CYMBALTA Reviews (DULOXETINE)

Average Rating: 2.7 (2745 Ratings)

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 ANTIDEPRESSANTS

 Type: Rx Drug

  

CYMBALTA  (DULOXETINE):  Duloxetine is used to treat depression and anxiety. In addition, duloxetine is used to help relieve nerve pain (peripheral neuropathy) in people with diabetes or ongoing pain due to medical conditions such as arthritis, chronic back pain, or fibromyalgia (a condition that causes widespread pain). Duloxetine may improve your mood, sleep, appetite, and energy level, and decrease nervousness. It can also decrease pain due to certain medical conditions. Duloxetine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). This medication works by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in the brain.   FDA Approval Date: 2004-08-03 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on CYMBALTA: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR CYMBALTACOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 2  depression Dry mouth and sinus. Terrible jaw clenching, dizziness, problems sleeping, constipation, I switch to Cymbalta because of some weight gain issues from Lexapro which I had been taking for over 2 years . But I'm going back to Lexapro, far less side effects and you can cut your pills to increase or decrease the dosage yourself. M 58 2 months
30 1X day
9/22/2010
 3  depression, fibromyalgia profuse sweating, tiredness, increased desire to be involved in social situations, severe dizziness with missed dose, minor relief of pain, mood swings, headaches. On the two occasions I could not refill my prescription, the dizziness was so excruciatingly severe that I nearly went to the hospital and could barely walk...it was if walking in quicksand while the contents of my head spun around constantly like a carnival ride going at 5000rpms! Very scary and unpleasant! The pain relief for fibro is very minor, but the benefit of not desiring to isolate myself from others is positive and something I have never felt in my life. I am terrified to miss a dose because I NEVER want to feel that level of continual dizziness again. F 43 4 months
30 MG 3X day
9/18/2010
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 1  Anxiety desorder It is hard to "briefly" describe the side effects of this medication. I had terrible nightmares of being chased every night, I had very major and scary hallucinations where I though I was being beaten, and I could not orgasm during sexual activity. I ran away from my home because of this medication and I tried to put a restraining order over my parents. This medicine made me paranoid and completely messed with my head. There are natural ways to deal with depression and anxiety, in my case this medicine has only made everything WORSE. Please really taking what i am saying into consideration. I don't want anyone to have to feel what I did and still do today. I even had road rage when I was upset or frustrated. I put my life and others lives in danger. Please prevent the use of CYMBALTA! I honestly wish I could sue for all the pain it caused me and the people I love the most... F 17 6 months
60mg 1X day
9/18/2010
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 1  Neck and Shoulder Pain/Depression Cymbalta did not work for me. It raised my liver enzymes. The FDA has issued a black box warning for this. This happened to me. I hope that you and your Dr. are careful and monitor your liver enzymes. Cymbalta did not work for me. It raised my liver enzymes. The FDA has issued a black box warning for this. This happened to me. I hope that you and your Dr. are careful and monitor your liver enzymes. M 33 60 days
60 1X day
9/16/2010
Patient History
 3  severe depressive episode ringing in ears, constipation, apathy, reduced libido went cold turkey for a week....was HELL, need to be on it now because am suicidal, if i get through this not looking forward to withdrawal M 37 5 months
60 2X day
9/15/2010
 3  Neuropathy related to MS Extreme sweating, over heating easily, dry mouth, constipation, insomnia, memory loss, unable to concentrate, lack of emotional feelings, headaches, weight gain Been weaned off Cymbalta for 2 weeks now and having what I didn't know was withdrawal symptoms...severe insomnia, nausea, severe stomach cramps and diarehea. Heart palpitations, anxiety. Hopefully these will pass soon. The doctor didn't tell me there would be withdrawals but I thought I had the flu last week so I wish I would have been better informed. I will ask more questions if there is ever a next time to be weaned off a medication. My neuropathy has increased but so far I can handle it. F 42 3 years
60mg 1X day
9/14/2010
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 5  Borderline Personality Disorder First week I felt "hungover," but that went away. Now I have occasional insomnia and feelings of being "hyper" or having excessive energy. I seem to be a little more spacey or forgetful of minor things in the short-term. Definite sexual side effects. I've been on almost every other Anti-Depressant on the market and Cymbalta is the only one that has brought me relief from depression and self-harm impulses associated with BPD. M 29 2 months
60 1X day
9/12/2010
 3  nerve pain loss of appetite which led to weight loss, dry mouth, dizziness, lightheadedness, fatigue, insomnia, nausea I switched to this drug from Gabapentin. Yes, it has helped somewhat with my nerve pain, but to me it's not worth it. I feel extremely tired yet unable to sleep due to the insomnia. I have no desire to eat food and the thought of doing so makes me ill. I have lost weight which some people may think is good but I'm a small person to begin with and can't really afford to lose any more weight. This drug makes me sick. F 26 8 months
30 mg 1X day
9/11/2010
 4  NECK PAIN This drug has really helped with my chronic neck pain. I have tried many drugs and this one has been the most successful. However, I have never had a weight problem. I am exercising and dieting and the pounds are still piling on. Then there is excessive sweating. If I am in the heat, it is horrible. I am totally drenched. I am going to talk to my doctor about decreasing the dose. I am so glad it has helped with my pain. I can take the sweating, but this rapid weight gain is horrible! F 57 3 months
60 1X day
9/8/2010
 2  depression Common ones such as dry mouth, lack of appetite, nausea, gas, dilated pupils and frequent waking at night. Initially, did seem to help general depression. Felt much more uplifted and good about life. Then severe twitching, muscle spasms and insominia began. Could not sleep with nerve twitching all over my body. Also very low labido. Am now weaning off. Feel the general depression was easier to deal with than the jerky, twitching, spasms and lack of sleep....also worry whether it will ever go away! Dr. wants me to try Prestique.....am thinking I'll try prayer! Am fearful of this drug. The side effects are worse than the problem. F 56 2 months
20mg 1X day
9/8/2010
 1  Major Depression Too numerous to list but the highlights are inability to concentrate, poor short-term memory, lethargy, periodic blurred vision, HAIR LOSS and weight gain. Don't get me started on the sweating, sleep disturbance, nausea, constipation, bad taste in my mouth. Icing on the cake, an unbelievably crappy withdrawal...4th week off and still getting occasional bouts of dizziness but at least the brain zap zaps spzls have stopped. Maybe not. I have been on other SSRIs and SNRIs. All had some side effects but none made my feeling so lousy, in every way. THIS IS A DIRTY DRUG. I not recommend it to anyone. TRY EVERYTHING before you resort to Cymbalta. Yeah, Depression Hurts but I never felt worse. I couldn't really tell whether there was any effect on my depression because I felt never felt well. GARBAGE drug. The withdrawal terrible and there is no step-down from the minumum dose. Cold turkey from 30 mg is a nightmare. RUN F 50 7 months
60 MG 1X day
9/8/2010
 1  neuropathy Severe confusion,anxiety,constant yawning, For the first two years of taking this drug the side effects where nothing i couldn't live with, because it help with the leg and arm pain from my neuropathy. But soon after my wife notice changes in my mood and i started having trouble finding words i wanted to say, as if i where in the first stages of alzheimer's. I stopped the drug and it took over a month for everything to return to normal. This Drug is dangerous. M 51 3 years
30MG 2X day
9/7/2010
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 1  depression Extreme overheating, sweating, and memory loss This drug was originally prescribed for my depression because i also had extreme pain that could not be diagnosed. Cymbalta did alleviate most of my depression symptoms, but I became aware that I had NO feelings - no empathy, sympathy, sadness or joy. I discontinued this drug over a year ago and I still suffer from profuse sweating and feeling overheated. My memory is very bad. I cannot definitely attribute these symptoms to Cymbalta, but they all began when I started taking this drug. I would not take it again. F 55 2 years
60mg 1X day
9/7/2010
Email
 3  depression, anxiety, mood swings oh where to begin, weight gain, constipation, jaw cracks, laziness,fought off the initial sexual side effects,dry mouth,still felt nervous,headaches, migranes 5 yrs have gone by so fast, sometimes i wish i never started it. but it did have good things like i became numb to alot of stuff that would have made me mad before,i have went from 60 to 30 without the dr approval for myself to try to loose some weight and dependency on drug, withdrawl symptoms better this time dont feel like a crack head coming off crack.. think its because i used prayer to help this time,if this is a last resort do it but if there are other options try them first.. F 31 5 years
60mg 1X day
9/5/2010
 1  panic attacks stiff muscles,increase in blood pressure, increased sweating, decreased appetite,alternately hot and cold;tingling or burning, A decreased sex drive or orgasm problems, Difficulty falling asleep, Waking up often during the night and having trouble going back to sleep Waking up too early in the morning Unrefreshed sleep. I am process to stop medication. If I take the med late or forget a dose within 12 hrs, I develop withdrawal symptoms. I want to scratch the walls, disoriented to time and in so much raw physical pain I could scream. My Physician is assisting with this process via medication She is not certain of the duration of the process. Withdrawal symptoms are horrible from this drug. No one should have to endure such agony. F 42 2 years
50 1X day
9/5/2010
 3  Depression, Anxiety Excessive Sweating, Headaches, Forgetfulness My mood may be better, and in a lot of ways the anxiety is better, but ever since my dosage was increased from 60mg to 90mg my sweating side effect increased 10-fold. I think the increase in side effects is enough to try other medication options. I plan to call the prescribing doctor as soon as possible and see if this can be resolved. F 28 30 days
90mg 1X day
9/4/2010
 1  Back pain & Depression Chills , Severe sweats , headache , muscle spasms( entire body would jerk uncontrollable !) B.P. raised ! Nausea ! Insomnia ! M 50 2 days
30mg 1X day
9/4/2010
 3  Fibromyalgia, Depression & Anxiety My digestive system seems to be a little off with a little occasional fleeting nausea. I don't feel "high" or "nervous" with these first two doses. I am always skeptical about new meds. Maybe it's a way to offset any perceived placebo effect. But, I have not felt well in 7 days; weak, joint pain, extreme fatigue. My Fibromyalgia has been in remission 2 years and it seems to have returned with a vengance! Although, Fibro never leaves you completely, I do not ever remember it making my joints hurt this badly or this much fatigue. So, I not only saw my rheumatologist but my PCP to make certain that there is no other underlying cause for all of this. She ordered a big blood draw and her nurse told me a lot about Cymbalta while filling the tubes. Apparently, patients in the practice are all responding favorably with great feedback. I just don't want to do anything walking, sitting, lying are still very painful. Since I started Salsalate at the same time, I am not sure if the negative digestive effects are attributable to it. Some of the side effects of Cymbalta will subside after a few weeks. I have nothing to lose and must feel better or I will go bonkers. F 61 2 days
60 1X day
9/2/2010
 4  Depression, Anxiety Weight gain, nausea, fatigue, feeling very hot & sweating profusely, constipation, headaches, thinning hair I tried Cymbalta as I had heard that it was weight neutral and I had gained a lot of weight on Prozac, Lexapro & Effexor. It has really helped with the depression and anxiety but am now finding that I feel 'flat' emotionally and am having more side effects. Find it very difficult to lose weight even on a low calorie eating plan. Intense sugar/salt cravings. Weird dreams. I want to go off the medication but my psychiatrist doesn't agree. The weight gain and exhaustion are more than I can take but I am so afraid of landing in a deep depression and becoming suicidal again. F 59 3 years
90 1X day
8/31/2010
Email
 4  Anxiety Excessive sweating, tired during day, weight gain of almost 13 lbs. Cymbalta helped my anxiety almost immediately and I am much calmer now. Sweating is really a problem though along with weight gain. Considering going off meds. F 47 4 months
60mg 1X day
8/29/2010

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