CYMBALTA Reviews (DULOXETINE)

Average Rating: 2.7 (2745 Ratings)

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 ANTIDEPRESSANTS

 Type: Rx Drug

  

CYMBALTA  (DULOXETINE):  Duloxetine is used to treat depression and anxiety. In addition, duloxetine is used to help relieve nerve pain (peripheral neuropathy) in people with diabetes or ongoing pain due to medical conditions such as arthritis, chronic back pain, or fibromyalgia (a condition that causes widespread pain). Duloxetine may improve your mood, sleep, appetite, and energy level, and decrease nervousness. It can also decrease pain due to certain medical conditions. Duloxetine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). This medication works by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in the brain.   FDA Approval Date: 2004-08-03 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on CYMBALTA: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR CYMBALTACOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 5  Diabetic Neuropathy Pain No bad side effects at all!! This drug has helped the pain, helped improve my mood, and also aids in helping me to sleep. F 50 21 days
30mg 1X day
6/11/2010
 3  anxiety/depression anxiety, drowsiness, insomnia, chills, loss of appetite, sweating, cloudiness, memory loss Over the last 6 months I've experienced the separation of my parents after 38 years, life-threatening surgery for my mother, first death of a family member and extreme job dissatisfaction. The collection of these events have made me pretty depressed and anxious. My relationship with my fiance has really taken a blow as a result of these occurences. I began seeing a therapist a couple months ago, but I wasn't feeling the effectiveness. I decided to reach out to my physician for information regarding medication treatment. He prescribed Cymbalta, which I've been on for the last 4 days. It's been pretty horrible, thus far. I've been anxious at times, paranoid, very drowsie, sleeping for no more than 3 hours per night, loss of appetite, sweating, very cloudy thinking, forgetfulness. I'm toughing it out for another couple days, in hopes that my symptoms improve. Wish me luck! M 28 4 days
30 MG 1X day
6/11/2010
 4  severe anxiety, mild depression First few days had major insomnia, which continues, but not as severe, and I've always had sleep issues to begin with. A little nausea here and there, extreme loss of appetite. I used to take Zoloft which emotionally worked great, but packed on 8lbs in just 3 months from it. After 1 month of taking Cymbalta 7 of the 8lbs are gone! I don't feel as "mellow" just yet as I did on the Zoloft, I still have major bouts of irritation and frustration, but it's slowly getting better. I plan to continue taking it, as I'm really happy with it so far. F 32 4 weeks
60mg 1X day
6/10/2010
 4  Depression (Dysthymia) , Anxiety Decrease in libido (not totally gone), ejaculation takes longer, morning nausea/loss of appetite, constipation, more frequent urination, excessive yawning (first two weeks), penile discharge (first week), jittery/high energy (first week), weight loss. -I also take 200 MG of Provigil twice a day for Narcolepsy. -For the first two weeks I took clonazepam for the anxiety until the Cymbalta kicked in. - So far it has worked great for me and the side effects have not become severe enough to cause an issue. I was somewhat hyper/ talkative the first week (a major shift from being extremely quiet, removed, and antisocial), but that was mostly with family members. If I eat much of anything in the morning while I still have the mild nausea I will get diarrhea, otherwise I have had some mild constipation but that usually only makes me take a little longer in the bathroom so I moved some books in there for reading (reading has always been difficult because of the lack of interest, and excessive daytime sleepiness that would cause me to fall asleep repeatedly and become disoriented). My general level of anxiety has dropped quite a bit. I still recognize some of the thoughts and feelings I had before, but they no longer keep me from being able to do things as simple as taking a walk and it is much easier to communicate. My motivation level has increased a large amount and allowed me to actually have interest in creating art (an interesting/nice feeling for someone who has gone to a Fine Arts college for the last 3 years) and in life in general. I have gained a good amount of energy throughout the day and am actually sleeping better (which is still "fragmented sleep"). - I'm going to keep watching things. M 21 1 months
60 MG 1X day
6/10/2010
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 3  Fibromyalgia Weight gain, constipation, and EXCESSIVE SWEATING!! I am sweating 24/7 and I hate it! It seems to help somewhat with the muscle pain from the fibromyalgia but I'm wondering if a lower dose would eliminate some of the sweating. I can't keep the temperature any lower than I alreaady do. F 54 6 months
30 mg 3X day
6/10/2010
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 1  depression/anxiety achiness, tiredness, restlessness, blurry vision, tingling in arms, legs and hands, increased anxiety, high blood pressure, belching, heartburn, loss of appetite, strange taste in mouth, alternating hot and cold spells, headaches, loss of feeling during sex I have only taken cymbalta twice and am going to stop now before my symptoms get worse. I feel a lot worse than I did before taking it. I constantly feel as if I am on the verge of a panic attack, I feel like sleeping all day, but have difficulty sleeping for more than 1 hour at a time even during the night. I have aches and pains as if I have the flu. F 33 2 days
30 MG 1X day
6/9/2010
 1  depression Short-term it helped my depression (6 mos). Then the dose was increased to 60mg and I began to experience panic and anxiety attacks to a much bigger extent. Heart palps, blood pressure and respiratory rise, anger, irritablity, inability to reason or function normally. Had to resign my job because of side effects. Withdrawl symptoms were so bad. (Headaches, insomnia, dizziness, nausea, emotional, easily irritated). Began to decrease amount of Cymbalta slowly by taking capsules apart and removing 5-10 beads on a weekly basis. It is taking forever. I do not recommend this drug for anyone. F 21 2 years
30-60mg 1X day
6/8/2010
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 4  Fibromyalgia For the first week, i had some nausea, loss of appetite & extreme constipation. After the first week, all but the constipation went away; however, I found a cure for that! Don't let the harsh comments on here scare you--just remember, everyone is different. I've only been on it 5 weeks & it has helped my fibro pain; hoping the longer I'm on it, the more it will help. I never thought I was officially "depressed" but the pain did get me down & made me think negative thoughts. Since I've been on the medication, my spirits seem to be uplifted & I'm just happier in general. The cure for the constipation? Mineral Oil. Get a bottle & take 2TBS @ bedtime like every other day. You will be amazed at the results! F 41 5 weeks
30 mg 1X day
6/6/2010
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 4  Anxiety / Depression First 3 days - Shivers, spacey, bad breath, numbness, diarrhoea, nausea, excessive yawning, loss of appetite, tremor, frequently needing to urinate. After week & now - All above reduced. Loss of appetite and excessive yawning?, reduced libido. Long term deterioration of Job opportunities and work challenges caused and increase in my anxiety/depression. 3 days on 30 MG and then onto 60MG. Most side effects disapeared after 3 days. Cymbalta has definitely removed the "lack of interest" or "negativity and anxiety that was building in me. I now have more motivation in going about my daily activities and feel "normal again". Although one annoying side effect has been the feeling of tired/excessive yawning. I wonder if its a common side effect of Anxiety drugs? Was on Effexor previously (5 years ago) and didn't notice the yawning side effect but it did cause high blood pressure problems and Weight gain. Therefore, I am happy with Cymbalta benefits and will continue to use it to bridge me through this phase and not intending to stay on it for too long. F 33 1 months
60 MG 1X day
6/5/2010
 4  Anxiety/Depression/Panic Attacks Muscle Twitches/Spasms I feel so much better now- I used to get anxiety/panic attacks anywhere from 5-10 times a week ever since before I was diagnosed at 11 years old. In my life I have had 2 suicide attempts (the last one was about 14 years ago). My anxiety manifests itself in fits of anger, tears or total introversion. It has also come through as mild OCD compulsions: locking my car 7 or 8 times, dusting Everything every single night for about 2 hours, folding and refolding clothes etc. Since I started taking it, within about 2 weeks I noticed a difference. When I explained to my husband after a month that I could not take it anymore because it was too expensive, he INSISTED that I stay on it. HE said that he and my boys noticed a dramatic difference and that they hoped it stayed that way. So- I am back on and I feel better than I have in many many year.... F 32 2 months
20 1X day
6/4/2010
 5  nerve pain from ruptured disc -neck none that were significant i'd been on assorted pain meds for the nerve pain from a ruptured disc in my neck. the nerve pain made me feel jumpy and irritable and uncomfortable. after i started cymbalta, the pain stopped. i didn't realize how significant the improvement was until i didn't refill immediately after i'd been on it several months. it was amazing the difference. perhaps those with bad reactions start with too high dosage initially? i know 30 mg is low, but it made a huge difference to my life. F 50 2 years
30 mg 1X day
6/3/2010
 4  corneal neuralgia constipation, dry mouth, dizziness, sweating, loss of sex drive and ability to have orgasm, inability to tolerate heat. First few weeks I had very bad nausea. Several times in the past 5 years I have forgotten to take it before bed. The next day I start feeling "weird" in the AM. As the day progresses I develop severe anxiety, dizziness, instability. I usually figure out that I forgot it but it takes several hours to start feeling normal again. Sometimes I feel confused or that I'm not completely "here" but that may be due to other meds. F 40 5 years
60 mg 1X day
6/3/2010
 1  depression diarrhea BIG time if I did not take w/big meal, slight nausea, extreme tiredness, dialated pupils, blurry vision I did not like this medication, too many negative side effects and no positive, could not keep up w/ my 3 yr old, and worse didnt want to play w/her any more, just felt like a zombie w/ diarrhea, yuck! F 30 2 weeks
60 MG 1X day
6/3/2010
 4  Anxiety and depression Nausea,dizzyness,weight gain, heart burn, loss of Sexual appetite. Its been a great experience. Of course we all know what we were without meds and what we are now is such a difference. I do feel more normal on meds, not as paranoid and I dont get uptight with the kids anymore. Im way more chilled. But I have a shocking memory now, Im warm alot - eg I dont wear alot of clothes in winter, and every morning I am nauseas. I hate the fact that Im not interested in sex anymore as I have been sexually active my whole life. Mind you I was also self sabotaging too. I just linked my weight gain to meds, and I realised recently my anxiety prob caused me to be super skinny. Whilst I like my new round curves, its a bit startling after 35 years of being skinny. When I startedon Cymbalta, I got heart burn for 3-4 days, and then nothing up until a week ago and now severe heart burn. I have only run out twice and those days were a nightmare. Dizzyness, nausea and other symptoms others were talking about. So I might go back to my doctor and see if I can go down to 30mg and see if the sex drive pics up and the weight gain and heartburn slows down. But yes, as mentioned before - not the best drug to run out of! YIKES. I used to take cypramol, and when I ran out of that, I didnt notice any side effects like Cymbalta. But it wasnt as good. F 40 356 days
60mg 1X day
6/2/2010
 4  Depression Initially; Restless Legs, yawning, inability to concentrate; tired during day. All subsided after 2 weeks. Longterm; Decreased Libido, not entirely gone. Difficulty reaching orgasm. Hair loss! Getting worse as time wears on. Incredible difference in my Depression and Anxiety levels. Able to function normally and partake in activities that would have caused tremendous anxiety for me. Depression has subsided but not totally gone. Definitely give this drug time to work. First few days were ROUGH. But the libido and hair loss i can't live with forever.. F 40 7 months
60MG 1X day
5/26/2010
 4  Bi-Polar, Anxiety, Psychosis Dry mouth, sleepiness (for the first few days), couldn't orgasm the first week I still tend to get dry mouth from time to time but I can tolerate it. I'm not sure exactly what it does to me since I started Neurontin at the same time. It does help with my mood but not the anxiety. F 24 6 months
60 2X day
5/26/2010
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 2  Depression Deep-end mania. For the first 3 weeks, life was getting a lot easier and I started to hope that I was going to come out of that long tunnel of depression. But at about 4 weeks, I became fascinated with geology and I could not stop picking up rocks. My pockets were full of rocks everyday. I would take time off work to collect. It took me a full 12 weeks to fully realize how delusional I had become (as opposed to moderately depressed but not delusional, before taking Cymbalta.) Hm, what else, yes...I was also missing meetings! My career was at an all time low! I kept getting fired. (But I was happy, well sort of.) If you have the time and inclination to become an artist however, this may be the drug for you. It really works great on depression. I also got incredibly fascinated with digital photography. I was extremely prolific. I loved what my senses were bringing me. I've got kids though and if I kept taking Cymbalta, I'ld be living in my van by now and not paying child support. M 47 3 months
100 MG 1X day
5/25/2010
 1  Depression/Anxiety So "high" I got on my own nerves. After 2 weeks the "high" wore off and I was left in worse shape emotionally than before I started Cymbalta. Completely ruined my sex life even after coming off the medication. I have been off this medication for 6 months now and I still have absolutely no desire to have sex at all. If your doctor reccomends Cymbalta for treatment of any condition you should run away. Quickly if you can!! M 32 6 weeks
30mg 1X day
5/25/2010
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 4  Anxiety First 2 weeks on 30mg(dizzy, loss of appetite, sleepiness, nausea) 2 weeks on 60mg(HR 120bpm, heart palps, increased pupil size, increased BP, sweating, increase breathing), 2 years later (no libido, constantly tired, no motivation) This med really has helped with my anxiety. I started out on 30 for 2 weeks then upped to 60. Had the aforementioned side effects and was brought back to 30. I have taken this for 2 years and have had no problems with anxiety. Unfortunately if I miss a dose I have the "light switch" problem as others have mentioned. It really does feel like lights are going off in my head and I get a severe headache, nausea, dizziness, and sleeplessness. Also, my libido has decreased to ZERO and it's awful. At my age you would never think this should be a problem. I'm calling my Dr. today to find out what we can do about this. F 25 2 years
30mg 1X day
5/24/2010
 2  Depression after my husband died Didn't seem to help my depression - although I was somewhat more organized and directed. Feeling very tired, which has continued through the months of taking Cymbalta. Think I'll discontinue, under my doctor's supervision. Good luck. Hope it works for you. F 71
1X day
5/24/2010

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