CYMBALTA Reviews (DULOXETINE)

Average Rating: 2.7 (2745 Ratings)

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 ANTIDEPRESSANTS

 Type: Rx Drug

  

CYMBALTA  (DULOXETINE):  Duloxetine is used to treat depression and anxiety. In addition, duloxetine is used to help relieve nerve pain (peripheral neuropathy) in people with diabetes or ongoing pain due to medical conditions such as arthritis, chronic back pain, or fibromyalgia (a condition that causes widespread pain). Duloxetine may improve your mood, sleep, appetite, and energy level, and decrease nervousness. It can also decrease pain due to certain medical conditions. Duloxetine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). This medication works by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in the brain.   FDA Approval Date: 2004-08-03 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on CYMBALTA: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR CYMBALTACOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 1  depression Did not experience too many side effects while taking Cymbalta, other than flat affect, decreased sexual drive and oftentimes dizziness upon standing. It is the withdrawal that has been horrible. I was weaned from 90 mg. to 30mg. then to 20mg. Psychiatrist said to stay on each dosage for one week and then stop after the one week on 20mg. I stayed on each for two weeks. I have now been off Cymbalta since Sept. 11, 08. I experienced "swooshing" in my head, lightheadedness, nausea, some vomiting, aches and pains. Symptoms subsided for approximately 2 days (October 1 and 2) However, on October 3, until today, October 6, my symptoms have rebounded. I am so nauseous. lightheaded, losing my balance and feel helpless. I have been taking Bonine and Benedry which help relieve symptoms. How long do these symptoms last? I had a false sense of hope during those two days without symptoms. Is this normal. This is a terrible drug. Horrible drug. I recommend psychotherapy and strong support groups before embarking on drug therapy. F 60 2.5 years
10/6/2008
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 5  Severe Anxiety/Depression Extremely tired all the time, migrane headaches, loss of appetite, constipation I had taken cymbalta a few years ago and it worked great for me. Despite the first few weeks of side effects it really is a great help. I lost my medical insurance and moved out of the area I was living in so I had to quit cold turkey when my prescription ran out. I would NOT recommend doing this. I was super dizzy for weeks, didn't feel right, always felt like I was going to pass out, fuzzy headed, I didn't feel right for a long time. However, if I had gradually been able to reduce dosage I think it would have been better. I am finally back on cymbalta and just started 60mgs today after taking 30mgs for a week. Exhausted and not hungry at all but already starting to feel like a "normal" person. Anxiety has dissapated greatly and less attacks. F 24
10/3/2008
 2  Depression, Stress, Panic attacks Nausea, mild disorientation, full loss of apetite, flu-like symptoms, zombie-like feeling,tightness in the jaw, constant forceful yawning, and EARLY morning insomnia This drug helped me with my daily massive headaches, and body pain. It helped me not care (about anything),it also eased my depression. BUT later that first day,as soon as i started working out at the gym i got a splitting headache and felt as if i was going to explode in my head. Later that night i woke up at 3am and couldn't sleep. i had this weird feeling ..something like i know im here, but when i looked at my body i wasn't sure, i didnt care to move my limbs if i stayed still...i cant explain it i was so spaced out, it made me more anxious because i didnt reognize the way my soul felt. I wanted to laugh and enjoy, but i didn't have the spark*--this was yesterday. and im not very sure which is worse,mild depression and panic attacks or this "medication"(depression for me is pain coming from my mind, and the pill felt like a mask on my mind and pain in my quality of life) . Cymbalta in my experience was like legal low-dose speed.I think i will try group therapy, red bull,a F 19 1 days
10/3/2008
 1  depression and fibromylagia pain I only took it 2 days; had horrible migraine, dizziness, nausea and ringing in the ears. I have stopped it and now on day 3 migraine is still with me. There is no way I could work with this and I will not take it again. It just isn't for me. F 47 2 days
10/2/2008
 4  depression Major weight gain, 30 lbs in 2 years Works great for my depression, but caused excessive hunger leading to a 30 lb weight gain in 2 years. My doctor took me off it 4 days ago and immediatly switched me over to Wellbutrin XL the next day. I have been having terrible withdrawl symtoms almost immedatly after stopping the med, dizziness, headache, nausea, sweating, I went back to the doctor today and got Cymbalta 30 mg tabs (I had been on 60mg) and now are being weened gradually while still continuing the Wellbutrin XL. After taking the 30 mg tab this morning I already feel much better. Be careful coming off this, it is a very powerful drug. F 40 24 months
10/1/2008
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 5  Painful Sensory Neuropathy During the settling in period I was very sleepy, had nausea, and felt "stoned." But all that went away and now I feel really great. No terrible pain in my fingers and feet and no sexual side effects. I take 120 mg per day. I think that is the highest dose allowed but is common for nerve pain. I think this is a great drug if it fits with your physiology and you can tough it out the first 2 to 3 weeks. F 50 6 months
9/30/2008
 3  depression and anxiety Sweating, hand tremors, racing heart, insomnia, bizarre dreams Cymbalta definitely helped with the depression. In 3 weeks it was gone, as was my anger and inability to focus. It's been somewhat effective with the anxiety, but I find valium works much better for that. As with any antidepressant, please, please be careful when taking this. And even though I found it effective, I agree that it is horrid to wean off of it. I've been going down 5 mg at a time a week at a time, and even so I've had withdrawls. I find taking just 1 mg of valium per day has helped a lot with the withdrawls. I had a friend who also went off Cymbalta and she took Adivan to help with withdrawls and that worked for her. F 36 5 months
9/30/2008
 4  fibromyalgia & ME nausea, loose bowels, absent minded, bit of a sweaty betty lol!......lack of orgasm, fatigue but thats normal for me anyway! been on in for about 3 weeks rhumo guy wanted me to try it.....have to say its the best thing i have ever tried, the pain re-fibro is hardly there now and i can function again...altho there are side effects they are nothing in comparison to the pain so there fore i am loving this ' wonder' drug...obviously my mood has lifted too, i was apprehensive as i had done research on the net prior to taking the drug ....but it is working for me, i have missed taking the tablet a few times due to been forgetful on it..however i did not experience any other side effects, so i am lucky really, the only thing i have noticed apart from the minor side effects is the sex part however thats no big deal and a small price to pay to be out of pain, i guess!! F 37 21 days
9/28/2008
 3  anxiety, mild depression fatigue, weight gain, loss of sex drive I started with 30mg of cymbalta and after a while increased to 60mg. Seemed like my body would get used to the med and not work as well. I was on Lexapro prior to this and same thing happened. I had plantar fascilitis (pain in arches of feet) and the cymbalta really helped. It also helped with my anxiety for a while, but if I skipped a dose even less than a day I would have bad side effects such as dizziness, anxiety, very irratable, nausea, and a thumping sensation in my tongue. My sex drive has gone down to nothing. I have gained over 30 lbs in last year! This is strange but if I missed a dose by hours or a day, I felt more creative. I decided to come off of Cymbalta because it didn't seem worth it. I have been weening off for 6 wks now and it has been a nightmare!! The side effects are driving me crazy! I get very dizzy, nauseated, almost drugged feeling. I ache and hurt all over to where I can't hardly stand. I cry practically every night and feel so mean to everyone. I keep F 39 2 years
9/26/2008
 3  Depression Nausea, vertigo and extreme fatigue to begin with (first week or so). Emotions were very flat for the first month or so. The nausea subsided but still suffer from the fatigue and horrible night sweats. Also very low libido and anorgasmic (difficulty achieving orgasm). Finding it very difficult to come off the medication now. Very severe withdrawl after only one day of not taking the drug, which include disorientation, vertigo, nausea and what they (weblog which supports users coming off Cymbalta) call 'brain-zaps' where you experience some kind of electrical shock type feeling in your brain. Very disconcerting and unpleasant! As a result I am afraid of coming off the medication. F 30 5 months
9/24/2008
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 5  fibromyalgia/depression First week, a little sleepy, mild and short episodes of dizziness, resolved after a few weeks. Started with the 30mg. dose for 1 week and then progressed to 60 mg. once daily. Had been taking Prozac for about 20 years, but it just seemed to stop working. Became depressed from dealing with daily pain of fibromyalgia and realized I needed help. Doctor suggested I try Cymbalta because it had been used to treat the pain of fibro and has been effective in about 50% of the women who have tried it. I am one of the lucky ones!!! After a week on the meds, my pain is GONE, my energy level is great and my mood has greatly improved. None of the feared sexual side-effects. No problems and very thankful. F 51 30 days
9/22/2008
 3  neorpathy and anxiety acid reflux not very effective against my neuropathy F 61 4 months
9/19/2008
 3  Major Depression, Anxiety, & Pain I really need help on what is a good time to take this medication, since my doctor told me to experiment ?????... I have migraines but had before the Cymbatla was on Paxil which I had to be weaned off for a month so I was taking both medications, now they are regular headaches, NIGHTMARES that are so real not monsters... but people around me and they are so real I have to wait when I wake up to realize it is "just a dream?" My Doctor told me I have to experiment when I take it , so who better then people who are actually are on Cymbalta? Please let me know what you found is a good time for you, to avoid some of the effects. I have gained 4 pounds may not be related but, I am trying to lose weight so please any comments on the weight, headaches, dizziness, tiredness, & nightmares, what is a good time to take it? Would be so greatly appriciated! :) Thank you so much! I have been on Cymbalta 60 mg per day for almost 2 months. Seems to help a little with the nerve pain in my hands, my back and neck it is hard to say because... I still have to take pain medicine, seems like I am taking less pain medication? I also was on Ambien for sleep and now that Cymbalta is in my system seems I do not need it at this juncture? So that is some good news I have been on everything for depression, but now that I am feeling better I want to lose weight I have heard mixed things about Cymbalta please send me your comments on that or any other issue. Thank you :) Since my accident 12/03 , which let to a doctor who is no longer parcticing medicine did a "non invasive" prodedure on my neck 5/06 called a cervical percutaneous discectomy this almost killed me and made my pain worse, but I am so lucky to be alive and walking, so since Cymbalta is prescribed for pain too please if you are ever offered this to relive pain RUN to another doctor! There is not much r F 34 2 months
9/17/2008
 5  Depression/anxiety Insomnia, decreased appetite (though that's a good thing in my case; the depression had me overeating). Cymbalta has changed my life. I didn't realize how bad my depression was until looking back on it--I wasn't motivated to do anything, had paranoid delusions, was always achy and unwell, and was just generally unhappy. I started Cymbalta after finally dragging myself to the doctor at my mother's insistence, beginning on 30mg for one week and moving up to 60mg. I noticed a difference within the first week. Now, it's an incredible change; I feel like I'm a *person* again. I have been experiencing insomnia due to it, but with 25mg of Trazodone, that's evened out wonderfully. I'm so happy with this medicine! F 24 4 months
9/15/2008
 4  Anxiety and depression Weight Loss, Loss of so sleep I personally have seen no real problems with this drug. I stopped crying all the time and now feel "happier". I noticed that I do not want to eat as much. I kinda have to make myself eat. I don't like the way it messes with you taste though. Makes sweets taste ucky to me. But besides that I like it. F 22 2 weeks
9/15/2008
 2  fibromyalgia The weight gain was terrible. My eating habits and caloric intake was the same. Nothing I did allowed me to lose the weight. Can't take it anymore, so I decided to stop taking the medication. Did not help with the everyday pain. F 48 1.5 years
9/15/2008
 1  severe depression/BPD 20 lb weight gain in 4 months, increased acne on back and shoulders, night sweats, dizziness, insomnia, suicidal, hair loss if you want your apperance to go down the toliet, take cymbalta F 21 4 months
9/13/2008
 1  bi-polar disorder Tired all the time, Constipated, abnormal dreams, loss of memory and fuzzy head. I have ate 90mg before and went down to 30 without a problem. A week ago my doctor took me of it in all and I have horrible withdrawal with dizzyness. It feels like I have petit mal or something like that almost all the time if I'm walking or doing something fysical. I can't turn my head without getting dizzyspell that feels like a lightning shoots through my body. On the good side, my stomace works fine for the first time in a year, yippie. F 44 1 years
9/13/2008
 3  fibromyalgia/headaches My side effects have been minimal, shakes at night when I wake up to turn over, mild sweats, dry mouth. Have had some bouts of constipation. I used to hurt all the time, I would freeze to death in a building/vehicle that had the a/c going. My fingers would be freezing, and they would get a numbing/tingling feeling. I have only been on this medication 8 days, I slept good the first two-three nights that I took it, but the next 2 nights, I would wake up, go to turn over and would just shake uncontrollably. I have low tolerance to depression medication, I have panic attacks but so far, I haven't had any of these on this medication. Right now, relatively, sleepness, mild sweating and dry mouth are all that is occurring, the shakes have stopped for now. This has really helped me with the pain, I haven't had a headache since I've started taking Cymbalta, 30 mg at bedtime. If this doesn't work, I don't know what I will do. I've tried everything that I can think of. Will keep trying this and hopefully, these side effects will gradually disappear. The first night I took Cymbalta, the next day I had goosebumps all day long, but F 47 8 days
9/12/2008
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 1  Anxiety The first time I took it (within hours) I had SEVERE sweating, diarrhea, dry heaves, disorientation, tingling and dizziness. I was slumped on the floor of the bathroom dripping sweat and unable to speak clearly when the EMTs arrived. That was 2 days ago and I haven't touched it again. I'm still groggy and have slower and slightly impaired speech. All in all the experience didn't lower my anxiety much! M 52 1 days
9/12/2008

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