CYMBALTA Reviews (DULOXETINE)

Average Rating: 2.7 (2745 Ratings)

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 ANTIDEPRESSANTS

 Type: Rx Drug

  

CYMBALTA  (DULOXETINE):  Duloxetine is used to treat depression and anxiety. In addition, duloxetine is used to help relieve nerve pain (peripheral neuropathy) in people with diabetes or ongoing pain due to medical conditions such as arthritis, chronic back pain, or fibromyalgia (a condition that causes widespread pain). Duloxetine may improve your mood, sleep, appetite, and energy level, and decrease nervousness. It can also decrease pain due to certain medical conditions. Duloxetine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). This medication works by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in the brain.   FDA Approval Date: 2004-08-03 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on CYMBALTA: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR CYMBALTACOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 5  depression, anxiety No side effects if I take it early in the day. If I forget and wait until late in the day I experience "brain zaps" and an irritating but interesting increase in volume in my hearing, accompanied with a slight echo. Very annoying but goes away quickly after I take my dose. Also I get weepy if I wait too long to take it. It has changed my life for the better. I love it and will continue taking it. I don't get so emotional over silly things, my thinking is clearer and I use better judgement when making decisions. I am more patient, and wish I had been taking it when my kids were younger, I would have been more tolerant as a mom. I am very grateful to my doctor for prescribing Cymbalta, I can't imagine using anything else. F 54 5 years
60mg 1X day
3/10/2011
Email
 1  Depression and Pain Weight gain, crying, agitated, more pain, daily headaches, suicidal!!! Hated it!!!!!!!!!!! M 47 10 days
60mg 1X day
3/10/2011
Email
 1  Bipolar Disorder At first,nausea, lack of appetite, headaches. Now, brain zaps, incredible weight gain, complete loss of sex drive, lethargy, depression I used to love this drug!! It helped my depression so very well for a while. Now, it has done nothing but make me fat and lazy. I cry for no reason. I don't want to play with my son. I have NO interest at in sex. I hate what this drug has done to me and I am afraid to come off it. F 32 1 years
60MG 1X day
3/9/2011
 3  Depression, anxiety Nausea at first. Weight gain, memory gaps. Complete loss of sex drive and the relationship issues that come with it. Cymbalta has definitely helped with my depression but the weight gain and depletion of my sex drive have definitely hurt my relationship. This last week I got the flu and couldn't get my prescription filled, I didn't take it for five days. By day two I had headaches and the worst dizzy spells I have ever had. It wad like my brain and vision shook for a few seconds and then a weird tingling sensation would radiate from my chest to my finger tips. It also made me depressed again when previous to this I had been feeling good for a long time. It made me decide to and plan to leave my partner for no reason! That's when I started looking up the side effects of coming off Cymbalta and saw the horror stories... Please do yourself a favor and look them up yourself, this is the part that the doctors don't tell you. F 24 10 months
60 mg 1X day
3/8/2011
 2  Neck, shoulder pain and numbness I started this with great expectations. After the first two days I thought I had found my cure without surgery. However, I started having problems around day 4. Upset stomach, GERD, loss of appetite. Then the diarrhea started and the cramping and pain followed. I ended up in the ER after suffering for 3 days with the pain. I was diagnosed with Colitis. The diarrhea has not stopped yet, and my pain specialists does not believe that the Cymbalta was the problem. I believe it was/is and I will not take it again. I cannot afford to with all the new doctors and medical bills. I thought this was going to be my answer to help me off the pain meds, but it made me sicker and in more pain. Now all my doctors think that I am seeking more pain meds. Great! F 46 9 days
20mg 1X day
3/8/2011
 4  Post Lyme Fibromyalgia Side effects: dry eyes, sight digestive changes - constipation and occasional flights of nauseated feeling. Initially weird dreams. Lately have had increasing bouts of itching skin and tiny pimple-like eruptions feeling like insect bits at groin and underarms. My Fibro had nearly incapacitated me and this med works wonders to keep me functional and able to manage my pain at tolerable levels. I have learned NOT to miss a dose when traveling of for other reasons as this causes a revisit of pain increase. If lack of meds is coupled with other fibro-triggers such as stress or lack of sleep, I have a full fibro flare-up. So for me, this drug has been wonderful, but concerns of liver damage keep me getting regular liver studies M 58 2 years
20mg 1X day
3/6/2011
Email
 2  anxiety harding to go pee, dry mouth, yawning a lot, tired early before my normal bedtime, loss of appetite. lost two lbs. had to pee more, and noticed pee was darking than usual, so I thought it might have something to do with the liver, I would zone out and focus on one thing at a time, so that was weird. the second day on it, I cried a lot and felt a bit like a zombie but not too bad. It did help with racing thoughts, however the problem with the pee thing and the fact that is has really bad side effects and withdrawal effects made me decide not to go on it. I don't want to have the withdrawals. I read about the withdrawals and I felt that the advantages of the drug did not outweight the side effects. I would consider the drug again after more trails and longer time on the market. I prefer drugs that are older and I feel more safe. F 39 2 days
20mg 1X day
3/3/2011
 1  depression nausea, complete loss of appetite, weight loss, extreme anxiety, agoraphobia, exhaustion, mental fog I only took it for a short period of time because of my extremely severe and negative reaction to the meds. It scared me from ever taking another anti depressant and made me far worse. Take with extreme caution. I had my first panic attack 30 mins after first pill at work (I have never had anxiety issues) and then panic attacks every 3 hours (delayed release of pill) despite taking it at night to try to sleep off the initial effects of the pill. Due to the panic attacks, I started to disassociate because couldn't call out of work or go home. Made me completely consumed and unproductive. Tearfulness reappeared two days in because of anxiety. Some do fine on it. No side effects getting off of it, just return to tearfulness and relief from any anxiety. My brain said NO! to this one. A side note to all those who suffer from anxiety naturally, I do not know how you do it. I became a sleeping hermit because that was the only way I could deal with it. It is a powerful and very frightening emotion. F 28 5 days
30 MG 1X day
3/3/2011
 1  pain,myalga,depression tired but cant sleep,stomach up set, inability to eat ANYTHING even a bite of an apple,itchy,deep bone and muscle pain, confusion,deeper depression,itchy mouth. more needs to be done with this medication and making people aware of ALL the side effects even the less common ones, so they dont think they are losing it. F 42 10 days
30mg 1X day
3/3/2011
 5  Depression and panic attacks Funny electrical feeling in my head I have been treated with several anti-depressants this is the only medication that has actually made me feel whole again. I am able to handle much more stress than I was able to prior to taking this medication. I have nothing bad to say about it but I do wonder about those zaps in my brain what are they doing! F 59 4 months
60mg 1X day
3/2/2011
 4  Fibromyalgia Chills, colder than usual, some appetite loss, dry mouth, lighter feeling limbs! Muscle relaxers, Lyrica, Savella did nothing for me but have bad side effects. I used Cymbalta a year ago (60 mg/day)for FM, but stopped cold turkey without any problem due to no libido. Restared now because I'd rather have less aches and be able to tolerate moving during the day. My arms and legs no longer feel like lead weights. I never had lot's of tender "pain"; I mainly can't climb stairs or lift my arms and legs normally. So far, I've lost some appetite (yay!), mainly just the first day, and have frequent chills. I'm colder than normal. But, I would recommend trying this when nothing else seems to work. I am happier with it than without it, and am starting to feel better. No strange feelings, but I was never depressed. I'm hoping this is not a temporary improvement, although it could be better. I take the capsule early in the morning, so I don't have insomnia at night. F 50 4 days
60 mg 1X day
3/2/2011
 3  depression and mild anxiety Constipation, nausea, loss of appetite, weight loss, dizzy if i get up too quickly, very sleepy. This is my fourth antidepressant (lexapro, effexor and the new Valdoxan did not work at all). The side effects are similar to that of Lexapro for me but I would have hoped for them to have lessened after three weeks and they haven't. I notice no improvement in mood but certainly no dis-improvement which i experienced with other meds. Just have to wait and see. F 29 21 days
40 1X day
3/1/2011
 2  MDD Complete absolute loss of sexual desire/function. Emotional blunting (not necessarily bad). EXTREME LETHARGY. Had to stop taking this as I was requiring 12 hours of sleep at night and also taking several naps during the day. Burned thru all of my vacation trying to acclimate. Had to quit or lose my job. Even cutting capsules and taking 10 mg a day caused me to fall asleep at work. Stopped suicidal ideation. Stopped almost all ideation of any sort hah. Probably only good if you are suicidal and don't need to hold down a job. Discontinuation syndrome wasnt that terrible. Email for more if you want, but this about covers it. M 37 6 weeks
40mg 1X day
2/23/2011
Email
 3  Major depression Loss of interest in sex, severe memory loss, inability to ejaculate, need to urinate frequently and immediately, nervous leg, severe withdrawal when I forget to take a dose on time I'm on a combination of meds - Cymbalta, Abilify, Seroquel, & NAC for depression, Vyvance for ADD, and Metformin, Simvastatin, Fenofibrate, & Diovan for the diabetes from the meds I've taken over the years & the blood pressure is caused by the Cymbalta. I think the meds work okay, but quite frankly, I'm prepared to say that they aren't all that great. Since my suicide attempt in late '09 I've started using MMJ and I go in for regular shock treatments every 8 weeks. Now those two things have been very effective. I've given up alcohol (I never drank that much), and the benzo's the psychiatrists were prescribing, and I don't take/need pain killers anymore I don't live in agony any more and I rarely think of suicide. I've been chronically depressed since I was a teen and it has worsened over time. I told you all of that to tell you this. I'm afraid to stop taking the anti-depressant cocktail I take even though I doubt that it is that effective. Even one day without Cymbalta brings on pretty severe depressive symptoms. Some of that may be because I'm on such a high dose although I've been on as high as 180mg a day for a few years. If I had it to do all over again, when it seemed clear that medications were only marginally effective I would have added MMJ and if it didn't improve, I would have gone to ECT (the PC term for shock treatments) much earlier. If nothing seems to be working for you, consider ECT and MMJ. There is hope. Really. M 53 6 years
120 MG 1X day
2/20/2011
Email
 1  Pain Caused a lot of problems. M 33 2 years
60 1X day
2/20/2011
Patient History
 3  Clinical depression, neurological p Sweats, muscle tics, unable to find the words I want (very unusual for me!), dry mouth & some dizziness/nausea. Not too bad now, but it hasn't really lessened my depression or anxiety yet...just switched by my dr. to 60 mg per day plus added Lexapro, & gabapentin for pain & anxiety...the side effects went away after a short time, but now I'm waiting to see if the upped dose & added meds will help...also going to counseling...when I gradually took myself off Cymbalta earlier, I felt like I was flirting with the flu for a few weeks, but it went away. I think this is an all right medicine for some folks, the jury is still out for me. F 36 2 months
30 mg 1X day
2/17/2011
 4  depression, PTSD, anxiety constipation, insomnia, intense and disturbing nightmares. nausea during the first week. F 26 1 months
60 1X day
2/15/2011
 4  panic disorder Side Effects are sleepy, low libido, and CONSTIPATION. the constipation is the WORST. Cymbalta helps me be a good mom. I don't really have panic attacks on this medicine. DO NOT cold turkey off of this. My doctor tried that and I was committed to the hospital. F 32 5 years
60mg 1X day
2/14/2011
 3  depression insomnia, loss of appetite* I took Cymbalta because I was out of Lexapro. Cymbalta lifted my mood more. My mind raced at 100 miles a minute, but my body was exhausted, so sleep was slim. The loss of appetite I wasn't sure to attritube to the Cymbalta because I'm a finicky eater anyway, but I couldn't function with only 5 hours of sleep in 10 days. F 25 10 days
60mg 1X day
2/12/2011
 1  Chronic Pain d/t Ehlers-Danlos Debilitating Headache, diarrhea, severe nausea, heart palpitations and racing heart, funny head feeling. I paid a fortune for this medication as it was not on my insurance formulary. Could only take it for 2 days as the side effects were unbearable. I have been on many medications in the past and this felt like I was putting poison into my body. It was the worst feeling I have every had from a medication! Glad that I got off of it quickly before I had to do the taper and suffer the withdrawels. I wish I would have seen all of these posts before I bought and started the med! F 44 2 days
30 mg 1X day
2/10/2011

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