CYMBALTA Reviews (DULOXETINE)

Average Rating: 2.7 (2745 Ratings)

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 ANTIDEPRESSANTS

 Type: Rx Drug

  

CYMBALTA  (DULOXETINE):  Duloxetine is used to treat depression and anxiety. In addition, duloxetine is used to help relieve nerve pain (peripheral neuropathy) in people with diabetes or ongoing pain due to medical conditions such as arthritis, chronic back pain, or fibromyalgia (a condition that causes widespread pain). Duloxetine may improve your mood, sleep, appetite, and energy level, and decrease nervousness. It can also decrease pain due to certain medical conditions. Duloxetine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). This medication works by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in the brain.   FDA Approval Date: 2004-08-03 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on CYMBALTA: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR CYMBALTACOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 1  antidepressant I am writing this for my mother . She has been takin this drug for five years . I will say that from what i have gathed from site affects over the years . I wish i would have caught it sooner ! This drug has affected her with every site affect ,dry mouth rash seeing things . I have not got all the information i need yet !But i will say my mother is not her self anymore ! She never will be , I am doing research now !with medical records ! so i know im on the right track.I wish my mother would have never been on this drug . or zoloft prozac! If they cant diagnose somethin they give you a pill! Well to much of anthing will have its on side affect! If there is anyone out there that has been on this drug or a person taking care of someone on this drug ! I would appreciate any advise you could share with me !This is my mother i am an only child , no one but me to take care of her !i am 46 and loosing my mom in front of me day after day ! I want to see if i can help her in any way!Thank You F 64 5 years
60mg 2X day
9/12/2011
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 1  Slight depression/anxiety vomiting/nausea, dizziness, vertigo, severe stomach cramps, shaking violently,no energy, sleepy I took this drug for the first time today and within 45 minutes I was vomiting and had severe stomach cramps and was dizzy. About a half hour later I was shaking violently like I had the flu and I was freezing cold. It has been 11 hours since I have taken it and I am still very dizzy/ have vertigo and I am very tired eventhough I didn't even get out of bed all day. Earlier I couldn't walk straight at all. It is slightly better now but still very dizzy. I am not taking this again. I have wasted the entire day. I hope these effects are gone tomorrow but I doubt they will be considering how bad I still feel. F 38 1 days
30 mg 1X day
9/9/2011
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 5  DEPRESSION/ANXIETY I just came across this blog and I have noticed that most people on here have not liked this medication. I have been on it for 6 months and for the first time in 3 years, I feel like myself again! Most importantly, I feel normal. I have been on several anti-depressants and this is the one for me! I have actually lost weight on! I think it’s because I actually feel like taking care of myself and exercising. I have recommended this drug to 2 other people and they are both very pleased with it. I know that is doesn’t work for everyone and a lot of these drugs are trial and error. But I definitely would give this one a try! F 25 6 months
60MG 1X day
9/7/2011
 4  Long-term major depression/anxiety Really I haven't noticed any side effects when taking it but a bit of sleepiness initially. It has worked exceptionally well for my depression. I can tell you from mine and others experiences that the drug withdrawal symptoms are very severe and affect every body system you have. I missed a couple once and the side effects are the worst I have ever encountered from my many medications I have taken over the course of 30 years with this disorder. I have been on almost the whole array of psychiatric drugs and withdrawal from this one is the worst I have ever encountered. I have a friend whose husband takes this drug for fibromyalgia and tried to get off it because they can't afford this medicine, but the withdrawal was so bad for him. I guess they will have to keep the extra job to pay for the medicine. I looked online to find at least 15 pages of withdrawal symptoms and over 30 pages to document the symptoms. When I started with the medicine it was pretty new and I guess they did not know about the withdrawal side effects. F 56 6 years
30 mg 1X day
9/6/2011
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 1  Depression No sex drive, dry mouth, weight gain, lack of emotion, like a zombie. I have come off of Cymbalta after a year of weaning. It was horrible and I now have Atypical Trigeminal Neuralgia. Was it caused by this drug? I can't get any answers from anyone. None of the Dr's I've been to know or care to know anything about this drug. "Discontinuation Syndrome" is a known problem but the only people that care are the ones experiencing it. It's horrible and not worth it. F 53 5 years
90 1X day
9/6/2011
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 1  Fibro Weird dreams, panic attacks F 34
1X day
9/2/2011
 1  sleepless headache, constipation; But all drugs are poisoness eventually, I have gone to nutrition for total cures; as Nancey Reagan said 'just say no to drugs'! If you have sleeping trouble/ depression, fibromyalgia or almost anything else including RA and MS, you should go with vitamins and minerals - mega B, C, and apple -cidar vinegar; it's mostly at doctoryourself.com; but I'm outta space, you can e-mail me. M 56 5 days
20 mg 1X day
8/31/2011
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 1  Muscular pain, depression, back pai Medication made me feel detached, tired, irritable, lack of sexual interest. muscle ache increased Doctor took me off the Cymbalta, prescribed taking 1/2 cap. for 3 days then discontinue. I have been having severe muscle spasms in my hips and thighs since I discontinued. The spasms have been for nearly a week. Muscle relaxers help, but cause fatigue, so I can only take a low dosage. F 79
60 MG 1X day
8/29/2011
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 2  Sever depression Cymbalta made my nervousness and depression worse! I have taken many, many drugs and this one was a doozy. Stay away from Cymbalta. Or don't. I love this site. The fact is that this is a first line antidepressant/all around drug for those with suspected Bipolar disorder. It shouldn't be. M 26 4 weeks
20mg 1X day
8/25/2011
 3  Severe migraines, mild depression Was pleased with Cymbalta at first, reduced the frequency of my migraines but not the severity, lost weight, and had more energy. After about 6 months I began noticing difficulty orgasming, constant yawning and incredibly vivid dreams. After 12 months noticed that I was constantly waking up tired, and after a consultation with my doctor we realized I had been having tachycardia the duration of my time on the drug, which was why I was constantly tired even though I was sleeping. I am a generally healthy individual with no previous allergies to medications. F 20 13 months
30 MG 1X day
8/23/2011
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 1  Depression and anxiety Headache, constipation, extremely bad side effects when you try to stop taking Cymbalta. Worse than any other drug I have been on. I have been on it two years, yes it does work, but you pay the price. Once I get off of this physically and mentally addicting drug, I will never take it again!!! It takes months to titrate off of it so beware!! F 52 2 years
60 mg. 1X day
8/23/2011
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 3  chronic lower back pain F 47
60mg 1X day
8/22/2011
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Patient History
 3  Anxiety & Depression Excessive thirst, dry mouth, fluid retention, constant sweating, interrupted sleep, fatigue, anaemia, tremor The drug helped with the anxiety and the depression, but the side effects were more annoying than anything else. I was drinking more than 2 litres of fluids day. Juice, water, soft drink, coffee, tea -- whatever I could get my hands on. My body struggled to cope with the massive fluid intake due to the thirst and my excessive sweating so it held onto alot of the fluid, causing me to put on weight. I never slept through the night while on this drug. I'd wake up at least once. I became anaemic and tired as well. F 33 5 months
60 mg 1X day
8/20/2011
Email
 5  Depression No side effects to speak of. I read about weird dreams and I've noticed I remember my dreams more clearly. Frankly, the dreams have been very entertaining! I have to highly rate this med. I've had no problems thus far; in fact I feel pretty darn good! F 52 30 days
30mg 1X day
8/19/2011
Email
 1  Fibromyalgia Horrible side effects from one pill. Felt "empty," detached, scared, like I was on some horrible illegal drugs, and suicidal though I am in no way depressed normally. Cymbalta frightens me and I strongly urge anyone considering this drug to do their homework carefully. I actually forbid my mother from taking the drug (she is mentally unstable) and went so far as to call her doctor myself. I took ONE PILL and within an hour or so felt all wrong. My head felt like it was a balloon on a string, not attached to my body. I could not think or talk, I felt paranoid, and terrified to be alone with my own children and totally not in control of my thoughts or actions. At one point I found myself in the garage staring at the rafters imagining hanging myself! I am VERY against suicide, not depressed, and had NO REASON to feel that way so I quickly realized the culprit was Cymbalta. I called my best friend (a nurse) to come and "babysit" me (and my kids) until my husband could get home and she was alarmed at my condition. The next day I took the rest of the unopened samples of Cymbalta back to my doctor and the opened ones to a pharmacy to be disposed of. Cymbalta was the scariest medication I have ever taken and I truly would not recommend it to anyone. F 32 1 times
30 1X day
8/18/2011
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 4  Fibromyalgia. Depression. I went from Paxil directly to Cymbalta. I felt uncomfortable in my own body for weeks,,but not enough to quit. It is a feeling difficult to describe, everyone is different, you will know it if you ever experience it. Over the course of time. I gained an additional 20lbs. I am fatigued, have fluid retention, my pain has broken through again and my depression has come back. I am now on 90 mg. My doctor suggested I try 120 mg. I don't know what to do. To sum it up, Cymbalta is a good medicine to try if nothing else is helping and especially if you have fibro and depression. F 47 2 years
90 MG 1X day
8/15/2011
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 5  depression and nuerophophy none M 65 155 years
60mg 1X day
8/14/2011
 4  Depression and body pain I have had nothing but a positive experience on this drug so far surprisingly. I was having a very bad experience with Wellbutrin (but years ago had had a great experience on it). I am able to exercise for the first time in a long time and have only had pain 1 day in the past 2 weeks. (They just increased my dose from 20 mg and it made a huge difference.) I had a couple days of extreme tiredness but it was when I had my period so I didn't think anything of it because that's normal for me. My depression is gone 95% of the time. It's amazing!! I hope it lasts because after reading so many negative comments, I am slightly worried. Thank you for all sharing though!! F 32 3 months
60mg 1X day
8/12/2011
Email
 1  Anxiety and slight depression I don't remember having symptoms in the beginning. Started with one week on 30 mgs and upped it to 60 mgs after that. Have been on it for over 4 years. Have a low libido and find it very hard to orgasm. Very frustrating since I consider myself a newlywed. I have gained about 40 pounds which is why I WANT OFF of it NOW. Read an article in the August edition of Men's Health called My Chemical Romance. I started my taper down on Monday. Opened up my capsules and took out half so I assumed I was going from 60mgs to 30 mgs. Monday was fine. Tuesday after 30 mgs, I experienced diarrhea all day long, dizziness, nausea and brain zaps. I was able to eat a small lunch and still work out on the elliptical. Ate eggs and toast for dinner. Went to bed at 10. Today, Wednesday, a completely different story. Slept through my alarm. I have never done that in 47 years. I could not get out of bed. Had horrifying, vivid dreams/hallucinations that I could control. I could keep going in and coming out. CRAZY. And I can remember everything about every dream. I have horrible stomach cramps and diarrhea. I could not get out of bed until 5 pm today with my husband's coaxing. He finallly called my Psych doc and told her what I was doing. She said STOP. Take 60 mgs immediately!! And she is forcing me to take 60 mgs tomorrow and call her at 5pm. She said she will help me withdraw from the Cymbalta. So for now, my three days of tapering down is on hold. I am angry, crying, dizzy, sick. I would never, ever, ever have started this drug if I knew I would become addicted and that the withdrawal would be so difficult. I don't want to be dependent on ANYTHING. I will update as I move forward in my withdrawal. Right now, I am defeated. F 47 4 years
60MG 1X day
8/10/2011
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 3  Chronic Daily Tension Headaches Nausea and loss of appetite for first 3 weeks taking Cymbalta. Insomnia, loss of sex drive, and hot flashes during the whole time taking Cymbalta. My doctor put me on Cymbalta 3 years ago to help with the chronic daily tension-type headaches I've been dealing with for 7 years. I started with 30 mg daily. The first 3 wks of Cymbalta made me very nauseous and I had no appetite. Cymbalta started to help with my headaches after about 2-3 months. It decreased the severity of the headaches and obviously put me in a better mood. But after about a year, I noticed a decrease in effectiveness so my doctor bumped me up to 60 mg daily. The increase in dosage didn't provide as significant relief as when I first started the drug. During the time I was on Cymbalta, I experienced frequent hot flashes, insomnia, and a complete lack of sex drive. Last month, I talked to my doctor about switching to another antidepressant because my headaches have gotten worse again. She switched me directly over to Prozac 20 mg claiming I shouldn't have any withdrawal side effects. Unfortunately, I have had horrible nausea that comes and goes, worse headaches, and mood swings and irritability for the last month. I decided to get off the Prozac 6 days ago. I stopped it cold turkey (even though that's never recommended for antidepressants) because Prozac has a longer half-life than most so it has a more natural tapering effect. So far still feeling crappy. The nausea comes and goes. I definitely wouldn't recommend taking Cymbalta because even though it gave me some relief, the relief did not last and the withdrawal symptoms are miserable. F 25 3 years
60 mg 1X day
8/9/2011
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