CYMBALTA Reviews (DULOXETINE)

Average Rating: 2.7 (2745 Ratings)

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 ANTIDEPRESSANTS

 Type: Rx Drug

  

CYMBALTA  (DULOXETINE):  Duloxetine is used to treat depression and anxiety. In addition, duloxetine is used to help relieve nerve pain (peripheral neuropathy) in people with diabetes or ongoing pain due to medical conditions such as arthritis, chronic back pain, or fibromyalgia (a condition that causes widespread pain). Duloxetine may improve your mood, sleep, appetite, and energy level, and decrease nervousness. It can also decrease pain due to certain medical conditions. Duloxetine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). This medication works by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in the brain.   FDA Approval Date: 2004-08-03 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on CYMBALTA: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR CYMBALTACOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 1  Fibromyalgia Well I was talked into this after a year of trying something else. Read my comments and others comments. Right now, symptoms include severe night sweats, vivid dreams/nightmares, severe dizziness, stuffy head/achy/fever, chills, etc. Sometimes cannot stand and/or walk. I was grinding my teeth before this; much worse now that I'm not it. RICO and/or other class action lawsuit is in order here! Stop the ride, I want off! I emailed the doctor, and am awaiting instructions. I would think it was all the Cymbalta EXCEPT that my wife has a few odd aches and pains too. Now, if Cymbalta is causing some sort of weakness in my immune system that ALLOWS normally weak viruses to grow, that could be a problem. Our bodies could normally encounter thousands of viruses and we'd never know it. But it could be that Cymbalta enables certain, normally ineffective viruses to take hold in our bodies or mutate into something that can affect normal, healthy people. I don't know. Things may change when I go to the 60mg dose here in a few days. I'm not sure. But seeing what other people have been saying for side-effects, I'd have to agree with most of them. I can't attribute all the symptoms to Cymbalta, nor can I say which ones are truly sickness related or which ones are purely Cymbalta. But I will say that I DO seem to have gotten 'sick' twice now in a relatively short time, which NEVER happens with me. And my M 40 5 weeks
11/2/2006
 4  GAD and Depression Lack of eating, foggy feeling, drowsey, sexual drive is way to low..My poor husband. Helped inprove my memory and panic attoks F 33 4 months
10/30/2006
 1  severe depression I started to get migraine headaches, gained 20 lbs, started seeing black bugs crawling all over my house, had anger outbursts, started cutting myself, tried to commit suicide, had brain shocks and lost the feeling in my left leg. also felt like my chest was being compressed alot. THIS IS A DRUG FROM HELL AND THAT IS AN UNDERSTATEMENT! PLEASE DO NOT TOUCH THIS POISON BECAUSE IT WILL SCREW UP YOUR ENTIRE LIFE. F 45 4 months
10/30/2006
 1  Depression Hair loss, weight gain, no motivation, headaches. Due to major hair loss and weight gain (20 lbs) that I could not lose even while dieting and excercise. Three weeks ago I decided to stop taking this med the withdrawel symptoms are horrible, I feel like I have been hit by a train but I have motivation and feeling back. I wouldn't recommend this drug to anyone! F 44 2 years
10/29/2006
 5  depression and diabetic neuropathy I was prescribed the drug by my Cardiologist who examined me in hospital for persistent chest and arm pains which he demonstrated were not cardiac related but most probably due to Diabetic Neuropathy.I have been afflicted by Type 2 diabetes for about 20 years. The Cymbalta was prescribed to replace a daily dose of Effexor XR 150mg.and he gave me a 3 week sample supply which worked very well indeed. However when I presented his prescription at my usual drug store they could not fill it due to refusal by my insurance carrier, Blue Cross of Pennsylvania, Personal choice,to pay for it. They declared Cymbalta to be an " unsupported experimental drug" unproven in value for my situation, in spite of my personal trial experience which is why they refused to pay for it. My Cardiologist Dr. Ramesh Adiraju prepared and submitted an appeal which Blue Cross again rejected. Their refusal is still open to further appeal,can you possibly suggest any supporting evidence I can present to them? M 69 21 days
10/28/2006
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 2  Spinal Cord Injury/Neuropathy I initially experienced some nausea. If I missed a dose, I experienced little "explosions" in my brain, dizziness and a feeling that my eyes wouldn't move with my head. Getting off of this medication was truly miserable. I had numerous "brain explosions" and dizziness the first three weeks. I was not put on this medication for depression, but experienced incredible mood swings and crying jags for at least a month after quitting. There is no good way to taper off, given that the lowest dosage made is 20mg. I took Cymbalta every other night to taper off, but it was still a very difficult thing. My doctor had said, "If it doesn't work for you, just stop taking it!" Right......... F 54 5 months
10/28/2006
 1  severe depression Extreme fatigue, unclear thoughts, indigestion, bloating, flatulence, frequent need to urinate (but unable to do so fully)and worst of all: very serious constipation. I did not have a single bowel movement in 8 days! Can't say if it might have worked eventually. Normally, I would give it 3-4 weeks, but could not stay on it because of the side effects. The tiredness wasn't as severe after the first few days, but the constipation was absolutely intolerable. F 45 9 days
10/27/2006
 4  mild depression SEVERE night sweats and increased sweating during the day, and somewhat difficult (but not impossible) to reach orgasm. I had intense headaches for the first 3 days of taking Cymbalta, but then the depression "fog" cleared and I felt much less weighed down by my thoughts. During the first few months of taking Cymbalta (30 mg) I used to wake up at least 2X during the night to change pajamas & sheets/bedding due to intense sweating & was losing lots of sleep. Now I don't wake up until morning but I am soaked with sweat. Overall, I have felt more like myself & much less depressed, but occassionally when I experience a setback, I don't dwell as much on my sad thoughts. Both my therapist & psychiatrist are extremely puzzled by the instense sweating, as though they're hearing of this side effect for the first time. F 36 8 months
10/26/2006
 4  depression the usual: initial sweating and sexual difficulties/innabilities. One thing I havent read much about that cymbalta definetly caused/aggrevated was difficulty to urinate! It literally cut my frequency down to 4 times a day - even when i felt 'somewhat full' I couldnt go without difficulty. THIS WAS HUGELY IMPROVED WITH WELBUTRIN XL. Ask your doctor about combining Welbutrin XL with cymbalta. Within two days - I could use the restroom like normal and sexual drive/ability to 'O' was almost normal (still difficult but nowhere NEAR how it was). Am on 120mg cymbalta and 300 welbutrin XL. I cannot emphasize what a side-effect improvement adding the welbutrin was!! M 31 6 months
10/25/2006
 1  anxiety and depression suicidal thoughts! a complete breakdown after two weeks. Terrible insomnia after a few weeks of somnolence. These are just MY experiences. I've never been on an antidepressant. When I first started on 30mg in the am, I felt nearly immediate relief for anxiety. Then horrific insomnia hit at 60mg. I'm sure part of my reaction was sleep deprivation, but I've never had a suicidal thought in my life, and last weekend, I basically broke down. Uncontrollable crying, hopelessness, completely afraid to be alone. The worst--thoughts of suicide for the first time in my life. When I went to the doc, he took me off Cymbalta immediately (replaced by Lexapro--I'm now sleeping like a baby and feel like my old self). I am happy for those for whom this med works--and it may be right for some. Just a warning--monitor yourself carefully for side effects, worsening of your symptoms, and do not delay getting help if you notice a negative change! F 49 15 days
10/25/2006
 1  Lups & Depression Burred vision, extreme fatigue, droopy, watery eyes, and grinding teeth. I'm tired (can't stay awake) but feel very wired and jumpy at the same time. Horrible blurred vision after 2 days of starting the drug and the worst fatigue ever. Sleeping 13 hours at night and then napping during the day. Felt wired one day, and have been grinding my teeth ever since. Depression isn't really better either. I just feel "empty" and devoid of feelings. Didn't help with pain either. I have stopped taking the drug for 4 days now and none of the side effects are going away...yet...and they better. This is a horrible drug and should not be perscribed to anyone. My biggest question is how long will it take before the blurred vision goes away? Please email me if you have experience with blurred vision from this drug and how long it took before it went away. F 33 30 days
10/24/2006
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 1  Major depression/anxiety Two hypoglycemic events resulting in seizures requiring hospitalization. Profuse sweating, vivid nightmares, apathy toward everything, insomnia. even with use of Ambien. I feel very fortunate. After being on it for almost 2 years, I forgot to take it for a few days and when I realized all the above side effects were gone, I was very pleased. I had so much anxiety with Cymbalta tbat I was using Xanax to control it; when in fact it was supposed to help depression and the anxiety that goes along with depression. Nothing mattered, I wasn't paying my bills and didn't have an interest in anything - I was just "surviving" the best way I knew how. I would love feedback on any other person who had hypoglycemic events resulting in seizures. F 55 2 years
10/21/2006
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 3  Major depressive disorder Insomnia, excessive sweating, blurring vision, appetite loss. Have only been on drug for one week, and already I can see I am not getting the creeped-out feeling I have from a half dozen other antidepressants I have tried. But the sweating and the insomnia are VERY problematic, as I am exhausted. Plus my vision is very blurred and I have no appetite (no weight loss yet, though). Also having weird sort of mental mania at night when I am cannot sleep - repeating of tunes and beats in my head that I cannot stop, which makes me feel very jittery, and then I really cannot get back to sleep. Ugh. I am concerned about the toll it takes on the liver, though. All in all I am hopeful about this drug. With time, my discomfort should subside, at least that is what my friends who are on the drug tell me. I am still on the fence about this drug, but it does seem better than some others like Paxil, Zoloft, Wellbutrin, etc., that I have briefly tried. F 50 7 days
10/19/2006
 2  depression and anxiety Worst side effect of this med is insomnia. Cannot get off to sleep although very tired. Drowsy during the day. At first I had constipation and lethargy. Apart from that in comparison with other meds low side effects. After about 4 days on this med I n oticed a definite uplift in my mood and my anxiety was a little lower. I was surprised because I had just stopped taking Sertaline and expected to be suffering some withdrawal from that so was pleased with how i felt. I have been on this medication for 11 weeks today and my mood began to dip about two weeks ago. I am very disappointed because I have had a few meds since I stopped Seroxat a year ago and have not had any therapeutic effect from them and really thought this med would be the one to work. I am up and down on this medication in general. I have to admit that my anxiety is not as bad and my depression is not as bad. I don't cry as much which is a bonus but I do feel like crying at times during the day and I really hoped to be feeling much much better at the 11 week stage. F 48 11 weeks
10/19/2006
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 1  Neuropathy I had no problems with the drug initally, then gained 15 pounds in six weeks. After four months on the drug with no problems besides weight gain (25 pounds total) I tried tapering off over two months and am having terrible withdrawal symptoms. Went back to original dose (50mg) and no help. I am now going to discontinue quickly over the next two weeks. I anticipate at least six weeks of terrible withdrawals. I've heard of people having problems up to six months after stopping the drug. If you start this drug it will stop working eventually and then you will be hooked and unable to get off. I highly recommend not taking it. M 29 6 months
10/18/2006
 3  depression short term memory loss I felt it was difficult to perform at my best due to memory loss, which seemed significant at 60mg/day. After I quit, the memory and recall greatly improved. I feel my side effects undermined my professional performance and casual conversation. F 43 120 days
10/17/2006
 3  depression short term memory loss I felt it was difficult to perform at my best due to memory loss, which seemed significant at 60mg/day. After I quit, the memory and recall greatly improved. I feel my side effects undermined my professional performance and casual conversation. F 43 120 days
10/17/2006
 3  Severe Depression Mild weight gain, excessive sweating, lethargy - if I forget to take a dose I feel like there is electricity running from my brain down my arms It has been just OK. In the beginning it was really good but about 3 months in it started being less effective. I didn't have the weight gain like I did on Zoloft. I'm worried about withdrawal when I stop taking it because if I forget to take it for a day I feel completely out of it. And I have major "brain zaps". I so wish I could take Wellbutrin (I'm allergic to it) because that drug was the best one for depression! M 29 9 months
10/17/2006
 3  depression have gained weight so quit. Most suspicious is intense foot and ankle stiffness, pain when getting out of bed, out of the car or standing up. Goes away quickly. Seems may be a w/d symptom. also freakish dreams at night waking up afraid. waking up often in sweats. Actually is a good depression reliever, completely removed the wolf just waiting at the back door. Nothing noticable just the doom and gloom were gone. but, i do feel it has caused me to gain about 10 to 15 lbs so feel I am experiencing w/d. F 57 13 months
10/14/2006
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 1  chronic back pain Started at low dose of 20. After two weeks moved to 40 and side effects started. Headaches, insomnia, sweating,nausea, feeling of edgyness. Reduced back down to 20, but headaches, sweating, nausea continued. Quit after 5 weeks as side effects too awful. Withdrawal is horrible, even from 20mg. Terrible, terrible 24/7 headache that nothing stops, nausea, insomnia and weakness from not sleeping, even after 5 days off.Would never take this again. F 56 5 weeks
10/9/2006

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