CYMBALTA Reviews (DULOXETINE)

Average Rating: 2.7 (2744 Ratings)

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 ANTIDEPRESSANTS

 Type: Rx Drug

  

CYMBALTA  (DULOXETINE):  Duloxetine is used to treat depression and anxiety. In addition, duloxetine is used to help relieve nerve pain (peripheral neuropathy) in people with diabetes or ongoing pain due to medical conditions such as arthritis, chronic back pain, or fibromyalgia (a condition that causes widespread pain). Duloxetine may improve your mood, sleep, appetite, and energy level, and decrease nervousness. It can also decrease pain due to certain medical conditions. Duloxetine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). This medication works by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in the brain.   FDA Approval Date: 2004-08-03 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on CYMBALTA: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR CYMBALTACOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 4  depression, neuropathy hot sweats, regular powerful muscle aches, loss of sexual libdo, 40 lbs weight gain I don't know if its worth it M 48 3 years
10/13/2009
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 4  Depression, Anxiety aorgasmia, decreased libido, weight gain, concentration, focus, short term memory issues, mania As with all SSRIs and SNRIs, your results may vary. I have found it astoundingly useful as a mood elevator/anti-anxiety drug (my mood changed within two hours of the first dose, though my understanding is this is abnormal). The major side effects have been libido and energy decrease to the point of total inability to complete tasks. Presumably this is due to sensitivity to the product on my part. In short, it did what it was supposed to do quite effectively, but at a rather high cost. Am now taking Vyvanase to combat the cognitive problems. M 48 2 years
10/15/2009
 4  Anxiety, Fibromyalgia Horrible initial nausea, then, over time, increased fatigue, short term memory problems, lack of focus. Long period of withdrawal symptoms when ended. I was initially a devotee of cymbalta. For my anxiety and fibro, it was fantastic. I didn't wake up feeling like a 90 year old trying to move since my joints no longer ached, and the constant pressure of anxiety evaporated. I was able to focus again at my job. Problems began after three months with fatigue, which by month 6 had increased to include memory problems and the inability to stay on task. I tried several medications in combination to help address the problem, which included vyvanse, ritalin, adderall, and provigil. Each worked, but had their own problems (look for other 41 year old comments posted on 8/30/09 on this site for my issues with those drugs). About 4 months ago I finally decided I needed to stop. I read elsewhere about experiences regarding withdrawal symptoms, which can be very pronounced for some with the one agreement being never do it cold, and developed a plan with my psychiatrist to minimize these effects. Over a two month period, I moved from 60 mg/day down to 5 grains taken from a capsule every two days, and then stopped completely. There were still w/d effects, such as the 'brain zaps' many note, but these were bearable, periodic and short lasting when they did occur. Including the two month plan, it was still a little over three months before all of the withdrawal symptoms vanished. M 41 1 years
8/30/2009
 4  Severe Depression Urine retention, vivid dreams, loss of appetite (which is a good thing), minor stomach problems It seems to be working quite well for me. My mood has definitely been elevated since I've been on it. I had been on other medications but they had not been working as well. I am taking it in combination with Welbutrin. M 64 2 weeks
9/14/2009
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 4  Depression The primary "side effect" for me is a CONSTANT ringing (buzz) in the ears. In reviewing others comments, I seem to be the only one experiencing this side effect. Overall, I am very pleased with the effect it's had on my outlook and interaction with family and friends. My daily dosage is 60mg. M 56 3 months
8/13/2009
 4  depression delayed orgasm so far so good. delayed orgasm, but unlike paxil, still functional. overall, feeling much better depression-wise. i have tried many medications over the past 20 years, and so far this is the most optimal in terms of dealing with the problem, but with manageable side effects. this was going to be my last attempt at medication. i'm glad it has worked as well as it has. i am going to stay on it for the long haul if it is continues as well as it now. hope it comes out in generic soon because it is expensive. but it is worth it if it can help keep me employed. able to function at work and with family much better. has also helped me cut way back on booze. i just hope it keeps on working as well as it does now. i feel almost like a complete person. M 56 2 months
7/21/2009
 4  GAD all the usuals First off anyone who posts here should wait at least a month as to really get the effects of this med. You are not special and we all experience the side effects. BUCK-UP and give it a real try or live with your problems. I do understand it does not work for everyone and effects everyone differently. OK, so, as for me it is not a magic bullet but has improved my life. Coping with work and stress has surely improved. I do recommend trying everything else first then when you need give it a whirl be prepared to stick it out for the chance at the full benefit . It just maybe worth it. So far I am glad I did , Good luck all. If I can help anyone my email is listed. America is for the people by the people. Obama/socialism is the wrong direction M 45 3 months
7/21/2009
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 4  Depression None at first After about a year of taking this drug, I went from 30mg to 60mg. Since then I have noticed some problems. Extreme tiredness, loss of concentration, constipation, headaches, yawning, sleepiness, insomnia. I hope to be able to keep taking this med. I am working with my doctor on how to address these problems. M 44 18 months
7/15/2009
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 4  Anxiety/Panic Attacks So far the only real side effect is sometimes a I experience abdominal pains, like I ate to much. Upon a rare occasion, I have trouble sleeping. I have been treated for anxiety/panic attacks for 14 years now. From Paxil to Prozac, sleep aids and tranqs., but this medicine has provided the most relief. I liked the paxil CR, but for now I am going to continue to try this drug. No more attacks, mood swings, or anxiety, but from reading on here, I will keep an eye on things. Oh do not drink, the alcohol hits harder, trust me on this one. M 44 3 months
6/26/2009
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 4  Neuro pain, Fibromyalgia Sexual side effects, typical for this class of drug. DO NOT be afraid of this drug. I am taking this for neuropathic and fibro pain, and within 2 weeks, it has made a huge difference. I don't have to rely on the narcotics as much, eventhough it takes time. NO, I repeat NO side effects except sexual dysfunction, if that's an issue to you personally. Nausea? Very very slight for like a day or two. Nothing serious. BUT IF YOU TAKE FOR PAIN, try it. It has helped me a LOT, don't read the reviews of people and be afraid. I have been in pain for 2 years, very serious, and this drug has HELPED ME GREATLY. Relax, breathe, give it a try. Everyone is different so don't be turned away by people's bad reactions. If you need to try it for pain, go for it. I'm one example where it has HELPED DEARLY. Thanks. M 38 4 weeks
7/4/2009
 4  Depression/anxiety Chronic pain Only been on it 3 days at 30 mg before moving up to 60 mg tomorrow. So far a bit sweating at night, tired and yawning, a bit of stomach upset and some buzzing type feeling in my arms and legs that comes and goes. Too early to say much about Cymbalta either way. It really either seems to work really well for people or very poorly. I have bad depression anxiety and somatization disorder and have developed recent chronic pain in my mid chest & back with a tight chest feeling. So far all the detailed blood and diagnostic tests/scans have been negative as to a cause of the chronic mid chest and back pain pain, which included a body ct scan with dye, bone scan, ecg's, thoracic spine MRI, heart echo, nuclear stress test and gastrocopy, chest x ray and Ultrasound. I am really hoping this drug works for reducing my chronic pain and eventually elevates my mood because I am so down :( M 40
6/20/2009
 4  depression night sweats, dry mouth, dizziness, constipation (decreased over time) It's certainly not perfect, but Cymbalta has worked pretty well for me. Imporant to note that almost all of the side effects started off as severe, then very gradually tapered off to a minimal or acceptable level. I was doubtful that the side effects would significantly diminish, but, over time, they did. For those who feel extremely sleepy when taking this drug, I experienced that too--until I underwent two sleep studies and found out I have narcolepsy. It's my understanding that often the Cymbalta lifts depression enough that people become aware of other medical and/or psych problems they may be having. One other note: on the very first day that I took the Cymbalta I did have a brief episode of anxiety. Nothing that caused a change in my actions, but for three or four hours I had increased feelings of self-doubt, anxiousness, paranoia, etc. However, after the first day, this never recurred. M 47 9 months
4/8/2009
 4  Anxiety Slight constipation & lack of sex drive at first, but it went away after 2-3 weeks. So far it seems to be helping. I had a few side effects at first, but they went away after the first couple weeks. Now I really don't have any side effects, unless I forget to take the medicine, otherwise I get strange brain zaps. The past couple days I have noticed a rash on my torso, I do not know if this is from the medicine, although I have been on the medicine almost a year now. M 24 11 months
5/7/2009
 4  Major Depression Restless legs. Just as I start to fall asleep my legs jerk so badly I get out of bed so my husband can sleep. During the day I can take a nap and this does not happen. I have taken 2 mg of klonopin for years for RLS and until now it has always worked. OH YES CONSTIPATION. I feel 90% better. I have more energy, no suicidal thoughts, able to concentrate on reading. I can actually use the coping skills I have learned over the years! M 47 4 weeks
3/8/2009
 4  Anixety and mild depression At first the side effects were AWFUL! Racing heart, stomach cramps, constipation, night sweats, I had it all. But after a couple of weeks things have leveled off and I feel great. All I can say is, stick with it, it will work if you give it a chance. I first satred taking it at night and it kept me awake. I now take it in the am, and I sleep like a baby. M 40 23 days
4/24/2008
 4  anxiety, depression, migraines Involuntary jaw-clenching, nausea, loss of appetite. Side effects disappeared after approximately two weeks. I don't feel a lot happier or free of worry, but depression and anxiety are most definitely less severe since I began this medication. Migraines are also less frequent (every four to five months instead of 1-2/month). I am definitely not disappointed with the results I've had with this medicine. Yes, the initial side effects are quite troubling but it was worth it. M 33 9 months
5/8/2008
 4  Radicular pain Vivid trippy dream and thoughs when I begin to fall asleep and when I am waking up. During the day I do not notice. In low light I have noticed some very mild hallicinatory effects. I can't seem to lose weight. Sweating. Particularly night sweats. Very bad when I started as it was everynight. THis has diminished over time, but when I do sweat at night I get soaked. I feel a little more resistant to the cold weather as well. Sexual side effects are present. No issues with arousal, but it takes a while to orgasm. And sometimes when I do things don't happed in the order I am used to (we are all adults here!). Occasional dizziness. Nausea. If you are taking Cymbalta for depression, please review comments specific to that. It seems there is a big disparity on the ratings between taking it solely for depression or nerve pains. It is hard to ascertain the exact side effects when I started cymbalta. I had to abruptly stop taking lyrica and experienced severe gastrointestinal disturbance (kind way of putting it), huge emotion swings, weight loss. This lasted about 2 weeks and can't tell if it was the cold turkey from lyrica or starting cymbalta. The side effects with lyrica were more pronounced for me.. severe confusion, drowsiness, numb hands, extreme weight gain. There are side effects with cymbalta but they are more manageable. I think it beats having to take pain killers and muscle relaxers. M 39 6 months
1/30/2009
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 4  spinal stenosis Initially, increased sweating for about one week and nothing more. Upon discontinuing, definite "brain zaps" and some minor gastrointestinal discomfort. Dosage initially 60 mg/day for first 12 months, then increased to 120 mg/day for last 8 months prior to weaning off. Weaned off from 120 back to 60 mgs once every two days for one week. Probably should have weaned off a bit longer, but it's behind me now. Cymbalta was pretty effective for me, at least I didn't notice any increase in pain. It actually helped me to psychologically deal with the frustration of my pain, but began to lose its effective after 9 to 10 months. Side effects were minimal and withdrawl "brain zaps" were nothing more than the old "rushes" we got back in the 1960s. Did not experience onset of withdrawal for 6 days after last dose, then lasted for roughly 7 days. M 55 20 months
12/29/2008
 4  Depression Nausea, dizziness, increase in urination & bladder discomfort (felt like a UTI). That lasted about a week or a bit more once I was on the 60mg dose. Miss a dose and I get headaches. Continuing side effects are jaw clenching, difficulty remembering short term memory, difficulty staying asleep and not feeling refreshed when awakened, lack of motivation (more desire to just sit around) & generally feeling fatigued. I could sleep any time in naps but long, 8-hour continuous sleep is not easy without a Tylenol PM or some alcohol. I tried Celexa, Welbutrin and Prozac and so far Cymbalta has been the absolute best that I have tried. I have actually lost 30 pounds in 6 months with this drug. It helps me with my mood swings and rage and "grumpiness" outbursts- I was on the verge of getting fired because I was always angry and just plain mean to talk to. I find it takes more concentration to do things and I am drawn to tasks that involve repetitious tedious type things (like sorting and counting out a bucket full of mixed nails, for example). However with Celexa it was like my sex drive was cut off completely and I had difficulty orgasming. Cymbalta is nowhere near as bad. I do notice that orgasm is a bit delayed but also I am not 17 anymore so that's not so bad. Actually I feel like I did on Prozac however it's not as bad, on Prozac I felt spaced out and could happily sit on the floor counting the grout lines in the tile floor all day long. Cymbalta has made me feel a lot better- I realize there are s M 39 6 months
1/20/2009
 4  Depression & Anxiety Some insomnia and decreased libido, difficulty achieving erection and delayed orgasm. Every medicine has side effects as well as benefits. The true solution to treating depression & anxiety is to address the cause (i.e. its not always about a chemical imbalance in the brain...that's one theory). Your brain doesn't come with a dipstick to measure the levels of neuro-transmitters!!! Cymbalta and other anti-depressants are not the solution but a temporary band-aid to help you cope. They won't make you miraculously feel better or happy. In fact, the drug companies who research and manufacture these chemicals don't really know how the 'medicine' works in the brain (its just a theory). Seek the professional services of a Psychologist for Cognitive Behavioural Therapy at least once per week for at least 3-4 months. Also read Eckhart Tolle's books 'The Power of Now', 'A New Earth' or buy his DVD titled 'Findhorn Retreat'. Re-learn how and why your thoughts affect your mood. Exercise (cardio) at least 4 times per week for 30 minutes each time, and eat a healthy, well-balanced diet. You can cure yourself! M 37 4 months
11/9/2008
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