CYMBALTA Reviews (DULOXETINE)

Average Rating: 2.7 (2745 Ratings)

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 ANTIDEPRESSANTS

 Type: Rx Drug

  

CYMBALTA  (DULOXETINE):  Duloxetine is used to treat depression and anxiety. In addition, duloxetine is used to help relieve nerve pain (peripheral neuropathy) in people with diabetes or ongoing pain due to medical conditions such as arthritis, chronic back pain, or fibromyalgia (a condition that causes widespread pain). Duloxetine may improve your mood, sleep, appetite, and energy level, and decrease nervousness. It can also decrease pain due to certain medical conditions. Duloxetine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). This medication works by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in the brain.   FDA Approval Date: 2004-08-03 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on CYMBALTA: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR CYMBALTACOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 4  Anxiety and Depression Profuse sweating, hair loss, insomnia Anyone taking 90 milligarams? Took cymbalta 60 milligrams for a couple of years. Depression increase and was placed on 90 milligrams which last for a couple of years. I take ativan as needed for added anxiety which seems to help. Lateley I have noticed more severe depresseion, I dont really like to be areound people. I have insomnia but dont like to take the ativan for sleep every night because it is addictive. I have taken the drug this long because I dont feel drugged and can concentrate on this drug better than any drug that I have taken. In the past on this drug I felt fairly happy and motivated. Lately feel depressed and tired although I cant sleep at night. I have been on prozac zoloft paxil lexapro and none to compare to the cymbalta up to now. Now i feel so tired of it all and depressed that I rececntly had a breast biopsy that was benign( although the lump still has to be removed) and i kink=d of wish that it was cancer. becouse of my religion i would not kill myself. I F 55 5 years
9/11/2008
 1  anxiety, PMDD, dysautonomia headache, nausea, dizziness/vertigo, increased anxiety/panic, sleep disturbances, bulging eyes, blurry vision, hyperactivity, possible tics, heart palpitations. Took 1 30 mg capsule yesterday at about 2:30 pm, by 6:30 pm I was nauseated, dizzy, and had a mild headache. about 7:30 I developed anxiety, felt stoned, hyper--yet could not stop yawning (I was not tired--this would be a form of a tic), and generally felt very "out of it" in addition to the earlier symptoms. By 8:00 I fell into a deep sleep, awoke about midnight and was unable to return to sleep. Continued to wake up about every hour throughout the night. When I woke up for good this morning at 5:15, I felt like I was vibrating, that my eyeballs were bulging out of my skull and like my head was going to explode. I was speaking and doing everything very fast like I was on speed. Currently it is 12:00 noon and I am still a little dizzy and have a headache that won't quit even after 800mg Motrin. You cannot hold a job and take this drug. This drug sucks and has convinced me that you have to be pretty bad off to take it for anxiety because its side effects are worse than F 31 1 days
9/11/2008
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 4  Depression, PTSD No sex drive, no motivation, heartburn, no emotions, weight gain. I've been on Cymbalta for a year and a half and has admittedly helped to relieve my symptoms of depression and Post Traumatic Stress Disorder thus have hurdled my way through a fair share of side effects. For the time that I've been on Cymbalta I've experience weight gain, zero sex drive, unable to orgasm, no motivation and heartburn to name a few. Not until about 3 days ago I've always thought these "symptoms" coincide with my depression. After reading someone's blog who had the same exact symptoms, they said that these symptoms could in fact be from being over-medicated. This has made so much sense to me and pretty much answers a lot of questions even my PCP couldn't answer. So now I will be speaking to my Psychiatrist of my concerns and with his help ween off Cymbalta entirely not only because of these symptoms which, if I may say, has also put strain on my 8 year relationship for the lack of intimacy, but also because I feel I'm ready to tackle the world without the hel F 26 1.5 years
9/8/2008
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 2  depression and anxiety Facial rash, sleeplessness, nausea. After stopping the medication I had the shakes, tearfulness, anxiety. It relieved my depression, but the side effects made me even more depressed. F 42 2 months
9/8/2008
 5  sleep difficulties/fibromyalgia dizziness went away; still have "withdrawal" nausea after naps I take low-dosage, a.m. only, and it regulates my sleep patterns very well. I ACTUALLY REACH DEEP SLEEP, and in less time. I know that because I finally stretch (revitalized muscles) upon wakening, and I remember dreams again F 44 1 years
9/7/2008
 2  depression night sweats, dizziness, nausea, suicidal ideation, insomnia, numbing effect For a few months, Cymbalta worked like a dream. Then, my body got used to it--if I was a few hours late in taking it, I would get withdrawal symptoms--dizziness, nausea, and anxiety, followed by an extremely upset episode and the desire to kill myself (suicidal ideation is not a usual problem for me). Seven or eight months into taking it, I noticed that I was having a hard time caring about anything; my emotions were numbed. The withdrawal symptoms are really what's terrible though. I was in bed crying, trying to kill myself, having to be monitored, for a month. Then three more months before I really felt normal. During that first month of withdrawal symptoms, I couldn't sleep despite being exhausted, was constantly dizzy and nauseated, was crying and in a rage most of the time, and couldn't function at work at all (had to take a leave, which luckily I was able to do). Since then, almost a year ago, I've had problems with stuttering--not sure if that's related or not. DO NOT get on Cym F 29 18 months
9/7/2008
 5  Mild Bipolar/more severe depression Don't really remember any side effects except maybe some nausea I've taken Cymbalta at 80mgs. a day for over a year. Before this I've tried Lexapro, Effexor XR, and years ago Desyrel. This is the only medication that has made me feel like a normal human being. I still have mood swings, but I never sink into the severe depression that I used to live with. Before Cymbalta I was suicidal at times, cried daily, and rarely left my bed. I'm back to teaching elementary school and I feel great. I realize this is not for everyone, but it has definitely helped me. M 51 1 years
9/5/2008
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 3  NEUROPATHY F 77 1 days
9/5/2008
 1  Fibromyalgia, depression insomnia, vivid dreams, syncope, a detached from the body feeling, confusion, restlessness, shaky, trembling. Took the med for only 3 days and the first night, I think I got a total of 2 hours of sleep. On the third day at work, I experienced what felt like an 'acid trip' after about an hour of taking the recomended 30 mg dose. I couldn't talk without stuttering, was very confused, couldn't concentrate. Had to have me b/f pick me up and take me to ER. Said it was side effects of med. I had low blood pressure for about 2 weeks after I stopped taking it which caused me to have fainting spells. Fainted at work, hit my head and had to go to ER again. So after all is said and done, I still have fibromyalgia pain, now even worse it seems, and have a shit load of ER bills. Highly reconsider taking this med if you have not already done so. F 27 3 days
9/5/2008
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 1  Depression I was depressed, this medication made me suicidal. Nightmares, night sweats, severe brain zaps, restlessness. I hate this drug! I took this drug for 8 weeks and have now been off it for 8 weeks. I came close to killing myself 3 times while on it or coming off it. I'm never taking an anti-depressant again because of my experience with this "medication." M 23 8 weeks
9/5/2008
 4  Pain Dry Mouth, upset stomach, dizziness upon standing. I love this stuff. I have severe pain in my shoulders, neck and jaws due to arthritis, bursitis and TMJ. This drug helps me live through the pain. I have to drink tons of water to help me with the dry mouth and constipation. I drink approximately 80 ounces of water a day. F 31 180 days
9/2/2008
 5  Fibromyalgia and depression Dry mouth, reduced sex drive, inability to orgasm, night sweats, weight gain, and hot flashes Cymbalta has eliminated chronic fibromyalgia pain and muscle stiffness. I have been on multiple drugs in the past, but the best before Cymbalta was Trazazone - but it only reduced the pain and stiffness. The pain relief is worth all the side effects. F 63 10 months
8/31/2008
 3  anxiety and mild depression no bad side effects when i started taking it. only withdrawl symptoms after stopping. after finding out i was allergic to paxil my dr. put me on cymbalta. just called in the rx for me, didn't bother to explain the drug to me at all. I started off at 30mg a day, after 3 days I felt a noticable difference. I wasn't irritated all the time, very calm, almost oo calm like i didn't care about anything. After 2 weeks I was pretty much emotionless. I told the dr. how I felt and I was put on 60 mg! This made me feel like I was loosing my mind. I took 60mg for only 2 days then went back to 30 mg for a few days, then stopped taking it all together. The withdrawls weren't too bad.....headaches, sweating, bad dreams, and crying spells. i'd rather have to go through anxiety attacks than feel like an emotionless zombie all day. F 24 1 months
8/31/2008
 5  Very severe depression. Headache, severe dizziness, which went away after taking the medication for a couple of weeks gradually increasing the dosage. This medication saved my life. Literally. The depression was so bad that I couldn't go on much longer. I was taking Wellbutrin and I must have built up a tolerance to it or something. F 55 6 months
8/29/2008
 4  depression The first couple of days a battle with nausea,sleepness,and lose bowels. Works very well had less depression,but very light headed. Stop taking it and had brain zaps,felt like I had the flu, very dizzy. It did work for me I felt less worried about everything. F 39 10 months
8/29/2008
 5  Pain/Depression First week... Nausea, sleepiness, and a disconnected feeling. All people react differently to all medications. I decided to try Cymbalta after suffering from chronic pain, which has caused insomnia for many years. The lack of sleep began to affect my day to day mood and life. I was severely depressed and tired all the time. I roughly saw 2-3 hours of sleep a night while taking Ambien to sleep. Since I started Cymbalta, I have had one night of no sleep. The remaining nights have been 6 - 8 hours of restful sleep, even with two nightly trips to restroom. It's amazing how important sleep is to your mood. I became a much happier person in life and to be with. This drug has not stopped my pain, but it is much easier to deal with pain when I'm rested and have a positive outlook. To explain the side effects, the first week I was very nauseated and sleepy. I had a sort of fog surrounding me that went away as I got used to the medication. Remember you will not experience the side effects repeatedly if you remember to take the dose at the same t F 37 2 months
8/28/2008
 3  depression The first week I was on it, I threw up every day. My doctor begged me to tough it out. Lost 10 pounds. Other than that bad week of not being able to eat, no other side effects. Still unsure if it's working. Haven't noticed any improvement in my mood...still very depressed. F 25 14 days
8/27/2008
 2  Vulvar Vestibulitis Insomnia in the second half of the night (Waking up a 2am, 3am, 4am and not falling back to sleep); decreased sex drive and anorgasmia (difficulty achieving orgasm) F 24 30 days
8/27/2008
 1  Depression Insomnia for up to 36 hours and then crashing and sleeping about 6 hours. Paranoia, major depression, crying, Fibromyalgia got worse. Eating very little & gaining weight & sitting and staring. Hot flashes at night and chills at time during the day. I also had no urge to read my mail or walk to basement to do laundry. I wss changed to Trazadone by my Doctor last week I can at least usually sleep. Wondering if I should have come off of it gradually. I also take Xanax (orange pill). Went off of Effexor last Nov. because I am now on SSD and couldn't afford Effexor, my doctor has been giving me samples of the Cymbalta. I thought I was crazy because the insert just mentioned insomnia in the Cymbalta60. Glad I came here!! F 59 9 months
8/27/2008
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 1  fibromyalgia While it took away my pain at first, it also took away my sex drive. I didn't want my husband to come near me. After that, I had an episode with attempted suicide though I've never been suicidal. I also got physical with my husband during one argument and I have never been like that. It gave me insomnia so bad I have to take sleeping pills at night just to sleep. I am trying to wean off now. Today is the 3rd day. And it's been horrible. I have terrible anger outbursts at my children. I am so angry I can't stand it. I want to punch a wall as irrational as I know that is. I also get very dizzy. I hate this drug with a passion. My aunt had fibromyalgia and between a homeopathic doctor, a healthier diet, and RELIV shakes, she doesn't have fibromyalgia anymore. I'm going the natural way. Doctors and drug companies are just making us sicker and sicker each year. I feel like cymbalta has poisoned my body. F 32 6 months
8/27/2008
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