CYMBALTA Reviews (DULOXETINE)

Average Rating: 2.7 (2745 Ratings)

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 ANTIDEPRESSANTS

 Type: Rx Drug

  

CYMBALTA  (DULOXETINE):  Duloxetine is used to treat depression and anxiety. In addition, duloxetine is used to help relieve nerve pain (peripheral neuropathy) in people with diabetes or ongoing pain due to medical conditions such as arthritis, chronic back pain, or fibromyalgia (a condition that causes widespread pain). Duloxetine may improve your mood, sleep, appetite, and energy level, and decrease nervousness. It can also decrease pain due to certain medical conditions. Duloxetine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). This medication works by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in the brain.   FDA Approval Date: 2004-08-03 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on CYMBALTA: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR CYMBALTACOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 3  anxiety, obsessive thoughts, panic on 30 mgs: dry mouth, sweating, decreased sex drive, but better, longer and more intense orgasms; on 60mg: in addition to beforementioned symptoms, sleepiness during the day (2:00pm, intense dreams (positive/neutral), sometimes not able to climax at all and no sex drive I have been on Cymbalta since 4/7/05 and at first the drug was as some have said "a god send". Obsessive thoughts/worries about health and wellbeing of loved ones and myself subsided. Panic attacks are under control, which means I recognize when they come on, and what they are and try to difuse them through rationalization. I had been feeling great (except for really no sex drive) so I tried to "ween" myself and cut my dose back to 30mg 4 months ago. Sadly, I have been feeling increasingly "lost", without a drive, worn-out, depressed for the past 3 months, so I have a choice to make that I need to discuss with my doc. Feel free to email me. F 44 14 months
5/7/2006
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 3  Depression After 10 months, I've gained about 20 lbs and am feeling emotionally flat and unmotivated. I don't feel extremely depressed but don't feel particularly happy about anything, either. I don't think it's related, but I started having blood pressure problems (for the first time in my life) a few months after starting. I've been on antidepressants for years and can't seem to find something that will remain effective for more than a few years. I feel a little jealous of all of the responders who have had more success with the medication. I'd be interested in hearing from anyone who has had similar experiences. M 53 10 months
5/3/2006
 1  situation stress and anxiety headaches, drowsiness during the day, insomnia at night, loss of appetite but also stomach pain that prevented me from eating, night sweats, heart racing at night, more edgy and irritable, emotions up and down I was prescribed Cymbalta because of on going stress in my life that was giving me higher blood pressure and causing me to have a lot of anxiety. I had tried Lexapro, which made me go off the wall, Dr. said it had not worked because I was not depressed so seritonin was not my problem but Cymbalta should work for me. I was told I had to give it some time to work but after almost 2 weeks, I could not handle it anymore. I was an emotional wreck, very depressed and upset and had not been really at all before. I was more nervous and edgy than before starting it too. I could hardly eat my stomach hurt so bad; I lost 8 pounds in 2 weeks time. Good thing but we need to eat more than next to nothing. I could not sleep, and really just became more stressed than before I was taking it. It costs too much money and my insurance is not that great, so I could not afford the money or what it was doing to me. Don't get me wrong, for people who are taking Cymbalta and it has helped them out, I F 33 11 days
5/3/2006
 1  OCD/Depression/Back pain/ I am experiencing severe lethargy, dry mouth, occassional abnormal heart beats, severe muscle spasms(driving me nuts!),increased appetite, and weight gain. I also have a harder time reaching an orgasm. When I first started this medication, I heard voices while half awake(they were way too clear). Voices???? This was something I had NEVER experienced before! It really scared me. I told my doctor, and was told it could be me adjusting to the medicine. I was on Paxil, and I did not have as many side effects. I think I will be switching back to Paxil very soon. My symptoms have just gotten worse over the time, while taking Cymbalta. It's just not doing what I expected. I feel that this may be good for some, and not for others. I definitely don't think it is good for me anymore! I will be speaking with my doctor about another medicine I can take, during my upcoming visit. F 36 6 months
5/2/2006
 1  Depression 30 mg, 1 day: Stupor, disturbed sleep, night sweats, day sweating, dizziness, confusion, mild nausea. I've tried lots of antidepressants over the years. I usually feel the side effects first, and then never do feel the benefits. Cymbalta gave me the worst side effects I've ever expereienced. I stopped after one day, but the side effects lasted for a full week. M 49 1 days
5/2/2006
 5  Recurrent Depression 120mg - Sleepless, shaky hands & feet, more energy, decrease in appetite F 26 3 months
4/28/2006
 5  major depressive disorder None. In the past 10 yrs., I have been on a multitude of different antidepressants with poor to fair results. This is the first one that has me interested in life again (am taking 60 mg). For me, it has been a godsend. F 57 6 weeks
4/26/2006
 5  Depression/Anxiety slight dizzyness/nausea at first, then jittery/agitation continuously, occasional sweating. As far as sex goes, i'm not sure what's wrong with everyone here, but I've had so much energy and sex drive has easly gone up 10x. Orgasm is delayed, which my wife prefers anyway, and when I finally do finish, the orgasm feels twice as powerful as it normally did before taking this medicine. Lovin' it. Especially, if u smoke marijuana. Lots more energy now, require less sleep, less tired in the morning, don't worry about things I can't change. Overall, I'm much happier. It takes awhile to adjust to the side effects, but they subside. M 25 5 days
4/24/2006
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 4  anxiety/ depression dry mouth(first couple days), tremors(spasms), sleeping more, loss of energy, sweating, lost interest in sex because had trouble climaxing overall this medicine worked. noticed change in a day or two. i took 60mg for four maybe five months but have gone off cold turkey. been six days so far. only problem so far is vertigo. feels like my brain is riding a wave every once in a while F 29 5 months
4/24/2006
 1  Neuropathy 60 mg - 25 pounds quick weight gain, decreased fine motor in hands/finger with numbness in hands and feet worst of... DEPRESSION < new for me. I understand why this medication is prescribed, but perhaps there are better medications with fewer side-effects out there. F 40 3 months
4/22/2006
 2  depression, nerve pain night sweats, nausea, increasing apathy, short-term memory loss. Sleep disturbances. Because it is a relatively new drug I did not want to take it at all. My luck with anti-depressants has been poor. However, my doctor (a very young family practice M.D.) swore by it and I accepted his recommendation. Started @ 30 mg. and had sleep problems immediately. Either too much or too little. After almost5 months on the drug (the last 4 @60mg.) I now want OFF of it. I have progressed from mood swings to to ONE mood --the basically "I don't care" mood and want to sleep all the time. My pain level is worse because of spending so much time in bed, but I feel exhausted all the time. I feel as if I am living under a blanket with no real feelings. I would NOT recommend this drug to anyone. I do not think there is enough study on it to do so, and with my own experience being more negative, I just could not do so in good conscience. Not even in the "try it" maybe it will be good for you category. M 59 5 months
4/20/2006
 5  Major chemical depression, Parkinso nson's disease, Fibromyalgia, Addison's disease............ I became a night owl but sleep well when I do turn in at 12-1AM, very hard to reach orgasm. This drug has given me a new lease on life..Before Cymbalta I was on Lexapro and did not look or feel depressed. But I couldn't seem to get going until about 3PM. I would become more energetic and alert as the day wore on. Now I can be efficient in the morning as well. I take 120mg in the AM Cheryl F 57 1.5 years
4/17/2006
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 4  Neuropathy Tired at first and a little nauseated. Always eat something first before taking Cymbalta. Some dizziness at first. Started on 30mg. Have lost 16 lbs. since February which I really needed to lose after being on Neurontin, Lamectal and Ponstel since December. I will never go on Neurontin and Lamectal again. I'm abit more spunky than I used to be. The Dr. increased me to 60mg. a day after about 3 weeks. That seemed to help me alot. Noticed after about 2 weeks that not only the pain and burning in my legs disappeared but also the pain I had been having with Cervical Spondylosis has subsided too. I've been suffering with that since 1996. Its nice not to get up in pain every day. All I have to do now is find a job that I'm happy with again as my boss has been a first class pain in the butt since all this started in October 2005. F 48 2 months
4/15/2006
 5  neuropathic pain - low back I am a doctor and I can tell you....BE VERY VERY CAREFUL WITH THIS DANGEROUS DRUG!!! Began on 30 mg and had insomnia, nervousness and anxiety. Went to the therapeutic dose of 60 mg to help my back pain AND I HAD A PSYCHOTIC EPISODE THAT ALMOST PUT ME IN THE ER. By now I'm sure you know a college girl killed herself during the drug trials. It can happen. This is not just an SSRI. It alters THREE neurotransmitters and for some - that's a serious problem. I flushed $120 worth down the toilet after one horrible night. This is a SCARY drug and should be re-examined by the FDA. See if your Doc knows the details of this drug before you take it. Sure, it may help some, but it is dangerous with others. Question is, how do you find this out? Are you willing to be test subject? This drug should be pulled and re-studied to be safe. When you start, have a friend or spouse alerted to potential bizzarr behavior and perhaps the ability to get to a hospital. M 52 5 days
4/14/2006
 1  Anxiety - Depression Whoever coined the term Brain Zaps - PERFECT NAME, as that is exactly what it feels like. I have been weaning myself off 60MG to 30 to 20, very quickly. Over a week and 1/2 - All was generaly OK until I stopped taking the 20MG - BRAIN ZAP City. Dizzyness, etc. I am somewhat afraid to drive. Also, VERY difficult to wake up in the morning - I feel like have been hit by a truck. I am hopeful the zaps will subside soon - I am going to take suggestions of water, fish oil and vitamins to see if they help. As for the male sterility - I went to a new GP as I recently moved from Atlanta to Houston - I am 36 and my wife is a very healthy, very fit 26 years of age. We have a beautiful 26 month old daughter and have been trying for almost a year to get pregnant again - Although I have read about the sexual sde affects......suffice it to say my new GP indicated he has heard about Cymbalta causing issues for men when trying to get their wives pregnant - I am not sure if it truly lowers M 36 1 years
4/13/2006
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 1  Mood swings, headache, fatigue Severe abdominal cramping, nausea, raise in headache, rash, lack of energy/motivation, depression, loss of apitite,loose stools, burping, acid indigestion I only took Cymbalta for 5 days. It was an awful experience. I was MUCH worse on it than I was before. The withdrawal symptoms were stronger than those from taking the medication. After 10 days of being off Cymbalta I am still having serious problems with my GI tract. After eating the pain gets much worse. I am shocked that a medication can cause symptoms for so long after discontinuing it. Cymbalta is in my opinion a very harmful drug that shouldn't be taken lightly. F 44 5 days
4/12/2006
 1  depression I had a HORRIFYING experience with Cymbalta! This drug is worse than any medication I have ever heard of. It is horrible to try and go off of. Do a search for Cymbalta withdrawal and see what you find! It should NEVER be given out to ANY patient!! If you want to email me for more in fo, please do. We have a class action lawsuit in the works. There are 100's of us already that may never be the same again due to Ely Lily's incompetence. F 48 8 months
4/12/2006
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 1  depression weight gain (15 lbs first 3 mos), no emotional feeling at all, either happy or sad, insomnia, vision problems (could no longer read the newspaper)hot flashes, vivid dreams I decided to quit this drug because it didnt seem to be doing much for me and was actually making me feel worse. GETTING OFF THIS MESS: Dizziness to the point of being non-functional (for 2 wks) left arm/hand went numb several times per day (still happening 1 mo later) electrical shocks (brain zaps) in the head,stress urinary incontinence (they prescribe cymbalta for this-I never had it until I quit taking cymbalta-go figure) nightmares, crying spells that lasted for hours, earache, flu like symptoms lasting 2 wks, unbelievable body and muscle aches, to name a few. It truly felt as if I was losing my mind and my physical body as well. It was a horror I will never subject myself to again. I am happy to have this out of my system, for the most part, and will be happier when all of the withdrawal symptoms go away. I hope they go away. F 48 3 months
4/12/2006
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 5  IBS Some slight constipation, but that's better than what I was having before! Helped my IBS sooo much! I take the lowest dose once a day (before bed) and can eat so many things that I couldn't before taking this. The lowest dose is not strong enough to help depression, but that wasn't my problem. The norepinephrine that is in Cymbalta slows down the digestive tract, but the serotonin that is in it keeps it from slowing down too much and causing severe constipation. VERY HAPPY with Cymbalta. F 22 4 months
4/9/2006
 4  severe chronic depression inability to orgasm, dry mouth, vivid dreams, extreme night sweats This med stopped the harrowing bout of depression and suicidal obsessions. I take 90mg, which is an ungodly high dose and is probably eating my liver. Sex isn't much fun without being able to orgasm, but at least the night sweats keep any prospective partners away F 39 3 months
4/9/2006

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