 Type: Rx Drug

  

CYMBALTA  (DULOXETINE):  Duloxetine is used to treat depression and anxiety. In addition, duloxetine is used to help relieve nerve pain (peripheral neuropathy) in people with diabetes or ongoing pain due to medical conditions such as arthritis, chronic back pain, or fibromyalgia (a condition that causes widespread pain). Duloxetine may improve your mood, sleep, appetite, and energy level, and decrease nervousness. It can also decrease pain due to certain medical conditions. Duloxetine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). This medication works by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in the brain.   FDA Approval Date: 2004-08-03 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on CYMBALTA: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR CYMBALTACOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 5  Extreme Anxiety & Panic Attacks Sort of makes food, especially my beloved coffee, tast bland and uninteresting. Mild loss of appetite, which is welcomed. Mild weight loss. Markedly reduced my craving for sugar. No real nausea. Using low (10mg.) dose of Cialis to counteract the sexual side effects. Cialis highly effective. Modest delay of orgasm although they seem to be more intense when achieved. I guess that's a fair trade. First couple weeks experienced some sleep disturbance, which is resolving. Doctor helped me through that rough spot with Ambien CR. Fast acting. For me it is the only drug in its class which has virtually obliterated my anxiety and panic attacks. I would say 95% positive benefits vs. 5% negative side effects. All other things being equal I will stay on it. Celexa, Lexapro, Welbuterin did nothing compared to this. Only Serzone, which is no longer available, was better than Cymbalta. M 40 4 weeks
9/11/2006
 5  Extreme Anxiety & Panic Attacks I am the same person who commented immediately below. I forgot to add that this is the only drug, including beta blockers, that has ever slowed my heart rate down to a reasonable level. I have been EKG'd, ultrasounded, had my thyroid checked, wore portable monitors and cardiologist could never find out why my heart was fast & would palpitate. 50mg. Toprol XL did NOTHING for me, not even 100mg. Toprol did anything except wipe me out. Within two days of taking Cymbalta my heart rate slowed into the low 60's beat per minute resting rate, and it no longer races. Huge benefit for me. M 40 4 weeks
9/11/2006
 1  bi-polar, borderline personality constipation, night sweats, constant headaches in left eye and ear, felt drunk, dizzy, numbness in lips, extreme weight gain (from size 4 to a size 12) Anxious feelings went away...didn't even care if I was late or hadn't done homework. Relieved neck pain the first 2 weeks - but then it came back 10-fold. I take lamictal for depression. Cymbalta only relieved my anxiety. The side effects were horrible. I'd rather feel anxious. F 35 6 weeks
9/10/2006
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 1  fibromyalgia I had severe night sweats. I would wake up drenched. I had very bad diarrhea at first then constipation. I ended up with very very painful hemorrhoids. This is one scary drug and I would caution anyone to look into it very carefully before just taking it. My doctor started me on 30mg and within 6 months I became severely depressed. I had never had a problem with depression before. My Doctor then put me on 60mg and the depression decreased. Cymbalta worked well for my joint pain but getting depression was worrisome. My mood was very one sided. Always emotionally "up" no matter what. The real big problem with this drug was the withdrawal. I had to stop taking it when I changed jobs and was out of insurance for a time. The drug is very expensive. It took me 5 months to withdrawal from Cymbalta and it was hell. I had hallucinations, horrid nightmares, high blood pressure, heart palpitations just to name a few side effects. I had rapid weight gain because I would get seriously ill if I didn't eat several times a day. I had to very slowly taper myself off the drug until I was only taking 5 mg of granules and then i just F 49 18 months
9/9/2006
 3  Depression Profuse Sweating at all times, Nightmares, Shaking, Insomnia, Restless leg Cymbalta was like the 4th anti-depressant my Dr tried on me. The last one I tried was Effexor which I reacted to so badly - I couldn't think of anything Except ways to kill myself. I was so scared to try anything new, I had been on St John's Wort for two weeks when Dr gave me Cymbalta. I NEVER take the Cymbalta without the St John's Wort too, 'cause I was scared of the side effects. It took about 2 weeks, but I was the happiest person ever for the first 4 months. Absolutely no side effects at all. But in the last 3 months, things have changed a bit. The sweaating is horrible, my hands shake constantly, I only just realized these nightmares are not normal - And yes I've had the voices too. Only after reading here do I realize it may be the medication. I've had insomnia for 3 years now, so I'm not sure about that, but I can guess that the Cymbalta doesn't help. F 37 8 months
9/7/2006
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 1  Fibromyalgia/nerve pain The worst side effects I've ever experienced.Pounding heart, IBS,stomach pain,nightmares,limb pain,scary thoughts,feeling of worthlessness,paranoia. This drug shouldn't be on the market. It does things to the brain that I'm sure Eli-Lilly knows about, but is hiding the results from the FDA. My Dr. is gonna know about the side-effects after the holiday weekend, when I can get his service to have him call me. I'd gladly go back on Paxil to try and even-out my thoughts right now. That's saying something after all the bad press that Paxil got. DON'T USE THIS MEDICATION, IT IS DANGEROUS TO YOUR HEALTH. M 45 1 days
9/5/2006
 4  Major depressive d/o In the first two weeks on 60 mg, I experienced some nausea, mild to moderate feelings of hypomania, mild anxiety. I have also been urinating two to three times more on a daily basis, experiencing much more bowel activity. Two persisting side effects that are quite distressing to me are that I've become completely anorgasmic (never had a problem with this in the past), and my hair started falling out. I was on 60 mg of Cymbalta for 1 month; after I talked to my doctor about the side effects and my unhappiness re same, we agreed to reduce my dosage to 30 mgs daily to see if any improvements might occur. I've been on the 30 mg dosage for two weeks, and the hair loss and sexual dysfunction continue. Although Cymbalta began to reduce my depressive symptoms within the first two or three days I started taking it, and it has been more effective in that respect than any other antidepressant I've taken (including Trazodone, Prozac, Zoloft, and Wellbutrin XL), I don't think I'll continue taking it. I'm not interested in going bald, nor do I want my sex life to evaporate altogether. Now my biggest concern is being able to stop taking it. From multiple comments I've read on online from many others who have taken and then stopped taking Cymbalta, it sounds like a nightmare. I'm still on Wellbutrin XL, which stopped working for me over a year ago, but will probably stay on it while I'm &quo F 48 50 days
9/4/2006
 3  FIBROMYALGIA NAUSEA IT SEEMS TO HAVE STOP WORKING I AM AGAIN VERY FATIGUED AND IN ALOT OF PAIN FROM THE FIBRO. F 37 3 months
8/29/2006
 1  Depression and Pain Nervousness,Waeught gain in stomach, heart arthymia,electrical shocks,sweating,increased appittie,Blurred vision,dizziness,headaches,cold or flue like symptoms,nausea and throwing up,feelings of not caring about anything, no emotions, pain in stomach,paralysis in arms and legs,no energy,memory loss. Flushing it today! The risk are to great! Not enough known about this drug, I think. Anything that messes with your Brain and starts shocking your body like that has to be dangerous.Don't know the long term effects yet. Will wait to see. God Bless those that it has helped though. F 41 1 months
8/28/2006
 5  bipolar/panic disorder/major deprs im not having many side effects,having to urinate alot,orgasm problems, can seem to sit still, nightmares. Ive been on so many anti-deressents zoloft,efexor,wellbutrin,prozac, you name it i was pry on it, im on 2 anti depressents wellbutrin and now cymbalt pluss lamictal for a mood stabalizer,cymbalta has got to have been the best so far im more pain free, better mood,more energy, i think people who are depressed should ask the doctor about this med. thanks to whom evere made this tho im not cured,but im managing much better. M 26 3 weeks
8/27/2006
 2  depressive disorder extreme nasuea, inability to orgasm, terrible acne Has not seemd to help and side effects have not lessened F 20 2 months
8/27/2006
 2  Depression and Pain Heart Rythem problems,alone with other side effects, I have mentioned ealier. The Cymbalta is comming out of my system and I'm feeling much better now. Still have some numbness in lower part of arms and legs. Nausea is gone. There seems to be one major side effect to this drug that has not gone away yet and that is some how it changed the metabolism so now I'm hungry all the time. But will control that myself! I'll be back, because I know enguiring minds want to know. Can't spell. So sorry. Anyway, Cymbalta is horrible when it comes to giving it to anyone with a bad heart, how many times did I write that now. yeah I know. I have decided that since this medicine is so bad on my heart then, I will take one or two pills a week for the pain control. I don't think anyone needs to take to much of this medicine, like taking it everyday caused me to feel sick, in a daze, brain zappes,whatever. I'll take 30mg pills for one month and take one or maybe two pills a week. To much cymbalta is not good and just a little may be better. The verdict is still out, But I'll come F 41 1 months
8/27/2006
 1  Depression and Pain Sweating,Heart Papitations, Headache,dizziness,sore throat,very cold,Major flushing feelings in my head,Dizzy feeling,Flue like symptoms,High degree of shaking and nervousness ,bleeding in stool,throwing up. Not feeling to well right now to say the least! This is the withdrawl stage. I think thier needs to be more Studies done on this medication before giving it to certain people. While I have read that it has helped many people.I think this is great. What works for one person, does not always work for the other. This medication seems to work well when it came to my Pain. I was so happy that it did control my Pain But, since I am comming off of this medication cold Turkey, the side effects are Horrific! Also, these where the side effects while I was on the drug as well.I don't think this drug is for me! Wish me luck on comming off of this Medication, since I feel to bad to go see My doctor that placed me on it! Also, I'd like to add that I take heart medication for Heart Arythmia. I don't suggest anyone that takes heart medication should be on this drug.But, good Luck to the people that it has helped! In case anyone was wondering I was first on the 60mg for about two weeks and then my doctor placed me on the 30mg after I complained of Feeling that I did not feel F 41 1 months
8/26/2006
 1  Depression and Pain Horrible heart Problems.Along with other extreme bad side effects. If you have any kind of heart condition, PLEASE do not take this medication. My heart is still not ok and if these side effects along with heart problems continue I'll have to see a Heart Doctor.My Doctor did not discuss the side effects with me or that it would cause Extreme Heart Problems. I was on the 60mg at first and then I went back to my Doctor and Told him that it was making my heart feel funny. My Doctor said he would then try me on a lower dose, of 30mg, still the same feeings for me and the same side effects.Watch Out If You Have Heart Problems with Cymbalta! Good Luck to the people that it has helped and so sorry for the people's Heart it messed up! F 41 1 months
8/26/2006
 1  Depression and Pain Heart rythem problems along with horrible other side effects. Cymbalta did not help my Depression either. I have been crying for days now! Watch Out for this Drug! F 41 1 months
8/26/2006
 5  Agitated Depression First few weeks -- decreased appetite, nausea, leg twitching, forgetfulness. All except forgetfullness went away within a few weeks. I love it, I feel like my old self again. I have lost 15lbs over the last two months, because I stop eating when I feel full. I am very happy with the drug, and the forgetfullness could just be me. It does take a while to experience orgasm, but it is more intense than before. Not a problem! F 42 2 months
8/25/2006
 3  Anxiety I'm only on my third day, but I've had extreme insomnia, clenching of the jaw- mostly when I yawn, but I do feel a little more relaxed, hopefully the side effects will get better in the next week or two F 18 3 days
8/24/2006
 1  depression Profuse sweating during the night, day, and at any outside or room temperature. Sometimes have to sleep with towels to soak up all the water. Induced severe fibromyalgia-like body pain after a couple of weeks of use. Increased and prolonged the depressive episodes. Intense suicidal thoughts not previously present. Impossible to withdraw from this medication after even a short period of use. During the first two months it seemed to relieve the depression and anxiety but then it quit working and actually seemed to actually cause the problems along with the appearance of the terrible side effects. If you have never experienced hell try to stop using this stuff. The advertising is false and the manufacture should be rounded up, tried, convicted and imprisioned on RICO charges for knowingly distributing a dangerous drug. M 52 6 months
8/24/2006
 5  severe depression lost 6 pounds in one week! loss of appetite, some stomach pain/discomfort I used to SLEEP all day, after 10 days on the med I no longer feel like doing that, it's great! I also LOVE the decreased appetite and weight loss, I def need to lose lots of weight and hope it continues. I used to eat out of boredom but now I'm doing other stuff. F 33 10 days
8/22/2006
 1  depression and anxiety no sex drive, naseau, head spinns, forgetfullness, increased anxiety, foggy headed, blurred vision, headaches, muscle aches/joints. the withdrawls are even worse F 38 1 years
8/22/2006
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