CYMBALTA Reviews (DULOXETINE)

Average Rating: 2.7 (2745 Ratings)

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 ANTIDEPRESSANTS

 Type: Rx Drug

  

CYMBALTA  (DULOXETINE):  Duloxetine is used to treat depression and anxiety. In addition, duloxetine is used to help relieve nerve pain (peripheral neuropathy) in people with diabetes or ongoing pain due to medical conditions such as arthritis, chronic back pain, or fibromyalgia (a condition that causes widespread pain). Duloxetine may improve your mood, sleep, appetite, and energy level, and decrease nervousness. It can also decrease pain due to certain medical conditions. Duloxetine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). This medication works by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in the brain.   FDA Approval Date: 2004-08-03 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on CYMBALTA: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR CYMBALTACOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 5  depression none I have been taking Cymbalta for almost four and a half years. It has saved my life. M 38 4.5 years
2/27/2008
 4  Anxiety Depression Nerve pain I sweat a lot at night, I actually do not look forward to going to sleep knowing I will wake up drenched. I also have crazy wild dreams that are violent and sometimes sexual. My body is much looser, more comfortable. I had seized up because I was so tight. I am happy I laugh and smile. I was very angry for a long time. I can function much easier. I like my job and husband better. My husband is very glad. Probably saved our marraige. Not sure I can stay on because of the intense dreams. F 49 5 months
2/26/2008
 1  Nueropathic Pain This drug raised my blood pressure and caused me to have eye problems including retinal edema. F 38 10 months
2/26/2008
 1  anxiety This was the worst experience of my life. I was told to take one pill before bed so I would sleep through the side effects. I woke up around 1 in the morning shaking uncontrollably. I then started to sweat and have a high fever but I was freezing at the same time so I couldn't decided whether to get under a blanket or not. Every time I closed my eyes to try to sleep I would see intense colors. I then started to hallucinate and dry heave. When I started to black out I realized I would never take another one of these EVER again. I took one pill on Friday night and by Sunday morning I had to be taken to the emergency room. TERRIBLE! I would never take this drug. I have a strong stomach and never have had any bad side effect with any other medication. F 19 1 times
2/26/2008
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 1  bi-polar disorder sweating, weight gain, nausea, constipated, tired all the time, insomnia, tremors in hands, eyes tearing or dry, my doctor started me at 30, then 60 now 90 and after reading about the horrible withdrawals I am scared. I wish I had read about it the first time I was prescribed it. F 65 1.5 years
2/26/2008
 1  fibromyalgia and depression At 30 mg I felt better for awhile, but then I experienced a depression that was dibilatating in nature. My doctor began upping the dosage until I was at 90 mg. At that point I was having suicidal thoughts constantly, sweating, and in a brain fog from hell. I stopped taking the drug without tapering and my withdrawl symptons were frightening: shaking, motion sickness, headaches, nausea, diarreaha.... I have been off it for almost a month and I am still experiencing these symptoms to a lesser degree. Be very careful. My take is that the cure is worse than the disease. I am in the process of trying achieve wellness with lifestyle changes and therapy. I would recommend doing your homework before taking any SSRI drug. F 40 1 days
2/22/2008
 5  Depression, anxiety, panic Very vivid dreams, if I miss a dose I have these weird sparks in my brain, dry mouth sometimes. I have tried effexor XR and lexapro these drugs changed me for the worst! Quit them over 3 years ago refused to take anything. My depression got really bad so my Dr. had me try Cymbalta 30mg. It worked for about a month.then i felt it quit working went up to 60 mg. 60mg makes me sleepy so, I take my dose before bed and the next day things are great! My sex drive is also good. The only bad thing I have experienced is if i forget a dose the night before the next day my brain has these weird sparks! i love Cymbalta but after reading comments i am very affraid to come off! F 29 4 months
2/21/2008
 2  
2/21/2008
 1  minor anxiety Stuttering, slurred speech and hand tremors; excessive sleep Throughout the several months I took Cymbalta I was always tired and took long naps during the day. After a few months I had "spells" where I would stutter, slur my speech and my hands would shake. My behavior would infrequently change to a "drunken" state. I was hospitalized for nearly week. MRI, CAT scan and EEG during "spells" showed no physical problems. Cymbalta was discontinued when I was admitted and "spells" disappeared within 4 days. Two months later, no problems. F 48 7 months
2/21/2008
 1  Fibromyalgia & depression After 6 months, I developed posterior vitreous detachments in both eyes Cymbalta was recommended to me by my doctor to aide the symptoms of fibromyalgia that I had had for 12 years. I was very happy with the pain relief and mood elevation and decreased anxiety. Then out of the blue, the right eye developed a posterior vitreous detachment (floaters and tears in the retina) followed by the left eye a few weeks later. I found in the literature that retinal detachment is a rare but very serious side effect and reported it to my physician who reported it to the drug company. This was in early 2006 and my eyesight has never improved-multiple floaters and sensitivity to light daily. The retinoligist said that there is nothing that can be done and it could progress to a retinal detachment in the future. Not a safe drug to take although it was effective. F 55 4 months
2/21/2008
 1  depression fatigue, sleepiness, increased sweating, ringing in the ears, and weight gain F 32 6 months
2/20/2008
 1  depression tremors, weakness in muscles, brain zaps....should I go on? BEWARE! F 39 2 years
2/19/2008
 1  depression All the bad side effects started after about 2 weeks. Started on 60mg. I have been on it 6 months. WORST DRUG ON THE MARKET TODAY. NO ONE SHOULD BE PRESCRIBED THIS MEDICATION. M 35 6 months
2/19/2008
 1  fibromyalgia/anxiety after only one dose of 20 mg,i vomited and had diareah,then hallucinations,and my thorat was numb and had trouble breathing,was instructed to to ER from doctors nurse I have never felt so detached ever from one dose of a medication in my life! This was a scarey experience,i had a severe allergic reaction to it,weirdly,it did help a little with my pain,but not worth it for all the other side effects from hell. use caution!! M 42 1 days
2/14/2008
 5   Not of any significants. I you are having problems with insomnia have your Dr. prescribe some Trazadone. It's available on the $4.00 prescription plan at most pharmacies. M 58 3 months
2/12/2008
 5  Neuropathy Diarrhea, nausea, loss of appetite My neurologist prescribed this for my neuropathy in my feet after I tried various other drugs and none of them helped. The first time I took cymbalta, I had severe diarrhea and nausea and for about a week with same side effects. AFter going off of it for about a week, I realized how much it had helped me the short time I was on it as the severe pain in my toes returned. I tried it again after my dr. encouraged me to stick with it 2 weeks. After just about 2 weeks the side effects disappeared and I haven't felt this good in a long time. It has helped me tremendously and all side effects have gone. F 61 30 days
2/12/2008
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 1  pain associated w/pos fibromayalgia Initially, heightened mood and energy with relief of pain. Within 6 weeks, return of pain and swelling and unpleasant sensations upon urination. Pain in what I thought was my stomach area; amazing weight gain. I connected the dots.Sought to discontinue use as urinary symptoms were progressing dramatically along with general malaise. Decreased dosage to avoid increased side effects from abruptly discontinuing this medication. I realized that I decreased as best I could, it was horrible. I stopped to avoide further damage to my body. No doctor wants to listen to this. The after effects were intolerable- I had excruating pain in my organs- the spastic cramping in my urinary tract, increased joint pain. 2 1/2 months after discontinuing this med., I felt that I was doing better; at this time I had a liver function test done; it showed increased liver enzymes. I had a hepatitis test, which yesterday showed pos. for hepC! This drug is POISON. I am not a drinker, so there is more to cymbalta liver damage than eli lilly is letting out. Everyone should have a liver profile before thinking about taking this med. And certainly, during use. The prescribing physician did neither of these things for me, and now I'm in serious trouble, and Cymbalta is the reason. F 51 4 months
2/12/2008
 1  antisocial & social anxiety nausea, lethargy, awkward feeling I don't really know the extent of my depression or if I'm depressed at all. I'm far from suicidal. I'm a bit meloncholy from time to time but I keep a regular regimen of excercise cycling and lifting weights. I play golf and enjoy my job. Despite all this I went to the doctor and asked for help. I feel antisocial and have a hard time relating to a lot of people. I need a couple of drinks to loosen up in social settings. I also have a difficult time sleeping through the night. I am begininning to realize this is just who I am and that I have plenty of positive attributes as well. I do have $14,000 of credit card debt which I'm chiseling away at and just broke up with my girlfriend of three years. She's living with a new guy within just two months of our split. I think these matters have weighed on me a bit. The doctor recommended Cymbalta. Today is the sixth day on the drug. The nausea is awful and I'm sick of yawning. Last night I sat in a chair in the living room and stared out the wi M 34 6 days
2/12/2008
 5  Depression/GAD Sad all the time. No interest in anything no motivation I have been this way for as long as I can remember. I just thought it was my personality. But as my marriage has been getting worse partly because of the depresion I looked for answers. I tried prozac & Zoloft nothing happened. Then I went to a new Shrink and he wanted me to do a clinical trial of Cymbalta at 120 mg the first two days were very hard but I think It was because I was coming off pain killers. I now feel great very upbeat playing with my kids like I never did before. I am enjoying my life. I am scared that it won't last but I will take this feeling for as long as I can. The trial is for 1 year I will try to keep you informed on how it's going. M 32 7 days
2/11/2008
 4  Depression Sweating, loss of interest in food, and sleepy at the wrong times. I see some improvement with depression (more content, don't wish I was dead, not weepy) and have enjoyed not obsessing over food. F 43 4 weeks
2/11/2008

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