CYMBALTA Reviews (DULOXETINE)

Average Rating: 2.7 (2745 Ratings)

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 ANTIDEPRESSANTS

 Type: Rx Drug

  

CYMBALTA  (DULOXETINE):  Duloxetine is used to treat depression and anxiety. In addition, duloxetine is used to help relieve nerve pain (peripheral neuropathy) in people with diabetes or ongoing pain due to medical conditions such as arthritis, chronic back pain, or fibromyalgia (a condition that causes widespread pain). Duloxetine may improve your mood, sleep, appetite, and energy level, and decrease nervousness. It can also decrease pain due to certain medical conditions. Duloxetine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). This medication works by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in the brain.   FDA Approval Date: 2004-08-03 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on CYMBALTA: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR CYMBALTACOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 1  fm and anxiety very sick. awoke with fluid diaharea, thick confusion, symptoms for a day like the bad part of l.s.d. experience, restlessness, chills for a full day, went from couch to bed, couldn't sleep, had to be absent from work, nausea and vomiting, terrible thoughts, extremely dizzy, headache and eye ache, hit by a bus feeling, stopped drug and wonder if it will cause brain problems continuing, a fuzzy pressure remains in back of brain this following day. Yuck!! not for me!! F 61 1 days
30 1X day
2/21/2010
 3  Depression I don't experience side affects while on Cymbalta but when I am off. If I forget even a single day of this medicine I feel completely gone the next. Dizzy, lightheaded, tired. It makes me think it works i guess but I hate the withdrawals. I forgot to call in my prescription once and had to skip for a whole weekend (this was the first time). I was DEAD for the next week. I wanted to do nothing but sleep and sleep and sleep. It helps depression but beware of the horrible withdrawals. F 22 2 years
60 MG 1X day
2/20/2010
 2  PD patient - depression M 55 90 days
90 1X day
2/20/2010
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 1  Pain Depressed, angry, lost, personality change My husband had Cushing’s which resulted in high levels of pain from neuropathy & osteoarthritis. His endocrinologist prescribed Cymbalta. At 60mgs all his pain left. It was amazing. Almost immediately he became depressed, angry. He stopped working, could not sleep or hardly drive. He was lethargic; he would just say, “I don’t know” like somebody lost. Sometimes he could not eat. His memory was all but gone. It was HORRIBLE! So I started researching the side effects and found this website. I was totally shocked! People were describing the same side effects he was suffering from. When I told him how it was the drug that was doing these things to him he got angry with me. I could not reason with him at all. (He was mostly unaware of what was happening to him.) To make a long story short his doctor thought I crazy, but I was determined to keep fighting for him. A second doctor suggested he drop the dosage. Are you kidding me, my husband has lost his mind and you want to keep him on this mind-stealing drug? However, the lower dosage did the trick and, almost immediately, he started getting his mind back. He suffered bad withdrawals but came off of it completely. It has been over a month & he is back to normal. He still suffers from pain but nothing compares to what Cymbalta put them through. The drug company has sold this horrible drug as a “wonder drug” to doctors. Some of them, doctors, believe the drug company over patients. Don&# M 51 4 months
60 1X day
2/20/2010
 1  depression amd anxity major mood swing. dr jeckle mr hyde syndrom, insomnia, hunger increase, manic episodes, sense of entitlement, very argumentative, amnesia, overspending... The worst drug My husband has been taking this drug for 8 weeks now and it has totally changed him for the BAD 100%. When I try to tell him the med is not working.That it has ALTERED HIS PERSONALITY 100%. He tells me it has changed his life for the better and nothing but good came from it. When it has not it has taken him out of depression yes. However it has stole him of his sense of responsibility, his priorities are 100% reversed, he has had major amnesia episodes from misplacing the car to spending sprees he did not recall doing. to this day he believes his car was stolen and i was the one who spent the money. when in fact he was the one who did these. He refuses to talk to his doctor regarding the changes his family and friends have noticed in him.he is very confrontational with family and strangers. he says very inappropriate things. He has a strong sense of entitlement. Just the other day he was opening fire hydrants because he felt he was entitled to because he was the one who dug the out from the snow. He talks at length about nonsensical things. Other days he is so manic he can't stop moving. I believe CYMBALTA HAS STOLEN THE HUSBAND AND FATHER WE HAVE ALL GROWN TO LOVE. PLEASE RECONSIDER OTHER OPTIONS PRIOR TO TAKING THIS LIFE ALTERING DRUG!!!!!!!!!!! I JUST WANT MY HUSBAND BACK AND FOR MY DAUGHTER TO HAVE HER FATHER BACK TOO!!!!!!!!!!!! IT HAS MADE OUR LIVES A LIVING HELL!!!!!!!! if anyone else is experiencing the same thing with a loved one please post it. M 48 8 weeks
60mg 1X day
2/20/2010
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 1   dizziness, muscle pain, facial pain, vivid dreams that are unpleasant, tightness in throat, I feel like a zombie. I withdrawled from cymbalta a few months ago it took me 4 months to have my DR tell me I need it again. I have to withdraw again I am scared because it was hell the last time. I was good for 2 weeks on the drug it was like I was normal then I started having all these side effect worse then the last time. F 41 30 days
90 1X day
2/18/2010
 3  Neuropathy Side effects included dry mouth, weird dreams, total personality change from grouch to happy all the time. Until recently did not realize that my sex drive increased almost to an addiction. For the neuropathy I had to change to the 60mg per day because the insurance woul not pay for 2 30 mg. The 2 30mg were working pretty good but the 1 60mg was not working as well. Doctor changed me to 2 60mg a day and that put me over the edge. My sex drive was making me become a nymph and I ended up having sex in my office. Got caught and fired. Be cautious if you are starting this pill about the hidden side effect of thinking you can do anything. The happy feeling all the time was great but now after all these years of working to loose a job and damage you mariage is not worth it. It did help the pain in my feet. Currently being weened off of it. M 64 370 days
30 2X day
2/17/2010
 2  Anxiety Zombie feeling, tired, spacey, nausea, dizziness, swelling in legs I've only been taking this medication for 4 days and I can tell it is not going to do any good. I dont feel like myself and have felt "disconnected" from friends and co-workers. It may work for some but it's definitley not for me. F 21 4 days
30mg 1X day
2/16/2010
 1  Depression & anxiety Dry mouth, severe headaches, body aches, nausea, foggy, angry, unable to concentrate, brain zaps, tired, feel "out of it," depressed. I've only been on it for a couple of days and know already that I won't continue. My husband was on it for a few months, came off cold turkey, and was severely sick from not weaning himself off. He was vomiting over several days & had flu-like symptoms including brain zaps. This stuff is very, very strong - scary strong. I feel worse than I did only a few short days ago. F 39 2 days
30mg 1X day
2/16/2010
 4  MDD Have some heart palpitations, dizziness..most recently has totally messed up my menstrual cycle..any other women have that problem?? F 30 2 months
30mg 1X day
2/12/2010
 3  diabetic neuropathy in feet and leg Just recently, but not in the beginning several years ago when I began taking Cymbalta, but in the last one year, it made me have terrible diarrhea. When I eat a meal, I begin having stomach cramps, and then have to run - run to the bathroom to have a watery stool, explosive watery stool. I take it for diabetic neuropathy - i have a young neighbor who takes it for depression. She asked me one day if I have any problems with diarrhea since being on cymbalta - said she was experiencing the same problem I was having - words were coming from her describing the problem just as if I were telling her what to say - so I went off cymbalta and after about 2 weeks being off the medication - the diarrhea went away but my terrible pain in my feet and legs came back - it is amazing how cymbalta works on taking all the pain from my feet and legs - it is like a miracle - but can't take it any more due to the terrible, painful diarrhea it gives me. cymbalta great for diabetic neuropathy in feet and legs. I was taking only 30 mgs. once a day, and pain is all gone. too bad the pharmaceutical company can't work on whatever is in the medication that gives you diarrhea and correct that side effect. My stomach was feeling like it was completely irritated - the whole entire digestive tract felt raw. F 56
30 mgs. 1X day
2/11/2010
 3  depression didnt want to eat first two weeks, cant sleep, felt sick when working out/shaking when i first started taking cymbalta i started at 30 mg and i took that for a month.. and i saw no differneces in my depression but my mom said i was a little happier.. then i was given 60 mg and i have been taking that for about 3 weeks now and i have highs and lows all the time. i either wanna go out or stay in bed. it really hasnt made me much happier though.. but i hope with time it will help me. F 17 2 months
60 mg 1X day
2/11/2010
 3  depression/Anxiety Initally- very sick, head aches, "out of body" type experiences, felt like a zombie, over sleeping, over eating. At the moment- horrible night sweats, insomnia, ANGRY, crying spouts (for no reason at all.),less appetite. loss of libido I started taking cymbalta about 9 months ago, I am only 19 years old. This drug was horrible at first, i was severely sick for about 2 weeks, no engery and i felt like i was completely out of my body and not in control, i wasnt able to drive for about 2 weeks because i couldnt keep my concentration on the road. After a while my body & mind adjusted to it, it helped BIG TIME with my anxiety attacks which i usually had daily which was now dramatically cut down to pretty much none. I have been having very vivid dreams but nothing bad or scary just very...um imaginative. My family and friends said they have noticed sever anger strikes lately, i have been on people about everything, and not quite myself, yelling all the time, upset about "spilled milk" kinda situation. i over react to everything. i have noticed my feelings are more sensitive now. i also have noticed that my sex drive has went down DRAMATICALLY, being only 19 that is not normal for my age. I never want to have sex with my boyfriend and when i do i rarely climax. this is really hurting my relationship and i cant deal with it much longer. NEVER EVER EVER skip a dose of this medicine! i accidentally missed a dose one day because i was out of meds. It was only one day and night that went by i had horrible night sweats and i mean HORRIBLE, the bed was soaked even the matress itself was soaked. i experienced bad nausea and very bad shakes, i could not sit still. i honestly thought i was going to die from F 19 9 months
60 mg 1X day
2/11/2010
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 1  Fibromyalgia, anxiety Weight skyrocketed from 145 lbs. to over 200 lbs. Personality went from positive, sunny, and cheerful to becoming a complete BITCH!! Sorry for that declaration but there is no other way to describe this major side effect! There's more; spending with no abandon, charging up credit cards, and not remembering what exactly was it I purchased. It gets worse: suicidal thoughts, planning to go through them, and beginning of heart trouble. Withdrawal--a nightmare I never wish to go through again--try lightning strikes in your head and incoherent thinking. DO NOT TAKE unless under very close supervision from your doctor!! Be on the look out for any strange changes in behavior and never, never, take it personally if your doctor or any of your loved ones confront you with your changed demeanor. Any thoughts of harming yourself--call 911 immediately and accept medical treatment graciously. In withdrawal, insist on very close medical supervision, hang in there, and vow not ever to take mind-altering medications ever again. I'm now presented with a second chance at living and I do not intend to throw it away. If nothing else, I shall be happy to be living and welcome being able to fix my mistakes and my family and best friend's forgiveness for being so bitchy and vindictive to them. F 44 6 months
60 mg 2X day
2/11/2010
 4  depression and anxiety I felt that this was a wonder drug. I no longer had to use so much psychic energy to pull my mood up on a regular basis. However, I have been slowly adding weight. Exercise doesn't seem to help at all. I have always been slender, but now weigh what I did when I was nearly full-term in my pregnancies! It is about 10-15 lbs of excess weight. I also have a greater appetite and could sleep more. No insomnia. I also have some memory issues (words, names, etc.) but that could be my age. Libido is an issue. I find it harder to achieve an orgasm, sometimes can't at all. My desire has flagged. This is disturbing to me. I also have urinary incontinence issues, which I understand can be related to the drug. I will be talking with my doctor and also the psychiatrist who has prescribed this for me. I am on a subclinical dose, but that has been all I've needed. It has been nice to have my life be less exhausting, emotionally, and I have become much more successful in leadership and work areas as a result. It is a tough call for me, but it may be worth discontinuing cymbalta (under Doctor's supervision) to see if some of my side effects subside and my mood stays more level. Tough, tough call! F 61 2 years
30mg 1X day
2/9/2010
 3  Anxiety/Depressions spaced out, difficulty sleeping, headaches(shocks), night sweats For the first two weeks I felt very spacey and drugged, a feeling similar to taking extasy. But after my body adjusted, I did notice quite a difference in my anxiety, and length of dressions bouts. I have suffered from anxiety (anxiety attacks), bouts of depression, sadness and anger since I was a young teen. I am almost 30 and have tried several other medications which had much worse side effects and no positive effects, such as: paxil and celexa. The only current side effect I have is the night sweats and I do get "headshocks" as I call them, if I forget to take my pill on time. F 29 1 years
30 MG 1X day
2/9/2010
 3  Depression This drug worked for a while, but didn't last. Weight gain, tired, zombie-like, never cried or felt emotions, anxious, Horrible withdraw symptoms, even while tapering off with doc. approval... Even when I forgot to take a pill in the morning by noon my body would let me know, by feeling dizzy, vertigo, sweaty, tired, thirsty and fainting spells. NOT FUN.. I will never going on this drug again! Be careful when coming off this medication. F 22 3 years
60mg 1X day
2/9/2010
 2  Depression/Anxiety Extreme sleepiness and increased appetite I am falling asleep in classes (never happened before in my entire life). At home I often take 2-3 hour naps. I am also chronically hungry. I am gaining weight quickly. M 23 3 weeks
60 MG 1X day
2/8/2010
 1  depression being forgetful, ANGRY, sleepy, weight gain, lack of care. The first time I tried Cymbalta, I thought, this might work even though it made me sleepy; I thought that symptom would go away. Not only did it not go away, other things started to happen. I became very 'spacey' and forgetful of very simple things, in the middle of conversations, I would just forget what I was saying. The worst for me though was the anger I felt. I am normally very mellow and avoid conflict, however, I found myself picking at people, becoming so angry about everything. Finally, some dear friends and my husband let me know the changes they were seeing and thus started the decision to stop taking the drug. It isn't worth it to me. F 51 3 months
20mg 1X day
2/8/2010
 4  Fibromyalgia Pain Sexual Side Effects such as inability to orgasm or have sex for prolonged periods of time. Weight gain at first which subsided over time. Pronounced hair loss. I was virile until I started Cymbalta. Erections were rock hard and hair was thinning, but was not bad. Two year later, It's hard to achieve an orgasm or even become erect at times. It's hard to ween off Cymbalta, as well. I take this with Lyrica to help with nerve damage. Both work well when combined for the pain. Sex drive is still there, but I need to take Cialis or Viagra to be a rock star in the bedroom again. M 43 2 years
30 MG 1X day
2/6/2010
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