CYMBALTA Reviews (DULOXETINE)

Average Rating: 2.7 (2745 Ratings)

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 ANTIDEPRESSANTS

 Type: Rx Drug

  

CYMBALTA  (DULOXETINE):  Duloxetine is used to treat depression and anxiety. In addition, duloxetine is used to help relieve nerve pain (peripheral neuropathy) in people with diabetes or ongoing pain due to medical conditions such as arthritis, chronic back pain, or fibromyalgia (a condition that causes widespread pain). Duloxetine may improve your mood, sleep, appetite, and energy level, and decrease nervousness. It can also decrease pain due to certain medical conditions. Duloxetine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). This medication works by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in the brain.   FDA Approval Date: 2004-08-03 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on CYMBALTA: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR CYMBALTACOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 1  Fibromyalgia All over numbness, extreme fatigue, foul smelling flatulence, excessive hunger, disturbed sleep, vertigo I was given a free trial for 30 days by my doctor yesterday, I took the first pill last night and did not take any of my other meds because I wanted to see its full effect solo. I woke up this morning and for the 1st time in about 4yrs I was able to get out of the bed and stand on my feet without cringing pain, i cried with joy. Then as I walked I was dizzy, then vertigo hit. I woke up at 5am, never do I wake up in the middle of the night and i was so hungry but nothing tasted good so i went back to bed. I am up now and feel so exhausted and have no energy. My whole body is numb and its annoying, my ankles still feel good tho but because my body is numb. This is unnatural to me to feel this numb and so tired. I am taking the med back to the pharmacy for them to dispose of. I read about the wean off period and I have gone thru that before with no plans to experience it again. I do not recommend this and I have only taken it for less than 24 hours. F 29 1 days
30 1X day
8/9/2011
 1  Fibromyalgia Negative: Extreme agitation, yawning all day long, constant diarrhea Positive: Weight loss, increase in libido This drug did not work for me. The negative side effects were too extreme to stay on it more than 8wks. The withdrawl symptoms were absolutely horrible. I quit smoking cold turkey and the withdrawl of this drug was 10 times worse than the withdrawl of nicotine. Beware! It takes at least two weeks to feel normal after getting off this drug. F 44 8 weeks
60mg 1X day
8/8/2011
 1  Depression Lack of emotion, night sweats, high blood pressure. Beware starting this drug because it will alter your brain. I have been having withdrawals and I completely stopped taking it 3 months ago. I had to ween off of it over a period of about six mos. with the help of a holistic doctor. I believe that the supplements that she gave me helped decrease the severity of the withdrawals. Now after being off, I have nightmares almost every night. It seems to pull the hidden fears out during your sleep and turn them into nightmares. I have never had a problem with this before and read about the night terrors that others have had. Also, I get angry very easily and feel irritable a lot. I started out with Lexapro about 8 years ago for depression and that stopped working, so my doc put me on Cymbalta. Every time I went for my physical, I asked him about going off of antidepressants, and his reply was "if it's not broken, why fix it." I believe that the doctors now are getting kickbacks from the pharmaceutical industry to get people started on these addictive drugs. They don't warn you ahead of time what a horrible experience it is when you don't want to be on drugs any longer. My depression was mild-moderate, and I wish that I had never gone on any drugs at all. I see a holistic doctor now and she is able to help me with my moods with natural supplements. I am hoping that the nightmares will eventually go away. I feel like I have permanent brain damage from this drug. Consider yourself warned if you have been advise M 51 5 years
30 mg 1X day
8/5/2011
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 5  generalized anxiety disorder weight loss, decreased appetite, increased sex drive, refreshing sleep I love this medication. Truly a miracle. Please try it because you are worth it. F 40 4 months
60 mg 1X day
8/4/2011
 3  Depression Slight nausea, sleeping a lot Cymbalta should be recommended for people with chronic pain. I had severe back pains and that's about all it took care of. I ran out of Cymbalta for two days and it was two days of hell. Worst withdrawal symptoms I've ever experienced. I've been on it for ten months total, and I'm down to 60 mg. F 26 8 months
90 1X day
8/2/2011
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 1   Mind racing, brain sparks, talking without thinking, over aggression, aggition, sleeplesness, and loss of appetite (extreme weight loss)!!!!!!! M 30 8 months
60 1X day
8/2/2011
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 2  Depression, anxiety, lack of energy Anger, hostility, aggressiveness, agitation, suicidal thoughts, odd behavior. Psychiatrist changed me from Paxil to Cymbalta to treat norepinephrine levels to increase my low level of energy that was significantly affecting my quality of life. Paxil only treats serotonin so Cymbalta was an obvious choice because it is used to treat both serotonin and norepinephrine. A VERY BAD choice for me. I was hospitalized with what I call an "anger stimulated adrenaline rush." I actually slammed my head through a wall and had thoughts of unimaginable evil rage during the outburst. TOTALLY out of character for me! The feeling of anger was so intense I had a small heart attack (documented) and have to take heart related drugs, now. My Cymbalta experience caused me embarrassment, a big hospital bill and a heart attack. ACT EARLY IF YOU HAVE SIDE EFFECTS! Don’t wait for them to worsen like I did. M 55 30 days
60 MG 1X day
7/30/2011
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 5  Fibromyalgia, chronic fatigue first two weeks excessive yawning and mild nausea...went away Helped greatly with my FM pain and gave me lots of energy. Absolutely loved it as long as it worked. After 2 years the "poop-out" came and the withdrawal was truly hell. Had no other side effects than listed and no effect on libido. I wished it would have helped for longer than just 2 years...I felt like on top of the world. Make sure to taper down over a 2-3 months period and have Xanax handy. F 41 2 years
60 1X day
7/29/2011
 2   Weight gain, brain zaps, blurred vision This is my second time on Cymbalta. I begrudgingly allowed my Rheumatologist prescribe it for Fibro even though I had taken it several years ago and hated it. Weaning off this med is brutal. The best way to do it is work with your physician and establish a tapering down schedule. When you get below 30mg ask your dr. to prescribe lower dosages through a compound pharmacy as they can make it into 20 mg liquid doses x 5cc. The idea is you go down to 20 then 10 then 5 and voilá. It is not painless but it is definitely more tolerable than just reducing doses to 30mg and skipping days. I'm in the process of weaning off it due to weight gain. F 47 3 months
60mg 1X day
7/28/2011
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 4  Migrain Nauseous really bad for the first week but knew it would go away.. Weight loss and tiredness. Everyone reacts differently to drugs and I am so glad I had the patience for the side effects to subside. I have tried everything and anything to get rid of migraines...pain killers did not work anymore. I do have a history of depression, nerve pain and arthritis. This drug covers all of these symptions. I am 30 day without losing a day to a migraine and as a woman losing weight is a positive F 46 45 days
60 mg 1X day
7/26/2011
 5  Headache / Chronic Migrane My doctor started me on the 30mg for the first month. Intially I had slight nausua and lack of appitite. After the first month I upped the dossage to 60mg since my headache always came back about 3-4 hours before my next dose. My slight nausua and lack of appitite increased, but as per my doctor's instructions I took the medicine with a full meal in the evening and tried to eat snacks throughout the day. After about a month, my intial symptoms disappeared but I did have to go on prevacid several months after the nausua went away because it came back rather severly. Now my symptoms are feeling hot all the time, never feeling cold, vivid dreams, dreams where I'm trying to wake up but I can't (which is solved by an alarm clock), occasional nausua, and weight gain due to increased appietite. I was diagnosed with "atypical" migrane which is basically the cover term for severe head pain. My headaches would last weeks and months. No other medications worked, no pain killers worked, and I was wasting away and very sleep deprived (and perhaps a little depressed). At my 30mg dose I at lease got a headache everyday about 3-4 hours before my next dose (sometimes I just had a headache all day). At the 60mg I just sometimes had a headache all day (3-5 times a week). Now I'm on blood thinners with no headache in the past 3 weeks, and am thinking of weaning off the cymbalta. F 22 7 months
60 1X day
7/25/2011
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 1  Diagnosed with Fibromyalgia One year after I was diagnosed with Fibromyalgia, I was prescribed 20 mg Cymbalta & gradually the dose was increased to 60 mg. After taking Cymbalta for 4 months, I experienced negative side effects, including worse depression, anxiety, severe insomnia, irritability, changes in my personality, lack of motivation, mood swings and rage. I informed my doctor about these negative side effects & requested she discontinue Cymbalta. I wanted to slowly taper off Cymbalta, but my doctor refused. After experiencing intense depression for 2 months, I asked my doctor, again, if she would help me taper off Cymbalta, but she claimed I could go "cold turkey." Then she literally "dismissed" me as her patient. I went to 5 different doctors in desperation to obtain help to taper off Cymbalta, but I could not find one doctor to help me. How come doctors are more than ready to hand out prescriptions, yet, so hesitant to stop a medication when it's obviously causing serio CYMBALTA NIGHTMARE FROM HELL: When not one single doctor would help me taper off Cymbalta, I decided to attempt it on my own. After a few short days, my fibromyalgia flared up severely and I ended up staying on 30 mg Cymbalta to try to reduce the pain. Fast forward to Sept 2010, I had an appointment with a new doctor who suspected something was wrong. He had me check with my pharmacist & it turned out that Cymbalta was SEVERELY INTERACTING with 4 of my other prescriptions. Unfortunately, so much damage was done by this point. During my gradual taper, I experienced severe debilitating symptoms, including physical, emotional & cognitive impairment. I became suicidal and I overdosed. Thank God, I lived through this pure hell! It has been the worst experience of my life, but my deep faith in God is the ONLY thing that got me through the worst of it. For 8 months, I've been Cymbalta-FREE! I highly recommend individuals DON'T take Cymbalta. There are serious long-term debilitating consequences involved with this drug. If you have encountered a similar experience, check out Erin Brockovich's website to consider taking legal action. Also, check out the Facebook Cymbalta Withdrawal support group to meet others suffering the same nightmare from hell. F 47 2 years
60 MG 1X day
7/22/2011
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 4  Nerve Pain Extremely sleepy. Constant yawning. Diarhea every afternoon like clockwork. 10 lb weight gain in 2 months. I am getting off this drug. It helped the pain but all I want to do is sleep and eat. I need to go to the gym and/or walk an hour a day and I just have no desire or energy to do either (or anything else for that matter). Its not worth it. I'd rather feel the pain. F 54 8 weeks
20 mg 1X day
7/21/2011
 1  Fibro Watery Stool Dizziness Vertigo Stomach Cramps Feeling of not being able to breath Vomiting Sweating Chills Shaking Loss of energy/ absoloutely none. Worst day of my life the day I took that crap. I took it that night, and about two hours later I had a pretty bad stomach ache, but was able to fall asleep. Woke up at five that morning running to the bathroom because I had crap all over me. Had severe stomach cramps all that day, could barely breath. I took it for one day and two days later can still feel the effects, I am so insanely tired, shakey and cannot think straight, it is horrible. F 21 1 days
30MG 1X day
7/21/2011
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 4  stomach pain and anixiety Coming off drug I have blood shot eyes now. Dizzy. I gained 20 lbs in one year. I workout every day and I WAS in good shape. I was hungry all the time and I drank too much When I was on it I did feel more confident. I would not have decided to quit taking it if it wasn't for the weight gain. I don't think he causes weight gain but it does make you want to eat more often. I ate at 10pm every night, an extra meal. I felt like it didn't matter, so what, who cares. I was a little foggy and I did not like that either. M 47 15 months
20 1X day
7/20/2011
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 2  mild depression I took Cymbalta for 2 years, initially for mild depression during a stressful time at work. Decided to go off med this summer. I felt like i was coming off some major illegal drugs. Horrible effects. I tapered for two weeks and then said to heck with it and quit taking altogether. Dizziness, brain zaps, forgetfulness, insomnia. I will never take another med for mild depression...not worth it. Cymbalta worked for depression, but I felt more like a zombie. Can't remember the last time I had any real feelings. Sex has been nonexistent...no desire. Sweating constantly, and feeling hot ALL the time. I was dripping when I walked or worked out and others with me were not breaking a sweat. I gained 30 pounds over the two years of taking Cymbalta...I already feel the stomach bloating subsiding. The doc doesn't believe weight gain was caused by this med. I have never been this overweight. Doctors should warn patients of the effects once you get off the med. It is insane. F 51 2 years
60 1X day
7/15/2011
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 4  Major depression, panic attacks My psych warned me Cymbalta had a 3-6 mo. break-in period, was also fairly new. I'd tried everyting else, chose to go ahead. Horrid nightmares which gradually diminished, are now gone. Strange heart activity, palpitations, fibrillation, strong beating at times, so had EKGs and wore a Holter minitor. Suddenly at 6,5 mos. all symptoms disappeared. Glad I hung in, but was desperate for something that would work. Panic attack history was awful, haven't had one since. Was battered wife 7 years, helped with PTSD symptoms, still here but mild. Overall my libido's gone, but that began w/ hysterectomy in 1989. Husband is 80, I'm 69, still much in love so don't miss it most of time. Went from a fear-ridden lifespan to fearless and assertive, sometimes too much so, one of 2 complaints. Other is I still have deep depressive episodes 2-3 times a year & lasting 2-7 days, see all through a negative filter, become agoraphobic, stay in bed on worst days, complain, cry, pick fights. My honey has been great in putting up with it. Having always had trouble sleeping due to PTSD, stimulation from norepinephrine makes it worse, take 1.5-2mg Xanax to sleep, have a doctor who's fine with it, all others have refused. If I ever need to stop & withdraw I'll hopefully be able to use Xanax to get through it. Other than having to watch my fearless aggressiveness, tolerate the infrequent deep depressions, and deal with insomnia, Cymbalta has been by far the best antidepressant I've tried, and I've done them all. I'm happy, even silly, have no self-consciousness about letting my inner child out, am seldom embarrssed any more, accept and like myself most of the time. Hope I can continue and things don't change with time, causing a need to experience that horrid withdrawal I read about. F 69 5 years
40 mg 1X day
7/14/2011
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 5  depression, anxiety, joint pain Dizziness the first couple of days, flashbacks after 13 days (not bad flashbacks) I have actually lost a little weight, yay! I had flashbacks last night of my childhood, and it was all good memories. It was like this medication released some trapped memories, and it was nice not to have nightmares. I do zone out from time to time but it's worth it not to be anxious or depressed all the time. F 34 14 days
30 mg 1X day
7/7/2011
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 4  skeletalmuscular pain post accident At first shadow headaches that didn't materialize. Thirsty. On 60mg overwhelmed and brain zapped?! More anxious. I didn't realize that depression and anxiety followed the accident where I was rear ended not once but twice in just a few weeks. My physiatrist noticed the depressions with the pain. She put me on 60 with a choice to try 30. One dose of 60 and I stuck with 30. Did not like the feeling with 60. I feel great and haven't felt this good in years. Overall, I love it! F 53 2 months
30 1X day
7/5/2011
 3  Mood swings nausea, tiredness, insomnia, blured vision, headache, muscle spasms, loss of appetite My doctor put me on the 30mg once a day for 7 days and then is bumping me up to 60mg once a day but the side affects I am having are horrible. I haven't been able to eat because of the nausea and I wake up around 6am every morning and can't go back to sleep. If the side affects go away and it works then it will be great but it's hard getting through the first couple of weeks with the side affects. F 29 7 days
30mg 1X day
7/1/2011
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