CYMBALTA Reviews (DULOXETINE)

Average Rating: 2.7 (2745 Ratings)

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 ANTIDEPRESSANTS

 Type: Rx Drug

  

CYMBALTA  (DULOXETINE):  Duloxetine is used to treat depression and anxiety. In addition, duloxetine is used to help relieve nerve pain (peripheral neuropathy) in people with diabetes or ongoing pain due to medical conditions such as arthritis, chronic back pain, or fibromyalgia (a condition that causes widespread pain). Duloxetine may improve your mood, sleep, appetite, and energy level, and decrease nervousness. It can also decrease pain due to certain medical conditions. Duloxetine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). This medication works by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in the brain.   FDA Approval Date: 2004-08-03 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on CYMBALTA: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR CYMBALTACOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 2  FIBROMYALGIA Weight gain, suicidial ideation, dry mouth, leg cramps. My rheumatologist ordered this drug for my fibromyalgia. I really didn't notice any difference in the amount of pain but did have an increased appetite. Terrible dry mouth and leg cramps at night. Decided on my own to get off the drug--not such a good idea because the first few days felt suicidal and dizzy, poor concentration and general tiredness. F 67 1 years
1/30/2009
 1  depression and arthritis pain In the beginning, extreme nausea, digestive upsets..got better but never went away completely. Horrid hot flashes and sweating at night. I have tried almost every antidepressant and this is BY FAR the worst. My mood improved but I became "flat" and became a recluse. My legs became restless and felt tight however the drugs worked well for pain for the most past. Going off this drug was horrible. I took prozac instead of the cymbalta and that helped alot. The nausea resumed however for nearly a week. The medicine is very pricy and prozac is $5 generic. I had been on prozac 15 years with mild side effects...I will stick with that. Check out the other options before you chose cymbalta. F 43 4 months
1/30/2009
 1  depression/chronic back pain Mania, anger compulsive behavior. Diminished sex drive. Severe constipation not even responsive to high doses of laxatives. Reclusive desires. Compulsive drinking, smoking, shopping. Quit upon recognition of all of these bad sideffects. Cut from 120 to 60 to 60 every three days to none.Anxious to be off took only three weeks for withdrawal. Horrible withdrawal symptoms...It still feels like a brick is in my head, but glad to be free from this drug F 45 8 months
1/30/2009
 1  Depression/fibromyalgia Dizziness, weakness, extreme pain, anxiety, depression worsened. I was on Cymbalta for about six months, last year. The side effects crept up slowly, at first I thought it was helping the depression and I'd noticed a lessening of my fibro pain, but the longer I took it the worse my dizziness became, I started getting weaker, couldn't walk more then 50 feet without needing to rest and almost collapsing. Then the fibro pain started getting worse and my depression worsened to the point of becoming suidicidal. F 62 180 days
1/27/2009
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 5  Depression/Anxiety For the first 2 weeks I experienced nausea, dizziness, loss of appetite and dry mouth. These slowly went away over time though and after 2 weeks they were pretty much gone. I just kept telling myself that after my body adjusts it will be worth it and I was right. Remember to hang in there and give it a chance! THIS MEDICATION GAVE ME MY LIFE BACK! It took almost a month to fully kick in but the difference I notice in myself is absolutely amazing. I can concentrate again and the dark cloud that has been constantly chocking me for the last 4 years is completely gone! I went from someone who had turned off all her emotions to someone who can laugh and be passionate about life again. Honestly, give this a fair chance. The side effects might be brutal at first but they DO go away and from then on it's all up-hill from there! As far as I'm concerned the hardest part was going to my doctor and telling him I thought I needed help. I WOULD LOVE TO OFFER SUPPORT OR ADVICE TO ANYONE WHO WANTS IT SO PLEASE FEEL FREE TO SEND ME AN EMAIL! :) F 23 1.5 months
1/25/2009
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 3  fibromialgia Vivid Dreams, hot flashes (not related to menopause),dry mouth, insomenia (1st few months), olfactory hallucinations, increase in sweating with a very unique unpleasant odor that only I can detect (olfactory hallucinations or a heightened sense of smell either way it is unpleasant). Irritatiability and less patience. Weight loss initially and now weight gain. Cymbalta when first taken gave me increased energy, relief from fibro pain and diabetes related foot numbness & tingling and weight loss so it was worth the insomia that I first experienced, I had found the right medication finally and recommended Cymbalta to persons who suffered fibro. After about 4-5 months the hot flashes, sweating, and olfactory hallucinations started. There have been pros and cons to my experience with this medication but the cons are starting to outweigh the pros so I plan to wean off of it in the coming months under my physician's care. F 50 1 years
1/24/2009
 3  Fibromyalgia, radicular pain, HA's 30-40 lb wt. gain, initial vivid nightmares, extreme constant thirst, dizziness, flat affect, complete loss of sex drive, continuing migraines- post concussion syndrome ha's unrelieved, dizziness, brain "zaps", and probably more that I've not yet even realized. I started Cymbalta after being on numerous antidepressants for Post concussive migraines, as well as leg pain from low back problems & post-op lumbar surgery. I would very much appreciate anyone who would like to discuss via email of this drug- or many others I've also had severe reactions to! (I need to find a support system) as I'm an RN, and been through a lot as I see many others as well have. Forgot to refill and had horrible withdrawel- flu-like, vomiting, vertigo etc. lasting for days. Got back on the med and leg pain greatly relieved. 40 lbs. later and I've decided to stop the med. I've always been a bigger person, now I'm obese and on BP meds as well. Trying to slowly become drug-free, very hard! Hoping being off of Cymbalta will help greatly! F 44 1 days
1/24/2009
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 5  Extreme Depression/General Anxiety Diarrea, hot and cold, dizziness, this has been a real God-send for me ---- It has worked tremendously. My moodswings, raging, suicidal thoughts and tendancies have pretty much disappeared. The side effects are worth the benefits. I hope this works for others as well. F 35 9 weeks
1/23/2009
 3  depression/anxiety constipation, rapid weight gain, zero sex drive, too long to orgasm and then orgasm was weird(no sensation/feeling???), blurred vision, headaches, cant not sleep yet sleepy all the time, hand tremors, yawning, at 4 weeks-decreased appetite, and increased of all of the above.... depression is gone, yet so is almost all of my feelings in general. husband very understanding, is happy I am not so nervous and grouchy, yet I feel so "sick" all of the time. If I gain anymore weight, I will have another depression. I am currently on 60mg daily, I want to go on 30mg daily, and see what happens. F 42 1 months
1/23/2009
 5  Fibromyalgia/Depression I experienced no side effects whatsoever. Started taking about 2 months ago. Haven't felt this good in years. It has taken away the Fibro pain by at least 80%. Also feel like me again. Cheerful, happy, motivated, energized. Also started sleeping soundly again, so deeply that I am actually dreaming again. I have not experienced any side effects at all, have no more "Fibro fog", am finding myself getting alot more accomplished in my day. And just feel really good. I started taking 30mg once a day every morning, doctor was going to move me up to 60mg but feel it is unnecessary as I am doing great with current dosage. Would recommend doing your research, asking lots of questions, pay attention to yourself, having a good support system, and taking good care of yourself. Everyone is different, what works for some, might not work for others. Good luck to everyone out there. F 33 2 months
1/22/2009
 3  Anxiety, Fibromyalgia Dry mouth, dull headache (for about the first 2 weeks), reduced sex drive, feeling out of it (sometimes numb), tired all the time but not able to sleep for long periods or through the night, vivid dreams, weight gain regardless of cutting calories and exercising, poor memory, loss of words, dizzy/nausea if I get up too quickly or turn too quickly, KILLER heartburn. I started taking anti-anxiety drugs when I went into menopause. I have severe symptoms. I take the meds 30mg in the am and pm because I am unable to take large doses at once. I was on Effexor XR and was doing great. I did so well my PCP took me off. But I only cut down to 1 a day when the anxiety attacks started again. So, I went back up to 2 and they didn't work. I went to a psychiatrist that told me I should never have been taken off and sometimes when you come off and you try to go on again, it doesn't work...it didn't. F 54 4 months
1/21/2009
 4  Depression Nausea, dizziness, increase in urination & bladder discomfort (felt like a UTI). That lasted about a week or a bit more once I was on the 60mg dose. Miss a dose and I get headaches. Continuing side effects are jaw clenching, difficulty remembering short term memory, difficulty staying asleep and not feeling refreshed when awakened, lack of motivation (more desire to just sit around) & generally feeling fatigued. I could sleep any time in naps but long, 8-hour continuous sleep is not easy without a Tylenol PM or some alcohol. I tried Celexa, Welbutrin and Prozac and so far Cymbalta has been the absolute best that I have tried. I have actually lost 30 pounds in 6 months with this drug. It helps me with my mood swings and rage and "grumpiness" outbursts- I was on the verge of getting fired because I was always angry and just plain mean to talk to. I find it takes more concentration to do things and I am drawn to tasks that involve repetitious tedious type things (like sorting and counting out a bucket full of mixed nails, for example). However with Celexa it was like my sex drive was cut off completely and I had difficulty orgasming. Cymbalta is nowhere near as bad. I do notice that orgasm is a bit delayed but also I am not 17 anymore so that's not so bad. Actually I feel like I did on Prozac however it's not as bad, on Prozac I felt spaced out and could happily sit on the floor counting the grout lines in the tile floor all day long. Cymbalta has made me feel a lot better- I realize there are s M 39 6 months
1/20/2009
 4  Fybromyalgia metalic taste in mouth, inability to orgasm, "medicine-head", loss of appetite/slight nausea, trouble concentrating or staying focused. I started becoming a total shut-in due to my FM symtoms so my Dr. recommended I try Cymbalta. I got some 30m capsules for 2 weeks with plans to ramp up to 60 afterwards. I have been on it for 4 days now & have noticed a few side affects. I feel more energized but it makes me feel as if I have had a bit too much caffine, which I kicked 3 years ago (very sensitive to drugs). I feel happy overall & have much less pain & achiness. The drug is doing what it is supposed to so far. My dr. warned that I could have a "fuzzy" feeling for a couple weeks so we will see if it gets better. Not 100% sure about it's sexual impact, as I may have had too much on my mind, but I suspect it is the case after reading other comments. So far the side affects have been mild & expected, so I will continue taking cautiously. I have not had anything else have such a possitive impact on my pain like this has. F 36 4 days
1/20/2009
 1  Anxiety and depression Insomnia, dizzy, anxiety, dry mouth, muscle aches, lack of concentraction, memory loss, whole body is numb. I have been on pazil for 7 yrs. Worked very well with minimal side effects but felt my anxiety was starting to get worse. I am tapering off pazil. Second week added 30 mg of cymbalta. Third week added 60 mg of cymbalta. Every one reacts different to medication but the side effects are so bad that I am going to call dr. To stop taking it. Good luck if u decide to take cymbalta. F 34 8 days
1/20/2009
 1  switched from Zoloft Severe drop in sex drive, abdominal pain, moodiness, if a dose was missed by 1 hour I would get those "Brain Zaps" as someone calls them, you just feel like your brain is shorting out if you move your head the least little bit. ZZZZZZZ ZZZZZZ Buzzzzzz AWFUL!! do not try to quit taking it "COLD TURKEY" you have to slowly get off of it and it does not happen over night, so be prepared. F 48 8 weeks
1/20/2009
 1  pain, fibromyalgia had dry mouth, constipation, horible tremors and double vision, and confusion F 85 21 days
1/19/2009
 2   brain Zings, nausea and dizziness if I missed a dose. confusion, disorganization, distractability 3 years
1/18/2009
 4  depression & anxiety At the start: Very queezy, tired, dizzy, dry mouth, lack of emotion. After 9 months, very tired, need to nap in late afternoon or early evening. Sometime my hands are swollen in the morning upon waking up. Weight gain 15 lbs. Crave sweets a lot, some brain fuzz if I take med later in the day (because of sleeping in). This med helped my depression and relieved my anxiety to a certain extent. Rarely, I will get an intense feeling of anxiety for 1 hour or so, then goes away. Very hungry, very tired. Don't want to go off med. Sometimes will need to take Lorazepam to sleep. Night sweats, dream intensly every night. F 44 9 months
1/17/2009
 3  Dysthymia Wellbutrin XL stopped working for me after 6 years. Cymbalta was the 2nd antidepressant my doctor had me try, after Celexa failed to help. On 60 mg Cymbalta daily, I had some nausea at first which went away after a few days. I also had a day or two of mild, somewhat interesting visual alterations, particularly at night; sometimes, lit objects would go dim as I looked at them. This visual weirdness went away after 48 hours. Cymbalta caused extremely dry mouth which lingered throughout the trial course. Cymbalta altered my orgasms; climax took much longer and was less intense. The worst side effect was severe restless leg syndrome which disrupted my already crummy sleep. I had some samples of Requip and Mirapex I received from my sleep doctor, which did help the RLS. However, my psychiatrist did not think it wise to add another drug to treat a side effect of this drug, and took me off Cymbalta. My dysthymia manifests as apathy, cynicism, lack of motivation, head-to-toe body, joint and muscle aches, dyspepsia/IBS, overeating, physical and mental fatigue, word retrieval difficulty, 'brain fog', insomnia, and a generally unsociable, 'bah humbug/grumpy old hag' attitude. 60 mg Cymbalta daily helped my IBS a lot and modestly improved my mood, attitude and motivation. Cymbalta reduced my aches and pains by about 50-60% (Celexa actually worked better with a 90% reduction in pain). Cymbalta did not worsen my insomnia and may have even helped a bit. I was able to enjoy a cocktail or glass of wine in the evening without problems. Unfortunately the negative side effects outweighed the benefits. I was able to stop Cymbalta cold turkey with no problems, but I also immediately started taking Pristiq and I've remained on Wellbutrin XL, which may have minimized any withdrawal symptoms. F 46 4 weeks
1/17/2009
 5  Depression nausea, ongoing; arm and leg tremors that lasted about 3 weeks, then went away Cymbalta has stablized my moods. A surprising and good side effect was that it eliminated nerve pain in my neck, which I had suffered from for thirty five years. I have been very pleased with Cymbalta, but I wish I knew more about long term usage. F 54 2 years
1/14/2009

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