CYMBALTA Reviews (DULOXETINE)

Average Rating: 2.7 (2745 Ratings)

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 ANTIDEPRESSANTS

 Type: Rx Drug

  

CYMBALTA  (DULOXETINE):  Duloxetine is used to treat depression and anxiety. In addition, duloxetine is used to help relieve nerve pain (peripheral neuropathy) in people with diabetes or ongoing pain due to medical conditions such as arthritis, chronic back pain, or fibromyalgia (a condition that causes widespread pain). Duloxetine may improve your mood, sleep, appetite, and energy level, and decrease nervousness. It can also decrease pain due to certain medical conditions. Duloxetine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). This medication works by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in the brain.   FDA Approval Date: 2004-08-03 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on CYMBALTA: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR CYMBALTACOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 3  
8/5/2008
 3  
5/22/2009
 3  
5/15/2007
 2  
2/21/2008
 2  depression Extremely tired, low motivation and energy. NO LIBIDO, anxiety, s/s of OCD ie biting nails and lips, lightheadedness/dizzy, occasional nausea. I was on wellbutrin and prozac combo, but I had decided to take myself off as I was getting alot of severe headaches. I was not sure if meds were contributing to this. However, the depression and moodiness quickly returned and my psychiatrist decided to try Cymbalta. Started out on 30 which did nothing. Eventually increasing dose to 90. I have actually felt more tired during day and difficulty with sleeping. I have a tendency toward seasonal affect disorder and cymbalta has not done anything to improve this. In fact, I feel worse this year as compared to last year when I was on Welbutrin and Prozac. Further, I suffer from PMS and Prozac was highly effective for relieving those symptoms. I am now back on Wellbutrin to start and will see how it goes. 47 4 months
11/22/2008
Email
 2   brain Zings, nausea and dizziness if I missed a dose. confusion, disorganization, distractability 3 years
1/18/2009
 2  Pre PMS Well I was on it for about 2 months .. the only thing I got from this drug was uncuntrolable urges for sweets. I have gained 10# so far... The first time I took the drug I did feel something(heart paplatations..) but not want I needed. Still had the feelings of emptyness and cry very easelie. Felt like people were laughing and talking about me. I felt more from the drug comeing of it... On days I don't work I can sleep till 3:00pm. And the days I do work I come home around 4:00pm and sleep till 6:00pm just to get up to make supper for hubby. Don't go anywhere no desire. Brain sizzle sensations. Hard to explain. Foggy thinking. On my 7th day of detox'g from it. 6 days and up took every other day now on the every 3 days. I have 4 pills left I am go'g to try and open caps and split the littles balls in them to taper down even slower. 42 60 days
1/28/2006
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 1  depression I have been taking Cymbalta for approximately 5 months and have not noticed any real differences from the Prozac, regarding my mood. However, the differences in side effects has been very pronounced. Since taking the Cymbalta, I have experienced significant insomnia, INTENSE sweating, especially during the daytime, constant diarrhea, dizziness, and arrhythmia. I am going to reconsider going back on Prozac. I only discontinued it because it did not seem to be as effective as it had once been. I had been on it for many years and thought a change in meds might be warranted. 56 5 months
8/21/2005
 1  
3/18/2007
 1  depression/ anxiety 41 14 days
60 1X day
5/1/2011
 1  sadness, crying after knee replacem yawning,sweating, irritability, anger, forgetfull, insomnia frequent voiding, zero patience, lights and sounds magnified. daytime sleepiness, craving sweets & smokes. Oh yes & swollen hands that resolved as the day went on. This med seemed like a miracle the very first week. I only had nausea for a couple days then felt happy again upon wakening. During the last year I have been asked by my boss to look for another job due to forgetfullness as a med/surg RN. Anger, complaining and innapropiate rudeness to my patients. I have been off work for several months and when all my issues did not resolve with the lack of job stress I had to look at the Cymbalta as the cause. My husband is also on it and he has had such severe insomnia, night sweats and daytime fatigue that I feel this med has robbed us of 4 years of our lives. No sex drive at all and inabiliy to orgasm for us both. I am weaning off slowly taking a few of the little balls (30-40) out of 300 inside the 60mg cap. My plan is slow withdawal over 3 months. 57 4 years
1/14/2009
Email
 1  depression/anxiety Headache, dizziness, heart "flutters" and palpitations, insomnia, muscle aches, joint pain. My doctor put me on this after I'd been on Zoloft for 2 years with no bad effects. He said most depression patients are under-medicated and thought the Cymbalta would help with anxiety better. This has been a HORRIBLE 4 days, constant headache, muscle and joint aches, insomnia and daytime sleepiness, and today I've had scary heart palpitations and light-headedness. I am only on 30 mg but am going back to Zoloft tonight! 4 days
1/4/2009
 1  Depression associated with MS Getting off this drug is A LOT worse than the symptoms of depression! This is the drug from hell to get off of. Class action suit, anyone? 52 2 days
1/27/2008
 1  depression weight gain 26 pounds in 3 months. I went from a healthy 115 lbs to 141 pounds practically overnight. I don't have the money to buy a new wardrobe, I spent it all trying to find a decent anti-depressant. 5 months
12/24/2007
 1  
3/27/2009
 1  Bi- polar depression My lawyer will be contacting you. 52 6 days
60mg 1X day
12/19/2014
Email
 1  nerve pain from a stroke Woke up 5,hrs after taking one diarrhea vomitting all muscles sore 45 1 days
30 mg
3/13/2015
 1  facial pain Anixaty 1 days
at night
6/21/2014
 1  Chronic back pain Nausea, chills, severe leg twitching, very bad cramping in upper legs at night with sharp pain, headache, swelling under eyes, inability to urinate until later in the day, increase in back pain I just don't think I can take this drug though I wasn't on it for long. It seemed dangerous given the severity of side effects. I know some people are able to tough it out, but this seemed extreme. I have tried many drugs, and can take opiates without trouble. But the anti-spasmodics and the anti-depressants (exception being Amitriptyline) cause many problems. This is the worst set of side effects I have ever experienced and don't feel it's safe to continue. 71 3 days
30 mg 1X day
10/12/2013
 1  Depression I have experience the following list of symptoms, thus am no longer taking Cymbalta. o Orthostatic hypotension o Fatigue o Vivid nightmares o Increased sweating o Decreased appetite o Blurred vision o Paresthesia o Disturbances of the gut, such as nausea, constipation, diarrhea, indigestion o Shakiness (tremors) o Anxiety, nervousness, agitation o Palpitations o Hot flashes o Taste disturbances o Difficulty passing urine o Cold hands or feet o Inflammation of the liver On January 9, 2009 my doctor prescribed Cymbalta for excessive depression that my other anti-depressent, Celexa, was not taking card of. The first 4 weeks I felt great. Sadly February the side effects were beginning to take hold. By May 7th they were at their worst. May 8th I saw my doctor who took me off Cymbalta that day and was placed back on Celexa which is helping just fine now. I feel no depression. 4 months
8/24/2009

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