CYMBALTA Reviews (DULOXETINE)

Average Rating: 2.7 (2745 Ratings)

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 ANTIDEPRESSANTS

 Type: Rx Drug

  

CYMBALTA  (DULOXETINE):  Duloxetine is used to treat depression and anxiety. In addition, duloxetine is used to help relieve nerve pain (peripheral neuropathy) in people with diabetes or ongoing pain due to medical conditions such as arthritis, chronic back pain, or fibromyalgia (a condition that causes widespread pain). Duloxetine may improve your mood, sleep, appetite, and energy level, and decrease nervousness. It can also decrease pain due to certain medical conditions. Duloxetine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). This medication works by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in the brain.   FDA Approval Date: 2004-08-03 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on CYMBALTA: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR CYMBALTACOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 3  Depression and anxiety agitation, dizzy spells, yawning, fatigue, anxiety It seems to help the depression but not the anxiety, but I am willing to wait and see if this improves with time. I have lost weight and still losing. Previously on remeron which made me gain weight, even with exercise and controlled eating. I hope this works because so far no weight gain or sexual side effects. F 30 2 weeks
4/13/2007
 2  Depression Couldn't really notice this medicine having any effect I didn't feel bad but didn't feel good either. Strange thing is, shortly after I stopped taking it (abruptly), I felt much better. I felt good although not like myself. I'm not sure if the medicine actually started working or if I was just having strange withdrawal symptoms. I felt sort of electric shocks going through my body every once in a while, and I had strange episodes of simultaneous violent and happy feelings. I started taking it again and had a seizure due to combining it with tramadol. (You shouldn't take tramadol with any SSRI as far as I understand now). M
4/13/2007
 5  depression and panic attacks i noticed that i sweat quite a bit at night while asleep, i had a dry mouth for the first month, i lost 20 pounds in about 2 months because i wasn't ever hungry (i'm not complaining about that...) and DO NOT ever not take more than 2 or 3 days. the jolts and zaps throughout the body are incredibly uncomfortable and it makes you very, very cranky. oh! and if you drink alcohol, you won't remember a thing about the night and you will act like a jacka**. i had to lower my amount of consumption to keep straight. other than those small side effects, i reccommend cymbalta for anyone with depression. i absolutely adore it. F 30 5 months
4/12/2007
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 5  depression and panic attacks i noticed that i sweat quite a bit at night while asleep, i had a dry mouth for the first month, i lost 20 pounds in about 2 months because i wasn't ever hungry (i'm not complaining about that...) and DO NOT ever not take more than 2 or 3 days. the jolts and zaps throughout the body are incredibly uncomfortable and it makes you very, very cranky. other than those small side effects, i reccommend cymbalta for anyone with depression. i absolutely adore it. F 30 5 months
4/12/2007
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 2  depression Off feelings throughout my body, sensitivity to sounds, light and touch sensations. Others have referred to them as 'brain zaps'. Irritability and the desire to have an angry outburst are increased. M 31 9 months
4/11/2007
 2  Depression Insomnia, anxiety, a bit irritable (but I think I'm irritable because of the insomnia). Did not help much with the depression. I see my doctor next week and will ask him how to slowly wean myself off this drug. F 57 15 months
4/11/2007
 1  Major Depression pain anxiety None, never took it due to this web site..looks like a horror show....very expensive...just a money maker for Lilly Should be off the market before someone dies M 60
4/11/2007
 5  Anxiety/Depression For the first week, I experienced extreme tremors and extreme fatigue. I was thinking about stopping the med because of the fatigue, but I persevered. After about two weeks, those side effects were gone. I love the way I feel. Happy. Way more calm. Confident. Creative. Excited about life. Motivated. I do have some strange side effects: hesitation to urinate, yawning (big yawns), some insomnia, some fatigue (due to insomnia?), missed period (not pregnant), and the craziest is very vivid dreams with many details. Some are nightmares and some are wonderful. I compare it to the movie Jacob's Ladder Heaven and Hell mixed together....only not quite so bad. :) I have only recently began taking Wellbutrin and Cymbalta. Wellbutrin for about one year and Cymbalta for two months. I feel like the benefits of Cymbalta are the reason I decided to try medication (I hate taking medication). The concerns I have are that I want to feel this way without medication. Also, I am very concerned about missing a period since I want to have kids some day. F 32 2 months
4/10/2007
 5  chronic lower back pain The first few days were really strange - I felt happy, but wired and a little out of sorts and not much pain relief. Now the symptoms have narrowed down to increased sweating - especially night sweats - I take 2 showers a day now (I'm a little concerned about this with the TX summer coming), dry mouth, fatigue - I yawn a lot, increased self confidence and overall sense of well being :), some pain relief (not as much as I'd hoped, but it has been an improvement, especially in my ability to cope with chronic pain); I've had a few rounds of upper respiratory crud (virus/bronchitis) - not sure if this is related to the drug as much as exposure to other people spreading "the crud" around work though. I'm actually coming to enjoy the fact that my brain is marinating in seratonin- it makes the side effects seem very minor, though occasionally annoying. The side effects really have been seeming quite minor - though I've gotten pretty hooked on having my morning cappiccino now in order to fully wake up! I posted before, as I was really scared after reading this blog, but my experience has been very positive. I have to stop taking the drug within the next 6 months - as we are planning on having kids next year, but I have a goal in mind, and can really pace myself and get off slowly (I'm feeling pretty good about this, based on conversations with my doc and other information I've read out there on tapering off, and nutritional supplements that can help ease withdrawal symptoms.) I'll post again then and let you know how it's going! F 26 3 months
4/10/2007
 3  nerve pain in legs/arms I began Cymbalta with 2 side effects- inability to orgasm and constipation. They contintued until I went off this med. Nerve pain was greatly reduced for 9 months until the med. just stopped working. Pain began to come back. I experienced all the side effects I had read about thinking it was my "age and hormones", then realized through this site that others have had it stop working. Night sweats and vivid dreams were difficult. After worsening side effects for about a week, they stopped, constipation is gone, and I have my libodo back!!!! My doctor told me that Cymbalta can just stop working (I wish he had told me that earlier.)He has prescribed Wellbutrin XL now, but it is not helping the pain, only making me feel like I will fall over when I turn my head. I don't know what else may help at this point. I also gained 20 pounds over the course of this med. I jope it comes off now. Any suggestions for another nerve pain med.? This med. may just stop working one day, and you'll begin withdrawal symptoms. Be observant!!! F 37 9 months
4/10/2007
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 4  Anxiety/Depression First week was rough - insomnia followed by fatigue, dry mouth, constipation, zombie like (like when taking cold meds) for one day. Then most symptoms left. Only side effects now are CANNOT DRINK MORE THAN ONE OR TWO DRINKS OR WILL GET DRUNK AND BLACKOUT - also inhibited orgasm. Was on Celexa - knocked me out and felt drugged. Tried Lexapro with good effect but difficult getting out of bed - always tired. Cymbalta total works on my anxiety and depression. I have tons of energy and my mood is great! I do not feel drugged at all. My husband says I seem much less stressed and irritable. Fantastic drug for me but I miss social drinking and consistent orgasms! F 34 5 months
4/9/2007
 4  Depression Insomnia, dry mouth, constipation, nausea I had a really rough year last year which included a fmaily member dying, getting out of a bad relationship, and almost getting kicked out of school. My doctor put me on 30mg for a week then bumped me up to 60mg which I've been on for 2 months. It has worked wonders for me. The best time for me to take it is around 5pm with a good meal. This gets rid of nausea and lessens the insomnia and dry mouth. I take a stool softener to help with the constipation. I get to taper down to 30mg in about 3 weeks then eventually get back to normal life M 22 60 days
4/9/2007
 2  GAD, depression Dry mouth, extreme night sweats (changing clothes 4 times a night), very vivid & crazy dreams (& the ability to remember ALL the details), no libido, strong cravings for sweets, constipation, clumsiness. The side effects finally overtook what little "good" the pills were doing, & after trying to taper & still experiencing withdrawal, I decided I might as well go cold turkey. It's been 7 days now, & I've had tons of withdrawal symptoms. Nausea, severe headache, flu-like aches, panic attacks, disoriented, brain zaps, "whooshing" feeling, vertigo, dizziness. But every day gets a little bit better, so there's hope. I almost feel normal again. I had previously taken Lexapro a year or so ago & had trouble discontinuing it as well. F 38 6 months
4/9/2007
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 4  Social Anxiety and Depression nausea if taken on an empty stomach; dizziness when dose is missed; frequent night sweats Despite the uncomfortable side effects this medication has been helpful - elevated mood, better concentration, fewer physical effects from anxiety (i.e. no increased heart rate; no sweating) M 33 2.5 years
4/8/2007
 3  Fibromyalgia; Vulvar Vestibulitis I still get very tired in the afternoon. Also, not sure if this is cymbalta, but I have a swishy feeling in my ears (not a ringing--more of a cloudy sensation) that comes and goes. Cymbalta was prescribed to address pain associated with fibromyalgia and vulvar vestibulitis. It hasn't really done much for the pain, but it has affected my mood very positively. Initially, I was euphoric, now after 6 months, I am starting to notice old feelings of annoyance creeping in. I am considering going off since it does not address the primary issue of pain. F 39 6 months
4/8/2007
 3  depression, anger, agitation Cymbalta has cured me of my constant "chip on the shoulder" symdrome that I have experienced with my husband and children for the past few years. My anger and depression is totally under control with this med. I initially had an inability to climax, both with my hubby and solo, but that has seemed to pass, thank goodness. I have extremely vivid, epic dreams every night. Wild stuff! Also, my hair is falling out. Not in clumps, but after every bath the drain has 10-15 hairs in it, and any time I run my fingers through my hair several will come out. I am anxious about this, don't wanna be bald. This would depress me, make me angry and agitated!!! I don't want to be dependent on meds forever. I am trying to wean off. I have been on 60mg daily for about 5 months. I am currently doing every-other-day dosing which is working ok, though I am noticing my agitation returning. I missed a dose last week and boy howdy was that freaky. Vertigo, nausea, did not feel like I could pull through. That was at the beginning of my weaning, though. I now feel like I could skip 2 days without severely adverse effects. Maybe. Also, I can no longer dring hard liquor--I also black out. But I hear I'm a fun drunk... F 36 6 months
4/8/2007
 2  Depression Fatigue, extreme changes in body temperature (hot to cold), slight headache, insomnia, agitation and anxiousness, fidgeting, food tasting odd and loss of concentration. The side effects are worse than the benefits. I decided to stop taking the drug as I made me feel worse than I did before I took it. I was not prepared to endure the side effects for 2-4 weeks to see whether the drug would work or not. I can't see how it can be an anti-depressant when some of the side effects are depressive thoughts and actions. F 21 1 days
4/6/2007
 3  depression , anxiety I have only been on it 2 days and I have this funny feeling in my head. I feel these weird brain sensations. Almost like needles poking my brain. I am also on concerta, but am trying the cymbalta for depression. These are the weirdest side effects I have ever fealty. Almost feel like electricity is tuning through my body and I am real jittery. Will this go away? Has anyone else experienced this? Let me give you a brief history of the meds I have taken. I started having panicky attacks at the age of 18 and tried all the ssri's and was put on ativan as needed. The whole benzo road was a nightmare getting off, so I decided to just deal with the depression. Around 2003 my Dad was dying of cancer so I was put on valium and effexor. On top of that I was doing some heavy drinking and taking a lot of opiates. I became heavily addicted to opiates and finally tapered down with my doctor and have been off for 2 weeks. Now I feel like my life is wasted. When I was on the opiates I wasn't depressed but everything around me was falling apart. My doctor has me on concerta (which helps me focus at work), klonopin 1mg as needed for anxiety, bisoprolol (blood pressure) and now the cymbalta for depression. I just don't know if this is a good combo. The reason for getting off the opiates was to feel better, and now I just don't know what I feel. I just hope the cymbalta works because the side eff M 26 2 days
4/5/2007
 2  Depressed w/ Chronic neck condition Severly damaging to the stomach lining. No ability what so ever to orgasm, Vomiting for over 2 weeks in a row. Night sweats, vivid dreams, hot flashes, bad. I want to share my story with Cymbalta, because I read alot of the reveiws. The first thing, some drugs DO work for some people. We need to look at the age and sex of an individual, and their problems. I do beleive that the DR knows best, but no one knows your body like you. I took Cymbalta, I LOVED IT. LOVED IT. I felt great. No more crying, virtually no more pain, I suffer with a great deal of pain everyday, and have been taking also narcotic pain meds, that still didn't work as well as Cymbalta. But, I started noticing problems with my digestion. The IBS is normal when taking med's like this, so that never was a real issue, but I always had like a rock feeling in my esophagus, and stomach was bloated adn aching. Then the vomiting started. I cold turkey stopped Cymbalta, needless to say I ran out of my narcotics at the same time, and BAM! It was awfull. Any body who may have had an addiction can understand, I went through the worst thing I have ever been through, a chemica F 29 4 months
4/5/2007
 5  Neuropathic Pain due to Cervical di The only side effects were minor weight gain and some dizzyness if I missed a dosage. Slightly edgy for the first week but that went away quickly. Absolutely Fantastic. Got me through an incredibally difficult time. Before Cymbalta I tried Anti inflamatories, Steroids and on occasion, Vicodin for the pain which was severe at points. I was significantly limted for 6 months before trying Cymbalta. None of them worked. Cymbalta took about one month to build up to concentration and reduced the Nerve pain to the point i could easily resume regular activities. I'm just now reducing dosage 10 months after starting and having no side effects. M 40 10 months
4/4/2007

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