CYMBALTA Reviews (DULOXETINE)

Average Rating: 2.7 (2745 Ratings)

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 ANTIDEPRESSANTS

 Type: Rx Drug

  

CYMBALTA  (DULOXETINE):  Duloxetine is used to treat depression and anxiety. In addition, duloxetine is used to help relieve nerve pain (peripheral neuropathy) in people with diabetes or ongoing pain due to medical conditions such as arthritis, chronic back pain, or fibromyalgia (a condition that causes widespread pain). Duloxetine may improve your mood, sleep, appetite, and energy level, and decrease nervousness. It can also decrease pain due to certain medical conditions. Duloxetine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). This medication works by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in the brain.   FDA Approval Date: 2004-08-03 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on CYMBALTA: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR CYMBALTACOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 4  Depression Mild dizziness and diarrhea the first few days. Vivid dreams. Oddly warm hands. Sometimes I get a cool, "menthol" feeling up my spine and down my arms. Inability to reach orgasm. Has reduced my depression a great deal. I've tried many medications over the past 10 years or so and never gotten this much relief. I'm not all the way where I'd like to be, but for the first time I feel that I'm better and making progress. I can tell a big difference from the drug. F 44 7 weeks
5/9/2006
 4  depression/anxiety/stress nausea at the beginning, sleeplessness, now I am gaining a lot of weight People around me have definetly noticed a positive improvement in my mood and I myself feel better (beats Paxil - do not EVER take that stuff!) I am concerned though that I have gained 19 pounds in the last three months (have been taking this for about 6). It all seems to be centered in my stomach area, which is getting bigger by the day, despite not changing anything about my regular diet/exercise habits. F 30 6 months
6/17/2006
 4  Fibromyalgia, depression Brain buzz if even an hour late taking dosage, weight LOSS of 10 lbs, insomnia (I take Ambien for it), increased energy, decreased pain, Cymbalta brought on jaw grinding which I never had a problem with before, spasms in my feet and decreased libido. Pretty emotionally void. I started on 60mg but I was wired so the Dr. decreased the dosage to 30mg, which has worked wonders for me. It particularly helps with my fibro pain and has given me my energy back. I would NOT recommend taking an opiate with Cymbalta; I took Darvocet and it quickly got less effective so I took more and more often-got addicted-NOT good! I am off Darvocet now, which I did cold turkey (thank GOD!) and I have much better days. After reading the ratings here, I hope I never have to go off Cymbalta-the withdrawal sounds like hell. F 50 2 years
6/23/2006
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 4  Major depressive d/o In the first two weeks on 60 mg, I experienced some nausea, mild to moderate feelings of hypomania, mild anxiety. I have also been urinating two to three times more on a daily basis, experiencing much more bowel activity. Two persisting side effects that are quite distressing to me are that I've become completely anorgasmic (never had a problem with this in the past), and my hair started falling out. I was on 60 mg of Cymbalta for 1 month; after I talked to my doctor about the side effects and my unhappiness re same, we agreed to reduce my dosage to 30 mgs daily to see if any improvements might occur. I've been on the 30 mg dosage for two weeks, and the hair loss and sexual dysfunction continue. Although Cymbalta began to reduce my depressive symptoms within the first two or three days I started taking it, and it has been more effective in that respect than any other antidepressant I've taken (including Trazodone, Prozac, Zoloft, and Wellbutrin XL), I don't think I'll continue taking it. I'm not interested in going bald, nor do I want my sex life to evaporate altogether. Now my biggest concern is being able to stop taking it. From multiple comments I've read on online from many others who have taken and then stopped taking Cymbalta, it sounds like a nightmare. I'm still on Wellbutrin XL, which stopped working for me over a year ago, but will probably stay on it while I'm &quo F 48 50 days
9/4/2006
 4  chronic pain (vulvodynia) Severe stomach pain for the first 5-7 days at 30mg. Slight stomach pain for the first 3-5 days at 60mg. At first, I couldn't tell if it was working; it took a couple of months to be completely effective. Since I began taking Cymbalta, I have had an 80% reduction in the amountof time I am in pain, and when I do have pain, it is much less severe. I was also able to stop taking my migraine preventative (Topamax) and am experiencing less anxiety. F 27 8 months
1/26/2006
 4  Depression, Anxiety Nausea, rash (may or may not be from medicine), loss of appetite, constipation, some dizziness, lack of sex drive; nausea and dizziness went away after 1.5 weeks on 20mg, came back for a few days when I moved up to 40mg. Still have everything else. It's worked for me so far. I'm willing to deal with itchy skin and not eat if it will get rid of the depression. I was on Paxil throughout high school, took a break from meds and then couldn't stand it anymore. On Cymbalta, I'm more comfortable in social environments, not as anxious about everything, have more get up and go. I don't space out like I used to, it's easier to pay attention to what's going on around me, I don't stay in bed all day anymore, I can do things like a normal person. After reading other comments, I'd say it's definately not for everyone, but no medicine is. Also, stopping a medication without consulting your doctor first is dangerous, not to mention dumb. I tried it with Paxil, and the first day I didn't take it I passed out during a volleyball game. It wasn't the drug's fault, it was mine. F 21 3 weeks
8/16/2006
 4  Depression/Interstitial Cystitis I'm having headaches almost every day and some nausea (not sure if it's from the CYmbalta or the Elmiron). My head feels a little funny once in a while. Sometimes my legs and arms feel funny, not tingly, but hard to get them moving sometimes is the only way to describe it. Someone mentioned weird surges like sticking your finger in a light socket, that's what Lexapro did for me, I was so scared to shut my eyes for days until I figured out that's what it was from. However Cymbalta doesn't do that to me. F 24 1 months
10/25/2005
 4  major depression/anxiety headaches (which have gone away), bruxism (teeth grinding/jaw clenching), loss of appitite, weight loss, heartburn started taking 30mg about 3 weeks ago after being on wellbutrin for close to a year. wellbutrin was great at first, but i noticed a decline in it effectiveness even with an increase in doseage. in addition, i gained more than 25 lbs while on it. since taking cymbalta, i actually feel normal again, despite the few side effects, which are going away. some days i have heartburn (which i've never had before!), dry mouth, diarhea or constipation on a daily basis, gas, and had terrible headaches the first 2 weeks. the side effect that has been by far the worse has been grinding my teeth at night and clenching my jaw during the day. i did not have this problem prior to taking this. in my third week now, the headaches are gone or at least more manageable when i have them, my teeth grinding/jaw clenching is getting better, i actually HAVE energy to do things again (!!), i'm not as irritable, don't get angry or panic over the 'small stuff', and best yet, i am losing the weight i gained on wellbu F 35 3 weeks
11/4/2005
 4  depression, migrains, ptsd,anxiety, first night no sleep, second night same thing, but with a headache, ibuprofrin worked to rid the headache. not sure what i feel yet. dry mouth. bloated , no apatite.gas. i feel ok one moment then not another, just need time to see. i am afraid of weight gain and hair loss, loss of libido etc.clonzapam helps the anxiety and trazadone helps me sleep. i almost feel as if i need to take this drug in the morning rather than at night, as i get tired in the afternoon and awake all darn night., F 26 5 days
1/30/2006
 4  fibromyalgia pain sleepiness in afternoon, bad taste in mouth, nausea if not taken with food Starting feeling differences about 2 weeks into the full dosage. While not pain free, I am feeling much better. I take 60mg in the morning as well as Nortriptylene at night - they work well in the pair. F 26 3 months
3/4/2006
 4  depression, neuropathy For the first two weeks I was very nauseous. After the two weeks the neuropathy pain subsided and had a loss of appetite which was a good thing for me. I continue to lose weight right now I have lost thirty pounds in about 8 months. My mood is better I now get excited about things that are good. I do have sleeplessness but, I am willing to deal with that in exchange for the pain, weightlose and the feeling of happiness. 8 months F 42
2/4/2006
 4  Depression and Anxiety The first day I took the drug I had insomnia, and couldn't sleep due to brain activity taking place and body adjustment. Experienced some pressure in head, nausea, butterflies in stomach feeling, and headache. Side effects are going away second day. Think this drug is great for low side effects Great drug for depression, anxiety and OCD. The first day I took the drug I was amazed at how fast it started working. I was suddenly happy about everything and smiling all day. It was almost difficult to be sad about anything. This drug works wonders. For those who don't know about cymbalta, it is a great anti-depressant with low side effects, at least for me. I recommend this drug to anyone suffering from depression. THANKS CYMBALTA! F 27 2 days
5/11/2006
 4  FIBROMYALGIA AND DEPRESSION I LOVE IT!! I do get dry mouth and some insomnia but my overall mood is so much nicer. I don't hurt near as bad and don't mind the insomia. I had insommia anyway. I have some great nights of sleep and others I am awake but in a peaceful state that doesn't seem to bother me. I dont' feel drugged just better with more energy like I felt at 30 years old. F 59 4 months
5/15/2006
 4  Fibromyalga and depression Night Sweats, lack of concentration and spacy feeling-living up to the dumb blonde sterotype Since starting it 2 years ago I have left my husband of 20 years. I definitley have an "I don't care" attitude and things that used to be important to me simply don't matter anymore. I'm scared to go off of it because it helps my muscle pain so much-I don't want to go back to lying in bed all day. F 47 2 years
5/22/2006
 4  FIBROMYALGIA AND DEPRESSION I LOVE IT!! I do get dry mouth and some insomnia but my overall mood is so much nicer. I don't hurt near as bad and don't mind the insomia. I had insommia anyway. I have some great nights of sleep and others I am awake but in a peaceful state that doesn't seem to bother me. I dont' feel drugged just better with more energy like I felt at 30 years old. F 59 4 months
5/15/2006
 4  chronic depression I'm new to it (2 weeks) but am already experiencing clarity and weight loss (app. 5 lbs). I switched from 225 mgs Effexor to 60 mgs Cymbalta, and the difference is striking. Feel much more upbeat and motivated. Some difficulty with orgasm and dryness, but very minor. Very happy about the weight loss -- still trying to lose the 15 pounds I gained with Celexa 3 years ago. Very hopeful this will work. I've tried Prozac, Celexa, and Effexor -- all with happy initial results but eventual dissatisfaction. F 30 14 days
5/17/2006
 4  severe depression I can't tell what the side effects are because I take other meds. It helped me to know the benefits can ware off after a while because that happened to me. You know how depression is, I wondered if it was in my head. Thank you When I started I felt great. I was so excited because I han't felt well for years (had a major set back 3-4 yrs ago.) Not only felt good it gave me hope. Then after 9 mos. it stopped working. I just thought I was going through a lull in depression. I'm glad to know I'm not the only one. F 39 1.3 years
12/16/2006
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 4  GAD and Depression Lack of eating, foggy feeling, drowsey, sexual drive is way to low..My poor husband. Helped inprove my memory and panic attoks F 33 4 months
10/30/2006
 4  Depression/Anxiety ADHD When taking at night, Cymbalta caused insomnia something awful. I would have heart palpitations and awake 3-4X a night. My doctor switched my dosage time to morning and I noticed a world of change. My only symptom now is sweating (clammy feeling). My mood is a serious one with some laughter. I wonder if anyone has figured out how to find the return of the "fun” and "carefree" side of themselves? Great drug! Initially I felt as if I was "awakened." This seemed to subside. Don't know if I am used to it or it is no longer effective? F 30 3 weeks
9/17/2005
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 4  10 years of depression/anxiety/ocd have only had one dose but am suffering from intermittent nausea and could not come to orgasm tonight. (Kinda hard to feel sexy when your stomach is rolling around) I will be interested in what happens in the next weeks. If there is any way I can feel better and be a better partner and mom then I want to try it but I'm not sure I want to give up sex. I'm also taking Wellbutrin with the Cymbalta. F 49 1 days
11/28/2006
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