CYMBALTA Reviews (DULOXETINE)

Average Rating: 2.7 (2745 Ratings)

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 ANTIDEPRESSANTS

 Type: Rx Drug

  

CYMBALTA  (DULOXETINE):  Duloxetine is used to treat depression and anxiety. In addition, duloxetine is used to help relieve nerve pain (peripheral neuropathy) in people with diabetes or ongoing pain due to medical conditions such as arthritis, chronic back pain, or fibromyalgia (a condition that causes widespread pain). Duloxetine may improve your mood, sleep, appetite, and energy level, and decrease nervousness. It can also decrease pain due to certain medical conditions. Duloxetine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). This medication works by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in the brain.   FDA Approval Date: 2004-08-03 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on CYMBALTA: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR CYMBALTACOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 2  mild depression, social anxiety Extreme sleepiness and tiredness. Some bouts of sudden depression and anxiety while on it. Intense feelings meaning whenever I was happy, I was extremely happy and sad I was extremely depressed and crying. Wild dreams. I dreamed my sister tried to kill me. It made me feel worse. I was just weaning off Lexapro after 2 1/2 months because Lexapro stopped working and caused fatigue and my doc switched me to cymbalta. I was hitting caffeine everyday on this med. Made me extremely tired especially more while weaning off lexapro with the combination of the two drugs. Not near as good as Lexapro was when I first started taking it. Saw that it was not working after a month, just making me worse and I decided to get off it. I am on effexor now and I'm not sure I'm going to stay on it. I heard it was making people dense, like Lexapro started to do to me. The withdrawal I heard was also a pain. Overall, Cymbalta made me worse over the month period. I think it worth trying, because everyone is different. I don't think it is an anxiety drug though. F 1 months
4/18/2007
 2  depression / anxiety / chronic pain dilated pupils, blurred vision, nausea, irritable, tired, but very jittery and uneasy, so I can't sleep. Ravenously hungry, but nothing tastes right so I can't eat. Dizzy,confusion, agitation, extremely dry mouth, clenching jaw all day, unable to stop, uncontrollable muscle spasm. I took it for the first time last night, and today has been the worst day of my life. The side effects are so bad I don't know if I can keep taking it to get through the initial stages. I can't do anything, standing up for more than a few minutes makes me dizzy, and I'm so tired, but can't sleep. Does anyone have any ideas? if so, feel free to email me. I'm sure that it's not a bad drug, and someone else stated, if you had problems with it, you're more likely to tell someone that if it was great, but it seems like the patient informationthat the company puts out isn't accurate...only 4% of people have any adverse side effects according to them...so all 4 % of us managed to find this site? F 26 1 days
6/10/2007
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 2  Severe Depression/Moderate Anxiety Severe dry mouth, minor weight loss (no complaint there), extreme bowel irritation, blood in stool, fatigue. I used to be on 40 mg of Lexapro, but that left me feeling empty, so my therapist prescribed Cymbalta, in hopes that the norepinephrine would give me a mood boost. It doesn't. I started on 30 mg and am now up to 120 mg of Cymbalta a day. It is doing very little to help the depression. F 19 3 months
4/26/2007
 2  Depression, chronic nerve pain dizzyness, palpatations, speediness, no appetite, diarheah, interrupted sleep (no dreams) Day 1 was bad - had problems breathing, forgetting to breathe and dizziness. Very 'electric' feeling. Day 2 was a bit better, noticed no depression and minimal nerve pain! But by the end of the day I was literrally pulling hair out of my scalp from itching. I took 30mg caps... I think I may ask for a much lower dose to start with. F 45 2 days
6/10/2007
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 2  Fibromyalgia/Depression Very Sleepy throughout the day,nauseous,pain actually got worse,could not sleep good at night, WITHDRAWEL EFFECTS ONLY AFTER TAKING FOR 10 DAYS!!Please take heed,vomiting,muscle twitches,anxiety,bad thumping headache PLEASE F 30 10 days
7/10/2006
 2  Major Depressive Disorder Severe sweating (day AND night), total insomnia, loss of sex drive, out-of-control hyperactivity, road rage (yes, really), bad taste in my mouth, inability to concentrate, loss of appetite. The side effects were too intolerable for me to continue this medication. When they didn't subside after 3 weeks, I begged my doctor to switch my meds. F 27 3 weeks
1/25/2007
 2  Anxiety HORRIBLE stomach issues- I had diarrhea within seconds of eating. I was afraid to leave the house unless I knew there would be a toilet nearby! Felt constantly sick from the diarrhea Sadly, this medicine worked REALLY WELL! I just could not function when running to the bathroom every 2 minutes. My anxiety was completly eliminated and if my stomach could have tolerated the medicine, i would have stayed on it. I am now taking Zoloft. F 21 3 months
8/19/2007
 2  Depression WEIGHT GAIN! 40 lbs. in 6 months. Unpleasant hallucinations when tired. Other side effects: muscle spasms, especially when trying to sleep, bizarre dreams that made me feel exhausted upon awaking, all sorts of problems associated with lack of sleep...did I mention WEIGHT GAIN?!?! Grrrr! I began with depression and now have another BIG reason for it! My doctor is usually caring and attentive, but simply would not accept that the incredibly rapid weight gain I experienced in the months after I began taking Cymbalta was caused by the drug. Went last week to a doctor who specializes in HRT and discovered that Cymbalta does indeed cause weight gain and also learned why and how. Am now on hormone replacements and being weaned off the Cymbalta. 60 mgs every other day instead of every day. Have felt overall better and far less hungry, though I don't yet dare step on a scale. Withdrawal symptoms: severe headaches, nausea, itching all over. However, I have also learned that the hormones I am taking will "plug into" the receptors that were being filled by the Cymbalta. Please see your doctor if your symptoms are similar to mine and consider HRT. It's working for me and I feel less depressed than while on the antidepressant Cymbalta. F 45 6 months
8/20/2007
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 2  Depression/anxiety I lost all desire to eat for a short while and then I became really hungry. No specific side effects beyond that really. I felt like I wasn't taking an antidepressant at all. I was back to mood swings, insomnia, inability to sleep when I should, but no problems sleeping when I shouldn't, I thought I was headed back to that freaking crazy depressive garbage that lead me to antidepressants in the first place. I usually feel positive effects immediately, but not with this one. I couldn't concentrate, couldn't motivate myself to do my job and chores, etc. Felt in a funk...back to depression...back to crying craziness and feeling like a psycho. Doc switched me to yet another one. Guess we'll see. F 36 4 weeks
7/11/2006
 2  Chronic Pain, Neuropathy Clenching jaw all day and I am unable to stop. dialated pupils, blurred vision, nausea, irritable, tired eyes but very jittery and uneasy, extremely dry mouth, trouble sleeping. I have felt some pain releif. The burning in my legs is dulled. The jaw clenching is really irritating...and I feel kind of apathetic. I will stick it out and see how this works. I am also taking duragesic, neurontin, and lortab. I would love to decrease the opioids. F 27 5 days
6/26/2007
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 2  Anxiety (GAD) SEVERE nausea, blurred vision, fatigue I have only been on Cymbalta for 3 days so far and the side effects are HORRIBLE! I'm constantly nauseous and feel so tired and lathargic, I keep falling asleep at my desk at work and have been in bed before 9pm the past 3 nights. I'm terribly worried about weight gain so I was googleing stuff on Cymbalta to make sure weight gain was not a common side effect (my doc. said it was not) and after reading all theis stuff, I'm scared to take it anymore! Brain zaps and weight gain...WTF!!!??? No thank you! F 25 3 days
8/23/2007
 2  manic depression fatigue,irritability,lack of appetite(without weight loss) Started at 30mg and increased to 60mg. Very bad fatigue Week#1 then a little less during Week#2, especially in afternoons. No impressive mood benefits, just drawbacks: the most notable was irritability everyday with a general negative outlook and being easily angered. Need a different drug. F 47 2 weeks
5/29/2007
 2  Depression/MS Depersonalization(felt detached from whatever situation I was in), insomnia, worsening depression, zombie like state all day, alcohol intolerance, digestive issues MY PDOC finally pushed this drug on me, never again! I was a zombie all day, even getting into a car accident. One day, I sat on the couch all day watching TV. My personality completly changed, i wouldn't socialize with my friends, I just sat there. I would have one glass of wine and feel like I drank the whole bottle. Did nothing for my pain and numbness. I am going back on Zoloft..stat!!!!! F 34 10 days
5/30/2007
 2  yes vivid dreams,decreased sex drive,night sweats with chills,hot flashes (feels like early menopause or something),excessive sweating,very bloated and swollen feeling,higher blood pressure,all over not feel good,weight gain of 4 pounds in four weeks,always hungry.sleeping difficulty either can't sleep or can't wake up. I have tried Lexapro and had side effects that were not good, so the doctor changed me to 30mg of cymbalta and the new side effects of cymbalta were worse this med may or not be for you it was'nt for me. I say stop taking it if you have too many side effects don't wait more than 6 weeks and just think it will get better if you keep taking it. F 32 4 weeks
5/29/2007
 2  Depression Insomnia, anxiety, a bit irritable (but I think I'm irritable because of the insomnia). Did not help much with the depression. I see my doctor next week and will ask him how to slowly wean myself off this drug. F 57 15 months
4/11/2007
 2  depression F 20
5/31/2007
 2  GAD, depression Dry mouth, extreme night sweats (changing clothes 4 times a night), very vivid & crazy dreams (& the ability to remember ALL the details), no libido, strong cravings for sweets, constipation, clumsiness. The side effects finally overtook what little "good" the pills were doing, & after trying to taper & still experiencing withdrawal, I decided I might as well go cold turkey. It's been 7 days now, & I've had tons of withdrawal symptoms. Nausea, severe headache, flu-like aches, panic attacks, disoriented, brain zaps, "whooshing" feeling, vertigo, dizziness. But every day gets a little bit better, so there's hope. I almost feel normal again. I had previously taken Lexapro a year or so ago & had trouble discontinuing it as well. F 38 6 months
4/9/2007
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 2  generalized anxiety disorder Extreme sleepiness during the day. Falling asleep on the sofa each night by 8:00 pm, then after getting up and getting into bed, waking up after an hour or so of sleep and having extreme difficulty returning to sleep, with frequent wakings. Problems focusing at work...loss of productivity. Vivid dreams. I am in the process of going off this med. Trading anxiety for exhaustion and sleep problems is not worth it. I think I would rather be anxious and sleep well. I will say that I did not cry (out of frustration, anger, anxiety) once while I was on this med, and did have more patience with my small children, which is nice, but again...the exhaustion and listlessness is not worth it. So far, I have been off of the drug for almost 3 days. Feel "herky-jerky", some small mind "zaps" but so far it hasn't been long enough to know the extend of withdrawal symptoms. I tried once before to get off the drug and felt bad and wierd enough to go back on. This time I am better prepared for what may happen and plan on sticking with it. Will report more later... F 40 6 weeks
5/4/2007
 2  depression cervical nerve pain I was on low dose of the drug, and had to go off because of an episode of pancreatitis. I was off for about 3 weeks. I took 30 mg, and within 3 hrs, had weeping, suicidal ideation, hopeless feeling. I couldn't stop crying. Thank god I knew it was just the drug, and the episode did pass. I had to re-titrate up to the 30 mg, over the course of a week. BE CAREFUL. This drug is not predictable at all. F 58 10 days
4/21/2007
 2  Neuropathy Itching and tingling in feet and hands Strange tingling in hands and feet started almost immediately. I thought it was starting to help with the pain, but couldn't tolerate the pins and needles in hands and feet. I was only on 20mg when this symptom started. F 45 8 days
4/14/2005

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