CYMBALTA Reviews (DULOXETINE)

Average Rating: 2.7 (2745 Ratings)

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 ANTIDEPRESSANTS

 Type: Rx Drug

  

CYMBALTA  (DULOXETINE):  Duloxetine is used to treat depression and anxiety. In addition, duloxetine is used to help relieve nerve pain (peripheral neuropathy) in people with diabetes or ongoing pain due to medical conditions such as arthritis, chronic back pain, or fibromyalgia (a condition that causes widespread pain). Duloxetine may improve your mood, sleep, appetite, and energy level, and decrease nervousness. It can also decrease pain due to certain medical conditions. Duloxetine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). This medication works by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in the brain.   FDA Approval Date: 2004-08-03 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on CYMBALTA: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR CYMBALTACOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 4  Depression and anxiety At first, very spacey, dizzy, jittery and tired - it was somewhat difficult to function at first, but now most side effects are gone except sexual side effects (there's some dulling, but my libido is not totally gone). I was skeptical that it was doing anything at first, but after 10 - 14 days on the right dose, Cymbalta really helped with my depression and anxiety. I'm glad I hung in there; it's a life saver. I would give it a few weeks before giving up. F 42 30 days
60 1X day
5/22/2010
 1  Depression and anxiety Dizziness and vision problems - trouble focusing eyes, seeing tracers, strange pupils; one bigger than the other at times. Fatigue. Loss of appetite. Trouble concentrating. Jumpy. The side effects are pretty bad. Especially the vision issues. The side effects are causing more anxiety, when I'm taking the drug to reduce it. Now I'm just constantly worrying about how I feel and if it's doing damage. I'm not able or motivated to do anything, since all I can think about is how messed up I feel and how hard it is to focus on anything and the strain of seeing straight is a constant distraction. I feel worse than I did before going on the drug. F 34 4 days
60 mg 1X day
5/22/2010
 3  Anxiety and depresseion Dry mouth Helped with depression but not with anxiety. I take clonozapam 2x day to help with anxiety & panic. Get panic attacks when going out of the house sometimes and migraines when under stress. F 68 8 months
120mg/day 1X day
5/21/2010
 4  Depression, Bipolar I took Cymbalta for several years with few side effects. Unfortunately, I had to go off of it for 7 months due to a lack of insurance. I just started taking it again and the usual side effects are waning, with the exception of a horrible headache that won't seem to subside. I wake up with it in the morning and if I miss a dose of advil/motrin it comes right back during the day. Is this common? F 38 2 weeks
60mg 1X day
5/19/2010
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 4  Fibromyalgia/myofascial pain: back Chills, very dry mouth, anorgasmia (inhibited orgasm). Fatigue that wore off after one week. Only drug (tried 6-8 prescription meds) that has controlled upper back pain rt. myofascial pain (muscles). Has reduced my pain meds from 8-12 + 1-2 narcotics a day to just the Cymbalta and 1-2 OTC meds. Hoping side effects decrease with extended use. F 52 3 weeks
60 mg 1X day
5/19/2010
 4  Depression & Anxiety Dizziness, inability to have eyes focus properly, headache. I only experienced these when quitting Cymbalta. If you are having any of this problems described above have your doctor increase or decrease in smaller increments. DO NOT EVER QUIT TAKING COLD TURKEY! Regardless of your reasons, you need to speak with your doctor about "weening" your system off of Cymbalta, as with all SSRIs. I love it. I took Zoloft on and off for 12 years, and found I have fewer negative reactions to Cymbalta. I do not have climax or intimacey difficulties now. F 29 2.5 years
90 1X day
5/19/2010
 3  FM/CFD/fibromyositis/dystonia hallucinations, loss of appetite, night sweats, night terrors, horrible after taste, etc... Eventually subsided. (Thank God!) Doctors haven't really figured out what type of pain disorder I have. However, Cymbalta has been helpful. At first, it was a NIGHTMARE! Getting used to it was difficult. I stopped taking this medicine 4 times, when my doctor told me I had to take for at least three months in order to effectively rule it out as ineffective. Took it for a while, and it proved to be helpful. Last time I visited Johns Hopkins, the dr. decided to increase from 60 mg to 120. Now that I'm used it, the side effects have subsided. M 30 1.5 years
60 mg 2X day
5/19/2010
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 1  nerve pain This is my second day i am using the CYMBALTA. My doctor didn't say about Nausea.So i was thinking i had bad food that why i am getting Nausea.Today i have read all the side effects. i am getting most of those(Nausea,Drowsiness,Vomiting, Yawning). I hate CYMBALTA. M 30 1 days
60 1X day
5/18/2010
 1  anxiety Chills, Extreme cold, loss of appetite, nausea, fatigue, drowsiness, dizziness, emotional numbness, racing heart, heart palpitations, panic attacks, vomiting, tight chest, difficulty breathing My doctor put me on cymbalta for general anxiety while moving/changing jobs. She had given me the 50mg samples but on day 2, I had to call the doctors office. The first day I was extremely cold (I was freezing while wearing a sweatshirt on a 85 degree day), felt sick to my stomach, and couldn't eat anything. All I could do was sleep and shiver. The second day I was still cold, couldn't eat, but the nausea turned into vomiting. What really sacred me was that my heart started racing & fluttering. This sparked a panic attack & something that felt like an asthma attack. I'd started Cymbalta at 7am Monday morning and by 3pm Tuesday I was on the phone with the doctor who lowered my dose to the smallest possible. Then I took a 10mg pill and STILL had chills, loss of appetite, extreme drowsiness, and a racing heart. Overall, Cymbalta gave me way more to worry about than it ever helped. F 24 3 days
10mg 1X day
5/18/2010
 3  fibromyalgia/chronic pain severe fatigue and lack of ambition I switched from Zoloft to Cymbalta because the Zoloft didn't seem to be working anymore. Also Cymbalta has been aproved for fibromyalgia. I also have a pain pump dripping in my spinal fluid (fentanyl).I have experience severe fatigue and lack of ambition. I sleep constantly and don't want to do anything. I am going to stick with it because my doctor says I need to give it a good try. Maybe I need to switch from taking it in the am to pm. I would love to hear from someone who had a lot of symptoms that went away and is happy with the drug. Also, I have found a solution to constipation. Citricel an orange juice daily. You have to take it daily and sometime more, but it works for me. F 61 10 days
60mg 1X day
5/15/2010
 3  Depression As I posted before, when I first began taking it, i loved it. It immediately helped (I even began keeping a journal of my experience with it), and after reading some of the posts here, I attributed that to a placebo effect. It even helped me sleep better and I actually enjoyed the vivid dreams. In any case, after about a week and a half, I didn't feel all that great anymore. Still okay, but not great. Weird, because this is about the time when these types of pills are supposed to START to work. Anyway, it is the only pill of this type that I have stuck with, because I actually felt better with it (at first). By the time I visited my doc on the 7th of this month, I just felt 'eeeengh' (oh, and I had gained weight). He has now placed me on 60mg, and when I asked him for something for weight loss, said that these pills actually help lose weight. So, I have been on 60MG for almost a week, and feel just okay - nothing like when I first started taking it. Will stick with it a wh Will continue to give it a chance. F 32 6 weeks
60MG 1X day
5/15/2010
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Patient History
 4  depression anxiety side effects were a little tough at first but i was told you have to stick through it to see if it works. it takes weeks to get full benefits . i am now able to function day to day. still dont feel good all the time but it put a big dent in my problems IF YOU RATE THIS DRUG WITHOUT GIVING IT THE PROPER TIME TO WORK THEN YOU DID LISTEN TO YOUR DOCTER IF YOUR NOT WILLING TO COMMIT TO THE WEEKS IT TAKES DONT WASTE YOUR TIME AND DONT POST HERE THAT YOU TRIED IT FOR 3 DAYS AND IT DIDNT WORK!!!! i do understand that these drugs do effect people differently and have considered this before my statement here. thanks...paul M 46 6 months
60mg 1X day
5/12/2010
Email
 2  depression and fibromyalgia sleepiness, constipation, lack of appetite, weight loss, insomnia I have found in begining this drug seemed fantastic and even lost a little weight; but then with doctor forgetting to renew my prescriptons, the nightmares started. In just the past year and a half, t times I have been forced to cut back to point of not having any medications for a month or two and then to go back on' it has been a nightmare, got to point of losing weight, not being able to eat, insomina, worsened depression, panic attacks and agoraphobia just to name a few. even though they eventually got my medicatons on track and take them like I am suppose to they no longer work for me; and terrified in going off them as symptoms were terrible; both physical and mental effects to where spent most of my days under covers in bed, and struggle to even go out when I need to, etc. If I had known all the side effects in taking and then being forced to go off, I would have never started this medication. If you have a choice, I would suggest that you not start unless you plan on taking it forever and your doctor will make sure you have it to continue to take. F 62 4 years
30 3X day
5/12/2010
Email
 1  Fibromyalgia anxiousness, very "high" feeling, could not concentrate, weight loss, no appetite, extreme sweating all day and night, runny nose, could not focus, come vision problems, The only good thing I experienced was weight loss. Taking this medication was like taking a street drug. Very Very bad medicine for me. It might work wonders for depression for some people. M 40 40 days
30mg 1X day
5/12/2010
 1  herniated discs- nerve pain POISON!!!!! Sick from day one, stopped a wk ago and still sick! a wk later!!!nausea, runs, flu like, sea sick feelings, dizzy, no appetite. This drug ruined my birthday, mothers' day as I've been home bound for over a wk now. I'll take my chronic pain anyday over this drug! no more meds for me! stopped my one a day hydrocodone now too! I've never believed in meds and deal pretty well with 5 herniations and fusions w/o meds, meds don't cure, they are just a "band aide" - no more of their "trials" on me! if one gets this sick in only 3 days, what is this drug doing long term to our brain????? Poison- nausea, runs, headache, dizzy, no appetite, horrid withdrawals!!!! F 54 3 days
30 mg 1X day
5/9/2010
 5  CFS/FM Excessive drowsiness the first 10 days. Spent most of that time sleeping. No drowsiness now. Dry mouth, slight dizziness on occasion. This medication has been a Godsend. I was diagnosed with CFS in 1995 which has morphed to FM. CFS/FM robbed me of life. I was always hesitant to commit to anything, not knowing how I was going to feel or how the activity would affect me. Though the FM pain was gone, the first 10 days on this medication was rough. I was so incredibly drowsy, sleeping most of that time. The day I had planned to call the doc to tell him I couldn't handle the trade off, I felt a little bit better so I held off on making the call. I am so glad I did. Within a few days I had my life back. I've pushed this drug to the limit by spending the last two weeks in the yard doing much neglected landscaping (moving rock & dirt, planting plants, etc.) without the typical crash and burn affects. Normally an hour or two of this type of activity would wipe me out for 2-3 days. The AZ heat normally wipes me out as well. I have also noticed that my joints don't pop like rice krispies anymore and my mood is much improved. I never realized just how much my mood was affected by my pain. I'm smiling, joking, loving and laughing again. My family and I are amazed at my energy level now. I understand this medication is not for everyone. In fact many of the comments here almost discouraged me from continuing it, after researching the drowsiness I was experiencing at that time. I'm so glad I didn't stop due to others experience. I'm living again. I'm gonna make up for some lost time now. F 44 1 months
60 1X day
5/8/2010
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 3  Nerve pain Excessive yawning w/weird after affect where my ears are plugged for several minutes. VERY sleepy & have no energy. Getting up & moving in the morning is difficult. I shut my door at work & take several naps each day. Dr. originally started me on 30mg. Pain in foot lessened a bit, but not much. 2 weeks later he upped me to 60mg. Pain has significantly reduced but this is when the sleepiness & lack of energy kicked in. I thought maybe it was because I was taking it so late at night (10 - 11pm) & then having to get up at 6am, so last night I took it at 8:30pm & feel much better than previously. I've only taken one short nap at work so far today & my yawns have been normal. Must admit most of the negative comments on here have scared me. I'm blessed that my Dr. did warn me about stopping cold turkey & to let him know if I want to stop & he'll wean me off. He also told me the co-pay for Cymbalta is expensive. So far he has just given me samples (he gave me a 'script yesterday). We'll see how it goes. F 39 1 months
60mg 1X day
5/5/2010
 4  depression, anxiety constipation, light headedness, some tingling, lightheadedness, spacyness. slight loss of libido and takes longer to ejaculate. stomach pains initially, but went away after a few days. This is my second try taking Cymbalta. I tried it 2-3 months ago and my doctor took me off due to the inability to ejaculate. However, after trying two other medications, Cymbalta had the only side effec that I could see myself coping and dealing with--so i went back on it. During this second go-around, I only take the medication at night (versus the last time i was taking it in the morning). I find this works so much better. I can ejaculate at night, but not in the morning. Maybe the drug has worn off a bit at night, not sure why. Also, the second time around, the side effects seem to be less severe than before, especially the brain zaps, this time don't notice it as much. M 41 1 weeks
30 MG 1X day
5/4/2010
 3  Depression and anxiety Decrease in Lidido, Difficulty in ejaculation; Increase in sweatiness I wish they could develop an anti-depressant for men that doesn't strip your libido, or make it difficult to orgasm. That is my BIGGEST complaint with Cymbalta. Despite it being one of the newest on the market, this side effect is something that the makers of Cymbalta can't seem to eliminate from their product. On the positive, Cymbalta has helped me with my anxiety. I no longer get butterflies in my stomach. It has helped my depression about 60%. Would I recommend it to another man? Depends how much they value their sex drive. M 43 1.2 years
60 MG 1X day
5/4/2010
 4  Fibromyalgia The first week I had mild dizziness, mild queasiness, and general fatigue. After about one week, these disapated. This med helped with the chronic pain and brain fog that Fibro causes. I think I might need my doctor to increase the dosage as I don't think it is helping as much as it did originally. Be careful not to gete off the drug "cold turkey." I ran out for a week and had moderate dizziness, tingly feelings in my face, queasiness, fatigue, a general feeling of being ill. Getting back on the meds helped a lot. F 38 45 days
30 MG 1X day
5/3/2010

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