CYMBALTA Reviews (DULOXETINE)

Average Rating: 2.7 (2745 Ratings)

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 ANTIDEPRESSANTS

 Type: Rx Drug

  

CYMBALTA  (DULOXETINE):  Duloxetine is used to treat depression and anxiety. In addition, duloxetine is used to help relieve nerve pain (peripheral neuropathy) in people with diabetes or ongoing pain due to medical conditions such as arthritis, chronic back pain, or fibromyalgia (a condition that causes widespread pain). Duloxetine may improve your mood, sleep, appetite, and energy level, and decrease nervousness. It can also decrease pain due to certain medical conditions. Duloxetine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). This medication works by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in the brain.   FDA Approval Date: 2004-08-03 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on CYMBALTA: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR CYMBALTACOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 5  depression and chronic pain. Some insomnia, but nothing that can't be cured with a sleep aid. Also, decreased appetite, weight loss (a good thing!), vivid dreams, increased sex drive with intense, almost painful orgasms. This is the first med that has HELPED with my depression and chronic pain. I was started at 30mg and bumped up to 60mg after 1.5 months. It has almost eliminated my anxiety. I don't fly off the handle. I FEEL HUMAN!!! I am consistantly losing weight and I'm really not complaining about the increase in my sex drive! LOVE IT! F 29 4 months
1/30/2007
 4  depression and chronic pain. Some insomnia, but nothing that can't be cured with a sleep aid. Also, decreased appetite, weight loss (a good thing!), vivid dreams, increased sex drive with intense, almost painful orgasms. This is the first med that has HELPED with my depression and chronic pain. I was started at 30mg and bumped up to 60mg after 1.5 months. It has almost eliminated my anxiety. I don't fly off the handle. I FEEL HUMAN!!! I am consistantly losing weight and I'm really not complaining about the increase in my sex drive! LOVE IT! F 29 4 months
1/30/2007
 4  depression and chronic pain. Some insomnia, but nothing that can't be cured with a sleep aid. Also, decreased appetite, weight loss (a good thing!), vivid dreams, increased sex drive with intense, almost painful orgasms. This is the first med that has HELPED with my depression and chronic pain. I was started at 30mg and bumped up to 60mg after 1.5 months. It has almost eliminated my anxiety. I don't fly off the handle. I FEEL HUMAN!!! I am consistantly losing weight and I'm really not complaining about the increase in my sex drive! LOVE IT! M 29 4 months
1/30/2007
 4  Depression/ Bi Polar DO The first month was terrible. Nausea and loss of appetite to the point where I ate almost nothing for 3 weeks. I slept most of the month. Gradually things got progressively better. This is a great medication minus the withdrawl symptoms (sweating,brain zaps, dizzyness). It has definitely changed my life for the better. I was very suicidal before and now it's an almost irrelevant contemplation. Like any medication, it takes some getting used to. I read some comments on this page and have had some similar side effects. Increased sex drive, hypomania, vivid dreams, increased orgasm (oh yeah!!!), i have become more aggressive than I was in the past. The bad part about this drug is the lack of creativity in my work being replaced with compulsiveness, i'm very verbally and could be physically agressive, i have to watch my behavior a lot of the time. night sweats (actually waking up drenched some nights), if i miss a dose the effects are very noticable,...i missed it for three or 4 It's Jan 29th now and I'm married, holding a steady job, i moved across the country, quit smoking, no drugs, rarely suicidal and most importantly very happy with my life and choice to stay on cymbalta. My advice is to tough it out during the first month. It can be hard and might be even harder for you than in my experience. You won't regret it. M 23 6 months
1/29/2007
 1  depression/anxiety/nerve pain tiredness, brain zaps/electrical explosions in my head, poor sleep, night sweats, agitation, severe mood swings and weight gain. I've been 'getting off' this horrible medication for a month and the withdrawal symptoms are as bad now as when I began. The brain zaps are the worst of all and I can't sleep. I'm exhausted all day, can't concentrate, my ability to think is impaired and my mind feels as if it's bogged down. I'd been on this medication for two years and then one day it crapped out and all of the depression symptoms returned with a vengeance. The Cymbalta simply stopped working for me. I warn anyone who's considering taking this medication to seriously consider the withdrawal symptoms they'll face when getting off of it, and the day will come. M 59 2 years
1/29/2007
 5  Clinical Depression Nausea and dizziness have persisted and worsened but I am afraid to consider discontinuing this drug because I have previously failed all others and was facing ECT. I take 60 mg daily. Cymbalta has unquestionably been the best antidepressant I have ever taken (in 30+ years) - A few years ago, I failed all other antidepressants and combinations of various psychiatric drugs. As a last try, my psychiatrist prescribed Cymbalta immediately after it was FDA approved. Cymbalta gave me back my life. I still cannot believe how well it has worked for me. Family and friends want me to continue on Cymbalta indefinitely. However, I have been having very severe problems with nausea, dizziness and vomitting and I don't know if I will have to discontinue Cymbalta soon to reverse these issues, unless another cause can be detected and treated. F 50 2.5 years
1/28/2007
 5  depression awful night sweats to the point where i am drenched I started out with Wellbutrin and lost 30 lbs, was never hungry. I liked the energy factor but it still wasn't doing much for depression. Starting taking cymbalta, and have gained 20 lbs since and for some reason can't get rid of it. Very upset because I really do like the drug. May look into something else. F 25 4 months
1/28/2007
 1  pain and depression 30 pound weight gain so far and I am continuing to gain. My cholesterol is up 50 points and my sugar is up too. My sex drive is over the top and stupid things come out of my mouth without thinking. F 48 8 months
1/26/2007
 5  Anxiety Loss of appetite, vivid dreams I feel great. Due to my loss of appetite I now think about things before I eat them and have acquired healtheir eating habits. The first few weeks were tough (getting adjusted) but now that I am starting to see and live with the benefits I am glad I stuck with it. F 26 5 weeks
1/25/2007
 3  depression feeling edgy, sweaty palms, foggy head, loss of appetite just started taking cymbalta 5 days ago. I take it in the morning as it makes me feel kinda speedy. I am on 30 mg. SE are better if taken with cereal. I just want to feel more balanced and not so emotionally raw. Today I feel better, not so anxious or speedy.. time will tell, I guess. how long did it take for you to feel better? F 49 5 days
1/25/2007
 2  Major Depressive Disorder Severe sweating (day AND night), total insomnia, loss of sex drive, out-of-control hyperactivity, road rage (yes, really), bad taste in my mouth, inability to concentrate, loss of appetite. The side effects were too intolerable for me to continue this medication. When they didn't subside after 3 weeks, I begged my doctor to switch my meds. F 27 3 weeks
1/25/2007
 3  Bipolar disorder / Depression Sexual side effects including dryness, pain, and inability to reach orgasm When I initially went on 30 mg Cymbalta daily, it worked very well for me. After a year my depression started to return and my dosage was increased to 60mg, however, I was recently married and the sexual side effects were causing problems, so I am in a transitioning period of my medications currently F 19 2 years
1/24/2007
 3  Major Depression Serious side effects, very unpleasant starting the drug, even more unpleasant stopping the drug!!! I am having a VERY hard time coming off the drug...I can't even move my eyes from side without becoming dizzy! I have never had so many unpleasant side effects from any drug i have taken. I would like to hear from other people on how to come off this drug...is it just with time? I have recently stopped wellbutrin as well, maybe too much too quick? Please if anyone can recomend some other medicine that is working for them...email me! If anyone just wants to chat about all this crap...plz email me! The drug was effective on my anxiety and did elevate my depression, BUT it in my case made everything OK...you and i both know EVERYTHING IS NOT OK!!! It is not ok to let the house go without cleaning to the point i will not let anyone in! It is not OK to just simply ignore anything that needs your attention, it is not ok to just to curl up and sleep through the weekend! I mean excessive sleep is one problem i want overcome, But with this drug, it's ok...Hell most everything is ok!!! This probably has it's place in some peoples treatment, but with me, it's not a good thing. M 48 6 months
1/21/2007
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 5  Social Anxiety and minor depression increased sex drive, more tired for the first few months and that went away around the 3rd month. Cymbalta has really helped with my general anxiety. Being in public is a lot easier now. It really works with depression and a lot of people have mentioned that it still allows you to feel emotions which is a plus. For the first 8 weeks I felt like a zombie but it went away. It takes time to adjust to these medications. Some people have a harder adjustment than others. The social anxiety is still there, but honestly unless you want to be a drugged up zombie who has no emotions I would reccommend counciling and learning how to relax when with people or in public. Part of it really is phychological. but the cymbalta is a great tool for helping me to concur the depression and the social anxiety. At first I noticed I was a little antisocial on the medication but I stuck it out and by about the 10th week that all went away. My muscle tension that was always with me...its gone.....but at first it actually induced anxiety and depression for me. that was for about a month. when I thoug M 20 3 months
1/18/2007
 5  Social Anxiety and minor depression increased sex drive, more tired for the first few months and that went away around the 3rd month. 60mg Cymbalta has really helped with my general anxiety. Being in public is a lot easier now. It really works with depression and a lot of people have mentioned that it still allows you to feel emotions which is a plus. For the first 8 weeks I felt like a zombie but it went away. It takes time to adjust to these medications. Some people have a harder adjustment than others. The social anxiety is still there, but honestly unless you want to be a drugged up zombie who has no emotions I would reccommend counciling and learning how to relax when with people or in public. Part of it really is phychological. but the cymbalta is a great tool for helping me to concur the depression and the social anxiety. At first I noticed I was a little antisocial on the medication but I stuck it out and by about the 10th week that all went away. My muscle tension that was always with me...its gone.....but at first it actually induced anxiety and depression for me. that was for about a month. when I thoug M 20 3 months
1/18/2007
 3  depression / physical aches &pains Inability to orgasm. Noticable dry mouth. Sleepy and groggy. A dramatic decrease in appetite. Frquent urge to urinate. Mild constipation I went to the doctor complaining of lethargy and bodily aches and mild depresion. I began taking 30mg, and then after 1 week moved up to 60mg of Cymbalta. I immediately lost ANY ability to reach orgasm. Belive me I've tried, to the point of exhaustion. After years of a good and active sex life this was not acceptable. I've never went this long without an orgasm since I was 12 years old. Went back to the doctor and he perscribed Wellbutrin SR ( 150mg ) to take in addition to the Cymbalta to counter the side effect. This is the first time I have ever been on any kind of depression medication, so I remain a little uncomfortable taking both of these pills. Only been on the Wellbutin a few days but am having the same ejaculatory problem, hope with time it will come back. I do think I feel a little less depressed overall, and the body aches have gone away completely. I am also losing weight (2lbs. in the first 10 days alone) which is a plus.I eat a 1/4 of what I used to before the Cymbalta. M 42 21 days
1/16/2007
 4  Major Depression and DPN Felt "off" for the first couple of weeks on 30mg, evened out and got upped to 60mg. Felt generally better, but developed a slight twitch in my left foot. DO NOT SKIP A DAY!! Went two days without perscription and felt AWEFUL, worse than the nastiest hang over. Now on 90mg. I love the dreams and the weight loss 10 lbs since first dose. Sex really no different, I'm just in a better mood to do it more often. I'm even keel on this after major depressive episode, not really up, not really down. DPN not going away, still have loss of some feeling in toes. Gotta kick the typre 2. Again, I feel like road kill if I miss even one day, two days is extremely unpleasant. I have noticed a bit of blurred vision and a tendancy to smoke more. Confidence is up and I'm less likely to be overly-sensitive. I do seem to get angrier more often, instead of a depressive shut-down. I'll try 90mg for a few months and see how it works out, then I'd like to wean off of it. M 31 8 months
1/15/2007
 3  Depression, OCD Nausea the first couple days, difficulty orgasming the first couple weeks, beyong that NO SIDE EFFECTS I have taken Cymbalta off and on since it first came out (lost my health insurance, got it back)...when I am on it I noticed an extreme difference in myself with worrying and anger issues, it helped a lot in my job and with obsessing over other situations. Results for me were within first week. No real side effects. 60mgs daily. When I've had to go off, nothing major...some dizziness but that's it. Nothing else had worked with me for my obsessiveness ... I wanted to write Eli Lilly a thank you letter when I first started taking it. Seemed to stop working after six months in a row not sure if that is because I had increased stress or I was drinking more than usual (never a good idea to drink to much when on a med). F 33 2 years
1/14/2007
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 5  Anxiety and Depression Delayed ejaculation, vivid dreams. I currently take 40 mg. of Cymbalta a day. At first I had some minor sexual side effects (no problems with erection, but I did have delayed ejaculation), but those side effects disappeared after a few months. The only side effect that I have now is extremely realistic/vivid dreams. The best comparison I can make about the dreams, is if a "normal" dream is like watching a dvd on a 13 inch screen, then a dream on Cymbalta is like going to see an IMAX movie. The dreams aren't bad though... just more interesting. Plus, I'm better able to remember my dreams after I wake up. M 32 6 months
1/13/2007
 5  Anxiety and Depression Delayed ejaculation, vivid dreams. I currently take 40 mg. of Cymbalta a day. It has GREATLY reduced my level of anxiety and depression. At first I had some minor sexual side effects (no problems with erection, but I did have delayed ejaculation), but those side effects disappeared after a few months. The only side effect that I have now is extremely realistic/vivid dreams. The best comparison I can make about the dreams, is if a "normal" dream is like watching a dvd on a 13 inch screen, then a dream on Cymbalta is like going to see an IMAX movie. The dreams aren't bad though... just more interesting. Plus, I'm better able to remember my dreams after I wake up. M 32 6 months
1/13/2007

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