CYMBALTA Reviews (DULOXETINE)

Average Rating: 2.7 (2745 Ratings)

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 ANTIDEPRESSANTS

 Type: Rx Drug

  

CYMBALTA  (DULOXETINE):  Duloxetine is used to treat depression and anxiety. In addition, duloxetine is used to help relieve nerve pain (peripheral neuropathy) in people with diabetes or ongoing pain due to medical conditions such as arthritis, chronic back pain, or fibromyalgia (a condition that causes widespread pain). Duloxetine may improve your mood, sleep, appetite, and energy level, and decrease nervousness. It can also decrease pain due to certain medical conditions. Duloxetine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). This medication works by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in the brain.   FDA Approval Date: 2004-08-03 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on CYMBALTA: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR CYMBALTACOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 2  Mild Depression/Anxiety Nausea, brief hot flashes, pressure in head, diarhhea, increased feelings of worthlessness/suicidal thoughts, insomnia, extreme fatigue in the afternoon, delayed orgasm. Cymbalta seems to have alot of side effects that work opposite to its claims. I felt these almost immediately. Decided to stop. Although I did feel a tad better emotionally...I'm not sure if that's just because I was preoccupied by its side effects. M 35 4 days
1/10/2006
 4  Depression/Anxiety Difficulty in reaching orgasm, a wierd sensation like that feeling you get just before you hit the top part of the first hill of roller coaster, sleeplessness, major decrease in appetite. I've been on a lot of different medications, and I was diagnosed with depression at a very early age. I took Cymbalta some time ago and it scared me because of the wierd feeling. But I'm going to try again. I guess maybe the wierd feeling is what most people feel normally. I'm not sure because I've never really been "not" depressed or anxious before. We'll see how it goes this time. M 29 2 weeks
1/3/2006
 4  depression/anxiety consipation, weight gain 20#, delayed orgasm, daytime sleepiness, vivid dreams helps with depression well but am worried about withdrawal if and when I stop it. When will wt gain stop? F 51 16 months
1/3/2006
 2  depression anxiety tired sometimes , minor weight gain ,night sweats , vivid dreams i tried cymbalta to replace effexor and have found that effexor was much more effective for both anxiety and depression. Has anyone else experienced this ? im willin to deal with the effexor side effects to replace cymbalta... M 33 2 months
1/1/2006
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 1  peripheral neuropathy initial insomnia, restless leg, severe nausea, constipation, and increased sweating, bloating stomach and gas. This drug was hard going on, but helped my pain a lot. I was happy for the pain relief so remained on it for 10 months. But the side effects continued to increase. I decided Cymbalta was the cause of my deteriorating health, including severe back pain, muscle weakness, and muscle and tissue inflammation in groin which has led to four MRI's 5 series of back injections for pain, and 2 CT scans. Going off of Cymbalta is a nightmare. Be prepared to have a rough road - I had dizziness, severe headaches, inner ear pain, flu like symptoms, stomach pain, nightmares - of which have subsided now but not completely. I still get the flu feeling which comes on suddenly and remains for hours, and still have some nightmares, and some headaches. The ear pain is gone and the dizziness. I hate this drug. For all the pain relief it provided, it was not worth the side effects and withdrawal suffering. I just had the CT Scan of my groin and do not yet have the results, but I do believe witho F 55 10 days
12/30/2005
 4  Panic Attacks/Depression The first few days insomina, after that I felt very tired all the time. Long Delay before orgasm. Loss of Libido I have been on 150 mg of Effexor for about 8 months. Was experiencing loss of sexual function, delayed orgasm. In the past many years ago I tried Zoloft & Prozac and had the same effect. My shrink felt maybe by switching to Cymbalta my libido would come back. It's too early to tell I have only been on it for one week at 30 mg's along with 37.5 & 75 Effexor. He is weening me from Effexor to Cymbalta. I really havent had any different side effect other than the fact I feel a bit more tired, maybe it will ease up as time goes on. I also take 0.05 klonopin for anxiety. When I go for my next visit I am sure he will adjust by taking more of the Effexor away not sure if he will increase the Cymbalta. I feel like I have gained so much weight with all theses anti-depressants, but I guess it beats having panic attacks and not wanting to go out of the house and enjoy life. I do have alot of extra added stress in my life right now. I am a student, mother, wife, and work part-tim F 42 1 days
12/28/2005
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 3  mood swings, lack of energy Fasciculation (muscle twitching) and vivid dreams Everything was absolutly great with this medication except for the muscle twitching and spasms. I had great energy and felt happy, but the spasms would keep me from falling alseep and would wake me up at night. F 30 1 months
12/28/2005
 1  Severe Depression, Cronic Pain Headaches, sweating, weight gain, severe insomnia, constipation, no libido, loss of hair, and tingling in hands and feet. Isn't that enough? I wouldn't give this to my worst enemy. I'm glad it's winter, if I had this sweating and night sweats in the summer, it would be unbearable. I never noticed any pain relief or extra energy. My doctor wanted me to stay on it, but after reading things here, no way! I'm going back to Effexor and Wellbutrin! By the way, in the physian section at the website, it says it's only effective up to 60 mg, makes no difference over that and it isn't recommended for Bi-Polar either. Good Luck, hope you find what will work for you. F 53 2.5 weeks
12/25/2005
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 4  depression, pain sweating, sexual dysfunction, insomnia, weight up, able to breathe better, pain way down, mood up, sex terrible 3+ months. to alleviate the sex side effects, have tried viagra, holidays, many others ... not much help M 60 120 days
12/18/2005
 4  depression, anxiety, panic Loss of libido, ringing/twitching in ears I felt very good, like myself again. No worrying all the time. Dr. took me off of it because of the side effects. Bad headache for two days after stopping it. M 39 1 months
12/11/2005
 1  depression/bi-polar This is the worse. Increased my blood pressure to unacceptable levels, also caused anemia and severe gastritis. I can bearly function some days. F 50 3 months
12/6/2005
 2  depression/bi-polar disorder 60 mg: extreme fatigue, weight gain (15 lbs) I kept waiting for the fatigue to go away but I have felt fatigued for the past 4 months! Plus, I do nothing except sit on the couch and cry all day now - I don't even feel the bipolar mania "high" anymore in which I clean the house all day - lol, my house is a mess! F 27 4 months
12/5/2005
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 1  Neuropathic Pain This drug caused me to have feelings of worthlessness. This drug did not help my Neuropathic pain. On a 1-5 scale, I give Cymbalta a 1. M 14 days
12/3/2005
 5  depression & lack of energy Slight nausea at first - but went away after a few days. Extreme sleepiness in the evenings during the first week - no problem now. Still have a night or two during the week when I can't sleep or wake up @ 2 a.m. I feel better than I have in a very long time! I have so much energy during the day and find myself laughing again. My moods are more even and I am alot nicer to be around. I don't explode when something stressful happens ... For example: my 8-year-old spilled a whole glass of coke in my car and my reaction was "Oh well, let's clean it up." Before I would have had a STROKE! I love this drug, but how long is it safe to take it? Does anyone know? F 40 30 days
12/1/2005
 1  Depression Insomnia, waking at 3-4 am and can't go back to sleep, lack of libido, unable to orgasm, no motivation at all, tremor in my jaw, constant yawning, increased appitite Only been taking Cymbalta for 2 weeks and think i am going to switch back to Wellbutrin. I switched to Cymbalta because Wellbutrin seemed to stop working but after taking this i feel it may have been helping me after all. The lack of sleep and lack of ability to enjoy sex with my husband is just making me feel more worthless than ever. I can't get the motivation to get anything done, i would rather lay on the sofa and try to get the sleep i lost during th night. Would only recommend this drug if you have exhausted all other avenues. F 25 2 weeks
11/30/2005
 5  depression stuffy feeling head (more in the begining) night sweats, more vivid dreams (not really a bad thing) I do drink wine often..... and should have my liver checked for I know I should not be mixing the two :( I feel more in control of my feelings, less pms(y). the week before my period I don't go around changing my whole life because I'm feeling like things are lacking or kicking people out of my life because of my imagained beleifs of what they are thinking...... F 34 2.5 months
11/28/2005
 1  Fibromyalgia, mild depression Headache, nausea, dizziness, insomnia, MANIA, vivid weird dreams. Problems with memory. Weight Gain. Stopped cold after one month of use. I should have followed my instincts about taking this very new drug. My doctors talked about this drug for a year trying to get me on it. After coming into a "flare", I tried it. SCARY drug. I am hoping I do not have lasting memory and weight gain problems. I would like to WARN everyone to NOT take this drug. F 50 30 days
11/24/2005
 1  depression I was so nauseous I couldn't eat for two weeks and it made me severly dehydrated no matter how much I drank, damaged my liver and kidneys, increased my anxiety...and I don't really remember much else because I was preoccupied with the distinct urge to off myself. I thought depression was bad, until I took Cybalta. Cymbalta is much worse. F 17 4 weeks
11/21/2005
 5  Multiple Sclerosis pain and fatigue Insomnia subsiding slowly hot flashes - sweating - I don't sweat much and now I sweat easily, even when it is cold - but it is subsiding. NAsty taste in mouth first two weeks GOOD NEWS - appetite decrease - I felt constantly hungry before starting Cymbalta (may have been Skelaxin side effect) I LOVE THIS DRUG. This drug has been a new lease on life for me. I was about to apply for disability. I had intense spasticity (stiffness), hurt all over - joints and muscles - and had a few spots of INTENSE pain and any movement was like walking thru knee deep mud. Within days, the spots of intense pain were GONE (after months) and after 10 days the other muscle pain subsided substantially and after 3 weeks, I almost felt normal. Was taking two Skelaxin twice a day just to move - now I am taking none. I had been on Zoloft twice before (it has been a couple of years) but nothing has worked like this. F 48 5 weeks
11/20/2005
 1  nerve pain Hair loss, constipation, insomnia I noticed almost immediate relief from pain but this subsided and the doctor upped the dose from 30 to 60 mg. Then, it did not work at all. I consider this a worthless drug. Beware. Getting off this is absolutely horrendous. Dizziness. Headache. Trembling. Nausea. I think the drug companies don't care at all what they are shoving on us. F 59 2 months
11/18/2005

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