CYMBALTA Reviews (DULOXETINE)

Average Rating: 2.7 (2745 Ratings)

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 ANTIDEPRESSANTS

 Type: Rx Drug

  

CYMBALTA  (DULOXETINE):  Duloxetine is used to treat depression and anxiety. In addition, duloxetine is used to help relieve nerve pain (peripheral neuropathy) in people with diabetes or ongoing pain due to medical conditions such as arthritis, chronic back pain, or fibromyalgia (a condition that causes widespread pain). Duloxetine may improve your mood, sleep, appetite, and energy level, and decrease nervousness. It can also decrease pain due to certain medical conditions. Duloxetine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). This medication works by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in the brain.   FDA Approval Date: 2004-08-03 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on CYMBALTA: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR CYMBALTACOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 2  Fibromyalgia INITIAL: Nausea, constipation, diarrhea, dry mouth, dizziness MONTH TWO: All of the above PLUS,headache, decreased libido, back pain, night sweats, hot flashes, flushing, heartburn, insomnia, constant yawning, blurred vision. MONTH THREE: All of the above,PLUS, profuse sweating, stiff neck, joint stiffness, weight gain (10 lbs. in 6 weeks), difficulty passing urine, extreme itching, difficulty reaching orgasm, cold sores, pins & needles in hands and feet. WITHDRAWAL SYMPTOMS: All of the above,PLUS,restless legs, chills, crying, fatigue & restlessness at the same time, eyes aching & itching, heart palpitations, multiple intense violent nightmares throughout the night, feeling drugged or hung over, flu-like symptoms, extreme flatulence, difficulty swallowing, difficulty concentrating or focusing, extreme thirst, pressure in the head, shortness of breath, itching & ringing in ears, loss of balance. Initial side effects were worth living with because my pain had decreased substantially. As time went on the side effects increased & became worse. Then i developed an itch in my breast that became so intense it began to blister. I experienced 3 weeks of hell going thru tests (mammogram, ultrasound, MRI & biopsy) to confirm it wasn't inflammatory breast cancer. I finally made the connection when reading another patient's comments with the same symptoms. I have been weaning off this drug over 3 weeks and still feel horrible. I wish I had found this site earlier. I would never have taken this terrible drug. F 52 3 months
60 MG 1X day
6/28/2010
Email
 2  Depression Heart racing, vivid dreams and/or nightmares every single night, total loss of interest in sex, difficulty concentrating/focusing, weight gain/impossible to lose weight, and my head feels strange - hard to describe like sort of light-headedness. Also, tiredness and lack of motivation. I was on lexapro for years and it worked just great - I am switching back. Cymbalta didn't even relieve my depression symptoms fully and I am not increasing my dosage because the side effects bother me. F 36 4 months
30 MG 1X day
8/11/2010
 2  Mastecomy Pain Syndrome, Neuropathy Horrible Sweating, Memory Loss, Confusion, Loss of Libido, 10# Weight Gain Cymbalta has helped my pain. It has also helped me get to the point of being in a better mood, having energy and being able to exercise. This has been huge for me. If only they could develop these pain drugs without the horrible side effects. I am now at the point of having to decide to stay with it or try to go off of it because the side effects I listed are wearing me down. I just don't want that terrible pain back. F 51 8 months
20mg 1XD 1X day
8/2/2010
 2  depression Common ones such as dry mouth, lack of appetite, nausea, gas, dilated pupils and frequent waking at night. Initially, did seem to help general depression. Felt much more uplifted and good about life. Then severe twitching, muscle spasms and insominia began. Could not sleep with nerve twitching all over my body. Also very low labido. Am now weaning off. Feel the general depression was easier to deal with than the jerky, twitching, spasms and lack of sleep....also worry whether it will ever go away! Dr. wants me to try Prestique.....am thinking I'll try prayer! Am fearful of this drug. The side effects are worse than the problem. F 56 2 months
20mg 1X day
9/8/2010
 2  bipolar frequent sweats, mental confusion, high blood pressure, high cholesterol, high sugar. also taking 60 mg vyvanse. hard to know whether one, the other, or the combination. severe constipation; periodic shortness of breath, chest tightening. major insomnia such that Ativan has become ineffective. spacey. problem focusing. horrible muscular skeletal pain. intensified insecurity, interference with work performance. extremely forgetful. worsened short term memory. like being in a mini straight jacket (description of physical sensation) not right for me. very serious medications with major side effects downplayed unfortunately for too long. F 58 1 years
60 mg 1X day
10/19/2010
 2  Anxiety/irritability/insomnia Nauseau Didn't really help with symptoms of irritability; did not help with insomnia; nausea occurred when I took it in the morning so started taking it at night but no change in nausea. F 47 45 days
15 then 30 1X day
12/29/2010
 2  Depression Anxiety to the point of panic (had to start taking Ativan to counteract this effect). Bruxism, racing thoughts, loss of appetite (but no weight loss), excessive thirst. Use caution on Cymbalta, I was on 20mg, the lowest dose possible as I am med sensitive and starting having severe anxiety to the point I needed Ativan to stop my anxiety. When I stopped Cymbalta, my panic, anxiety and bruxism was gone within 3 days, though after only taking the medication for a month, I suffered some serious withdrawal symptoms. F 37 1 months
20 mg 1X day
12/10/2010
 2  Anxiety and Depression Weight Gain, Severely Decreased Interest In Sex, Dry Mouth, Nightmares, Disturbing Dreams Leaving Me Unsure of Reality, Frequently Waking At Night, Always Tired, Sweaty, Commonly Abnormal Bowel Movements, Gas, Clenching Jaw It seems to help a bit, but is expensive. I've never had much luck with antidepressants, but this is definitely an improvement to my suicidal tendencies. I do still have mood swings, though not as often. The side effects all stink, and the things such as weight gain (I've gained at least 20 pounds!) and gas really effect my self esteem. I'm thinking about trying to switch mess again... This is not easy. Cymbalta has helped me the most, but the side effects are very significant. Plus the price is not fun for a poor, stressed out college student. F 19 1 years
1X day
11/9/2010
 2  Neck, shoulder pain and numbness I started this with great expectations. After the first two days I thought I had found my cure without surgery. However, I started having problems around day 4. Upset stomach, GERD, loss of appetite. Then the diarrhea started and the cramping and pain followed. I ended up in the ER after suffering for 3 days with the pain. I was diagnosed with Colitis. The diarrhea has not stopped yet, and my pain specialists does not believe that the Cymbalta was the problem. I believe it was/is and I will not take it again. I cannot afford to with all the new doctors and medical bills. I thought this was going to be my answer to help me off the pain meds, but it made me sicker and in more pain. Now all my doctors think that I am seeking more pain meds. Great! F 46 9 days
20mg 1X day
3/8/2011
 2  anxiety harding to go pee, dry mouth, yawning a lot, tired early before my normal bedtime, loss of appetite. lost two lbs. had to pee more, and noticed pee was darking than usual, so I thought it might have something to do with the liver, I would zone out and focus on one thing at a time, so that was weird. the second day on it, I cried a lot and felt a bit like a zombie but not too bad. It did help with racing thoughts, however the problem with the pee thing and the fact that is has really bad side effects and withdrawal effects made me decide not to go on it. I don't want to have the withdrawals. I read about the withdrawals and I felt that the advantages of the drug did not outweight the side effects. I would consider the drug again after more trails and longer time on the market. I prefer drugs that are older and I feel more safe. F 39 2 days
20mg 1X day
3/3/2011
 2  Anxiety Nasuea if I ate nothing After taking cymbalta for a couple of months I noticed that my urge to drink increased rapidly and dangerously. Also when I drink I black out and become violent. I do not remember where I have been, and find myself almost to have a second identity. I believe that Cymbalta is a dangerous drug. F 29 9 months
60 mg 1X day
3/24/2011
Email
 2  Depression constipation, tired, depression intensified and made me suicidal, rapid heart rate and jittery first day or so but went away, irritable, loss of appetite (positive for me), and the same sexual side effects as SSRI's (numbness in genital area/lack of orgasm). I admit that I didn't give this medication a chance to help my depression, but the reason that I tried it was because I hoped that it wouldn't cause the same sexual side effects like Zoloft and Lexapro, but it did, so it wasn't worth the cost. Retail price was $179 vs $30 for the generic form of Zoloft. Have since tried to other meds. F 41 10 days
30 mg 1X day
4/15/2011
 2  severe depression permanent voice damage It was 5 years ago, so I don't remember dosage or how long I took it, it would have been the lowest dosage because that's what my dr always starts me. I was experiencing severe heart burn and stomach problems which I thought were due to stress. it worked fine, which was impressive considering what I was going through, however one day I threw up and discovered why it's called stomach ACID. It caused permanent damage. Just be aware that this is a side effect for some people. I had no idea our bodies could produce acids so strong. F 56 30 days
don't reme 1X day
4/23/2011
 2  Nerve Pain Shakes every morning, Decreased Blood Sugar, Decreased Appitite, Cloudy Feeling. Was given for pain, did not help at all, did help with my depression. My doctor discontinued them because my blood sugar was dropping badly. I felt the shakes every morning and head did not feel right. Did help with my insomina, was not worth me continuing this drug. F 47 60 days
30MG 1X day
4/27/2011
Email
 2  Fibromyalgia Loss of appitite, sleep problems I am taking the highest dose of Cymbalta and I find it helps a bit. It sometimes keeps the pain to a slow moderate roar. This is the last medicine that I can take for Fibro. I have no appitite and have sleep problems. F 40 5 months
120 1X day
6/19/2011
Email
 2  (drug resistant) major depression Constipation was the worst side effect, as it has been on most SSRIs. Some dry mouth, weight gain and sugar cravings, extreme tiredness, lethargy, excessive need for sleep. Memory loss and poor word retrieval. Not effective for extreme anxiety, but definitely takes the edge off. In all fairness it can be hard to determine which effects are directly related to the drug, and which are due to your own chemistry. I took this drug both alone (for 2 years) and in combination with other meds (such as welbutrin). I ranged from 60g/day to 120/day over 4 years. I was at a place where I was borderline functional, and didn't want to mess with that regardless of still having major depression. But I think I can do better so I'm making the switch to an MAOI (not for everyone) and withdrawing from cymbalta. Withdrawal is NOT fun, so taper off over a few weeks and prepare for a week or two of utter uselessness. F 32 4 years
60 1X day
6/1/2011
Email
 2   Weight gain, brain zaps, blurred vision This is my second time on Cymbalta. I begrudgingly allowed my Rheumatologist prescribe it for Fibro even though I had taken it several years ago and hated it. Weaning off this med is brutal. The best way to do it is work with your physician and establish a tapering down schedule. When you get below 30mg ask your dr. to prescribe lower dosages through a compound pharmacy as they can make it into 20 mg liquid doses x 5cc. The idea is you go down to 20 then 10 then 5 and voilá. It is not painless but it is definitely more tolerable than just reducing doses to 30mg and skipping days. I'm in the process of weaning off it due to weight gain. F 47 3 months
60mg 1X day
7/28/2011
Email
 2  mild depression I took Cymbalta for 2 years, initially for mild depression during a stressful time at work. Decided to go off med this summer. I felt like i was coming off some major illegal drugs. Horrible effects. I tapered for two weeks and then said to heck with it and quit taking altogether. Dizziness, brain zaps, forgetfulness, insomnia. I will never take another med for mild depression...not worth it. Cymbalta worked for depression, but I felt more like a zombie. Can't remember the last time I had any real feelings. Sex has been nonexistent...no desire. Sweating constantly, and feeling hot ALL the time. I was dripping when I walked or worked out and others with me were not breaking a sweat. I gained 30 pounds over the two years of taking Cymbalta...I already feel the stomach bloating subsiding. The doc doesn't believe weight gain was caused by this med. I have never been this overweight. Doctors should warn patients of the effects once you get off the med. It is insane. F 51 2 years
60 1X day
7/15/2011
Email
 2  suspected fibromyalgia headache, dizziness, loss of appetite, extreme fatigue, disorientation, muscle weekness, chills The NP I was seeing at the time suspected me to have fibromyalgia. I knew whatever it was it slowly developed into something awful. I had severe pain in all my joints, debilitating fatigue and mailaise, Raynaud's phenomenon, hair loss, sudden dizziness, muscle weakness, extremely tender hands and feet, you name it I was suffering from it. She decided to put me on cymbalta which was a big mistake for me. I took the small dose of 30mg at bedtime. I had no recollection of the next day. I slept through the night right after I took it and all day the next day and all night.. It seemed like the only thing I could remember was a bunch of ppl coming in my room to check on me at one time. It was just a memory flash and was extremely vague. I was later told that it was only my mother and my granny. When I was finally able to get up my body felt really strange. I had extreme body chills, I couldn't unclench my jaws hardly and I constanly felt the urge to yawn. Try doing that while clenching your jaws lol, It hurts. I came to find out 8months later that I do not have fibromyalgia.. I have Lupus. Cymbalta is definately not for lupus patients. As for fibromyalgia, cymbalta has been shown to be effective for 1:4 ppl. My mothers friend has fibro and cymbalta helped her but of course its not for everyone. F 26 1 days
30mg 1X day
10/20/2011
 2  depression, bulimia, chronic pain restless legs, sleeplessness, hot flashes, anxiety. is helpful for pain I am down to 20 mg and trying to wean off. The withdrawals are severe. my family feels that my personality has changed for the worse. F 25 3 years
60 1X day
9/21/2011

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