CYMBALTA Reviews (DULOXETINE)

Average Rating: 2.7 (2745 Ratings)

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 ANTIDEPRESSANTS

 Type: Rx Drug

  

CYMBALTA  (DULOXETINE):  Duloxetine is used to treat depression and anxiety. In addition, duloxetine is used to help relieve nerve pain (peripheral neuropathy) in people with diabetes or ongoing pain due to medical conditions such as arthritis, chronic back pain, or fibromyalgia (a condition that causes widespread pain). Duloxetine may improve your mood, sleep, appetite, and energy level, and decrease nervousness. It can also decrease pain due to certain medical conditions. Duloxetine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). This medication works by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in the brain.   FDA Approval Date: 2004-08-03 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on CYMBALTA: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR CYMBALTACOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 4  Anxiety and Depression tiredness, inability to orgasm, the first week: a feeling of being in a fog I'm on 30mg of Cymbalta, and I'm already feeling the effects. Apart from the tiredness, I'm actually happier and I've had less anxiety, which is great. I just wish I could get my libido back! It's kind of unnerving when you're in a steady relationship and you can't "get there." I haven't felt many side effects, so I'm giving it a while. I'm hoping I stay like I am. If not, I'm definitely switching. F 18 10 days
3/17/2009
 4  Depression/Anxiety "Dream Zone", each night when I start going to sleep, I reenter the "dream" I was in the night before. I never wake up naturally feeling refreshed. For first 4 months, I had to fight to stay awake after 3PM. If I could I would go to sleep and sleep from 3:PM until 9:00AM the next morning. I started taking Welbutrin with it and now (3rd month with Wellbutrin) not as sleepy during the day but still have days where (just not every day) I could sleep +15 hours. Tried to take at night, but kept forgetting to take. The additional "heat" is nice in the winter. The increased smelling is not so good nor is the slight visual hallucination. This drug gave me less severe side affects than many others, so I stayed on. I just wish I could get out of the "dream zone". F 46 4 months
3/4/2009
 4  Depression constipation(still working through that), mild nausea (now gone), sleepiness I switched over from Prozac in an effort to combat my anxiety. Remarkable result with Cymbalta after only 2 weeks on 60mg. NO ANXIETY, NO WORRIES! I used to worry about everything. I feel much more centred. Like others, I feel somewhat lethargic and disinterested but I think that's part of my depression and will ease off once I reach steady state in about 4 weeks. Worth a try..I REALLY love the weight loss. 5lbs in two weeks without trying..just decreased appetite. F 41 2 weeks
5/6/2008
 4  Major depression In the very beginning I had headaches, they have subsided. Low libido. I started taking 30mg daily for a week and then increased to 60mg daily. I am also taking it with Wellbutrin XL 300mg (should eventually wean off of). So far things are good. No major problems at this point. F 44 1 months
4/30/2008
 4  fibromyalgia pain, anxiety a little nausea in the beginning but just a couple days. VERY tired in the beginning as well. Still somewhat tired after 3 months. Difficult to have orgasm. wish I had started it years ago. F 46 3 months
5/4/2008
 4  Anxiety and Depression Profuse sweating, hair loss, insomnia Anyone taking 90 milligarams? Took cymbalta 60 milligrams for a couple of years. Depression increase and was placed on 90 milligrams which last for a couple of years. I take ativan as needed for added anxiety which seems to help. Lateley I have noticed more severe depresseion, I dont really like to be areound people. I have insomnia but dont like to take the ativan for sleep every night because it is addictive. I have taken the drug this long because I dont feel drugged and can concentrate on this drug better than any drug that I have taken. In the past on this drug I felt fairly happy and motivated. Lately feel depressed and tired although I cant sleep at night. I have been on prozac zoloft paxil lexapro and none to compare to the cymbalta up to now. Now i feel so tired of it all and depressed that I rececntly had a breast biopsy that was benign( although the lump still has to be removed) and i kink=d of wish that it was cancer. becouse of my religion i would not kill myself. I F 55 5 years
9/11/2008
 4  fibromyalgia & ME nausea, loose bowels, absent minded, bit of a sweaty betty lol!......lack of orgasm, fatigue but thats normal for me anyway! been on in for about 3 weeks rhumo guy wanted me to try it.....have to say its the best thing i have ever tried, the pain re-fibro is hardly there now and i can function again...altho there are side effects they are nothing in comparison to the pain so there fore i am loving this ' wonder' drug...obviously my mood has lifted too, i was apprehensive as i had done research on the net prior to taking the drug ....but it is working for me, i have missed taking the tablet a few times due to been forgetful on it..however i did not experience any other side effects, so i am lucky really, the only thing i have noticed apart from the minor side effects is the sex part however thats no big deal and a small price to pay to be out of pain, i guess!! F 37 21 days
9/28/2008
 4  depression Major weight gain, 30 lbs in 2 years Works great for my depression, but caused excessive hunger leading to a 30 lb weight gain in 2 years. My doctor took me off it 4 days ago and immediatly switched me over to Wellbutrin XL the next day. I have been having terrible withdrawl symtoms almost immedatly after stopping the med, dizziness, headache, nausea, sweating, I went back to the doctor today and got Cymbalta 30 mg tabs (I had been on 60mg) and now are being weened gradually while still continuing the Wellbutrin XL. After taking the 30 mg tab this morning I already feel much better. Be careful coming off this, it is a very powerful drug. F 40 24 months
10/1/2008
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 4  anxiety I LOVED Cymbalta. I had energy for the first time in 10 years, my anxiety was gone. I would have rated it a '5', but exactly at the six weeks' mark...I started with severe diarrhea and it lasted until I finally quit taking Cymbalta a month later. I've tried to gradually re-introduce the Cymbalta at a lower dose twice since then, after 1 month rest for my 'gut'...but the diarrhea starts back immediately. I would love to know if anyone else has had experience with this & if the diarrhea finally went away. I felt so good on it, I'd gladly suffer the diarrhea if I knew it would pass in time. If you can tolerate it, hang in there! It worked better than anything else I've tried. F 49 6 weeks
4/8/2009
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 4  bipolar II - depression Unfortunately I can't remember exactly what they were, but I did have some. I guess they weren't too horrendous, except it severely hinders weight loss, so I finally decided I had to quit it. Worked very well for my depression; happy to report I had no complaints with that. You WILL need to discipline yourself and BE WISE with this med though: DON’T skip any doses, not even by an hour or so, or you may begin to not feel very well physically. Just follow these simple rules and you should be just fine, and in a pretty stable mood! If I’m social drinking with friends, which isn’t very often - maybe once a month - I might not take the med exactly when I’m supposed to, but I stick with it daily, and don’t recall it making me feel odd, mentally or physically as long as I'm consistent in taking it. HOWEVER, getting off of Cymbalta altogether requires following a VERY STRICT PROTOCOL. If you don’t follow it, IT CAN GET UGLY. REAL UGLY. (Quick, but necessary MY GOD (I never use that phrase - I'm atheist!), DO NOT RISK, UNDER ANY CIRCUMSTANCE, stopping this med cold turkey OR EVEN A BIT TOO QUICKLY or you may sorely regret it (no pun intended)! Husband calls it the 'heroin of antidepressants'. Make that mistake, you'd better prepare for nausea, dizziness, increasingly crappy feeling overall, & ultimately SEVERE BRAIN ZAPS. The ZAPPING is CRAZY depressing; I felt completely helpless, always in bed, didn’t want to move so zaps wouldn't start! Same reason for wanting to KILL MYSELF; just to be rid of the PHYSICAL AGONY of ZAPS! Not sure what those are? Fantastic blog: http://theblondepharmacist.wordpress.com/2007/11/17/brain-shivers-brain-zaps-brain-shocks/ - Cried & zapped while reading it. PLEASE. VERY SLOWLY wean off this if/when med change & ONLY UNDER CLOSE SUPERVISION OF DOC! PLEASE! Brain zaps are VERY COMMON & EXTREMELY DEBILITATING. For me, right after SEEMINGLY NEVER ENDING vision-screwing epileptic lightning storms FINALLY PEAKED, TAKING SEEMINGLY FOREVER to decr in intensity after several UTTERLY HELLISH days, I literally felt I had been repeatedly struck in the head for 24 hrs straight w/metal bats covered w/protruding nails. Scalp burned in pain the following AM. You know ‘head tenderness’ after a severe migraine or bout of flu? That’s what it’s like & and only when the zaps are BEGINNING to cease. One week later: FINALLY, zaps very mild, 99.7% gone; yet still frightenin F 40 3 years
4/10/2009
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 4  Anxiety Nausea, night sweats, severe chapped lips My anxiety has been 100 percent better since taking Cymbalta. It was a life saver for me. I was having severe anxiety and a lot of sleepless nights. About 2months after taking it I started getting my life back together and getting some good sleep. I still feel really sick to my stomach though and thinking of coming off of it. I tried taking it @ night but it keeps me awake. My next step is to cut my dose from 60mg to 30 mg per day. Has anyone else experienced this complete sickness to there stomach. It is especially worse if I drink caffeine. F 32 10 months
4/10/2009
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 4  depression very vivid dreams, often nightmares. intense withdraw side effects if I do not take medicine regularly. dry mouth. It's hard for me to rate my experience on cymbalta, as I have been on antidepressants since the age of 14 and can hardly tell myself from the side-effects anymore. However, I have been on this medicine the longest and am most satisfied with the results. I'm a very happy, easy going person now, whether that's from cymbalta or years of therapy. I don't really notice the medicine unless I forget to take it, at which point I start to feel incredibly ill. This makes me not want to get off it so I keep putting it off. Maybe there's a part of me that's afraid to see what I'm like without antidepressants too. It's just been so long. F 21 4 years
4/24/2009
 4  anxiety, panic, major depression nausea, cotton mouth, and lack of appetite Tried paxil, celexa, buspar, and depakote. Cymbalta works better than anything I have tried. I have been on Cymbalta for 2 days and I can all ready feel the positive effects. F 37 2 days
5/9/2009
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 4  Anxiety/Depression I feel good! I'm on day 5 and read all these posts before starting. I was previously on Paxil which was not effective. I feel good! I know its too soon, but I do not have any side effects, I feel more alert, focused and worry-free. I usually have very vivid dreams but I have slept well and have had calm dreams the last few nights. I do not feel "zombie-like" or tired, in fact I feel like I have more clarity and energy. I am on the low dose, 30mg daily. I don't see any correlation to this med and diarrea and I am not worried about the effects of "going off it" as I plan to "stay on it" as long as I feel this good. I have advice for those who still suffer: Get some sunshine on your face, just a few minutes will make you feel great. Get an old dog, not a puppy, an old dog that Needs you, that you can care for and that will love you back. If you can't handle a dog get a fish. Smile at a baby! They usually smile back at you :) Think of positive thoughts even if you have to make them up. I dare you! Buy something new even if its just a pair of underwear. Women know this really does work wonders. Give it a fair chance, good luck. Aloha~ F 52 5 days
5/1/2009
 4  depression Intense cramps in the abdominal aera. Basically in the stomach area and last between 10 to 20 minutus> The pain is so intense that I had to be taken to the hospital. F 54 1 months
5/12/2009
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 4  anxiety and depression INCREDIBLE nausea for the first few days, dilated pupils, blurred vision, forgetfullnes, UP and DOWN, constipation, tired eyes, teeth clenching/grinding, irritable, occasional brain fog, picking/scratching myself When i first took it i went to bed and then couldn't get to sleep, everything was spinning around i couldn't move and felt so nauseous but it was weird cos i had this sense of happiness. I thought if this is how it makes me feel i will put up with any amount of side effects cos i had never felt like that before. Well now i've been on it for 5 weeks and i still feel good!!! I had like a week where i was hypo and then the whole of the next week i was super low but i think it's balanced out now. Also i have only had one anxiety attack since i've been taking them and it only lasted for 5 minutes. F 23 5 weeks
6/1/2009
 4  Anxiety, Fibromyalgia Fatigue and overall sleepiness. Vivid nightmares. Withdrawal symptoms if not taken promptly on time (brain jolts, night sweats, prolonged coma-like sleep). Possible IBS-like symptoms and GI upset. I love Cymbalta. It is my miracle drug. It has restored my quality of life and I am now able to live as a normal person without being crippled by anxiety. There are side effects of course but for me they are nothing compared to anxiety and fibro pain. F 21 4 years
5/29/2009
 4  Anxiety/Panic Attacks At first had hot flashes and sweating. Within the first 2 weeks had some middle of the night insomnia. But within a week that went away. After taking several different medications over the past 2 years (lexapro, paxil, zoloft, celexa) this is the only one that actually was able to balance me out. I am not a zombie I can think clearly I am not ruled by my anxiety. I would recommend giving this medication a try if you have been unsuccessful with others and waiting a good 6 weeks before changing. It truly takes awhile to feel the benefits but well worth it. F 37 3 months
6/7/2009
 4  fibromyalgia sweating, bruising? F 72 120 days
7/11/2009
 4  fibromyalgia and bipolar It works well. May give diarreah for a bit till your system gets used to it. I had to go off of it for a while, and the weirdest thing happened. It felt like my joints all loosened up like they were all floaty, then that went away and I guess it just went back to normal F 33 8 years
7/6/2009
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