CYMBALTA Reviews (DULOXETINE)

Average Rating: 2.7 (2745 Ratings)

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 ANTIDEPRESSANTS

 Type: Rx Drug

  

CYMBALTA  (DULOXETINE):  Duloxetine is used to treat depression and anxiety. In addition, duloxetine is used to help relieve nerve pain (peripheral neuropathy) in people with diabetes or ongoing pain due to medical conditions such as arthritis, chronic back pain, or fibromyalgia (a condition that causes widespread pain). Duloxetine may improve your mood, sleep, appetite, and energy level, and decrease nervousness. It can also decrease pain due to certain medical conditions. Duloxetine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). This medication works by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in the brain.   FDA Approval Date: 2004-08-03 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on CYMBALTA: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR CYMBALTACOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 1  Osteoartthritis,neuropathy Severe Lethargy and Fatigue, falling asleep in middle of daytime conversations with people. Nightmares, sexual and sleep side effects. Uncontrollable crying Ironically,I wasnt depressed until I took CYMBALTA. I did get sad at times due to the limits my severe pain puts on me but who doesnt? Doc said it could help with the pain so what the heck, I trust him. Antidepressants are way over prescribed for issues like pain. If I knew the WD would be this hellish I would NEVER have taken CYMBALTA. Ive tried just about every AD and nothing, NOTHING is like this to come off of. JUST BE careful and INFORM yourself to both the poss side effects while on it and the WD while quitting it. I usually know better and this is a way to painful reminder. CYMBALTA needs to be more clear about all this but I believe the drug company dont want you to TRY coming off these so they only push the "POSSIBLE" (note: not probable!) benefits. F 37 3 months
60mg 1X day
2/7/2011
 4  Fibromyalgia & depression Severe itching. Insomnia. When I first started Cymbalta I had many side effects including insomnia,severe itch,jaw clenching,nausea,tinnitus,nocturnal urination,cold chills and dry throat. Thanks to some "practioner only" amino acids I now sleep for hours at a time even though I still have a lot of dreams. Unfortunatly, I can only apply anti itch cream as the itch will not go away although it has subsided. I have to say to perservere with this medication, as I have, and I am glad because life has become better and majority of the side effects are gone. F 55 5 months
60 mg 1X day
2/6/2011
 5   Early on some stomach issues (indigestion-type), sleeping difficulties. My neurologist suggested I give cymbalta a try after my experience with Lyrica was unsuccessful. It has been an amazing drug for me. It has replaced the Zoloft I was taking for depression.anxiety and has completely erradicated my neuropathic pain. I am so happy to have the daily arm, neck and shoulder pain GONE. F 51 4 months
60 mg 1X day
2/5/2011
 4  Major Depression Innability to come up the words I need. I will stop mid sentence because I cannot remember what I was talking about. The reason I know that I am doing it, is that my husband will tell me to stop and think before I open my mouth. I also find myself transposing letters when writing and cannot remember strings of phone numbers (it use to be very easy). It is extremely frustrating and adds to my depression because I don't want to look like a fool and do it in public. Inability to control urine. Peeing my pants. I wear a sanitary pad when in public. Wanting to sleep all the time. I can go to bed at 9pm sleep till 6:30am and want to take a nap by 11am. If I am able to take a nap I can sleep 2-3 hours and then go back to bed at 9pm. If I happen to have a glass or two of wine at night, I might as well not have any memory of the evening. My husband will say something about having sex, and I don't remember any of it. Cymabalta has helped me with anxiety and has lessened my depression. I have felt happy for extended lengths of time. My kids have noticed my improvement of happiness. I am debating what to do, the described side effects are becoming worse and I don't know if cymbalta is ruining my brain function. If I stop the medicine will thise effects go away? Or do I stay on it and have less anxiety and less depression? F 48 3 years
60 mg 1X day
1/26/2011
 5  interstitial cystitis, depression Tired, tinnitus, restless legs. I started taking Cymbalta for depression and also pain from interstitial cystitis and vulvodynia. Since I am very sensitive to meds, I started by opening the capsule and pouring most of the pellets out, recapping it, and taking the small amount left. I gradually worked up to 30 mg a day. I felt instantly calmer from Day 1, and had improvement of bladder urgency/frequency/spasm. I have since reduced dose to 20 mg per day. I initially had exacerbation of restless legs, which went away over time as I adjusted to Cymbalta. I can get tired and spacey in the afternoon when it kicks in, but I gladly take the med because it has given me my life back. M 54 2.5 years
20 to 30 1X day
1/25/2011
Email
 3  major depression As of right now, I'm having piercing headaches and gaps on the mental radar. My immediate, short-term memory fails me way too often; and, I don't have the attention to detail I used to. It just started to impact the quality of my work yesterday. The does goes up tomorrow to 30mg 2x a day. I am not ready to hang it up just yet though, because I was miserable. I seem to be a little better...at least am willing to go to work and not picking fights with my family anymore. F 41 7 days
30mg 1X day
1/20/2011
 4  GAD Exacerbation of restless leg syndrome, night sweats, vivid sometimes disturbing dreams, increased urination and thirst, some libido reduction (fixed by manipulating dose), possible gastrointestinal issues I started taking cymbalta when I realized my anxiety had no basis in reality, I was anxious regardless of whether I was worried about something specific or not. At that time I was severely underweight as I could eat only a few foods in small quantities without becoming nauseous and vomitting. In the first year I gained thirty pounds. In the second and third years I have gained and lost and gained about ten more pounds, my weight fluctuates with my level of physical activity. I feel that my weight is much more reasonable now as I have a bmi of 26 instead of 18. Restless legs syndrome runs in my family and I had had it very mildly before taking cymbalta. At about 2.5 years into taking cymbalta the restless legs became unbearable, I now also take mirapex for the restless legs. In the beginning I was taking 60 mg per day and my sex drive dropped to zero. I subsequently started taking 30 one day and 60 the next a d this has brought my sex drive back to normal. I have regular GI issues which my doctor thinks may be a result of dairy or gluten allergy tho I think it is a side effect of cymbalta. I have also experienced a distinct urgency and increased frequency with urination. Once before I realized how serious it was I actually peed in my pants on the way to a bathroom. I haven't peed in my pants since I was five years old so this was really shocking. I literally could not stop the flow but I had peed only an hour or so before. I also have very vivid dreams that are either fantasti F 25 3 years
30mg/60mg 1X day
1/10/2011
 5  fibromalgya and super bad nerves Needed more rest than. Unexpected adrenaline rushes and I've started drinking more water. Also, weight loss.. which in my case is a good thing. I've loss 20lbs. I like Cymbalta. It works very well for me. I've overcome cancer and without the ability to take added hormones life was difficult battle. Cymbalta has helped me to maintain my employment,friendships and go through life without pain and anxiety. F 63 4 months
60mg 1X day
1/9/2011
 5  Body pain and depression Dry mouth the first week , insomnia, increased sex drive, loss of appetite I feel like someone turned on the switch to life since I started cymbolta , I have so many friends wanting to try it. Everyone is is different and we need to remember how horrible we felt when not on cymbolta and ask ourselves if we want to go there again or deal with some side effects . I'm done with depression and am all in for life!! F 40 4 weeks
20 mg 1X day
1/7/2011
 3  fibromyalgia Had trouble sleeping. Started to feel like I was in a fog,became more irritable, had a few episodes of rage and suicidal thoughts. Slowly weaned myself off it. As I slowly weaned myself off I felt like I was going thru some sort of horrible withdrawal. Had nightmares with images flashing thru my mind at super speed as if my synapses had gone haywire and were exploding. Very scary. Night sweats. Continuous dizziness and fog as if I am drunk.Extreme irritability and crying. This has been going on for about two weeks. I will never take this med again. The withdrawal is frightning. F 60 2 years
1X day
1/6/2011
Email
 4  depression, neuropathic pain Nausea during first few weeks, but it subsided. F 68 1 years
90 1X day
1/4/2011
 4  Depression sweats, weight gain, dry mouth at beginning F 41
60 1X day
1/4/2011
Email

Patient History
 5  Depression,anxiety and pain slight weight gain Cymbalta is great.My anxiety levels are down,I'm calm,mental clutter is gone,sleeping better.Muscle pain from fibromalgia is reduced.Depression is gone.My out look on life is 100% better.Positive attitude.I'm very grateful my doctor put me on Cymbalta. F 51 8 months
30mg 1X day
1/1/2011
 3  Anxiety and related GI symptoms Extreme lethargy, weight gain, COMPLETE LOSS OF LIBIDO! I suffer from severe IBS, which was causing all kinds of havoc in my life. While the Cymbalta was a lifesaver when I first began taking it, I found that over time the side effects were piling up, and really making life unpleasant. My relationship suffered due to lack of libido and constant lethargy. I gained weight and had a very difficult time losing it. I have stopped cold turkey under the close supervision of my doctor. Hoping for improvement. F 33 2 years
60mg 30mg 1X day
1/1/2011
 3  Fibromyalgia none Feel much better when I take medication. F 40 2 years
60mg 1X day
12/29/2010
 2  Anxiety/irritability/insomnia Nauseau Didn't really help with symptoms of irritability; did not help with insomnia; nausea occurred when I took it in the morning so started taking it at night but no change in nausea. F 47 45 days
15 then 30 1X day
12/29/2010
 4  depression, FM weight gain, dizziness, brain zaps, I feel like I do not really experience emotions? muscle twitches or tics. This medication saved my life. I was suicidal with a plan to do it. This made all that and most of the depression symptoms go away. However, I have taken Cymbalta before and came off with God awful withdrawl. The brain zaps and dizziness are enough to make you ill but I get nauseous and extremely irritable as weil. I an scared to death that I will run out of the med and have to go even one day without. I have taken tons of other AD's and stopped cold turkey on quite a few. I was young and didn't feel like they were helping. I have experienced terrible withdrawl with quite a few of them. But Cymbalta takes the cake for being the worst. It is extremely expensive and I would love to come off my meds but I fear the suicidal thougts/tendencies worse than the withdrawl and side effects from Cymbalta. F 35 5 years
60mg 1X day
12/28/2010
 4  Major Depression/Anxiety Slight weight gain, NO libido at all, headache and nausea if I miss a dose or two, but the night sweats are THE worst. I also have scoliosis and suffer from moderate to severe back pain...fortunately, I have gotten the added benefit of pain relief! I began taking Cymbalta during a major/long term family crisis about 3yrs ago that brought on some serious depression and anxiety. Since I'm in my 40s, I attributed the sweats to perimenopausal symptoms, but after trying HRT, then weaning myself off of the Cymbalta slowly, and even switching to WellbutrinXL (the Wellbutrin made me feel enraged and out of control...a horrible mistake for me), I realize that the sweats ARE caused by the Cymbalta. My sweats stopped, but my back and neck pain came back with a bang, and my depression set back in along with the raging/anger and a feeling of being totally out of control from the Wellbutrin. I immediately stopped the Wellbutrin (after 1wk), got back on the Cymbalta (currently rampimg up at 30mg/day) and I feel better almost immediately. This "test" affirmed for me that the benefits of Cymbalta far outweigh the side effects. I'm going to try to stick with the lower 30mg dose for now and see if I get the mental/physical relief I need without the side effects. I didn't know how well it was keeping my moods stable and me civil until I stopped taking it and tried something else. F 43 3 years
60mg 1X day
12/28/2010
 3  GAD difficulty sleeping, waves of nausea, at times anxiety and nervousness, foggy, difficulty forming thoughts and some short term memory loss. The only side effect that was constant was the inability to sleep well and felt jittery all the time. Also, felt very foggy and unmotivated. However, other side effects would creep in from day to day and come and go... took for migraine prevention and it worked but too hard to tolerate side effects. Switched to 5 mg of Lexapro 3 days ago b/c I didn't want to tolerate the side effects any longer. F 38 16 days
20 mg 1X day
12/22/2010
 5  Major Depression and Anxiety I felt a little nauseated for a day or 2.. other than that I can't even tell im on a AD! Amazing. Negative thoughts disapeared within ONE day of 30mg. Since then I have improved 100%. Miracle drug for me. I am lucky enough not to have any side affects from the drug yet. Standard SSRI's gave me terrible side affects, and a wierd feeling in the head, I can't even tell im taking a drug! M 26
60 1X day
12/21/2010

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