CYMBALTA Reviews (DULOXETINE)

Average Rating: 2.7 (2745 Ratings)

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 ANTIDEPRESSANTS

 Type: Rx Drug

  

CYMBALTA  (DULOXETINE):  Duloxetine is used to treat depression and anxiety. In addition, duloxetine is used to help relieve nerve pain (peripheral neuropathy) in people with diabetes or ongoing pain due to medical conditions such as arthritis, chronic back pain, or fibromyalgia (a condition that causes widespread pain). Duloxetine may improve your mood, sleep, appetite, and energy level, and decrease nervousness. It can also decrease pain due to certain medical conditions. Duloxetine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). This medication works by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in the brain.   FDA Approval Date: 2004-08-03 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on CYMBALTA: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR CYMBALTACOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 3  Fibromyalgia Initially, sweating was terrible...I would literally soak my bra and would have sweat beads above my lip and on the tops of my hands. Not as bad after a year, but still having to wear clinical strength antiperspirant. My weight has always been low, but since using Cymbalta I have gained about 8 - 10 lbs. (especially in my waistline) Haven't weighted this much in 23 years...literally! Reducing calorie intake doesn't change my weight. I don't know about other side effects because I have symptoms similar to my fibromyalgia (and its preceding cause). YES! It DOES cause weight gain...at least is has for me. But when you are "small" to begin with, no one listens. All they say is you need to gain weight...even if it's not natural for you!! So, it seems to me that if a drug has this side effect, it should be acknowledged no matter how much you weigh to being with. F 43 1 years
1/14/2009
 1  Depression This is poison and Eli Lilly should be sued for what they've created. I was on Cymbalta for about a year and half and the first few months were great. After the first year, I gained 30 pounds in under 3 months and I believe that overall, this medication made my depression worse. I quit taking it cold turkey about a week ago and with the exception of dizziness and vertigo, I feel okay. I DO NOT RECOMMEND ABRUPTLY TAKING THIS DRUG. It was just time for me to stop poisoning by body & mind. IF YOU HAVEN'T YET STARTED TAKING THIS DRUG, CONSIDER YOURSELF LUCKY. F 35 1.5 years
1/14/2009
 1  sadness, crying after knee replacem yawning,sweating, irritability, anger, forgetfull, insomnia frequent voiding, zero patience, lights and sounds magnified. daytime sleepiness, craving sweets & smokes. Oh yes & swollen hands that resolved as the day went on. This med seemed like a miracle the very first week. I only had nausea for a couple days then felt happy again upon wakening. During the last year I have been asked by my boss to look for another job due to forgetfullness as a med/surg RN. Anger, complaining and innapropiate rudeness to my patients. I have been off work for several months and when all my issues did not resolve with the lack of job stress I had to look at the Cymbalta as the cause. My husband is also on it and he has had such severe insomnia, night sweats and daytime fatigue that I feel this med has robbed us of 4 years of our lives. No sex drive at all and inabiliy to orgasm for us both. I am weaning off slowly taking a few of the little balls (30-40) out of 300 inside the 60mg cap. My plan is slow withdawal over 3 months. 57 4 years
1/14/2009
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 2  migraines 30lb weight gain, night sweats, severe constipation, fatigue Not WORTH IT! I took 60mg once a day to treat migraines. Worked like a charm. Started gaining weight after 1 year of no problems. Stopped taking cymbalta and had horrible withdrawal symptoms. IBS, vomiting, sweating, light sensitivity, flu symptoms. Horrible for a week. Not worth taking the drug that causes more problems after a 1 or two of use. F 21 2.5 years
1/11/2009
 3  depresion anxiety blurred vision sweating on 60 mg has helped with depression but still working on anxiety i am starting to go up to 90 mg today M 53 2 months
1/9/2009
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 1  MIGRAINES I had extreme vertigo, felt out of it all the time. When weaning off of Cymbalta I had terrible side effects! I thought I would never get off this drug. I tried going to every other day & then every 2 days but this made the symptoms worse. It wasn't until I saw that another man had actually removed 7 of the beads inside the capsule every day until they were gone, that I got some relief. You physically have to open the capsule and remove 7 beads the 1st day, then 14 the next day then 21 the next day and so on. It worked! It was tedious but it worked. It took me about a month of doing this until all of the medicine was gone. I had minimal side effects and have now been off for 13 days and feel great!! I would suggest that you take a vigorous walk or some form of exercise when coming off of this medicine. It keeps me from getting headached and keeps the side effects down. I feel so much better now that I'm off of this junk! I felt like a prisoner in my own body! F 33 6 months
1/8/2009
 4  Migraines, head/nerve pain, anxiety Sleepiness, so had to take at night. Brain Zaps and dizziness if miss a dose I went from having 9-13 headaches per month, plus daily head pain to about 7 days of headache per month, and feeling much less "headachey" on a daily basis. It's not a miracle cure for me, but is working a lot better than Topamax, Amitryptiline, Nortriptyline, Propranolol, Botox and Natural therapies ever did. I am surprised because I fully expected this drug not to work like the others. I figured Topamax was the big guns,and if that did not work, nothing would. I also feel more positive in general, whereas before I felt frustrated and down because of all the pain. Now I am functioning better and only think about headaches when I get them. I would have had less headaches than 7 days if I had taken my Zomig like I should have. Instead, I took Motrin which made each headache drag on for two or three days. Overall, I am getting pretty good relief with no side effects. Taking 60 mgs. F 44 1 months
1/5/2009
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 1  depression/anxiety severe mood swings, complete loss of libido, short temper/irritability, worsening depression, tremors and restless-legs-type symptoms at night, sleeplessness, exhaustion, difficulty concentrating I am weaning off this drug after a year at a variety of dosages. Recently, when attempting to increase dosage, I felt suicidal and exhausted for a week, then woke up one morning to feel almost manic. I don't know how my family can bear to be around me. This drug has not helped my depression and I now wonder if it has made it worse. While on it I developed an addiction to shopping which has left me with a mountain of credit card debt. Please do your research before taking this drug. F 37 13 months
1/5/2009
 1  depression/anxiety Headache, dizziness, heart "flutters" and palpitations, insomnia, muscle aches, joint pain. My doctor put me on this after I'd been on Zoloft for 2 years with no bad effects. He said most depression patients are under-medicated and thought the Cymbalta would help with anxiety better. This has been a HORRIBLE 4 days, constant headache, muscle and joint aches, insomnia and daytime sleepiness, and today I've had scary heart palpitations and light-headedness. I am only on 30 mg but am going back to Zoloft tonight! 4 days
1/4/2009
 4  Depression Lost ability to orgasm as dosage increased. No decrease in sex drive: just couldn't "get there" regardless of partner or even eventually a vibrator. Decreased Cymbalta as prescribed, down 30mg each week, from 120mg down to 0. Once I hit 0 I was finally able to orgasm again, and shortly it was as if there had never been a problem. The medicine helped depression but having an understanding partner about the loss of orgasm was crucial. F 36 7 months
1/3/2009
 3  Depression, Fybromyalgia pain Still having some depression. Not sure why. Still having much pain so not sure it is helping although I'm afraid to stop for fear that my symptoms may get worse. I have been taking it for less than a year. F 64
1/3/2009
 1  Depression I've taking Cymbalta for only 2 days and I've experieced the worst stomach ache, nausea and headache EVER! I'm so sick I cannot even get off the bed.It's not worse going through all this! I'm quitting today! Will try natural alternatives We're been poisoned with all these chemicals! F 36 2 days
1/2/2009
 4  bi-polar depression taking it along with Trileptal, I haven't noticied any negative side effects of taking 120mg daily It has definitely helped with the frequency and severity of my migraines F 38 3 years
1/1/2009
 2  Anxiety-Depression Weight gain, horrible brain zaps when a dose is missed, zero sex drive, dry mouth, sweats, fatigue. It numbed me at first against the issues that would cause me great anxiety. After a while, I find myself just numb and blah. Severe depression has occurred again and came to a head last night. I am going off of the drug as soon as I consult with my doctor. I want the old me back...even with all my quirks! F 39 2 years
1/1/2009
 1  muscle pain fatigue, muscle cramping M 55 4 years
1/1/2009
 5  PAIN F 50 20 weeks
12/30/2008
 4  Depression Increased sweatiness, extremely oily skin and acne, weight gain, strange dreams, alternating insomnia and then fatigue, and constipation. After taking Cymbalta for about 8 weeks, I felt a lot better mentally. I recently was diagnosed with Polycystic Ovary Syndrome and Cymbalta is a terrible choice for PCOS patients as it can raise insulin levels (which causes weight gain and lots of the other side effects that are already PCOS issues). I have just weaned off this onto Lexapro and don't seem to have any serious side effects. My skin is clearer and the sweatiness has subsided. F 43 9 months
12/30/2008
 3  Depression, mood stabilizer Night sweats, "brain zaps" if dosage missed, slight weight gain (1-2 lbs.) Currently withdrawing from 60 mg of Cymbalta, taken 1x daily (at night). Also taking 30 mg. of Adderall. I stopped the Cymbalta cold turkey about three days ago and, for me, it has not been particularly oppressive. Granted, I haven't been taking it very long... only about 4 months. Also, I've taken anti-depressants for years, so I'm familiar with the "brain zaps" that come with weaning off various medications. Compared with coming off Clomipramine, this withdrawal is a walk in the park. In all, the Adderall has been extremely helpful and I did not notice much improvement in mood with the Cymbalta. I'm still tired all the time. So now my doctor upped me to 10 mg of Adderral XR 3x daily and put some Lamictal in the mix (25 mg to start... eventually up to 50 mg). Please, before stopping taking a medication though, talk with your psychiatrist. Stabilizing mental health is a long, excruciating battle---I've been there, suicidal and all. But you have to keep on going. And, you cann F 36 4 months
12/30/2008
 4  spinal stenosis Initially, increased sweating for about one week and nothing more. Upon discontinuing, definite "brain zaps" and some minor gastrointestinal discomfort. Dosage initially 60 mg/day for first 12 months, then increased to 120 mg/day for last 8 months prior to weaning off. Weaned off from 120 back to 60 mgs once every two days for one week. Probably should have weaned off a bit longer, but it's behind me now. Cymbalta was pretty effective for me, at least I didn't notice any increase in pain. It actually helped me to psychologically deal with the frustration of my pain, but began to lose its effective after 9 to 10 months. Side effects were minimal and withdrawl "brain zaps" were nothing more than the old "rushes" we got back in the 1960s. Did not experience onset of withdrawal for 6 days after last dose, then lasted for roughly 7 days. M 55 20 months
12/29/2008
 4  Severe Chronic Nerve Pain/ Migraine The first two weeks of taking the 30 mg dose I had nausea and extreme dizziness and fatigue. After 2 week the symptoms subsided and I felt tired. I started taking the meds at night and the helped me sleep. My migraines came back after a year and they upped the dose to 60 mg. It took the headache away but gave me very vivid nightmares which I'm turning into a novel. Anyway, never ever miss a dose. It's best taken at night. And take a vitamin b pill in the morning it helps with mental clarity and alertness while on this drug. Even with the side effects I found this drug extremely beneficial for nerve pain. It took my pain level from a 10 to a 2! :) F 29 2 years
12/29/2008

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