CYMBALTA Reviews (DULOXETINE)

Average Rating: 2.7 (2745 Ratings)

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 ANTIDEPRESSANTS

 Type: Rx Drug

  

CYMBALTA  (DULOXETINE):  Duloxetine is used to treat depression and anxiety. In addition, duloxetine is used to help relieve nerve pain (peripheral neuropathy) in people with diabetes or ongoing pain due to medical conditions such as arthritis, chronic back pain, or fibromyalgia (a condition that causes widespread pain). Duloxetine may improve your mood, sleep, appetite, and energy level, and decrease nervousness. It can also decrease pain due to certain medical conditions. Duloxetine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). This medication works by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in the brain.   FDA Approval Date: 2004-08-03 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on CYMBALTA: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR CYMBALTACOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 4  depression yawning, teeth grinding (not just at night),incredibly vivid dreams (I feel like years have gone by at a frenetic pace each night)delayed or absent orgasm, intense cravings for sweets in evenings I am taking several drugs right now and I cannot separate the side effects. I am taking Requip for RLS and have read a lot of info about the increase in compulsive/addictive behaviors with Requip. I have gained 20 pounds since starting Cymbalta 3 months ago, this is in addition to the 40 pounds I've put on since starting Requip over a year ago. I can't isolate which one of the drugs is causing this. Food seems to take on a persona and calls to me. :) I have taken Trazodone for over a year to help me sleep, and I also take allergy meds that can cause drowsiness(Zyrtec and Singulair). Is anyone else on this particular combination of drugs? I would like to know if anyone has had similar symptoms. I feel better on Cymbalta. Wellbutrin just wasn't doing the trick anymore. I feel light-hearted, better able to deal with stressful situations, and other have commented that my mood seems much improved. The sexual side effects are difficult to deal with, but not enough to stop taking the F 36 3 months
7/17/2007
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 4  Depression, anxiety, back pain None really. I have been tired a lot lately, but that could be from the depression. I am not really sure. I honestly have not had any of the major side effects others have mentioned. Taking 30 mg for chronic back pain, and depression. It has helped take the edge off my depression. Not a "cure" but it does help. I have been fatigued quite a bit, however, I am not sure if the drug is causing it or just the depression. If I miss a day, I do have weird withdrawals though. Dizziness, brain zaps (look this up if you don't know what I mean) and just an out of body feeling. Taking an Omega 3, 6 supplement helps with these effects. If I didn't take this drug, I would be in my pj's all day sleeping on the couch. Depression makes me unmotivated to do anything at all, even socialize. Cymbalta will help you. F 30 5 months
8/27/2007
 4  Depression, anxiety nausea, loss of appetite, disconnected, a lot of hair loss I work midnights and I am taking cymbalta, 30 mg so far. I work 7 in a row and get one weekend off a month. I do not get enough sleep. It seems to help some but I still get anxious. I DO NOT like the hair loss part. My appetite is horrible. I go back to the doc next week and I am interested in seeing how much weight I have lost. I hope it gets better as I am on it longer. I am still concerned about the hair loss. F 31
11/3/2007
 4  OCD, Depression I have not noticed any side effects. I have severe spinal stenosis and spend most of my life in severe pain. I take 30mg Kadian(Extended release morphine) twice a day, oxycodone 5mg every 4 hours, Elavil 50mgs at night,Baclofen 10mgs twice a day. My depression is partly situational as I am no longer able to work. I have a wonderful husband and a large loving family but I LOVED my job as a nurse on an orthopedic/neurosurgical unit. Cymbalta helps me not want to kill myself for being such a useless waste of space. F 55 11 months
10/28/2007
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 4  Depression/Anxiety naseated in beginning, loss of appetite (first few weeks), sleepiness (never really went away), vivid dreams, loss of libido, weight gain Cymbalta made me feel "normal" again. It was a very good drug for me in the beginning, helped me focus, make decisions After several months doc increased dosage. Did gain weight (about 15 lbs while on it and 30lbs when I went off - Yikes!) Had to go off when i lost my insurance. Withdrawal wasn't too bad, I cut down slowly. A few brain zaps and a general feeling of "unwell" for a few weeks. Not nearly as dramatic as many people have described. F 35 8 months
11/6/2007
 4  depression, anxiety, stress loss of apetite, weight loss My crying stopped, less headaches, less stress and so I think this also helped improve my overall blood sugar control(type 1 diabetes with pump), can deal with things better. If I take it with food at night, it puts me to sleep in 20-30 minutes. Lost 12 lbs. in two weeks, but also taking Symlin. F 26 3 weeks
11/6/2007
 4  Depression Sweating, shaking hands,definitely "brain zaps" but only in the first few months. Weight loss F 46 10 days
10/25/2007
 4  Depression and anxiety. Yawning, which subsided after a few weeks. Itching, which comes and goes. Vivid dreams, which can be rather interesting. Decreased appetite, which is rather nice. Diarrhea, which can be extremely annoying, but I am figuring ways to minimize it (taking it on a full stomach is helping). This medication has changed my life for the better. I felt its positive effects within a day or two, and pressed through the initial side effects because I was so encouraged by the anti-depressive features. After one week on 30mg, my MD increased my dosage to 60mg. This did not help me! My condition deteriorated rapidly, at which point my doctor wanted to increase the dosage further. I insisted that 30mg was working wonders, and he reluctantly prescribed a 2 week course at 30mg. Well, that's where I've remained for 3 months now. I'm very glad that I persisted with my opinion regarding the dosage. The doctor still claims that 30mg is not even considered a therapeutic dose, but I know what works. I do continue to have digestive issues with Cymbalta, but through trial and error, am learning to minimize this. Taking it mid-day on a full stomach seems to be working for me most days. F 41 3 months
9/30/2007
 4  anxiety and depression No real side effects at 30 mg. At 60 mg for 2 days I am extremely emotional and feel like crying all the time. I am asking Dr. to let me go back to lower dose. F 43 2 months
11/4/2008
 4  clinical depression, suicide attemp vivid dreaming, acid reflux, urinary urgency I was in a state of constant panic, mental anguish, night sweats, insomnia, suicidal thoughts and one attempt BEFORE Cymbalta. I am now at 60 mg. and am sleeping at night, feeling more capable every day, no longer having heart palpitations and breathing problems that I was suffering during panic attacks. Cymbalta has helped me immensely so far. I hope I never again feel the way I was before starting drug thereapy. F 50 2 months
11/3/2008
 4  Fibromyalgia Because of my fibro, I have issues with sleeping anyway. But this does seem to make my mind race at night when trying to sleep. I'll have the same dream over and over again. Makes me tired the next day and I yawn a lot. I do not get tired when I take it. Loss of appetite. I like this as I've lost 10 lbs in a month. Dry mouth and constipation. Over all I notice this helping with my fibromyalgia pain. So the side affects are worth it to me. I like the loss of appetite part. I am on 60 mg a day. F 34 1 months
11/3/2008
 4  depression, anxiety, headaches Constipation, increase in acne, weight lose Was taking Celexa and it seemed to just stop working. I was also having severe headaches and an insatiable appetite while taking Celexa. Even though I dieted like crazy and worked out like a weight lifter I could not loose any weight. After starting on Cymbalta, I almost instantly dropped 10 lbs. I am still loosing about a lb a week, because my appetite seems to be normal. I do not over eat and I have been eating what ever I want, but in smaller amounts and feel satisfied, that was not the case before. I do not have any problems sleeping, but have noticed an increase in the vividness of my dreams. I am happy with this drug because I do not have the ever-present headache and am able to loose weight. F 40 6 days
9/8/2007
 4  depression hesitation to urinate(2nd week),weight loss(5-8 lbs),late period,increase in sex drive. I like the way I feel as compared to other depression meds I've tried,and my husband can see a difference in me in only a month. a few of the side affects are a pain in the rear end, but others are great! F 31 6 weeks
3/29/2008
 4  Anxiety Depression Nerve pain I sweat a lot at night, I actually do not look forward to going to sleep knowing I will wake up drenched. I also have crazy wild dreams that are violent and sometimes sexual. My body is much looser, more comfortable. I had seized up because I was so tight. I am happy I laugh and smile. I was very angry for a long time. I can function much easier. I like my job and husband better. My husband is very glad. Probably saved our marraige. Not sure I can stay on because of the intense dreams. F 49 5 months
2/26/2008
 4  Headaches, Anxiety During the first few weeks: dry mouth, nasuea During the first few months: persistent fatigue This medicine has really helped to control my chronic daily headaches. It has also significantly improved my anxiety. I was really struggling for a while with fatigue, but I've learned to manage it. I try to get at least 8 hours of sleep each night (I do wake up a bit becasue of my daugheter but I always go right back to sleep). I usually take a nap one day a weekend. If I sit still for long, I will get drowsy and want to go to sleep - so I try to keep active. There's never any shortage of stuff to do around the house and I don't feel tired while I'm actually going....it's only when I stop. I do still have daily headaches, but they're now more of a 2-3 rather than a 6-7, so I call that a huge improvement. I hope this drug can help you too. F 36 10 months
3/5/2008
 4  Fibromyalgia Fatigue, body temperature dysfunction (i.e. always having hot flashes or always chilled to the marrow; little in between). This is a miracle drug for me, calming my anxiety and easing my fibromyalgia pain. One of the best things I've ever taken in recent years. F 44 1 years
1/22/2008
 4  anxiety I see so many negative side effects. I have had some minor ones, but this is my first type of medicine ever taken. Decrease of appetite( which all women im sure dont mind!), a little pukish feeling the first week . 30 mg is good but with the 60 mg I am very pleased with the results. I am much more alert and aware of whats going on. It has helped with my fiance and I. I am not worried over EVERYTHING! I recommend it. I am also taking with lamictal for depression. I was very scared and nervous all my life taking medications because of the negative way people look at those that have emotional unstability. F 26 1 months
2/1/2008
 4  Depression Sweating, loss of interest in food, and sleepy at the wrong times. I see some improvement with depression (more content, don't wish I was dead, not weepy) and have enjoyed not obsessing over food. F 43 4 weeks
2/11/2008
 4  depression decreased libido (worsened as dosage increased), increased energy, jaw clenching I started at 30mg and noticed an increase in energy and elevated mood on the first day. Cymbalta helped my depression immensely, but after 5 months it started losing its effectiveness so I increased to 60mg and it worked again. After another 7 months it seemed to suddenly stop working and my depression worsened. I tried going to 90 and then 120mg but felt extremely hazy and had terrible headaches. The Cymbalta was great while it lasted, about a year, but now I am switching to Wellbutrin, specifically because of the lack of sex drive on Cymbalta. F 25 13 months
10/31/2007
 4  Bi-Polar, depression very tired..head fog. went from effexor to cymbalta. felt tingling for the first 5 days. I have been on it for 2 weeks and I have finally seen the light. I have been feeling really good. Mood is great. but I can tell when it is time to take it I get this tingling feeling,like when I turn my head my brain is a bit behind....but other than that its been good to feel like life is worth living again. F 45 14 days
11/24/2007

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