CYMBALTA Reviews (DULOXETINE)

Average Rating: 2.7 (2745 Ratings)

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 ANTIDEPRESSANTS

 Type: Rx Drug

  

CYMBALTA  (DULOXETINE):  Duloxetine is used to treat depression and anxiety. In addition, duloxetine is used to help relieve nerve pain (peripheral neuropathy) in people with diabetes or ongoing pain due to medical conditions such as arthritis, chronic back pain, or fibromyalgia (a condition that causes widespread pain). Duloxetine may improve your mood, sleep, appetite, and energy level, and decrease nervousness. It can also decrease pain due to certain medical conditions. Duloxetine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). This medication works by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in the brain.   FDA Approval Date: 2004-08-03 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on CYMBALTA: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR CYMBALTACOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 1  anxiety and pain On 5th day I had overwhelming itching and genital blisters. Before that decreased appetite and nausia. I stopped taking after 5 doses. 4 days later and developed cold sores on mouth and genital blisters slowly going away. Would not recommend this F 49 5 days
20 mg
2/22/2015
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 1  Anxiety Side affects: Tingling in hands and feet, brain zaps, dizziness, insomnia, paranoia, confusion, disorientation, depersonalization, tongue necrosis, early dementia, hair loss, skin boils, Crying spells, depression, worsening of anxiety, rage, dehydration, appetite loss, but weight gain, mood swings, nausea, fatigue, restless leg syndrome, etc. etc. etc. YES IM SERIOUS!!! THIS DRUG IS EVIL and has stolen 2 years of my life... because the side affects slowly creep up on you. I honestly thought I had multiple sclerosis and contributed a lot of my symptoms to other things. PLEASE LISTEN when I tell you to RUN... Not walk away from this drug!!! Shame shame shame on you Eli Lilly! CYMBALTA WILL KILL YOU!!!!!!!!!!! And for anybody who says they don't have side affects, or give this drug a highly satisfied rating, you just haven't taken it long enough!!! Careful when stopping this drug as the withdrawal is gruesome!!!!! F 32 1 years
30
2/23/2015
 1  Bipolar disorder i was so dizzy any time I stood up I almost passed out couldnt drive on this medication due to severe dizziness F 57 1 months
60
6/5/2015
 1  Depression Neuropathic pain for MS I was recomnendedI this drug by my neurologist to help with MS symptoms and found my brain could not function as it had been. Very confused and bad memory loss, which was extreme considering I had to hold down my job.One day I felt extremely unwell and went to the doctor, while is was there explaining how I felt I had a huge reaction. Severe pains in my head with my blood pressure so high the machine would not work. I was rushed to hospital in an abulance in which the ambo thought I was not going to survive. I was in hospital for one month with at least five episodes per day of extreme debilitating pain and put on numerous drugs, mri scans, lumbar puncture etc. I felt my head was going to explode with the pain and was later told I could have died through the blood vessels bursting in my head. So I agree with the comments 100% it has been the EVIL PILL for me and would not recomend it to anyone else. F 55 6 weeks
30mg 1X day
3/11/2015
 1  anxiety,depression,fibromyalgia I was taking at night but it made me to irritable to sleep .I started taking it today during the day. It still makes me very irritable. Will this go away or maybe just stop taking it ? Its acting more like a stimulate in my system. Dr says stay on it for 2 weeks then see him again . I'm not sure I can handle it that long. Also headaches everytime I take it. He also gave me ambien for sleep but at even 10mg I'm miserable and can't sleep F 54 3 days
60mg
1/7/2015
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 1  fibro pain I went into anaphylactic shock taking Cymbalta F 60 1 weeks
8/20/2014
 1  pain Sweating, throwing up, stomach pain, can't sleep missed 2 days of work F 59 2 days
8/20/2014
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 1  chronic lower back and leg pain I had seizure-like symptoms. Shaking uncontrollable. Had to be taking to the hospital and got 3 different meds to stop it and a bag of fluid..bad thing is i cant remember any thing except getting up for work at 4 am till around 3-4 that afternoon..i still experienced some shaking for around 4-5 days afterwards... never again will i take this..now i'm very scared of taking any medicines. .., F 46 1 days
30
9/9/2014
 1  depression auditory hallucinations!!!! other side effects were minor, but I heard music coming out of the wheel of my car; initially I thought it was very funny, and figured if I know I'm hallucinating I must be OK, but then I started to hear things that I wasn't sure if other people heard. Called the doctor SO FAST to go back on to Cipralex! F 51 4 months
20 1X day
9/25/2014
 1  Depression and fibromyalgia both BODY ODOR!!! . Husband wouldn't touch me, even though I showered. Any time I perspired (or any body fluid actually) the slightest bit the odor was overwhelming! Sex life was irreparably damaged with husband for over 5 years after. problem stopped after a week or so of stopping the medicine. Never worked for depression, probably because I didn't take it long enough. F 48 5 weeks
1X day
11/10/2017
 1  pain, anxiety. SEVERE exhaustion. Non stop yawning. Severe restless leg while trying to sleep. No appetite all day. Im so tired, it's dangerous. Not "better make it two cups of coffee!" tired. Dangerous "probably shouldnt be driving. hope I make it through work without passing out" tired. F 28 5 days
30MG 1X day
10/21/2014
 1  depression and anxiety My Doctor First Started Me On 60 Mg And That Didn't Seem To Be Having Much Success As I Was Still Very Depressed And Had A Ton Of Anxiety. So They Increased The Dose To 120 Mg Per Day. That Helped With The Anxiety And Depression.I Was Very Low Energy Though. I Had Very Vivid And Disturbing Dreams On It as Well. At 4 Months I Decided To Discontinue UsE After Becoming Aware Of Side Effects That I Was Not Okay With And That Seemed To Be Worse The Longer You Were On It. I Was Plagued With Vivid Nightmares That Were Difficult To Wake Up From And That Would Continue From Where They Left Off When I Did Fall Back Asleep. They Were Accompanied by Terrible Night Sweats (Even When The House Was 68°). I Also Had Brain Zaps, NauseA, Headaches, Confusion And DifficultY Thinking. Pretty Severe Withdrawals For Such A Short Time Of Usage. I Did Not Experience The Weight Gain That Some Did (Though Perhaps That Was Because I Tried Living A Pro-Anna Lifestyle At First Then Stopped And Began A Healthier Lifestyle Characterized By Healthy Eating And Regular Exercise) And Was Only Aware Of The Slightest Hint of A Decrease I Libido. Some People ReportedLy Suffered From Insomnia But I Did Not, But I Also ContinueD Using Vistaril To Treat Any Anxiety Attacks And At Night As A Sleep Aid. F 33 4 months
120 MG
11/7/2014
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 1  depression... hip pain... Extreme anger....ears ringing,pissed F 56 1 days
60 mg
11/5/2014
 1  depression Nausea,loss of appetite, diarrhea, not feeling Well...feeling more depressed,No energy. I've decided to stop taking this Med. F 45 5 days
30 mg
12/16/2014
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 1  fibromyalga pain Massive head pain causing total blood shot eyes could not tell color of eyes swelling hands and feet ring size from 6 to 10 in ring size Worked like wonder drug had no pain from first dose like used to be then it turned on me I could have died drs say F 51 5 months
60 mg ?
12/22/2014
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 1  CLINICAL DEPRESSION AND LEG ACHES CONSTANT HEADACHE, HAIR LOSS, & EXTREME WEIGHT GAIN. EIGHTEEN YEARS AGO, MY SON SUDDENLY DIED AT AGE 32. FOUR YEARS LATER, I COULD NOT DEAL WITH IT ANYMORE. I TRIED SUICIDE, BUT WHEN THAT DIDN'T WORK, I FELL COMPLETELY APART. I WAS PUT IN THE HOSPITAL, & AFTER THE DOCTORS CHECKED EVERYTHING THEY KNEW, A PSYCHIATRIST WAS CALLED IN & AFTER ONLY 2 VISITS, HE PUT ME ON CLONAZEPAM, NEURONTIN, & ZOLOFT. I HAVE TAKEN THESE MEDS FOR ABOUT 13 YEARS UNTIL I STARTED HAVING LEG ACHES AT NIGHT. ABOUT 7 MONTHS AGO, MY REGULAR DOCTOR CHANGED OUT THE ZOLOFT FOR CYMBALTA. IT IMMEDIATELY TOOK CARE OF THE LEG PROBLEMS & I SLEPT VERY WELL. THEN, I STARTED NOTICING THINGS HAPPENING ALL AT ONCE. MY HAIR WAS SHEDDING AT AN UNUSUAL RATE, I WAS HAVING A DULL HEADACHE CONSTANTLY..LIKE 24/7, & I HAVE PUT ON AT LEAST 30 LBS IN THE LAST 6 MONTHS, ALTHOUGH I HAVE NOT CHANGED MY EATING HABITS. I DID NOT EVEN SUSPECT THAT IT WAS ONE OF MY MEDS UNTIL MY DAUGHTER, WHO IS A REGISTERED NURSE, SUGGESTED THAT I LOOK UP ALL OF THEM & SEE WHAT THE SIDE EFFECTS ARE. WHEN I GOT TO CYMBALTA...THERE THEY WERE...ALL OF MY PROBLEMS WERE RIGHT HERE WITH SOME OF THE OTHER COMMENTS. I SEE MY DOCTOR SOON FOR MY USUAL CHECK-UP & I WANT TO GO BACK TO ZOLOFT, BUT THE WAY SOME OF YOU DESCRIBE WITHDRAWAL, I'M REALLY SCARED. I DON'T EVER WANT TO FEEL LIKE I DID BEFORE I STARTED ON THE MEDS. PLEASE SEND ME YOUR SUGGESTIONS AS TO WHAT YOU THINK I SHOULD DO. F 72 6 months
60 MG
12/4/2014
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 1  depression, fatigue, sleepyness Nausea,hypersomnia,lack of interest , conservation and motivation,tiredness,anxiety,suicide thoughts,depression,fatigue,tongue and jaw pain, headache, tremors and weakness in my muscles, chest pain I had high hopes for cymbalta, I had hoped to be able to stay awake during daytime, to have strength and motivation to do household chores, or anything like that, but it took unusually long time to admit that not only did the drug not help me, but worsened my health until I finally found that I was awake only a couple of hours during the day. My strength had gone, I hardly could stand up and walk to next room, so weak I had gone. F 40 4 months
30 mg
12/14/2014
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 1   Nausea,vomiting,cant focus,walk into walls, fall,trip, dizzy,brain zaps,severe on sudden head pain,in crease nightmares,suicidal thoughts,worse depression,weight gain,severe stomach pain,painful bloating,numbing and tingling of arms,legs,fingers,toes,increased anxiety,rapid heart beat,loss of words,cant hold conversation. 2nd time i tried this med. Its horrible. I will never take take seroquel,cymbalta,effexor,any of those again. I used it for depression,ptsd,fibro,pain F 42 3 months
12/26/2014
 1  fibromyalgia Very fast Heart rate and high blood pressure, full body shaking, jerking limbs requiring duloxetine to be stopped and a 6 night stay in hospital. Postural hypotension, nausea, anorexia and black-outs with loss of muscle tone . Pain reduction by day 3 leading to improved mobility. By day 14 pain was increasing and occasionally my mobility was stiff. Day 54 my blood pressure and heart rate were high. Day 55 I felt unwell and my heart rate was 148. On arrival at A\E I collapsed and was rushed into resus where my heart rate was 175 and blood pressure 174/104. I was given oxygen, cannulated and given diazepam for total body jerking and spasms. I was so frightened. I was diagnosed as having a severe adverse reaction to duloxetine. I was admitted and the duloxetine stopped. The jerking continued for several days and I collapsed on several occasions. Whilst in hospital I felt suddenly drained of all energy and fell onto my bed unable to move for almost an hour. The medics agreed to allow me home providing I had someone at home with me. I had further episodes of collapse whilst remaining conscious/ losing consciousness and unable to move my legs and hold my head up. One of these occurred at the gp surgery and another I phoned for an ambulance. Neither the gp I had grown to trust nor the ambulance crew believed me. I was shouted at and told to move. Each time I became hysterical. I had further episodes of difficulty breathing, chest pain for which I spent hours in A\E. By day 11 my energy and appetite have started to return but this episode has affected my trust and destroyed the relationship I had in my gp. F 54 55 days
60mg 1X day
12/27/2014
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 1  Neuropathy Felt stupid , couldn't function properly ,couldn't eat right This drug sucks tried to come off it cold turkey and couldn't even function worse then when I was on it I saw my dr and she she said to break open the capsules and take out a little bit at at a time. Still don't feel well F 51 1 days
60 mg
12/28/2014
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