CYMBALTA Reviews (DULOXETINE)

Average Rating: 2.7 (2745 Ratings)

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 ANTIDEPRESSANTS

 Type: Rx Drug

  

CYMBALTA  (DULOXETINE):  Duloxetine is used to treat depression and anxiety. In addition, duloxetine is used to help relieve nerve pain (peripheral neuropathy) in people with diabetes or ongoing pain due to medical conditions such as arthritis, chronic back pain, or fibromyalgia (a condition that causes widespread pain). Duloxetine may improve your mood, sleep, appetite, and energy level, and decrease nervousness. It can also decrease pain due to certain medical conditions. Duloxetine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). This medication works by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in the brain.   FDA Approval Date: 2004-08-03 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on CYMBALTA: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR CYMBALTACOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 1  Chronic Fatigue and Depression Hot Flashes (thought I was going through menapause at 30), weight gain, insominia, axiety, zero sex drive, fatigue worse and depression seemed worse. Muscle aches and pains got much worse. I agree with everyone who says stay away. I am going on 6 days off Cymbalta and I am still having severe flu like symptoms. I can't seem to eat anything, loose stools, tired, headache. And for the first time I have felt severely depressed. I want to cry at the drop of a hat and keep crying. This drug is sooooo not worth it and at least for me did not live up to promises F 30 9 months
10/31/2007
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 1  Fibromyalia / depression Extreme exhaustion, feeling like I am not in life but out of body looking out. constipation, sleeping 18 hours a day and just depressed. PLEASE THINK TWICE BEFORE YOU TAKE THIS MED!!! I have had Fibromyalia and Neuropathy for 25 years and heard that Cymbalta is a life saver because it helps with the nerve pain and the depression that goes along with have the pain 24/7 so I thought what the hell I'll give it a shot. The first 2-3 weeks were heaven. I can't tell you how good I felt for those few weeks. Then one day I woke up with no energy and just felt tired, really tired. I chalked it up to the fibro and the doc told me to go up from 20mg to 40mg. I was also taking it with Elavil which I have been told you should never do. Anyway it has been 2 months and I have never felt worse in my life. My pain is all over my body and it takes every single cell in my body to get up in the morning. I HATE THIS DRUG AND I WILL GET OFF OF IT NO MATTER WHAT THE WITHDRAWALS BRING. I have a trip to HA to plan and I still don't have the energy to do that so you know it must be bad. F 3 days
11/6/2007
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 1  Situational Depression I took my first 30mg capsule of Cymbalta an hour before bedtime. That night I felt like helicopter rotors were going off in my head. I didn't sleep the entire night. I was wide-eyed and anxious the entire night. My stomach hurt, too. The next day, I felt hungover and spaced out and the next day, too. The doctor prescribed this antidepressant to help me with situational depression and osteoarthritis. I couldn't take it due to the horrible side effects. It took a few days to get Cymbalta out of my system. I never made it to a second dose. Nothing and I mean nothing would make me take a second dose of this drug. I have switched to Lexapro and so far I've had fewer side effects. I have a small frame and I was able to cut the Lexapro in 1/4's to take a smaller dose. You can't cut a capsule of Cymbalta in half. I am taking 2.5 mgs of Lexapro in the morning and sleeping great at night. This weekend I am upping the dose to the 5 mgs. Hope it works. F 53 7 days
7/11/2007
 1  Depression Not being able to express thoughts or remember words. After 4 months, it seemed to stop working. I became weepy and had intrusive thoughts of "who gives a shit! I'm outta here! Be here doesn't matter, we all suck" as in suicidal but not seriously, (I knew it was the brain chemistry being off). It seemed to still help with pain as it did immediately after taking it but the depressing thoughts seemed huge. Doc tried to tell me that I couldn't feel it right away and that it couldn't just stop working...right. I'm tapering off and it sucks...I was on 60 to 30 to 20 every other day. After two weeks I tried to do 20 then go two days without...not a good idea, I boo-hooed myself to death but at least knew what was going on. I'll stay at 20 every other day for two more weeks then go down a notch. That's the only bad part for me...no other weirdness...yet. Tapering because Lamictal seems to help me better. F 50 10 months
7/11/2007
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 1  Depression Cymbalta only work for short period of time (months). After nearly a year, I started to feel very very weak and easily tired. My doctor and I decided to stop taking it. The withdrawal side effects especially brain flashes or brain zap was VERY PAINFUL even though I tapered off the medication . I would NOT recommend taking this medication. The withdrawal side effects is worse than the starting side effects. I felt like a drug addict that could not function without the medication. F 33 1.5 years
7/16/2007
 1  neuropathy imbalance, confusion, erratic gate, sleep disorders, altered states, blurred vision (all the time) ringing in ears, weight gain, sleep without rest, I was on cymbalta for 18 months and I would not reccomend cymbalta to anyone, for any reason. I have been in withdrawl for almost two months with no end in sight. If one symptom lets up another one starts. I am confused, off balance sufferes from asphasia (severly was hospitalized) and was asked to take dissability from work for appearing "stoned." I am 59 do not take drugs have never taken drugs. I fear the damage will be permanent and pray every day it will stop. F 59 18 months
7/30/2007
 1  Depression Brain zaps; grinding my teeth; night sweats; constant shaking of my hands and limbs; not being able to stop my Head going into tremours; insomnia; constant fatigue; headaches; hair falling out; forgetfulness; sore jaw etc - you name it I got them all badly ! I think it is the worst thing I have ever taken - for almost a year I have tried to take it hinking it would help or blaming my body for the effects and now I have come to realise it is this drug / poison. I think people should be warned and that surely after all the blogs about Cymbalata that are negative that the Testing results of this drug should be investigated. Some blogs have hundreds of negative comments - something doesn't smell right - how did this pass clinical trials ? I am now trying to wean off it am in my second week of hell. F 33 11 months
9/5/2007
 1  major pain and anxiety and no energ night sweats, weight gain, dry mouth, constantly urinating, major and I mean major hypoglycemia, hand tremors and dizziness. When I first started taking cymbalta, after the first week and getting it in my system I was excited that I had finally found something that was working. I had took effexor for 9 years and had major complications with it...mostly hypoglycemia which would put me in a sugar stupor and that was scary. I wouldn't be able to move or anything until I got something in my system to balance my sugar. I swore I would never take another medication like that and here I am again. I have developed major side affects after all this time and am back to being major hypoglycemic again. I feel that all depression medications have this side effect and I am determined to get off of this medication and start taking the natural route. I know it will be hard because it was horrible coming off of effexor. I had buzzing noises in my head, no energy, nervousness and irritability and many other side effects from withdrawal symptoms. In fact, I have been trying to get a class action lawsuit started from ef F 50 2 years
5/17/2007
 1  mild depression, appetite control Profuse sweating...hot flashes, drowsy all of the time, brain fog, inability to concentrate, loss of sex drive, weight gain, constipation, muscle cramps, eye floaters...just to name a few. When I came off Cymbalta I had the worst side effects I could've ever imagined...it's been a few weeks and still have horrible effects...extreme muscle fatigue and muscle cramping and elevated liver enyzmes (no pre-existing liver damage or alcohol use/abuse,) just to name a few. My md is now completing more test and questioning if I have fibromyalgia or MS due to the test results and symptoms. These seemed to have been initiated after stopping the drug but symtoms did not exist prior to taking them...anyone else having these effects, if so, what was your outcome or did the symptoms go away? I can barely walk up a couple of stairs without a deep burning and fatigue within my muscles. Just curious of how dangerous this drug is and if I'm the only one with these problems. F 35 5 months
5/15/2007
 1  Anxiety Severe night sweats, vivid nightmares, migranes, digestive problems, dizziness, WEIGHT GAIN I am having a HORRIBLE time getting off Cymbalata. I have had horrible headaches, severe insomnia, nightmares, bad night sweats and--worst of all--on the days I don't take it, I am SO dizzy, it's like being drunk and underwater at the same time. I can't drive or balance (I do yoga but can't lately) and I am completely spacy and nauseous. F 28 5 months
8/2/2007
 1  Anxiety & Depression OMG only been on it 2 days and its horrible.I feel like i am speeding and paranoid when i drive. Please be careful this is a VERY powerful drug. I also have teeth grinding, hands shaking, my eyes look wired and my mouth urrrg i have no taste buds left dry and burning yuk. And after reading about the side effects of coming off i think i will stop now. I have had all the usual anti-depressants in the past but got myself off them all for the last 4 years and was taking a natural herb Holy Basil and that's it i am going back to that and my would rather stick to my lorazepam just 1mg a day takes all the fear and anxiety away. I only went on because of my life situation but no way i would rather take the above stuff than Cymbalta any day. F 38 2 days
9/16/2007
 1  Excessive Sleeping. Loss in family Complete loss of sleep, panic attacks, racing heart beat. Throat closed and had to go to ER. I have never felt more out of my head then on this medicene! Initally, I felt great- totally in control of my life. But the more that I took it the worse I got. I had horrible rage where I wanted to just lash out and break something. Sometimes I feel the desire to pull at my skin (altough I dont do it, it is constantly racing through my head). I was off of it for two days and even though never have cotemplated suicide, I was suddenly overwhelmed with sadness to the point where suicide seemed like a very logical and normal answer. I immediatly called my doctor. This stuff is BAD NEWS. I am working quickly to get it out of my system. F 36 6 weeks
5/22/2007
 1  Depression Insomnia, severe nervousness, disorientation, dizziness, heavy feeling, stomach upset, drowsiness, vision problems. Similar to a very severe case of the flu. I had been on Prozac and Lexapro for years. I was off all meds for the last 7 months. Doctor gave me samples of 30 and 60mg. Told me to begin with the 30mg at bedtime with a meal. Took it around 7:00 PM. Did not sleep all night. By morning I was nauseous and shaking. I tried to get out of bed and could hardly stand. I had dizziness and felt like I was going to fall over. Unable to go to work because I couldn't function enough to get dressed. When I called in to tell my boss I wouldn't be in he told me the following day that during that one call I cried, laughed and was angry. They were worried about my mental state. I hardly remember making the call. Finally fell asleep and slept the whole day and the next night. I only took one dose and will never take it again. F 57 1 days
8/16/2007
 1  mild depression suicidal thought, loss of appetite, sleeplessness, agitation,anger it needs to be taken off the market. F 24 2 weeks
3/29/2007
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 1  Depression, Anxiety Withdrawl-MAJOR flu, profuse swetting, brain and body zaps, total confusion, body pain, extreeme mood swings, bouts of uncontrollable crying, dizziness, weight gain, impaired speech, impaired motor skills, unable to put my thoughts together, upset stomach, jaw and tongue tightness, nightmares, night sweets, joint pain, headaches, swelling/puffiness cymbalta has MAJOR withdrawl symptoms not disclosed by lily or the doctors prescribing it. It did seem to help somewhat with the depression, but the withdrawl from stopping is far worse than the benefits it brings, go with a different medication, and not effexor, it is the same way. F 31 4 days
3/30/2007
 1  MDD & Anxiety. Extreme hot & cold sensations,Extreme sweating, Extreme apathy Extreme daytime sleepiness with insomnia, Extreme, extreme, extreme depression,Confusion & disorientation, Memory loss, Nausea, Severe mood swings, Suicidal ideations THIS DRUG IS A DISASTER!! PLEASE DON'T TRY CYMBALTA!! I have been treated for MDD on and off for over 20 years. Have tried just about every SSRI out there and have never, ever, experienced "side effects" anything like this. Cymbalta may work well for some people. But when it doesn't work, well, I firmly believe it will cause many suicides before the FDA wakes up. Had it not been for my extremely understanding and supportive husband, and finding another site (check out healtdiaries.com for more Cymbalta info.), I might not be here. I have never felt this mentally "ill" in my life. F 44 1 months
4/24/2007
 1  Fibromyalgia, depression Acute diarrhea, nausea, blurred vision, restless energy. I'd taken this drug for 5 days total (20mgs), suffered through adverse reactions for 4 days, then stopped. Withdrawal difficulty very real even after 4 days: shakes, disorientation, nausea, blurred vision. Couldn't wean off the drug since I was already at lowest dosage. But, I had felt some reduction of fibro pain and a week later, with some sense of desperation, decided to try it again. This is my 1st day back, and it will be my last. Acute diarrhea again. After reading this web site, I'm certain that effort is NOT WORTH THE RISK! F 53 5 days
3/1/2007
 1  depression Cymbalta initially made me feel agitated. My doctor thought that perhaps I was under medicated, so he increased my dose. I then started to feel manic. I had hot and cold chills while taking this medicine; I felt like I had the flu the whole time I took it. I also lost my ability to have an orgasm! I stopped taking this medication and now am back to normal, orgasm and all. I was told that this drug was great, that many people were doing well on it, but sadly, it did not work well for me. F 40 28 days
3/15/2007
 1  mild depression suicidal thought, loss of appetite, sleeplessness, agitation,anger it needs to be taken off the market. My 24 year old neice committed suicide while taking Cymbalta. Im planning on sueing the company for directly causing her death. Many people have committed suicide while on his horrible drug. Alot of families of victims have filed a Class Action Lawsuit against Eli-Lilly for their incompetence. Justice for the many victims of this death drug. F 24 2 weeks
3/29/2007
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 1  depression Major sweating at night. Had to change my clothes about five times a night. Very sedating and I was in a brain fog most of the time. Too spaced out to be depressed. It took me days just to get simple things done. I am now getting off this useless (for me) drug. In weaning myself off it, my brain is doing the weirdest things. I feel dizzy a lot, and I have this sort of white noise noise in my brain much of the time. It's been almost a week since I stopped and I can't wait until this drug has left my system. I can see now how zoned out I was and I'm looking forward to just being me again, without any drugs. The only drug that ever worked for me was Prozac, but that stopped working after about five years. F 41 5 months
3/29/2007

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