CYMBALTA Reviews (DULOXETINE)

Average Rating: 2.7 (2745 Ratings)

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 ANTIDEPRESSANTS

 Type: Rx Drug

  

CYMBALTA  (DULOXETINE):  Duloxetine is used to treat depression and anxiety. In addition, duloxetine is used to help relieve nerve pain (peripheral neuropathy) in people with diabetes or ongoing pain due to medical conditions such as arthritis, chronic back pain, or fibromyalgia (a condition that causes widespread pain). Duloxetine may improve your mood, sleep, appetite, and energy level, and decrease nervousness. It can also decrease pain due to certain medical conditions. Duloxetine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). This medication works by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in the brain.   FDA Approval Date: 2004-08-03 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on CYMBALTA: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR CYMBALTACOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 3  anxiety, mild depression fatigue, weight gain, loss of sex drive I started with 30mg of cymbalta and after a while increased to 60mg. Seemed like my body would get used to the med and not work as well. I was on Lexapro prior to this and same thing happened. I had plantar fascilitis (pain in arches of feet) and the cymbalta really helped. It also helped with my anxiety for a while, but if I skipped a dose even less than a day I would have bad side effects such as dizziness, anxiety, very irratable, nausea, and a thumping sensation in my tongue. My sex drive has gone down to nothing. I have gained over 30 lbs in last year! This is strange but if I missed a dose by hours or a day, I felt more creative. I decided to come off of Cymbalta because it didn't seem worth it. I have been weening off for 6 wks now and it has been a nightmare!! The side effects are driving me crazy! I get very dizzy, nauseated, almost drugged feeling. I ache and hurt all over to where I can't hardly stand. I cry practically every night and feel so mean to everyone. I keep F 39 2 years
9/26/2008
 3  Fibromyalgia, Arthritis,Depression Vivid dreams, and remember them in such great detail ! Increased sex drive, reduced appetite,neck pain. I haven't been taking this drug too long and I am stopping because of the dryness it causes in my eyes (swollen) and my scalp (scratching). I can't read or focus my eyes because of the dryness and burning, my eyelids are swollen and, although it has helped somewhat with fibro pain, it's not worth it. Also, affects sleep patterns, I'm exhausted earlier, but can't sleep well. I've been on Zoloft for years, and we tried Cymbalta because my doctor felt I had gotten too used to Zoloft and it wasn't helping as much. When I first tried Cymbalta, I stopped after a week or two because I was so angry, I was biting off everyone's head. Stopped and started again and now experienced this dryness. I won't try it again. F 66 4 months
2/23/2007
 3  anxiety, depression, MS pain Panic out of dead sleep, sudden nite sweat with drop in BP like I was going to faint, severe abdominal cramps/diarrhea with liteheadedness mood is "upgraded" to medium and stable, works well for my pain, some muscle tightness, palpitaions--but nothing as bad as Effexor (seizure) or Paxil (unable to stand up). I'll stay on the 60 mgs for another week at a time. BTW--Taking Provigil helps with the sleepiness. F 58 2 weeks
7/2/2006
 3  Fybromyalgia I was prescribed Cymbalta by my neurologist for fybromyalgia. After about 45 days, I developed chronic diarrhea....after 3 weeks of this, I went to my GP, who referred me to a gastroenterologist. A colonoscopy revealed lymphocytic colitis, which after exhaustive research was found to be a 'rare/infrequent' side effect of Cymbalta. My neurologist is weaning me off the Cymbalta with the hope that the colitis will resolve itself. It's been 6 months since it began.....five of which were spent finding out what could be causing it. I'm really disappointed in the side effect....and rather 'bummed out' that I have to stop taking it, because it truly worked wonders on the pain aspect of the fybromyalgia. If you don't have side effects, it's a wonder drug. F 49 6 months
4/25/2008
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 3  Depression Emotionally numb, wasn't happy or sad. No libido at all, was unable to orgasm from sex. F 27 6 months
3/7/2007
 3  Major depressive disorder Insomnia, excessive sweating, blurring vision, appetite loss. Have only been on drug for one week, and already I can see I am not getting the creeped-out feeling I have from a half dozen other antidepressants I have tried. But the sweating and the insomnia are VERY problematic, as I am exhausted. Plus my vision is very blurred and I have no appetite (no weight loss yet, though). Also having weird sort of mental mania at night when I am cannot sleep - repeating of tunes and beats in my head that I cannot stop, which makes me feel very jittery, and then I really cannot get back to sleep. Ugh. I am concerned about the toll it takes on the liver, though. All in all I am hopeful about this drug. With time, my discomfort should subside, at least that is what my friends who are on the drug tell me. I am still on the fence about this drug, but it does seem better than some others like Paxil, Zoloft, Wellbutrin, etc., that I have briefly tried. F 50 7 days
10/19/2006
 3  Depression, pain from neuropathy Extreme sedation, inability to move, excessive sleeping. Digestive tract discomfort which has lead to a flare up of IBS. May be a good drug, but I can't take it anymore because of the sedation and stomach problems. F 28 2 months
11/13/2006
 3  FIBROMYALGIA NAUSEA IT SEEMS TO HAVE STOP WORKING I AM AGAIN VERY FATIGUED AND IN ALOT OF PAIN FROM THE FIBRO. F 37 3 months
8/29/2006
 3  anxiety, depression, OCD, mood swin Before yesterday, I was tkaing the pill in the p.m. (30 mg) only to find a.m. nauseau and then switched to 6 p.m. and was better. I was instantly better, that is, the next day i felt really surprisingly great, which brought me a bit of concern that maybe i was not going to be processsing the emotions i needed to process. After two weeks on i went off for four weeks and now i am back on again. For the extreme anxiety flowing crazily through my arms i was on Paroxetine, but that was crazy - i could not feel ANYTHING, sexually, but the desire was still there and i did not like not being able to fulfill the desire. So - lolol- if you are on a spiritual quest towards chastity - Paroxetine would be great! lolol On the second round with Cymbalta, within a few hours i got this headache in the front of my brain. Today i feel the headache, still, but a cup of coffee helped and now i will take some ibu too. My forehead feels like it is constantly raised. I like the number of times i read on this post that Cymbalta helped people. F 38 1 days
11/28/2006
 3  Anxiety I'm only on my third day, but I've had extreme insomnia, clenching of the jaw- mostly when I yawn, but I do feel a little more relaxed, hopefully the side effects will get better in the next week or two F 18 3 days
8/24/2006
 3  depression short term memory loss I felt it was difficult to perform at my best due to memory loss, which seemed significant at 60mg/day. After I quit, the memory and recall greatly improved. I feel my side effects undermined my professional performance and casual conversation. F 43 120 days
10/17/2006
 3  depression short term memory loss I felt it was difficult to perform at my best due to memory loss, which seemed significant at 60mg/day. After I quit, the memory and recall greatly improved. I feel my side effects undermined my professional performance and casual conversation. F 43 120 days
10/17/2006
 3  anxiety/chronic fatigue After two weeks on this med, I have extreme itchy hives on my legs,arms,hands,and back. I am taking benedryl and the itching just will not stop. The hives keep spreading after I stopped the med two days ago. I always have insomnia trouble and this med did nothing to help that. However, the biggest plus is I was dropping weight a couple pounds a day. The weight I was losing was extra pounds due to my fatigue, so it was a blessing to lose some weight. However two days off the med, I'm gaining my weight back a pound a day so far. I have chronic pain. The first day I took this med my chronic neck and back pain disappeared. It was amazing!! If it wasn't for the hives, I would have stayed on this medicine. Didn't notice much help with the mood swings. F 33 17 days
9/20/2005
 3  Anxiety and Depression Dry Mouth, Anxiety, Depression, Fatigue, Dry Skin It took some time for my body to adjust to the medication. I wish that my physician would had warned me of what the effects and the initial phases of the medication would be because it would have been easier to adapt. Now, my body is adjusting, and like any other anti-depressant it is working. I think I am losing weight with this though and I feel a bit less spacy. F 22 30 days
9/12/2005
 3  anxiety, migraine headaches headaches, nervousness, loss of appetite, loss of sexual desire, not able to reach orgasam, not much sexual felling, constipation, sleeplessness, vivid dreams; not bad though, lack of motovation, short attention span. cymbalta seem to relax me, maybe a little too much. sometimes to the point were you just don't care if your house work gets done or not. It didn't seem to help my migraines though. F 41 5 days
11/29/2006
 3  anxiety, migraine headaches headaches, nervousness, loss of appetite, loss of sexual desire, not able to reach orgasam, not much sexual felling, constipation, sleeplessness, vivid dreams; not bad though, lack of motovation, short attention span. cymbalta seem to relax me, maybe a little too much. sometimes to the point were you just don't care if your house work gets done or not. It didn't seem to help my migraines though. F 41 5 weeks
11/29/2006
 3  Depression, anxiety/OCD Bloating, constipation, slight weight gain, even though my appetite is decreased and I have begun to exercise. The Good News-- it helped my depression. By the time I had been on 30mg for a month and went up to 60mg, I had more energy and was noticeably more cheerful. I was finally getting out of bed every day, cooking sometimes, even doing the dishes, watering the lawn. I even started exercising every other day. The Bad News-- I experience very severe bloating, especially premenstrually. However, having crohn's disease, I could not yet be certain that it was from the Cymbalta. But then we raised the dose to 60mg and the bloating has gotten even worse-- before when I got bloated, at some point my belly would finally go back down to its normal size. Now it never does. This is making me feel more depressed and anxious. Some of my depression and anxiety is due to the effects the crohn's has on my body-- I feel ugly and hopeless, don't want to leave the house, and obsess about it. So being bloated is very bad news for my emotions. I am tempted to go off of it, but I have already been on F 33 2.5 months
5/18/2006
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 3  mood swings, lack of energy Fasciculation (muscle twitching) and vivid dreams Everything was absolutly great with this medication except for the muscle twitching and spasms. I had great energy and felt happy, but the spasms would keep me from falling alseep and would wake me up at night. F 30 1 months
12/28/2005
 3  anxiety, obsessive thoughts, panic on 30 mgs: dry mouth, sweating, decreased sex drive, but better, longer and more intense orgasms; on 60mg: in addition to beforementioned symptoms, sleepiness during the day (2:00pm, intense dreams (positive/neutral), sometimes not able to climax at all and no sex drive I have been on Cymbalta since 4/7/05 and at first the drug was as some have said "a god send". Obsessive thoughts/worries about health and wellbeing of loved ones and myself subsided. Panic attacks are under control, which means I recognize when they come on, and what they are and try to difuse them through rationalization. I had been feeling great (except for really no sex drive) so I tried to "ween" myself and cut my dose back to 30mg 4 months ago. Sadly, I have been feeling increasingly "lost", without a drive, worn-out, depressed for the past 3 months, so I have a choice to make that I need to discuss with my doc. Feel free to email me. F 44 14 months
5/7/2006
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 3  DepressionOCD Headaches. Cymbalta stopped working for me after I had taken 60mg for approximately 5 months. I am withdrawing cold turkey from the drug at this point, and the withdrawl symptoms are awful. Brain zaps, diahreah, headaches, dizziness and numbness are common still, 8 days after going off the drug. F 26 5 months
11/14/2005

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