CYMBALTA Reviews (DULOXETINE)

Average Rating: 2.7 (2745 Ratings)

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 ANTIDEPRESSANTS

 Type: Rx Drug

  

CYMBALTA  (DULOXETINE):  Duloxetine is used to treat depression and anxiety. In addition, duloxetine is used to help relieve nerve pain (peripheral neuropathy) in people with diabetes or ongoing pain due to medical conditions such as arthritis, chronic back pain, or fibromyalgia (a condition that causes widespread pain). Duloxetine may improve your mood, sleep, appetite, and energy level, and decrease nervousness. It can also decrease pain due to certain medical conditions. Duloxetine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). This medication works by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in the brain.   FDA Approval Date: 2004-08-03 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on CYMBALTA: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR CYMBALTACOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 3  nerve damage in feet; depression Haven't noticed any side effects compared to the Prozac I took for over 10 years. But I've only been on 20mg for 3 weeks. Doc thought it might help my feet AND my depression. F 64 21 days
3/12/2009
 3  anxiety first two days: nausea, dry mouth, frequent urination, blurred vision, "bug eyed", unsatisfied yawning, fatigue, jitters, tackycardia, brain wanted to move but body didn't. days 3-14: constipation, yawning, fatigue. days 15-21: jitters, yawning, fatigue ok so i feel ok now that I got through the side effect stage. But i wanted to get to this point no matter what. Now im trying to see if this is helping me with the anxiety and I'm not sure. The first day i took it I laughed because I felt like i took a teeny bit of exstacy. My heart raced and I was nervous but I had this extra feeling that came and went that reminded me of exstacy. That only lasted a day though. I admit I was taking diet pills too so that may have had an impact on that. The constipation was only a day or two max at a time and I switched from taking it am to pm. I slept ok but still woke up sleepy. Sleepy and kinda jittery. I started out with only 15 mg for a week then 30 mg. after that once a day. I'm still waiting to feel results and so far I can only say that I'm happy to be at this point. I never got any crazy dreams or detached retina..but I wouldn't have minded that first day feeling a little longer. I gained weight on other medications..and I've trie F 24 21 days
3/12/2009
 3  anger outbursts, mild depression Nausea, buzzing through my body, stiffness in jaw, clenching teeth, blurred vision, no appetite, spaced out. I took my first 30mg cymbalta at 6 a.m. and by 7.30 a.m. my mouth was watering with a tight feeling, I felt quite nauseous. At about 9 a.m. I was dry reaching. It's now 8.30p.m. and I feel like my body just doesn't want to do what my brain does....spacey. After reading all the comments, I am quiet scarred to continue and will go back to the Doctor. F 44 1 days
3/20/2009
 3  back pain (neuropathic pain) extreme mid-day sleepiness, loss of sex drive, loss of motivation to excercise, loss of motivation in general, mild weight loss (which is a plus, I suppose) On my Dr.'s advice, I went on Cymbalta instead of taking 2 Alleve daily for my chronic back pain. I also get quarterly epidurals for my back pain, and have a standing prescription for Vicodin which I use very sparingly. Cymbalta has definitely helped with the daily pain, but the mid-day sleepiness in so overwhelming, many times I wonder if it is worth it. I now take Provigil to combat the sleepiness. My dose is 60 mg. Cymbalta. Overall, Cymbalta works great for pain but makes me really sleepy. F 41 8 months
3/6/2009
 3  depression/anxiety yawning, watery eyes(from yawning), runny/stuffy nose(from yawning), jaw clenching, tooth pain(from jaw clenching), slightly hyper, but yawning is the one i experience the most. I've taken it in the past and recently started again. It works well for me. It eases my frustration and anxiety. I let things roll off my back when i need to whereas before I couldn't. The one side effect that I'm relieved to hear that other people have is the yawning! I'm yawning constantly even while typing this. It's causing my runny/stuffy nose, watery eyes/blurred vision, and the weird thing is I'm not sleepy!! I just yawn. What causes this???? F 20 6 months
3/22/2009
 3  anxiety IBS At first just head tingling in my right side. Jaw clenching made worse. IBS better but terrible smelling gas at times and Belching. First two weeks nausea not hungry. Sweet cravings. I have lost 8 pounds in 4 weeks. I take it in the morning 60mg and have energy all day. Restless leg type jitters. No outburst on hudband or kids anymore. Feel Well and calm but take ativan in the late afternoon to relax. Oh I also crave beer sometimes is weird. Oh ya really sucky thing is hard to have orgasms. I am going to try to stick with the drug at least for 6 months it really seems to help. Hopfully then I can go off and keep the ativan for daily use. F 33 5 weeks
3/29/2009
 3  fibromyalgia/headaches My side effects have been minimal, shakes at night when I wake up to turn over, mild sweats, dry mouth. Have had some bouts of constipation. I used to hurt all the time, I would freeze to death in a building/vehicle that had the a/c going. My fingers would be freezing, and they would get a numbing/tingling feeling. I have only been on this medication 8 days, I slept good the first two-three nights that I took it, but the next 2 nights, I would wake up, go to turn over and would just shake uncontrollably. I have low tolerance to depression medication, I have panic attacks but so far, I haven't had any of these on this medication. Right now, relatively, sleepness, mild sweating and dry mouth are all that is occurring, the shakes have stopped for now. This has really helped me with the pain, I haven't had a headache since I've started taking Cymbalta, 30 mg at bedtime. If this doesn't work, I don't know what I will do. I've tried everything that I can think of. Will keep trying this and hopefully, these side effects will gradually disappear. The first night I took Cymbalta, the next day I had goosebumps all day long, but F 47 8 days
9/12/2008
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 3  NEUROPATHY F 77 1 days
9/5/2008
 3  fibromyalgia None yet, just started and am here trying to learn how others fared. F 51 0 days
7/31/2008
 3  anxiety and mild depression no bad side effects when i started taking it. only withdrawl symptoms after stopping. after finding out i was allergic to paxil my dr. put me on cymbalta. just called in the rx for me, didn't bother to explain the drug to me at all. I started off at 30mg a day, after 3 days I felt a noticable difference. I wasn't irritated all the time, very calm, almost oo calm like i didn't care about anything. After 2 weeks I was pretty much emotionless. I told the dr. how I felt and I was put on 60 mg! This made me feel like I was loosing my mind. I took 60mg for only 2 days then went back to 30 mg for a few days, then stopped taking it all together. The withdrawls weren't too bad.....headaches, sweating, bad dreams, and crying spells. i'd rather have to go through anxiety attacks than feel like an emotionless zombie all day. F 24 1 months
8/31/2008
 3  Major Depression, Anxiety, & Pain I really need help on what is a good time to take this medication, since my doctor told me to experiment ?????... I have migraines but had before the Cymbatla was on Paxil which I had to be weaned off for a month so I was taking both medications, now they are regular headaches, NIGHTMARES that are so real not monsters... but people around me and they are so real I have to wait when I wake up to realize it is "just a dream?" My Doctor told me I have to experiment when I take it , so who better then people who are actually are on Cymbalta? Please let me know what you found is a good time for you, to avoid some of the effects. I have gained 4 pounds may not be related but, I am trying to lose weight so please any comments on the weight, headaches, dizziness, tiredness, & nightmares, what is a good time to take it? Would be so greatly appriciated! :) Thank you so much! I have been on Cymbalta 60 mg per day for almost 2 months. Seems to help a little with the nerve pain in my hands, my back and neck it is hard to say because... I still have to take pain medicine, seems like I am taking less pain medication? I also was on Ambien for sleep and now that Cymbalta is in my system seems I do not need it at this juncture? So that is some good news I have been on everything for depression, but now that I am feeling better I want to lose weight I have heard mixed things about Cymbalta please send me your comments on that or any other issue. Thank you :) Since my accident 12/03 , which let to a doctor who is no longer parcticing medicine did a "non invasive" prodedure on my neck 5/06 called a cervical percutaneous discectomy this almost killed me and made my pain worse, but I am so lucky to be alive and walking, so since Cymbalta is prescribed for pain too please if you are ever offered this to relive pain RUN to another doctor! There is not much r F 34 2 months
9/17/2008
 3  fibromyelga pain F 50
6/3/2008
 3  Depression/Bi Polar EXTREME constipation!!! Initially had dialated pupils - looked like I was on Meth - Quit, reintroduced to my system by gradually increasing dosage - this worked... Other than the constipation... I loved this medicine! I no longer felt like hiding from crowds, was confident enough to express my feelings (calmly too)...However after about 6 months I had to stop taking it - that goes to show you how BAD the constipation was - was even taking presecip laxatives - am on Wellbutrin now and it's not giving me the side effects, but does not help with mood/anxiety NEAR as much - F 40
6/14/2008
 3  borderline pers. , fibromyalgia severe constipation for over a week, teeth grinding, immediate weight loss and loss of appetite I loved the weight loss, but stopped taking this because of the horrible constipation. It DID help with my anxiety/depression however immensely and with my fibromyalgia. I may go back on it because the other choices don't seem so great. F 29 5 months
7/15/2008
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 3  Fibromyalgia, Anxiety, Depression Catatonic, no emotion. Severe palpitations and irregular heartbeat. Stopped taking it and two weeks later still irregular. Seeking cardiovascular treatment. It DID help combat fatigue. I was able to function physically like a normal human being again for the first time in years, but I had no emotion whatsoever. F 37 7 days
7/16/2008
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 3  Depression loss of appetite, weight loss, nausea (subsided after a few days) I switched off of Prozac after being on that for around 2 years or so. I was hit with a lot of side effects of Cymbalta. My psychiatrist wants to now switch me to Zoloft. The loss of appetite and weight loss was one of the main side effects I had, I am already underweight, and losing weight isn't good for me F 18
6/16/2008
 3  depression, anxiety I take 120 mg/day. If I don't take it I start withdrawl on day 3. it is awful. I start getting waves of pressure in my head, am unable to think and get very crabby with my kids. I also get lightening bolts of numbness across my lips (best way to describe it). I also feel like everything is unreal and I have to really work at behaving normally. I have also gained weight. I still feel depressed and anxious so I'm not sure if it is helping much. I've tried almost all other antidepressants and frankly I don't know if any of them worked. I don't know if I could survive total withdrawl from this med. Be very careful about your decision to take this drug. Really think about it. I'm glad to read that it has helped some people. Just do'nt let your prescritpion run out. F 42 10 months
7/8/2008
 3  Depression, mood stabilizer Night sweats, "brain zaps" if dosage missed, slight weight gain (1-2 lbs.) Currently withdrawing from 60 mg of Cymbalta, taken 1x daily (at night). Also taking 30 mg. of Adderall. I stopped the Cymbalta cold turkey about three days ago and, for me, it has not been particularly oppressive. Granted, I haven't been taking it very long... only about 4 months. Also, I've taken anti-depressants for years, so I'm familiar with the "brain zaps" that come with weaning off various medications. Compared with coming off Clomipramine, this withdrawal is a walk in the park. In all, the Adderall has been extremely helpful and I did not notice much improvement in mood with the Cymbalta. I'm still tired all the time. So now my doctor upped me to 10 mg of Adderral XR 3x daily and put some Lamictal in the mix (25 mg to start... eventually up to 50 mg). Please, before stopping taking a medication though, talk with your psychiatrist. Stabilizing mental health is a long, excruciating battle---I've been there, suicidal and all. But you have to keep on going. And, you cann F 36 4 months
12/30/2008
 3  Dysthymia Wellbutrin XL stopped working for me after 6 years. Cymbalta was the 2nd antidepressant my doctor had me try, after Celexa failed to help. On 60 mg Cymbalta daily, I had some nausea at first which went away after a few days. I also had a day or two of mild, somewhat interesting visual alterations, particularly at night; sometimes, lit objects would go dim as I looked at them. This visual weirdness went away after 48 hours. Cymbalta caused extremely dry mouth which lingered throughout the trial course. Cymbalta altered my orgasms; climax took much longer and was less intense. The worst side effect was severe restless leg syndrome which disrupted my already crummy sleep. I had some samples of Requip and Mirapex I received from my sleep doctor, which did help the RLS. However, my psychiatrist did not think it wise to add another drug to treat a side effect of this drug, and took me off Cymbalta. My dysthymia manifests as apathy, cynicism, lack of motivation, head-to-toe body, joint and muscle aches, dyspepsia/IBS, overeating, physical and mental fatigue, word retrieval difficulty, 'brain fog', insomnia, and a generally unsociable, 'bah humbug/grumpy old hag' attitude. 60 mg Cymbalta daily helped my IBS a lot and modestly improved my mood, attitude and motivation. Cymbalta reduced my aches and pains by about 50-60% (Celexa actually worked better with a 90% reduction in pain). Cymbalta did not worsen my insomnia and may have even helped a bit. I was able to enjoy a cocktail or glass of wine in the evening without problems. Unfortunately the negative side effects outweighed the benefits. I was able to stop Cymbalta cold turkey with no problems, but I also immediately started taking Pristiq and I've remained on Wellbutrin XL, which may have minimized any withdrawal symptoms. F 46 4 weeks
1/17/2009
 3  Fibromyalgia Initially, sweating was terrible...I would literally soak my bra and would have sweat beads above my lip and on the tops of my hands. Not as bad after a year, but still having to wear clinical strength antiperspirant. My weight has always been low, but since using Cymbalta I have gained about 8 - 10 lbs. (especially in my waistline) Haven't weighted this much in 23 years...literally! Reducing calorie intake doesn't change my weight. I don't know about other side effects because I have symptoms similar to my fibromyalgia (and its preceding cause). YES! It DOES cause weight gain...at least is has for me. But when you are "small" to begin with, no one listens. All they say is you need to gain weight...even if it's not natural for you!! So, it seems to me that if a drug has this side effect, it should be acknowledged no matter how much you weigh to being with. F 43 1 years
1/14/2009

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