CYMBALTA Reviews (DULOXETINE)

Average Rating: 2.7 (2745 Ratings)

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 ANTIDEPRESSANTS

 Type: Rx Drug

  

CYMBALTA  (DULOXETINE):  Duloxetine is used to treat depression and anxiety. In addition, duloxetine is used to help relieve nerve pain (peripheral neuropathy) in people with diabetes or ongoing pain due to medical conditions such as arthritis, chronic back pain, or fibromyalgia (a condition that causes widespread pain). Duloxetine may improve your mood, sleep, appetite, and energy level, and decrease nervousness. It can also decrease pain due to certain medical conditions. Duloxetine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). This medication works by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in the brain.   FDA Approval Date: 2004-08-03 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on CYMBALTA: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR CYMBALTACOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 5  Major Depression, Anxiety Dry mouth (at my optimal dosage). I tweak my dosage to get the optimal results. 20 mg leaves me feeling too fatigued in the morning, while 30 mg has me tapping my feet with excess nervous energy and with less than optimum concentration and mental focus. To reduce the dosage, I twist open a 30 mg capsule and remove about a dozen of the time-release pellets, then re-assemble the capsule to leave just the right dose for me. It's amazing that just a few milligrams can make such a difference, but it does for me. I'm very happy with Cymbalta. M 49 8 months
10/23/2007
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 4  Anxiety, IBS, Migraines ESD, somewhat sedating - controlled by taking at bedtime This drug has been very effective for me. ESD is bothersome. My nuero-psych is recommending adding Neurontin then tapering off Cymbalta. M 50 4 years
10/23/2007
 1  Major Depression/ Bi Polar Uncontrolable crying, dark thoughts, exploded at anyone who looked at me wrong, gained 40+ pounds within 4 months.. shall I continue?? I never knew in a million years that I would be afraid of myself. What I mean is that during the 4 months I was taking Cymbalta, I almost took my life. I was on a different AD before this and the doctor switched it to this. After being hospitalized, my new doctor put me back on the previous AD which I can honestly say saved my life. F 31 4 months
10/22/2007
 5  RA and CHRONIC myofacial pain I took 30 mg first day, felt wierd and didn't sleep much. Now take 15 mg (sprinkled over applesauce)in morning. Doing great. Pain is minimal, mood is great!! Fatigue is gone!! So far this has completely changed my life. I have suffered pain and fatigue from my autoimmune disorders for 2 years. Nothing has worked. I first refused anti-depressents but, now I wish I had been on this sooner. I love my life again. I feel like my old "MEGA-MOM" self again!! M 40 2 weeks
10/18/2007
 3  Anxiety MAJOR night sweating, withdrawal feels like the world's worst hangover, crying and emotional during withdrawal I have been on Cymbalta for a while now, and have GREATLY enjoyed the anti-anxiety effects and the calming. I went from raging and being very emotional and angry to calm, able to talk through things and focus. Wonderful drug until... We have realized that this drug makes me want to drink more. It is really, really odd. I also have MAJOR NIGHT SWEATS. And when I say that, I mean that I wake up with my sheets completely soaked, my hair is soaking wet, my clothes are completely wet, etc. Miserable! My poor husband moves his leg over next to mine and it gets him wet :( I have gained 6 pounds and I am convinced it is the medicine as I have not changed my diet and have not gained 6 pounds in 4 or 5 years. The other complaint is the withdrawal. If I miss one day of medicine, I feel like I have a hangover. Two days and I am still hungover, but cry easily and feel like I am thinking negative things constantly. No bueno! It is a tough call though because for anxiety it is a wonder F 27 4 months
10/18/2007
 3  severe depression NAUSEA, horrible, horrible stomach issues , cold sweats and jitters. all of this happened starting the 1st day of treatment.Hope they will go away soon. M 2 days
10/17/2007
 2  GAD Tiredness, Insomnia, Listless, Unmotivated, Cloudy thoughts. I was only on the medicine for about a week before I couldn't deal with the side effects any longer. I didn't find it too hard to stop taking it at that short amount of time at least. Plus, the medication was a lot more expensive on my current medical plan than most others. M 7 days
10/17/2007
 1  IBS Syndrome brain zaps, tired,moody,numb face,on it a year trying to withdrwawl like going to hell every hour. I think its posion to our brain F 42 15 months
10/16/2007
 1  Anxiety/Adult ADHD, arthritis pain Horrible nausea, light-headedness, jittery, catch you totally off guard kind of diarrhea. I was tired of walking around in a state of "Everything is OK" when it was not so I took myself off of Lexapro about 6 months ago. But I can't focus, concentrate and little stuff is driving me nuts. So I had to admit that I need medication...again. I also have a body full of bone spurs and arthritis. I have taken just about everything else under the sun for my anxiety and Adult ADHD: Lexapro, Zoloft, Paxil, Prozac, Elavil, Tranzene, Xanax. NEVER have I had such horrible side effects as this. Zoloft was awful and gave me screaming nightmares but this is just horrendous. Now I am reading about withdrawal and I'm going to stop taking this. I don't trust the FDA one little bit and if there are this many side effects that are present immediately, what will come later? F 50 2 days
10/16/2007
 4  depression just started taking it none as of yet seems to be helping me with pain & depression 48 4 days
10/11/2007
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 5  Anxiety, Depression, OCD none. I switched from another anti depressant to this one and it was wonderful from the very beginning. i felt more like myself. F 17 1 years
10/10/2007
 5  Major depression, anxiety, and BPD I didn't have any side effects while taking this drug. Although, out of all of the medicines I have taken, this one was the worst to come off of. I couldn't speak as well and I had HORRIBLE brain zaps. I am now back on the medicine. Out of all of the psychotrophic drugs that I have taken (and there has been A LOT of them) this one has been the most beneficial. I would highly reccomend this one! F 23 3 years
10/4/2007
 4  sudden anxiety/stress from work Hand tremors, sleepliness. (Take in morning instead at night.) I went to doctor due to extreme job bullying and then sudden (unjust) negative job performance evaluation and fear of being fired. Due to my uncontrollable crying and anxiety, I was first prescribed Lexapro. Lexapro made me too lethargic within first week, so Dr. precribed Cymbalta 30 in addition to Xanax to take at night. It helped extremely. 3 months later was fired unjustly from job, and depression started all over again. Cymbalta increased to 60. Xanax continued at night. Increase from 30 to 60 Cymbalta has helped me immensely. I have regained my desire to get up and do something, rather that just sit around and dwell on crap. You must take Cymbalta in the morning. Withdrawal is a concern, as posted by other reviewers. Did they withdraw "cold turkey" and not gradually? I hope to stop taking all medication, once I overcome present stressful situation. I'm hoping coming off this drug is not as bad as other Reviewers have described. In summary, Cymbalta has benefited me gre F 50 3 months
10/4/2007
 3  Depression and anxiety Initially, I had constipation. When I tried to get off of it the first time, I had severe electro-shock tingling in my head, and thought I would go crazy. I have had suicidal thoughts too from time to time. I would use caution when using this drug or even when your doctor recommends it. My withdrawl symptoms where so severe that I am scared to stop taking it. M 37 6 months
10/4/2007
 1  anxiety It was great at first. Then when I tried to get off the drug I was out of my head crazy for the first 6 days. Now I am on day 8 and still shaking. i cannot get in to see the dr. because we have a balance at the clinic. This is horrible. F 39 12 months
10/4/2007
 1  Mild Depression/anxiety Shaky, jittery, total loss of appetite, dull nausea, depression. Absolutely impossible to sleep. Like I did 3 rails of cocaine right before bed. Anyone who has ever taken Ecstasy, it felt identical to that eaten up feeling of coming down. There is just no other way to describe it. Sort of like taking WAY too much pseudo ephedrine cold medicine, the daytime kind. I'm also really sensitive to meds, I have heard other people have had great experiences. Just figured I'd share. Within hours of my first dose, 30 mg, I started shaking, and I couldn't eat anything. I took it at 12:30 in the afternoon, and by 7:00PM I was shaky and jittery and all of my muscles, including my jaw, were tensing up. I tried to sleep, but I was completely wired, like I was on speed. I didn't sleep a wink, even after I got up and took 2 Unisom capsules. The next day I felt like I had the flu, hot and cold and still shaky and unable to eat. I was depressed and just stayed in bed all day. I won't be repeating that anytime soon. The side effects were ten times worse than being depressed and anxious. They say it goes away with time, but I don't think I'd survive even another night like last night. F 25 1 days
10/3/2007
 4  Depression and anxiety. Yawning, which subsided after a few weeks. Itching, which comes and goes. Vivid dreams, which can be rather interesting. Decreased appetite, which is rather nice. Diarrhea, which can be extremely annoying, but I am figuring ways to minimize it (taking it on a full stomach is helping). This medication has changed my life for the better. I felt its positive effects within a day or two, and pressed through the initial side effects because I was so encouraged by the anti-depressive features. After one week on 30mg, my MD increased my dosage to 60mg. This did not help me! My condition deteriorated rapidly, at which point my doctor wanted to increase the dosage further. I insisted that 30mg was working wonders, and he reluctantly prescribed a 2 week course at 30mg. Well, that's where I've remained for 3 months now. I'm very glad that I persisted with my opinion regarding the dosage. The doctor still claims that 30mg is not even considered a therapeutic dose, but I know what works. I do continue to have digestive issues with Cymbalta, but through trial and error, am learning to minimize this. Taking it mid-day on a full stomach seems to be working for me most days. F 41 3 months
9/30/2007
 4  Anxiety, Panic Attacks and Depressi Decrease in appetite. I'm on 30mg per day along with .25mg of Xanax and 10mg of Ambien to rest in the evening. I take Cymbalta in the evening before bed with an Ambien and find that I sleep and feel considerably better. I still use Xanax before I go to work to take the edge of my anxiety that leads to panic attacks. I have been diagnosed with post traumatic stress syndrome and have tried paxil, zoloft, celexa (gave me extreme internal cramping), lexapro (caused extreme weight gain) and now Cymbalta. It was within the last 6 days changed my mood to one that is upbeat and soothing to myself. I am not looking forward to the day when I have to wean myself from the medicienes however I was feeling so poorly that I felt I needed the relief I've found with the combo my doctor has prescribed. God Bless you all who live with the day to day symptoms of anxiety, panic attacks, depression and post traumatic stress syndrome. You are not alone. F 30 6 days
9/29/2007
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 5  depression I have not noticed any. I have been depressed for a long time; I have tried every anti-depresant. Usually I could only take one pill and my blood pressure would shoot up, teeth grind, and all my nerves seemed on end. I quit taking them (Zoloft, Prozac, Lexipro, Paxcil, Others) but was unable to sleep for several days after. Finally and with trepidation I tried cymbalta 30mg. I could tell after the first pill that it was going to make my life worth living again and this is important as I am stage IV breast cancer and don't want to waste any more time being depressed. I am going to try increasing to a higher dosage. Thank you! F 55 20 days
9/27/2007
 4  Depression, Anxiety Initial insomnia, weight loss, On it for 4 months now,and occasionally sweat profusely, and shake, but all in all, this medicine has worked wonders M 38 4 months
9/25/2007

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