CYMBALTA Reviews (DULOXETINE)

Average Rating: 2.7 (2745 Ratings)

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 ANTIDEPRESSANTS

 Type: Rx Drug

  

CYMBALTA  (DULOXETINE):  Duloxetine is used to treat depression and anxiety. In addition, duloxetine is used to help relieve nerve pain (peripheral neuropathy) in people with diabetes or ongoing pain due to medical conditions such as arthritis, chronic back pain, or fibromyalgia (a condition that causes widespread pain). Duloxetine may improve your mood, sleep, appetite, and energy level, and decrease nervousness. It can also decrease pain due to certain medical conditions. Duloxetine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). This medication works by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in the brain.   FDA Approval Date: 2004-08-03 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on CYMBALTA: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR CYMBALTACOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 4  sudden anxiety/stress from work Hand tremors, sleepliness. (Take in morning instead at night.) I went to doctor due to extreme job bullying and then sudden (unjust) negative job performance evaluation and fear of being fired. Due to my uncontrollable crying and anxiety, I was first prescribed Lexapro. Lexapro made me too lethargic within first week, so Dr. precribed Cymbalta 30 in addition to Xanax to take at night. It helped extremely. 3 months later was fired unjustly from job, and depression started all over again. Cymbalta increased to 60. Xanax continued at night. Increase from 30 to 60 Cymbalta has helped me immensely. I have regained my desire to get up and do something, rather that just sit around and dwell on crap. You must take Cymbalta in the morning. Withdrawal is a concern, as posted by other reviewers. Did they withdraw "cold turkey" and not gradually? I hope to stop taking all medication, once I overcome present stressful situation. I'm hoping coming off this drug is not as bad as other Reviewers have described. In summary, Cymbalta has benefited me gre F 50 3 months
10/4/2007
 4  major depression Jaw clenching, insomnia, excessive yawning, tiredness & nausea if not taken with food. Most of these side effects diminished markedly after 2 weeks. I wanted to make a positive comment about Cymbalta as there is a lot of negative out there on the internet. I noticed a major improvement in my depression after 2 weeks. The side effects that I experienced were not debilitating, the only one that bothers me is the waking through the night but I think that's improving now. I do not get any negative effects if I take my dose a couple of hours late. This is the 4th antidepressant I've tried in the past 6 months & the first to give me any relief from my depression. I was put off by all the negative comments, but am glad I went ahead. I think people are more inclined to post on these sites when they've had a bad time with a drug than when things are going well. I gave it a 4 out of 5 as it's still early days, but I'm very hopeful; I was in a bad, bad way before Cymbalta... F 38 3 weeks
10/26/2008
 4  depression fatigue, sleepiness, carb and sugar cravings and quesiness. Feel a bit bloated and gassy, may have put on a few pounds but afraid to get on the scale. So, far after 7 weeks, I'm now up to 60mg for major depression. This is so much better than the Prozac/Wellbutrin cocktail I was on. Libido is coming back and am able to orgasm. I actually smile now and my sense of humor has come back. I am also able to read for awhile, something that I could not do before due to a lack of concentration. F 37 7 weeks
6/20/2005
 4  Depression First day nausea..but started taking with a ginger capsule, now no problem with nausea. I feel happier, less "blue" I do have problems sleeping thru the night (I'm writing this at 4:30 am) but am hoping with continued dosage, that will subside. I have noticed decreased appetite and leg twitching (can't sit still). Hopefully these side effects will subside after a couple more days/weeks. One other thing is dry mouth..none of these side effects bad enough to discontinue drug so far. F 50 8 days
10/1/2006
 4  Migraine, Anxiety In the first few days experienced nausea, loss of appetite and lethargy. I have lost over 15 pounds because of the decrease in appetite and have only had a couple of migraines in 2 months. Before I was experiencing at least 2 or 3 a week! I would have given it a 5 but do seem to still experience a lot of tiredness. I was taking Wellbutrin before for over 5 years and had weight gain and no change in headaches as well as increased anxiety. I now wish my doctor had given me the Cymbalta sooner! F 43 2 months
10/7/2008
 4  fibromyalgia, depression, pain increased blood pressure, initial bouts of insomnia/somnelence Took for one month and quit. I then tried it a few months later when I had time to "deal with" the sleep issues. Once it got in my system I was Ok. Most of my pain is gone thanks to Cymbalta. Hot flashes b/c of high blood pressure are still a bother. Paxil did nothing for my pain. F 24 8 months
7/30/2006
 4  depression/anxiety Do NOT suddenly stop taking this med. The withdrawal period is miserable. Brain zaps and severe personality changes - taper off slowly with help from a doctor. I tried to take myself off of it when my Rx expired, bad idea. But it did stop my emotional outbursts and crying spells. F 32 2 years
3/14/2007
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 4  mild depression/chronic pain Occasional acid reflux. Mild insomnia but that subsides when I take it in the early AM. Inability to achieve orgasm. This medication has worked wonders for me. I don't have stress headaches anymore. I'm finally loving life again and can cope with the chronic pain that I used to have. F 32 32 days
8/2/2006
 4  Chronic Back Pain/Mild Depression Extreme sweating, sleepiness, lack of appetite It has helped considerably with my back pain, I'm hoping with more time it will aleviate the majority of the pain in my back. My kids have told me I'm not so grouchy. So, that is a good thing. I'm just hoping this sweating will go away. Plus the 100+ temps. are killing me. I started taking it at nite and now I am having trouble sleeping at night. Hopefully it will taper off when I get use to the dosage. 60mg, just bumped up to that after starting on 30mg. F 33 2 weeks
7/19/2006
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 4  anxiety/depression yawning, major increase in sweating, and constantly hot, very difficult to achieve orgasm if at all; has helped anxiety, much more energy, hasn't effected my sleeping negatively, don't feel 100% better, but definitely better... Trying this after many other anxiety/dep meds... I'd say it's one of the best F 27 3 weeks
7/17/2006
 4  back pain /mild depression initially.. very dizzy and teeth chattering (like I had taken too much cold medicine) and nausea.. that all went away within about 3 days.. now i take 60mg. and the only side effect I would say "bothers" me is the terrible night sweats.. wake up drenched! having a hard time putting ON weight (I have had this problem most of my life.. just adds to it) After suffering with terrible low back pain for two years( 3 bad discs and annular tears) I found myself mildly depressed. Back doctor prescribed this and has definitely helped me to "deal" better and also helped with pain down my leg. I would definitely recommend it for those with similar symptoms. F 34 4 months
2/1/2007
 4  panic disorder and depression Weight gain,high blood pressure, lack of orgasim, sleeping during day, awake at night I had taken Cymbalta about 2 years ago. It was the only medicine that literally stopped my panic attacks and lifted my depression. However I experienced very high blood pressure and was placed on blood pressure meds, not knowing the Cymbalta was the reason. However after about 3 months, my blood pressure went back down. Not as it usually was, but I was able to stop the high blood pressure meds. I was on 60 mgs. Gained 30 pounds which cause a great depression in me as I was always glad I was able to keep my shape. It seemed to stop working so I went off it. I found out after going off it, that I was worse. Maybe it was the holidays that were approaching. I lost my son a few years ago and holidays are not good anymore. I tried Wellbutrin. Wow, great med that decreased my smoking to less than a pack a day from 2 packs a day. I was losing weight but could not handle the high anxiety. Shaking so bad I could not hold a glass. I had to stop it. The doctor and I discussed start F 54 3 days
12/29/2006
 4  Depression/Suicidal The withdrawal from Cybalta was SIGNIFICANTLY uncomfortable. I actually ended up in the emergency room because I had fainted. I was told that Cymbalta withdrawal can be as severe a narcotic withdrawal. If I missed a dose, I felt as though I had a strange "buzzing" in my head. I had a dramatic weight loss (20 lbs) due to decreased appetite, along with dry mouth and some sleep loss. F 50 2 years
7/5/2007
 4  Depression/Anxiety In the first couple of weeks the only side effects I experienced were yawning(could not stop) and dry mouth. both of these subsided after about 3-4 weeks. Now, after about 3 months or so, I have gained about 15-20 lbs since being on Cymbalta. My jaw also hurts alot from clenching my teeth all the time. I'm not sure if these are direct side effects from the drug but I have been experiencing them. Overall, a good experience. I would rather have the side effects than feel the way I did before. F 24 3 months
9/21/2007
 4  ANXIETY SLEEPINESS DURING THE DAY & FEEL OUT OF IT ALOT,SWEATING,SOME INSOMNIA AT NIGHT ONLY,WEIGHT GAIN ABOUT 40LBS IN A FEW SHORT MONTHS,CRAVE SWEETS LIKE A DRUG,CAN'T SEEM TO GET ENOUGH,ALSO HAVE TREMORS WHEN I WAKE UP IN THE MORNINGS OR AFTER TAKING A NAP..VERY THIRSTY ALL THE TIME,SOMEWHAT CONSTIPATED TOO,BUT OTHER THEN THOSE SYMPTOMS I'M GENERALY HAPPY ALL THE TIME AND I NEVER HAVE PANIC ATTACKS...I THINK THE DRUG IS A GOOD THING. I AM A LITTLE WORRIED ABOUT TRYING TO GET OFF THIS DRUG ONE DAY, EVERYONE SEEMS TO SAY THE SAMETHING ABOUT IT BEING HELL TO GET OFF..AND THE FACT THAT IT CAN CAUSE LIVER DAMAGE,AND ITS INCREASED IF YOU HAVE A BEER EVERY ONCE IN AWHILE... F 42 2 years
6/8/2007
 4  Depression, Social Anxiety, ADD Nausea, headache, loss of appetite, racing thoughts, increased social anxiety. I've been treated for major depression and anxiety for about 2 years now. I took Zoloft and Xanax for about 6 months, but the combination made me feel like Frankenstein. Since taking Cymbalta, my depression has gotten a lot better, buy my anxiety got A LOT worse. After 3 weeks, I had to start taking Xanax again to be able to leave home without crying. For the first month, I took Cymbalta in the morning because the doctor said it would make me wired. It actually made me really tired. Over the weekends, all I did was sleep. Now I take it when I get home from work, and although I don't sleep straight through the whole night, I have a lot more energy during the day. The combination of the Cymbalta and Xanax helps me be more relaxed and productive at work and at home. F 28 6 weeks
6/13/2007
 4  Neuropathic pain /spondylolisthesis Nausea & vomiting for first week at 30 mg then mild nausea for first few days at 60 mg. At 60 mg. I now have hot flashes, night sweats, and increased sweating during exertion Started at 30 mg which provided excellent pain reduction for 3 months. Increased to 60 mg. when it stopped working and it's working well again. Despite the hot flashes and sweating, it's well worth it for pain reduction. I have missed the occasional dose with absolutely no problems. I have a friend who's been on Cymbalta for over a year for diabetic neuropathy and he's had no problems at all. F 47 6 months
6/2/2007
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 4  Depression & Pain for CTS Oh it helped and was nice for the depression. Felt like a new person after 7 weeks but I only had minor depression (SADD) I took it at the time i was diagnosed with Carpal Tunnel It helped that so much. Gained 12lbs in 30 days after 7 months out of no where. Dosed down from 60 to 30 for 3 weeks. Today is day 4 off it and I HATE IT. The withdrawls make you forget all the good I took it for 8 months for depression initially. It turned out to help my carpal tunnel. Once I got over my seasonal depression, which by the way I was a whole new person on it after 7 weeks. I wasnt willing to give cymbalta up because of the help with my hand, until someone turned me on to B-6. I am writing because I decided to dose down, what I thought was dosing down slowly. They had me on 30 mg to start for two weeks then 60mg there after. I went to 30 mg for three almost four weeks. I went off completley this past Tuesday. Everything they say on the forums about the hellish withdrawls are true. The ones that say they dosed down even slower and lower dosages have the same problems. Just a little note of your not the only one. I didnt think I would ever want to get off of it either but I did. Now I am wondering what in the heck I was thinking. Oh it might have been the 13lbs i gained out of no where in less than 30 days before i started the dose down. The withdrawal sympto F 37 8 months
6/9/2007
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 4  Anxiety/depression Vivid dreams, Horrible nights sweats(drenched but cold), occasional clenching of jaw initially I was on Lexapro which worked really well except I gained a lot of weight so I switched to Cymbalta. I have lost the weight. I initially had a decrease in my appetite but it came back. My only complaint is the night sweats. It is very irritating. I have very vivid dreams but those don't bother me. F 26 5 months
5/4/2007
 4  back pain Sleepiness & yhanning. Debilitating muscle spasms in back. not possitive that spasms are from cymabalta but it does decrease sodium levels which inccreases the need for mor pottasium and lack of potassium cause muscle spasms.... F 39 6 weeks
7/26/2007

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