CYMBALTA Reviews (DULOXETINE)

Average Rating: 2.7 (2745 Ratings)

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 ANTIDEPRESSANTS

 Type: Rx Drug

  

CYMBALTA  (DULOXETINE):  Duloxetine is used to treat depression and anxiety. In addition, duloxetine is used to help relieve nerve pain (peripheral neuropathy) in people with diabetes or ongoing pain due to medical conditions such as arthritis, chronic back pain, or fibromyalgia (a condition that causes widespread pain). Duloxetine may improve your mood, sleep, appetite, and energy level, and decrease nervousness. It can also decrease pain due to certain medical conditions. Duloxetine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). This medication works by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in the brain.   FDA Approval Date: 2004-08-03 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on CYMBALTA: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR CYMBALTACOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 3  Anxiety, Fibromyalgia Dry mouth, dull headache (for about the first 2 weeks), reduced sex drive, feeling out of it (sometimes numb), tired all the time but not able to sleep for long periods or through the night, vivid dreams, weight gain regardless of cutting calories and exercising, poor memory, loss of words, dizzy/nausea if I get up too quickly or turn too quickly, KILLER heartburn. I started taking anti-anxiety drugs when I went into menopause. I have severe symptoms. I take the meds 30mg in the am and pm because I am unable to take large doses at once. I was on Effexor XR and was doing great. I did so well my PCP took me off. But I only cut down to 1 a day when the anxiety attacks started again. So, I went back up to 2 and they didn't work. I went to a psychiatrist that told me I should never have been taken off and sometimes when you come off and you try to go on again, it doesn't work...it didn't. F 54 4 months
1/21/2009
 3  depression/anxiety constipation, rapid weight gain, zero sex drive, too long to orgasm and then orgasm was weird(no sensation/feeling???), blurred vision, headaches, cant not sleep yet sleepy all the time, hand tremors, yawning, at 4 weeks-decreased appetite, and increased of all of the above.... depression is gone, yet so is almost all of my feelings in general. husband very understanding, is happy I am not so nervous and grouchy, yet I feel so "sick" all of the time. If I gain anymore weight, I will have another depression. I am currently on 60mg daily, I want to go on 30mg daily, and see what happens. F 42 1 months
1/23/2009
 3  Fibromyalgia, radicular pain, HA's 30-40 lb wt. gain, initial vivid nightmares, extreme constant thirst, dizziness, flat affect, complete loss of sex drive, continuing migraines- post concussion syndrome ha's unrelieved, dizziness, brain "zaps", and probably more that I've not yet even realized. I started Cymbalta after being on numerous antidepressants for Post concussive migraines, as well as leg pain from low back problems & post-op lumbar surgery. I would very much appreciate anyone who would like to discuss via email of this drug- or many others I've also had severe reactions to! (I need to find a support system) as I'm an RN, and been through a lot as I see many others as well have. Forgot to refill and had horrible withdrawel- flu-like, vomiting, vertigo etc. lasting for days. Got back on the med and leg pain greatly relieved. 40 lbs. later and I've decided to stop the med. I've always been a bigger person, now I'm obese and on BP meds as well. Trying to slowly become drug-free, very hard! Hoping being off of Cymbalta will help greatly! F 44 1 days
1/24/2009
Email
 3  Fybromyalgia sweats, fatigue F 4 years
2/12/2009
 3  Fibromyalgia Reduced my daily pain pretty well. However I started having pain in my right side all the time. I could not tell when I needed to urinate except my side would ache more and thats how I knew. Lose of appetite (lost 7 pounds, yay!). Withdrawl is HORRIBLE!!! I've never had suicidal thoughts until I tried to wean myself off this drug. Headaches, vomiting, insomnia, bouts of crying for NO reason. I'm taking Zoloft now which is really helping to get me off Cymbalta. I've always been a happy person. My friends say its impossible to be sad around me. Not on this... F 26 6 months
2/10/2009
 3  anger, mood swings, fybromyalgia dry mouth, blurred vision,tired, constipated this is my 7th day, I started with 30mg, now on 60mg I don't feel angry anymore, actually feel calmer than I did before. I think I feel better with the pain. It just makes me feel different. Will write again in another week F 48 7 days
2/10/2009
Email
 3  fibromialgia Vivid Dreams, hot flashes (not related to menopause),dry mouth, insomenia (1st few months), olfactory hallucinations, increase in sweating with a very unique unpleasant odor that only I can detect (olfactory hallucinations or a heightened sense of smell either way it is unpleasant). Irritatiability and less patience. Weight loss initially and now weight gain. Cymbalta when first taken gave me increased energy, relief from fibro pain and diabetes related foot numbness & tingling and weight loss so it was worth the insomia that I first experienced, I had found the right medication finally and recommended Cymbalta to persons who suffered fibro. After about 4-5 months the hot flashes, sweating, and olfactory hallucinations started. There have been pros and cons to my experience with this medication but the cons are starting to outweigh the pros so I plan to wean off of it in the coming months under my physician's care. F 50 1 years
1/24/2009
 3  fibromyalgia Weight gain, periods of anxiety, did I say weight gain? severe dry mouth, hot all of the time I have been taking 30mg. Cymbalta for 13 months. Dr. first gave me 60 mg. and I felt horrible. Flat, zombie-like. No sex drive. Reduced dosage did better. Sleep better, ache less but now have gained over 10 lbs. Never had weight problem before. It seems the benefits are decreasing and the side effects are increasing. Made a dr.'s appointment to check my options. F 55 13 months
2/4/2009
 3  Migraine, Nerve Pain, Anxiety Tiredness, apathy, irritability, loss of appetite, lack of motivation and interest Taking 30 mg's and at first it was helping with the anxiety but then stopped. It may be helping some with reducing the frequency and severity of my migraines, but I just don't feel right on it. I was not depressed before taking it, but now I feel down all the time and unmotivated. It is certainly not giving me the lift in mood I would think it would. Paxil helped immensely with anxiety in the past, but caused me to gain a lot of weight. This drug at least has not caused any weight gain for me, in fact I have lost a few pounds. I think I'll give it another couple of weeks and then go off of it which I am not looking forward to based on the withdrawal I've read about. F 43 3 weeks
11/9/2008
 3  longtermdepression/dysthymia,anxiet nausea & dizziness at first, then, headaches, night sweats, excessive sweating overall, constipation, no sex drive, inability to orgasm, weight gain, incredibly vivid dreams, ability to sleep for up to 12 hours or more without feeling rested, chronic fatigue I have been on the maximum approved dose of Wellbutrin for two years. About a year ago, my psychiatrist decided to add the Cymbalta. The first day I took it was a complete nightmare. I felt like I was drugged. I could not eat without throwing up, my head felt like it was detached from my body, and it felt like I had tunnel vision and what I could see was "floating". Those symptoms only lasted 1-2 days, but they come back if I ever miss a day and then take it again the next day. I am not sure if the Cymbalta has actually helped my depression or not, and my doctor is switching me to Abilify starting within the next several weeks. What I do know is that the side effects of Cymbalta have been awful, and I've finally decided I can't deal with them any more. I am currently still taking the maximum dose of Wellbutrin, plus 90 mg/day of the Cymbalta. Soon after starting the Cymbalta, I started noticing that I was getting headaches every day, around the same time. In f F 27 11 months
11/14/2008
 3  Possible Fybromyalgia, Anxiety On day 2 of my 30mg dose I did notice that I felt a little "floaty". Things just didn't seem right. And I woke up several times at night wide awake. I don't feel refreshed today. After reading all the comments I'm a little concerned about taking it anymore, but I think I'll stick it out to see if my irritability goes away. Every little thing that goes wrong makes me blow up. And it seems it's all day long. I don't have any good thoughts so I'm hoping that will change. I'd like to laugh again. F 46 2 days
11/7/2008
 3  depression and anxiety Cymbalta works well with my Adderall - I don't notice as much when the Adderall runs off. However, due to my ADD, I tend to either forget to pick up my prescription or send it in on time before I run out of my Cymbalta so I have experienced the withdrawl symptoms. They are intense. The first day my brain gets foggy and I start to get more "emotional." The second day I started to get vertigo (intense dizziness, almost like I'm drunk) which gets worse and worse the more days I don't take it. I've only gone up to a week without taking it because I finally figured out why I was getting so dizzy..I didn't pick up my prescription haha. Stupid ADD. I've only been on it for a couple of months now at 30mg and didn't want to increase to 60mg as the doctor said I should do eventually. However, I feel like I need to increase in order to get better results because I feel like I'm not as in control with my emotions as I should be. F 20 4 months
4/21/2008
 3  depression It works fine with depression but the withdrawl is horrible. If I go one day without it I feel completely out of it. Almost like an out of body experience or drunk( but not in a good way). I cry, get irratable easily and will sleep all day with the withdrawl. I go through bad withdrawl with any med but with cymbalta it is bad. Also very vivid dreams and sweating Good with depression but with me personally the withdrawl comes hard and fast! F 22 1 weeks
4/10/2008
 3  fibro possible weigh gain F 62 3 days
4/8/2008
 3  Continued terrible working conditio Increased sweating 25+ pounds weight gain Fuzzy thinking Loss of interest in sex F 58 1.7 years
4/22/2008
 3  Depression Profuse sweating, dry mouth, constipation, migraines, weight gain of 40 lbs in 6 months, severe acne on face, and top back. This really helped with my depression and getting my life back but the side effects are becoming very bothersome as my weight and acne increase so...I will be asking the doctor to change my med. therapy. F 36 6 months
11/16/2008
 3  Depression, Fybromyalgia pain Still having some depression. Not sure why. Still having much pain so not sure it is helping although I'm afraid to stop for fear that my symptoms may get worse. I have been taking it for less than a year. F 64
1/3/2009
 3  pain, anxiety and depression Hot flashes, sweating, severe vertigo, dizziness, stomach problems (no nausea, but other sensations like stomach flu, diahrrea, awful gas), tiredness, spacey feeling My Dr. prescribed Cymbalta for all the reasons stated. It did help me. My back pain was better, I had no waves or flashes of anxiety, I was happier. But....when I had been taking it for 6 mos. at 40 mg., the severe vertigo and dizziness started one morning. I thought I was having a stroke. All of these side-effects were just too much for me, so the Dr. decreased my dosage to 20 mg. I did okay going back down to this dosage, no worse problems. The vertigo stopped and the other side-effects have decreased by half, except for the hot flashes and sweating. I am not as tired. I will stay at the 20 mg. for the time being. I will say that in all my years of taking prescription drugs, I've never taken one that has so many harsh side-effects as Cymbalta. I hope this entry will help someone as this website has helped me. Good luck to all of you. F 63 7 months
1/20/2008
 3  Depression/Anxiety I've been on this medication for years. Major constipation; fiber does not help. Confusion is really bad, lack of concentration is very bad. Short term memory loss. Loss interest in doing anything. I can sit for hours day in and day out with no interest in usual pastimes. I lost touch with all my friends because I have no interest in seeing them. However, I have no anxiety while taking the medication. Is it worth it? Helped me with anxiety. I don't think anything helps with depression. I've taken one medication after another for 20 years. F 61 3 years
1/19/2008
 3  depression, anxiety Very vivid dreams (not nightmares); teeth clenching; sleepy all the time and I can sleep hours and hours if I let myself; increase in blood pressure; weight gain of 10+ pounds over a period of months; night sweats (extreme -- I wake up with sheets and hair and pjs soaking wet, in the middle of winter, and then I am freezing!). After awhile, good (intended) effects started to wear off. I do think this drug helped me for awhile, but after several months I don't feel it is really helping anymore. I've tried lots of different antidepressants and at least in the short term, this one helped the most. I'm now tapering off (at 90 mg dosage, now down to 30 after 2 weeks) as I don't feel I'm getting benefits anymore and am tired of the side effects (even though overall they really aren't severe). I haven't had any bad effects going off except mild migraines every couple of days. I'm ready to find out what I am like when not taking anything -- I have had so many over the last 3 1/2 years. I might try a naturopathic route. Thanks for everyone's input and info; it does help to know I'm not just imagining things! F 40 8 months
12/31/2007

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