CYMBALTA Reviews (DULOXETINE)

Average Rating: 2.7 (2744 Ratings)

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 ANTIDEPRESSANTS

 Type: Rx Drug

  

CYMBALTA  (DULOXETINE):  Duloxetine is used to treat depression and anxiety. In addition, duloxetine is used to help relieve nerve pain (peripheral neuropathy) in people with diabetes or ongoing pain due to medical conditions such as arthritis, chronic back pain, or fibromyalgia (a condition that causes widespread pain). Duloxetine may improve your mood, sleep, appetite, and energy level, and decrease nervousness. It can also decrease pain due to certain medical conditions. Duloxetine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). This medication works by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in the brain.   FDA Approval Date: 2004-08-03 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on CYMBALTA: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR CYMBALTACOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 4  depression and fibro Nauseated, feeling of out of body experience, sleept all the time and could not stand lights Once I got through the first few weeks, I was happy and doing quite well, I was doing things and felt freer and just being me. Now in my 10 months and I'm having problems with welts on body, brain zaps, headaches and feeling of depression and suicidal thoughts? F 52 10 months
7/16/2009
 4  Depression None at first After about a year of taking this drug, I went from 30mg to 60mg. Since then I have noticed some problems. Extreme tiredness, loss of concentration, constipation, headaches, yawning, sleepiness, insomnia. I hope to be able to keep taking this med. I am working with my doctor on how to address these problems. M 44 18 months
7/15/2009
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 3  depression On cymbalta I had no side effects, it's getting off of it which is TERRIBLE. Just trying to get off of it I've gained 7lbs, have massive head aches, crying spells etc. It's been so bad I've had to go back on 20mg just so I can go about my day normally, and also so I don't gain more weight! It works well for depression, but you have to decide if its worth it because the side effects getting off of it are VERY painful. F 25 6 months
7/15/2009
 2  Fibromyalgia/CRPS pain Bad headache (migraine with blurred vision and photophobia), nausea, and a grotesque otherworldly combination of feelings like something is gonna jump out of my chest (a la "Aliens" fashion) while the room is sort of melting in an Alice-In-Wonderland psychedelic puddle which makes me feel like I'm on the verge of passing out a great deal of the time. My sleeping is fractured. Hard to fall and stay asleep. When I do sleep, I'm plagued with dark, disjointed, ADD-like dreams that constantly change as though I were channel surfing with a remote control on some demonic TV. Oh, and dry mouth (which seems trivial at this point). I'm an R.N., and as such I know that the initial period on any medication can carry significant side effects while your body is adjusting to it. But if these get any worse, or don't improve in a few days...I don't know if I can tolerate being on this medication. So far I have seen no improvement in my pain level. F 4 days
7/15/2009
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 2  sever depressive episode vivid dreams (followed by exhaaustion the next day, feeling that I hadn't slept at all), sense of dissociation from reality, constipation and bloating, lack of energy, horrendous night sweats. Withdrawal a nightmare, although I was to blame for that for not following medical advice. Was prescribed cymbalta after prozac became ineffective. Hated this medication- I felt completely dissociated fron the world (like I was watching myself on TV), unable to feel any emotion whatsoever. The constipation got to me the most- I was passing only small amounts of hard stool and these meds seemed to really slow down transit time. I was always bloated, probably due to all the poop refusing to come out in a timely fashion! Night sweats worse than with Prozac- I would wake up to find the sheets drenched with sweat. Dreams very vivid and sleep unrefreshing as a result. I withdrew this drug on my own and stupidly went cold turkey. I would not recommend anyone does this unless you like painful electric shock sensations in your head, vertigo, and all over aching like you're coming down with flu. F 25 4 months
7/14/2009
 2  Social anxiety. Depression. Extreme perspiration. Difficulty urinating. Insomnia. Erectile dysfunction. Libido mostly absent. Why did I even bother? M 34 1 months
7/14/2009
 2  depression, anxiety teeth clenching, migraine It really worked for relieving my depression and a significant amount of my anxiety, but I couldn't take the side effects. I was clenching my teeth so hard at night that my jaw would ache the next day. During the day, I could catch myself doing it and relax, but if my mind was on something else I didn't always. All the jaw clenching triggered my migraines, and I was running out of migraine meds for the first time in my life (I only get 9 per month, which wasn't enough). F 36 4 months
7/13/2009
 4  fibromyalgia sweating, bruising? F 72 120 days
7/11/2009
 1  Depression Sleeping as much as 20 hours at the time, heavy sweating in the feet, never happened before. Hot and cold flashes, fever, confused and just an overall feeling that I didn't care about anyone or anything. Loss of interest in everything, even my penis has gotten smaller. I should be in the ER now because the heavy sweating and all of the other symptoms. I would not wish this drug on my worst enemy! I cannot take serotonin drugs, so what does my doctor do, put me on Cymbalta. After the first dose that caused me to sleep for over 18 hours, I did feel some better. The next day I took my second dose and slept another 18 to 20 hours, I was in such a deep sleep that my daughter banged on my house for two hours before she called the police to break in. After that fiasco, I noticed that I was feeling dizzy and my feet began sweating, my feet have never sweat before, but I took another dose and and I have been completely out of it for two days. I am hot and cold, extremely dizzy, feverish with cold shakes to being so hot that I think I am going to burst into flames. I am most likely dieing as I write this because I am to stubborn to go to the ER and my doctor is closed now. It is a Friday evening and I am trying to wait until Monday to see my doctor. No one should take this drug, I don't care how depressed you are, at least you are alive! I know some people do well, but I have seen serotonin drugs prescribed for so many things and every single person I know that has taken them have had really bad experiences. Please everyone, let serotonin drugs be a last resort, it's probably going to be mine, because I really don't know if I am going to make it! M 54 3 days
7/10/2009
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 5  nerve pain in arms & hands diareha I have been on Cymbalta 60mg for four months. 3rd month the diareha started, may go 20/25 times a day, just like water. No stomach ache. Has anyone experienced this and did it pass? I went off of Cymbalta for 3 days and the diareha stopped and the pain came back. I started taking it again and the pain ended but the diareha was back the following day. My pain started due to disk in my neck, I had an anterial fusion on three disc in my neck and the pain was better but then it came back at a lesser degree but still had the pain and numbness. I like the drug, it does work. I took lyrica at first, it also worked but never could adjust to the horrible side effects. Can anyone share your experience with me about the diareha? F 51 4 months
7/9/2009
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 5  Fibromyalgia, anxiety, mood Mild nausea the first day, constipation the first week, and insomnia if I take Cymbalta after 12 noon. The benefits of Cymbalta by far out weigh the side effects. I noticed a benefit from the drug within the first few days and felt like a new person within a couple of weeks. My fibromyalgia pain is basically gone. My husband and my children comment on what a good mood I have been in since being on Cymbalta and I can tell myself such a difference in my anxiety level. I feel like a new person. It is hard for me to even imagine all of the horrible side effects and experiences that so many people write about on here. Give the drug a chance and time to work for you. It worked for me. F 34 60 days
7/9/2009
 2  depression heavy sweating I thought it was great for 5 months, and then it just stopped working. I went from 60mg to 120mg and there was no lift. I am now on effexor xr. A female friend had the same experience after 3 months. M 66 5 months
7/8/2009
 5  Panic Disorder, Agoraphobia lower sex drive, but you have to expect that with ssri's. Only been taking it for 8 days, so I think the sex drive will come back eventually feel energetic, motivated, anxiety free, less hungry(a good thing), I think this is going to be good, only thing is its expensive! M 29 8 days
7/6/2009
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 4  fibromyalgia and bipolar It works well. May give diarreah for a bit till your system gets used to it. I had to go off of it for a while, and the weirdest thing happened. It felt like my joints all loosened up like they were all floaty, then that went away and I guess it just went back to normal F 33 8 years
7/6/2009
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 1  Pain I only took only 30 mg of Cymbalta for one day (prescribed for pain from a hip and lower back dislocation), but I will never take it again due to the horrible side effects. I felt like a zombie on this drug, and my family was really concerned about me. I was "out of it," extremely sleepy, took accidental naps during the day, experienced horrible diarrhea, embarrassing stomach gurgling and flatulence, moderate nausea, loss of appetite, slight loss of coordination, occasional blurred vision, and generally felt numb both in body and in spirit. My pain is terrible and Cymbalta dulled it significantly, but it's side effects are not worth it. There is no way I could live a functional life on this drug. I'm a 30 year old graduate student who was prescribed this medication for serious pain combined with a little anxiety about my situation: I dislocated my lower back and hip in a sports accident and had multiple surgeries for my injury over a year ago, but I'm still in terrible pain and have trouble sitting for long periods of time. As a result, I'm extremely worried about finishing my PhD program with these limitations. I was hoping that Cymbalta would help. No way. This stuff reduced my pain from an objective standpoint, but the whole reason I want so desperately to get rid of my pain is to be a functional human being. Cymbalta made me feel like a numbed up zombie, in addition to making me extremely sick. I know they tell you to stick with the medication because it doesn't work for at least a week, but why on earth would I want to force my body to get habituated to something that effects me like poison? It's not worth it. Rather than targeting my pain alone, it was like trying to kill a flea with a jackhammer. If it works for you that's great (obviously stick with it), but after my experience I would caution others who are prescribed this drug for pain. I'm writing this the morning after I took Cymbalta for the first time, and I still feel a bit queasy and "out of it," like I'm slightly hung over. There is no way taking it again today! F 30 1 days
7/6/2009
 1  depresion, and rage loss of delayed orgasm, and then complete loss of sexual appetite, now can't even get it up even with partner. increase in appetite, never been on anti depressants before, and never will again, more depressing to be on this stuff than off. more sucicidal thoughts than ever, numb to life, tingling in extremities, fogginess, always feel hot. coming off was bad for a bit made raging more often until it cleared the system. not worth it M 28
7/5/2009
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 4  Neuro pain, Fibromyalgia Sexual side effects, typical for this class of drug. DO NOT be afraid of this drug. I am taking this for neuropathic and fibro pain, and within 2 weeks, it has made a huge difference. I don't have to rely on the narcotics as much, eventhough it takes time. NO, I repeat NO side effects except sexual dysfunction, if that's an issue to you personally. Nausea? Very very slight for like a day or two. Nothing serious. BUT IF YOU TAKE FOR PAIN, try it. It has helped me a LOT, don't read the reviews of people and be afraid. I have been in pain for 2 years, very serious, and this drug has HELPED ME GREATLY. Relax, breathe, give it a try. Everyone is different so don't be turned away by people's bad reactions. If you need to try it for pain, go for it. I'm one example where it has HELPED DEARLY. Thanks. M 38 4 weeks
7/4/2009
 4  Depression and Anxiety The first few days, I felt like I was in a fog, my pupils were dialated, and I had a slight headache, but they went away fairly quickly. I've been taking it now for 5 months now, and aside from sugar cravings and some unpleasant weight gain, I can't really complain. F 19 5 months
7/3/2009
 2  Depression/Generalized Anxiety Dizziness, Mild-moderate Nausea,Episodes of anger over minor events, VIVID Nightmares, Brain "zaps" if you miss a dose. I have taken both Cymbalta & Lexapro for Anxiety. I must say that I was better overall on Lexapro. This medication has done very little for me. It was 1 month of misery to go through withdrawal from Lexapro. Lord only knows how bad Cymbalta withdrawal will be... M 43 2 months
7/2/2009
 1  Depression & Anxiety On 30mg, none. On 60mg, mild constipation and delayed orgasm. The delayed orgasm was similar to Effexor, but without impotance. Effexor 150mg was effective but pooped out. I switched to Pristiq which was not effective so I stopped it. I then commenced 30mg Cymbalta for two weeks and then increased to 60mg for three weeks. Being an SNRI like Effexor, I was expecting it to be effective, but it's been underwhelming. Nortriptyline is next on the menu. Wish me luck. M 33 5 weeks
7/2/2009

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