CYMBALTA Reviews (DULOXETINE)

Average Rating: 2.7 (2745 Ratings)

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 ANTIDEPRESSANTS

 Type: Rx Drug

  

CYMBALTA  (DULOXETINE):  Duloxetine is used to treat depression and anxiety. In addition, duloxetine is used to help relieve nerve pain (peripheral neuropathy) in people with diabetes or ongoing pain due to medical conditions such as arthritis, chronic back pain, or fibromyalgia (a condition that causes widespread pain). Duloxetine may improve your mood, sleep, appetite, and energy level, and decrease nervousness. It can also decrease pain due to certain medical conditions. Duloxetine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). This medication works by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in the brain.   FDA Approval Date: 2004-08-03 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on CYMBALTA: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR CYMBALTACOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 1  Clinical Depression severe constipation; night sweats; headaches; very sleepy; feel zombie-like I have been on almost every anti-depressant in many different combinations over the course of the past 25 years. Cymbalta just does not feel right; I feel almost desperate in a panic sort of way to get it out of my system. I think I feel worse taking it than on the last combo that was not longer working well. Interest and motivation had been dropping but on Cymbalta I feel an almost complete disconnect between my head and my body in that I am very aware of things I want to do and yet cannot make myself do them. I have been using nutritional and cleansing products from a company call Isagenix for 2 years now and they have given me amazing energy and excellent physical health despite being on drugs that really slow down my head. So I still have what it takes to go running but the issue is forcing myself out the door which I do not manage as frequently as I need to. Cymbalta is supposedly a drug that is very effective for those who are quite drug-resistant but I admit I am very disco F 49 6 weeks
3/9/2009
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 4  Major Depression Restless legs. Just as I start to fall asleep my legs jerk so badly I get out of bed so my husband can sleep. During the day I can take a nap and this does not happen. I have taken 2 mg of klonopin for years for RLS and until now it has always worked. OH YES CONSTIPATION. I feel 90% better. I have more energy, no suicidal thoughts, able to concentrate on reading. I can actually use the coping skills I have learned over the years! M 47 4 weeks
3/8/2009
 1  Severe Depression Severe anxiety (I've never had anxiety before), general fatigue, loss of motivation, headaches Missing a dose resulted in 'Brain Zaps' and a vertigo like feeling eek F 33 4 months
3/8/2009
 1  Depression Headaches, dizziness, constipation, no emotions, no sex drive, mental lapses, sleepiness, slow to responses, and weight gain. I stopped taking Cymbalta cold turkey. Doses were 30 for the first month and 60 for the second month. I am on my 10th day of withdrawal. I am still suffering from vertigo, headaches, neck stiffness, dry mouth, low urine output, sweats, and blurred vision. F 57 60 days
3/8/2009
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 3  back pain (neuropathic pain) extreme mid-day sleepiness, loss of sex drive, loss of motivation to excercise, loss of motivation in general, mild weight loss (which is a plus, I suppose) On my Dr.'s advice, I went on Cymbalta instead of taking 2 Alleve daily for my chronic back pain. I also get quarterly epidurals for my back pain, and have a standing prescription for Vicodin which I use very sparingly. Cymbalta has definitely helped with the daily pain, but the mid-day sleepiness in so overwhelming, many times I wonder if it is worth it. I now take Provigil to combat the sleepiness. My dose is 60 mg. Cymbalta. Overall, Cymbalta works great for pain but makes me really sleepy. F 41 8 months
3/6/2009
 1  Depression and Anxiety Nausea, Nerve tingling,severe insomnia, heart palpitations I have been on antidepressants for years. I have taken Zoloft for 3 years and Wellbutrin for 2 years. My anxiety has recently started to increase so the Dr. suggested taking Cymbalta. The side effects are horrible. I have never experienced such severe side effects. I am going back to Zoloft combined with the Wellbutrin which has worked well for me in the past. F 44 3 days
3/6/2009
 4  Depression/Anxiety "Dream Zone", each night when I start going to sleep, I reenter the "dream" I was in the night before. I never wake up naturally feeling refreshed. For first 4 months, I had to fight to stay awake after 3PM. If I could I would go to sleep and sleep from 3:PM until 9:00AM the next morning. I started taking Welbutrin with it and now (3rd month with Wellbutrin) not as sleepy during the day but still have days where (just not every day) I could sleep +15 hours. Tried to take at night, but kept forgetting to take. The additional "heat" is nice in the winter. The increased smelling is not so good nor is the slight visual hallucination. This drug gave me less severe side affects than many others, so I stayed on. I just wish I could get out of the "dream zone". F 46 4 months
3/4/2009
 1  Anxiety/ Depression I had taken the 30mg dose before bed last night. Woke up with an extreme panic attack about 3 hrs. after taking it. I could not stop vomiting and crying. It got so bad I had to ask my husband to help me. I thought I was going to try to hurt myself. I started seeing and hearing things that weren't there. My heart was racing and my pupils were huge. It was like having a bad trip. F 26 1 days
3/4/2009
 3  Anxiety Weight gain (20 lbs in 6 months)--doctor said I would not gain weight. Low Sex Drive, increased heart rate, vivid dreams. I am trying to come off of Cymbalta with numerous side effects. Primarily, brain buzzing, heart palpatations. It has been 72hrs since I had a dose (30mg). I am hoping to get through this in a few days. I do not recommend! F 45 6 months
3/3/2009
 1  fibromyalgia and depression SEVERE constipation, dry mouth,indigestion,cough,high fever during sleep, increased muscle aching in my legs, rash, skin peeling off fingers/toes/lips, nausea and vomiting This drug is POISON. I am a nurse and have seen many of these symptoms in patients taking chemotherapy. The skin peeling was especially distressing because my fingertips and lips were extremely sore and sensitive for a long time-- I quit the drug after 2 weeks (30mg daily) because I could not tolerate any of these side effects. I generally tolerate medication well. I can't believe this stuff is still on the market. F 48 14 days
3/3/2009
 5  clinical depression insomnia, vivid dreams that continue from night to night as a story, can't lose any weight, no lobido This is the only drug that keeps me depression free even in winter. F 1 years
3/1/2009
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 1  Anxiety, slight depression Severe nausea, inability to sleep, anxiety. Took at bedtime, and woke up the next morning with my hands shaking so badly I could barely hold my spoon to eat breakfast, which I didn't feel like eating in the first place due to the nausea. I felt like I was having an out of body experience for the next 24 hours. I have irritable bowel syndrome, which doctors have told me is triggered mostly by stress. I finally gave in to the thought of trying medication to help my anxiety. I took my first 30 mg pill at bedtime, and within four hours was awake, feeling anxious with racing thoughts and nausea. I got up, drank a glass of water, and within 20 minutes had thrown up the water. Who throws up water? The entire next day I felt miserable - out of it, dizzy, nauseous, not connected to the world. Reading these posts has at least affirmed that I am not alone in my reaction to this medication. I was supposed to start taking the 30 mg and work up to 60, but I have no desire whatsoever to lose another day to feeling so badly and have not taken any additional pills. F 38 1 days
3/1/2009
 1  fibromyagia night sweats, weight gain, brain zaps, headaches,constipation, Please read on Cymbalta's website about side effects and precautions. They did NO studies longer than three mos. and you cant take Ultram with it.I was on cymbalta for 18 months. In the first 6 months, I loved it, then started having probs-night sweats, 30 lb weight gain in 3 mos even while dieting, headaches,generall having no emotion to anything, brain farts severely, other crap that I didnt have a clue that was because of cymbalta. I wean off from 60mg to 30mg,started taking 150mg of wellbutrin xl, Everyday i dumped a little bit of beads out, tried the 7 at a time-too much work- have been completey off for 5 days now. Only have brain zaps and jolts, and this weird pulsating in my head. hope it doesnt last too much longer. F 35 18 months
3/1/2009
 1  depression I have been reading everybody's posts and I am not sure if I should laugh or cry. For three years I have experienced terrible night sweats, teeth clenching and a 30 lb. weight gain. I reported these symptoms to my doctor but she only confirmed that night sweats are a side effect. I also experience the brain zaps if I miss a dose. I want to learn how to successfully get off of this drug asap! I am so glad I finally found the cause of a lot of my problems. F 46 3 years
2/28/2009
 3  Migraines, head/nerve pain, anxiety Sleepiness and at first, loss of appetite Started at 30 mg's, then went up to 60 mg's, but just cut back down to 30 mg's because felt that it was making me feel like a zombie during the day even though I take my pill before bed. Although it did cut down on the number of headaches per month and head pain, it was not a miracle cure for me. I am trying 30 mg's to see if i can get the same relief at a lower dose to avoid the fatigue. Had a few brain zaps cutting down to 30 mg's but not too bad. Helps the anxiety, but not a total cure. All in all, this drug works better than any other that I've taken for headaches and I've taken just about all of them plus tried every natural treatment there is. It makes me feel more positive and helps me to think about the headaches less - they don't get me down anymore. For anxiety, Paxil was much better but made me gain weight. F 44 5 months
2/27/2009
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 1  anxiety/depression tremors, bladder spasms, hair loss, insomnia, severe weight gain i have been off of cymbalta 4 days now..still have the severe tremors when i wake up..don't know how long that will last..a little dizzy but not as bad as before..this drug is really hard to get off of if you are sensitive to side effects..especially increased anxiety! F 31 18 months
2/27/2009
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 3  depression/post-partum vivid, bizarre and bad dreams, sweating at night, nausea for the first 3 weeks, weight issues, sweets cravings, decreased libido and inability to achieve climax, yawning, fatigue; brain zaps if I missed a dose and now while withdrawing I have not been able to lose ANY of my post partum weight despite adequate diet and exercise changes. THIS is depressing. I had 20 lbs to lose before starting cymbalta, now I have about 23. Initially I lost my appetite for 3 weeks and lost 5 lbs, but gained that back plus 3 more. I also saw an increase in night terrors, which totally freaks my husband out. The antidepressant effect was very good with medicine, but withdrawal is a real booger. I have the "brain zaps" I have been reading about and headaches as well as dry eyes, poor sleep and foggy brain. Wish I would have read up on the withdrawal of the med before I asked for an antidepressant. F 33 7 months
2/26/2009
 3  Yes I had no side effect while taking this drug, it worked great for depression but the side effect are horrible. I have vertigo so bad I have had to take Dramamine I am lethargic and can't focus.I wouldn't have stopped but I've lost me health insurance. This stuff is heavy and I have been on a lot of anti-deprpessents and this works great but going off might not be worth it, I miss my Citalopram...but mostly I miss having access to medical care. F 29 16 months
2/26/2009
 3  depression constant numbness on the right side of my body, tingling fingers, unexplained extreme yawning, trouble staying asleep, anxiety, accelerated heart rate in mornings, dry-mouth when working out, new sweating that continues hours after working out, constipation, loss of appetite/cravings I had lots of side effects the first 2-3 days of being on the 30 mg tablet, but most went away. I was kicked up to 60 mg starting week 2. I felt much better, although not completely better. 4-5 weeks into 60 mg I started to have extreme numbness & tingling on my right hand, arm, side, shoulder blade. I continued having the listed side effects at week 5. Doctors are unable to explain the numbness and think it is not associated with cymbalta. Numbness diminished after stopping the medicine & starting a new anti-depressant. F 26 5 weeks
2/26/2009
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 1  depression pms extreme sleepiness, yawning, lethargy. just awful. not to mention nausea! After feeling ill effects after the first dose I thought it would get better but after day 3 I realized I could not tolerate the side effects. I can barely get out of bed F 38 3 days
2/26/2009

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