CYMBALTA Reviews (DULOXETINE)

Average Rating: 2.7 (2745 Ratings)

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 ANTIDEPRESSANTS

 Type: Rx Drug

  

CYMBALTA  (DULOXETINE):  Duloxetine is used to treat depression and anxiety. In addition, duloxetine is used to help relieve nerve pain (peripheral neuropathy) in people with diabetes or ongoing pain due to medical conditions such as arthritis, chronic back pain, or fibromyalgia (a condition that causes widespread pain). Duloxetine may improve your mood, sleep, appetite, and energy level, and decrease nervousness. It can also decrease pain due to certain medical conditions. Duloxetine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). This medication works by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in the brain.   FDA Approval Date: 2004-08-03 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on CYMBALTA: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR CYMBALTACOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 1  GAD PVC's, Urinary Retention PVC's gradually subsided but lasted for a couple months, also noticed I wasn't emptying my bladder completely. When I gradually came off, it felt as though I emptied my bladder for several days! Also, SWEATING....I'm off for several days and sweat at the slightest move. Would NEVER recommend. F 57 4 months
30 1X day
4/25/2010
 1  depression, anxiety flu like symptoms, disconnected with family, zombie like The feeling is horrible from this drug. I want to feel the way I did 4 days ago, and after only being on it for 4 days, I'm not taking it any more. I feel worse from the side affects then I did from my depression. I cannot beleive they put this drug out on the market to put people's minds in a zombie state. Wish I never took the first one. F 51 4 days
30 mg 1X day
5/1/2010
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 1  fybromyalgia Lightheaded, increased appetite even when felt full, "light switch" effect, where it felt like an electrical current would speed through my body, decreased urine output - I couldn't hardly go. Withdrawl increased light switch effect and was HORRIBLE!!! The withdrawl was terrible and I was told there were no withdrawl symptoms. I have talked with some people who like this med. It was terrible for me...BE CAUTIOUS...they can't even explain HOW it works. Look up the parent company and see how they triied to pull off a very similar drug that ended in a recall. F 35 3 weeks
30 1X day
5/1/2010
 1  Depression This worked great on my depression. However I couldn't stop eating; especially sweets. I gained 30 lbs. in 7 months. But the side-effects coming off were worse: numbness and tingling in my arms and hands that never went away, nightmares, and shortness of breath. I don't know what to do about the side-effects that happened once I stopped taking it. The doctor didn't seem to have any answers. Any suggestions? F 48 7 months
30 MG 2X day
4/28/2010
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 1  herniated discs- nerve pain POISON!!!!! Sick from day one, stopped a wk ago and still sick! a wk later!!!nausea, runs, flu like, sea sick feelings, dizzy, no appetite. This drug ruined my birthday, mothers' day as I've been home bound for over a wk now. I'll take my chronic pain anyday over this drug! no more meds for me! stopped my one a day hydrocodone now too! I've never believed in meds and deal pretty well with 5 herniations and fusions w/o meds, meds don't cure, they are just a "band aide" - no more of their "trials" on me! if one gets this sick in only 3 days, what is this drug doing long term to our brain????? Poison- nausea, runs, headache, dizzy, no appetite, horrid withdrawals!!!! F 54 3 days
30 mg 1X day
5/9/2010
 1  depression shaking of body uncontrollably, nausea, headache, dizziness weknees , cannot walk, poor eyesight, can not think straight depression is worse. this is a horrific drug I strongly suggest NO ONE GETS ON IT. the withdrawal symptoms are magnified in what i just said. F 80 1 years
60mg 1X day
4/11/2010
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 1  Depression/chronic pain First-time-ever migraines, nausea, vomiting. 1.7.10: 20mg, 1.27.10: 30mg, 2.18.10: 50mg, 2.23.10: 60 mg. No help for mental or physical pain. Side effects began 3 days ago. Symptoms start like clockwork 2 hrs after taking med. Have to break up capsules now to wean myself off of this gradually to avoid withdrawal symptoms. Doc won't respond to my phonecalls about this development. F 55 55 days
60 mg. 1X day
3/2/2010
 1  Fibromyalgia, Depression I was extremely nauseated and debilitated and had had similar reaction to gabapentin-something else they put me on. I'm not going through that again. I read so many negative comments on this website that one day is enough to know-forget it. I've been detoxing my body and now also see a naturapath. We weren't made to have all of these chemicals in our bodies. It is amazing when you get rid of this stuff, how reduced pain can be. I never expect to be pain free but am trying to change my life to pace differently and not have to be "Superwoman" any longer. Medications can poison you and many of you sound as if this did just that. I'm not going through that again. Thanks to all of you for helping me make the decision to stop before I really got going. F 56 1 days
1X day
3/5/2010
 1  depression and anxiety episodes PROFUSE sweating, dryness in mouth, increase in irritability, insomnia, vivid dreams, sharp pain right side of body (liver?), muscle pain and increase in reflux pain, constipation Doctor suggested cymbalta, as I began to become more anxious on lexapro. Some nausea in early days. In second week, the sweating started...unbelievable! Totally drenched at times throughout day and night, withour rhyme or reason ie just relaxing and sweating would start...sweated through pillows, clothes...very embarrassing at times. I had to carry paper towels in bag to dry my wet hair, especially around neck and face. I am being weaned off cymbalts, then doc will try something new. Look, I don't expect anti d's to be totally side effect free...but the excessive perspiration was unbearable. F 60 3 months
60 1X day
3/12/2010
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 1  fibromyalgia Caused muscle damage to my leg. The withdrawal was horrific! I had atrial fib, intense itching with blistering, diarrhea, mood swings, with a suicide attempt, vertigo, brain zaps, headache, dizziness,joint pain,the list goes on. The drug should be taken off the market. This lasted for over four months and put my family and myself through torture! F 63 2 years
120 mg 1X day
3/25/2010
 1  Fibromyalgia, back pain, depression I thought I had come down with the flu... felt hot and sweaty like I had a fever, bad headache, no energy, irritable, frequent bms, pain like IBS. Also, such deep sleep that urinated while dreaming. It got worse and I just assumed I was sick with a virus for 4 days. No interest in people, felt like I had PMS. Then I realized it all began when I started the new medicine. I stopped two days ago and feel fine. I'd been on Lexapro, low dose, for years but still had back pain and some fibromyalgia so hoped Celexa would be better. But I felt terrible on it and will go back to the Lexapro and get more regular exercise, stretching, and try cumin capsules for anti-inflammatory effect as recommended by my physical therapist. F 64 6 days
30 1X day
3/20/2010
 1  depression symptoms increased anxiety/panic attacks which I never had before, sleepy all the time, still. Inability to concentrate at work due to anxiety or tiredness. Had to start taking .5 mg Xanax at least twice a day for the feeling of heart racing/anxiety. Started on low dose and increased dosage about every 2 weeks until I got to 120 mg. Increased dose would only help a few days and then I would go back to same symptoms and just have a good day every once in a while. Did not like taking Xanax, but "had" to take it for the feeling of heart racing. Fincally came to my senses that Cymbalta is not working and only made things worse. Back to square 1 with my doctor to slowly switch to Wellbutrin. Wish me luck. I am so sick of not feeling myself. I miss me! F 43 2 months
120 1X day
3/17/2010
 1  for Bipolar Depression At first I thought it helped. I ended up gaining 20 pounds, had no interest in sex, tired all the time, body would ache all over, joints hurt daily, abnormal orgasms, became a recluse in my home, horrible anxiety. 10 days ago I decided I had enough. I stopped taking this and boy have I been sick. It feels like electrical impulses running through my brain, leg cramps, rapid thoughts, nauseous, can not sleep more than 3 hours a night, horrible nightmares, sweating, i hear sounds in my head like a radio, i am miserable. F 33 2 years
40MG 1X day
4/5/2010
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 1  depression Worked great at first. Now I feel naseous, get bad headaches, anxiety is worse, I'm meaner, irritable, feel like I have pms all the time. I have horrible gas and have at least 3-5 bms a day. Makes me more hungry. Don't take it. F 31 4 months
60 mg 1X day
3/28/2010
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 1  Depression I have just completely weaned myself off Cymbalta and have been "Cymbalta free" for 4 days. Thank God because the negative effects (while taking it and withdrawal from it) far outweigh the reason for using it in the first place. While on Cymbalta (14 months) I was more aggressive, angry, prone to drinking alcohol, argumentative, (would say things I would never say in a million years to anyone) had severe mood swings, crying jags, stronger urges and feelings toward suicide, constipated, digestive problems, severe weight gain, did zero exercise (after being a health nut and avid exerciser for over 25 years) lethargy, didn't want to get out of bed, weird dreams when I did sleep, fatigue, no interest in anything, isolated myself. The list goes on and on. I went on line and found out that these symptoms and others that I didn't list but also experienced were common. I rather be depressed and in shape rather than fat and nuts. This drug should be taken off the market. As withdrawl symptoms keep me occupied right now, I am so glad there was info on line and most of all that I am not crazy!! The "brain zaps" that I am currently experiencing is not a stroke or brain aneurysm waiting to happen. I am hoping the lethargy leaves so I can clean my house and get myself in shape again. I am taking my life back. Cymbalta leaves you like a zombie. F 55 14 months
1/31/2010
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 1  DEPRESSION/ANXIETY AWFUL SIDE EFFECTS, FLU LIKE SYMPTOMS, COULDNT GET OUT OF BED FOR 3 DAYS, FINALLY HAD TO STOP TAKING THE MEDICATION. IT MAY BE GREAT FOR SOME PEOPLE BUT I HAD A HORRIBLE EXPERIENCE WITH IT. WHAT I CAN IMAGINE DRUG WITHDRAWELS TO BE LIKE IS WHAT I WENT THRU. I DONT REMEMBER CERTAIN PARTS OF THE PAST 3 DAYS...I FEEL LIKE I WAS IN A DARK HOLE AND FINALLY GOT OUT OF IT THIS MORNING. F 28 4 days
1/29/2010
 1  depression being forgetful, ANGRY, sleepy, weight gain, lack of care. The first time I tried Cymbalta, I thought, this might work even though it made me sleepy; I thought that symptom would go away. Not only did it not go away, other things started to happen. I became very 'spacey' and forgetful of very simple things, in the middle of conversations, I would just forget what I was saying. The worst for me though was the anger I felt. I am normally very mellow and avoid conflict, however, I found myself picking at people, becoming so angry about everything. Finally, some dear friends and my husband let me know the changes they were seeing and thus started the decision to stop taking the drug. It isn't worth it to me. F 51 3 months
20mg 1X day
2/8/2010
 1  Fibromyalgia, anxiety Weight skyrocketed from 145 lbs. to over 200 lbs. Personality went from positive, sunny, and cheerful to becoming a complete BITCH!! Sorry for that declaration but there is no other way to describe this major side effect! There's more; spending with no abandon, charging up credit cards, and not remembering what exactly was it I purchased. It gets worse: suicidal thoughts, planning to go through them, and beginning of heart trouble. Withdrawal--a nightmare I never wish to go through again--try lightning strikes in your head and incoherent thinking. DO NOT TAKE unless under very close supervision from your doctor!! Be on the look out for any strange changes in behavior and never, never, take it personally if your doctor or any of your loved ones confront you with your changed demeanor. Any thoughts of harming yourself--call 911 immediately and accept medical treatment graciously. In withdrawal, insist on very close medical supervision, hang in there, and vow not ever to take mind-altering medications ever again. I'm now presented with a second chance at living and I do not intend to throw it away. If nothing else, I shall be happy to be living and welcome being able to fix my mistakes and my family and best friend's forgiveness for being so bitchy and vindictive to them. F 44 6 months
60 mg 2X day
2/11/2010
 1  bi-polar/anxiety extreme vertigo/dizziness, headaches, brain "shocks", extreme fatigue, unmotivated, dull thought process cymbalta worked great while on it, but missing even one dose is where the problems begin. i have been off cymbalta for 7 days now and i regret ever going on it. i worked with my doc to ween off, yet i still have not been able to function as a mother or wife. the vertigo/dizziness is unrelenting! i still can not drive a car or even stand too fast. if i move wrong my body "zaps". i believe most of you know what i mean. i have began crying for no reason. the only good news from stopping cymbalta is i have motivation to get going, too bad i physically can not do much but lay on the couch, wishing i could do dishes without falling over. unless you plan on using cymbalta for the rest of your life, stay away from it! F 29 1.5 years
60mg 1X day
2/24/2010
 1  fm and anxiety very sick. awoke with fluid diaharea, thick confusion, symptoms for a day like the bad part of l.s.d. experience, restlessness, chills for a full day, went from couch to bed, couldn't sleep, had to be absent from work, nausea and vomiting, terrible thoughts, extremely dizzy, headache and eye ache, hit by a bus feeling, stopped drug and wonder if it will cause brain problems continuing, a fuzzy pressure remains in back of brain this following day. Yuck!! not for me!! F 61 1 days
30 1X day
2/21/2010

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