CYMBALTA Reviews (DULOXETINE)

Average Rating: 2.7 (2745 Ratings)

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 ANTIDEPRESSANTS

 Type: Rx Drug

  

CYMBALTA  (DULOXETINE):  Duloxetine is used to treat depression and anxiety. In addition, duloxetine is used to help relieve nerve pain (peripheral neuropathy) in people with diabetes or ongoing pain due to medical conditions such as arthritis, chronic back pain, or fibromyalgia (a condition that causes widespread pain). Duloxetine may improve your mood, sleep, appetite, and energy level, and decrease nervousness. It can also decrease pain due to certain medical conditions. Duloxetine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). This medication works by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in the brain.   FDA Approval Date: 2004-08-03 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on CYMBALTA: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR CYMBALTACOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 4  Lupus Decreased ability to orgasm which corrected in about a month; now after almost a year, seems to cause restless legs and foot pain as a result. It may have to do with the time of day I take it. At first, I couldn't sleep with it, so I had to time it for earlier in the day. Oh, yeah. Increased sweating. This is the most managed my lupus has been. I can really tell if I miss it. F 37 1 years
8/23/2007
 4  depression, hypomania sleepiness, constipation I've been taking Cymbalta for 3 weeks, and by the 3rd week it started to help. Usually I get very depressed on Sundays, but this past 3 day weekend I was fine all the time. No more feeling in a "black" mood, and sadness. Knock on wood, hope it continues. I've taken Zoloft, Wellbutrin, Lexapro, Lamictal, and Adderall. The Lexapro was great at first; almost felt high,it made my mind race, then it failed me. My psychiatrist called that partial recovery. On Cymbalta by the 3rd week I felt more optimistic, and calm. I sure hope it continues. My Dr. started me at 60mg. I just hope the fatigue is a side effect that will wear off in time as my body adust to the drug. F 55 3 weeks
5/30/2007
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 4  Depression & Anxiety Intially I felt more energetic like I had been given a dose of adrenaline. Even if I didn't sleep well, I still had energy. As I adjusted to the medication, I began to feel normal. It made me feel wonderful and for the first time in years I felt "normal". Unfortunately in week 5 I began to have dizziness from it but kept taking it a few more weeks to see what would happen. The dizziness got worse so I was lowered to 20 mg. The dizziness got a little better but the depression and anxiety began to worsen so I had to stop taking Cymbalta. It worked really well for me but the dizziness was worse than the benefits. F 36 10 weeks
5/30/2007
 4  depression, physical pain nausea, after a few days mild diarrhea, mild insomnia, the calves of my legs are COLD and it is summer, so far the side effects are tolerable. I'm told the nausea will go away as I get used to the med. I can't tolerate any anti-depressant at normal doses. I lack the necessary enzymes to metabolize them (this is genetic, some of us are born with low ability to metabolize many drugs). Fortunately I found a Dr. who understands this. He has me opening the capsule and taking only five of the tiny beads inside per day. Sounds absurd, but the improvement in my depression has been DRAMATIC. I feel glad to be alive again! F 51 8 days
5/9/2007
 4  Anxiety, Panic Attacks and Depressi Decrease in appetite. I'm on 30mg per day along with .25mg of Xanax and 10mg of Ambien to rest in the evening. I take Cymbalta in the evening before bed with an Ambien and find that I sleep and feel considerably better. I still use Xanax before I go to work to take the edge of my anxiety that leads to panic attacks. I have been diagnosed with post traumatic stress syndrome and have tried paxil, zoloft, celexa (gave me extreme internal cramping), lexapro (caused extreme weight gain) and now Cymbalta. It was within the last 6 days changed my mood to one that is upbeat and soothing to myself. I am not looking forward to the day when I have to wean myself from the medicienes however I was feeling so poorly that I felt I needed the relief I've found with the combo my doctor has prescribed. God Bless you all who live with the day to day symptoms of anxiety, panic attacks, depression and post traumatic stress syndrome. You are not alone. F 30 6 days
9/29/2007
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 4  Depression and Anxiety Dry mouth first couple of days. Maybe slight headache occasionally. I don't know about any sexual side effects yet. I have not gained weight yet either. The first couple of days I didn't want to eat much but my appetite has returned. I already had menopausal hot flashes and night sweats so I don't know if they are related to this drug or not, but I'm used to them. I took Prozac in the mid 90s and it worked fine, I went off it after a year and only recently got so depressed and anxious again to the point where I felt i needed help. I've only been taking it for a week and just increased to 60mg. I felt better the first day and it's really helped me. I feel good and my anxiety is much less. I can focus better on tasks and am not as distracted or worried about things. So far so good. F 53 2 weeks
3/30/2007
 4  chronic coccydynia (tailbone pain) nausea initially (3-4 days), dry mouth and eyes (initially), spaced out (initially), difficult to urinate, blurry vision, tense yet sleepy at the same time, repeated yawning, teeth clenching especially at night, wakeful at night (but was from depression too), itchy scalp, 1 very serious headache, napping during day (new behavior). If you take all these unpleasant side effects and add them together they are not nearly as bad as the constant pain I was in before cymbalta. There is nothing like constant pain and inability to sit to drive you to suicidal thoughts. My pain has been significantly reduced and I've been feeling so relieved and happy. I hope it lasts (and the side effects continue to subside). F 45 3 weeks
4/21/2007
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 4  Depression/Anxiety loss of short-term memory, difficulty concentrating F 33 4 months
5/3/2005
 4  severe anixiety/panic disorder/ocd loss of appetite, sleepy a lot (especially afternoons...usually after eating), some difficulty sleeping, vivid dreams or nightmares, inability to orgasm through intercourse, slow orgasm time otherwise, night sweats, headaches started taking cymbalta 30mg june 15, 2006, had dosage increased to 60mg july 29. so, been on cymbalta for total of about 4 mo, but 60mg dose for 2 mo. was prescribed for severe anixiety/panic disorder/ocd by my GP (general practitioner). had increased gag reflex & loss of appetite for first wk starting both dosages, but then went away thank goodness. most of my current side effects are not everyday, but enough. Not sure if headaches are from this, could be from tmd (teeth grinding), pillow not fluffy enough or glasses prescription. don't wanna go back to 30mg cuz still experienced occasional panic/anxiety attacks. right now, benefits far outweigh negative, cuz i function w/no attacks at all, YAY FINALLY! only anxiety/nervousness i get now only affects my appetite (every once in a while)…not as hungry. any help or recommendations w/sexual side effects, headaches & night sweats would be great! F 25 4 months
10/7/2006
 4  depression First 3 months, night sweats, vivid dreams, reduced libido and diffuclty reaching orgasam. 4th month developed chronic diarrhea, muscle twitches/jerks and fasciculations that could be related to dehydration from the diarrhea. All other causes of diarrhea were eliminated (bloodwork and other biological tests OK). Weird thing is I feel "OK" most of the time except for being tired, twitchy and always hungry (due to the diarrhea). I was willing to tollerate the other side effects, but this has got to stop. Otherwise, the medication seemed to work great! Was first time I've been on an antidipressant that didn't just make me feel "flat." I can enjoy both the highs and lows, without getting stuck or feeling dispondent for no reason. However, I wonder if how my body is metabolising the drug has changed, causing the side effects. I'm kind of disappointed because I was so pleased with it up to this point. F 36 4 months
9/27/2006
 4  Fibromyalgia Hair loss (2 mo), very dry skin, several areas on face (like age spots), gained 20 pounds in 4 mos, cravings especially during the night. I started taking it in October of 04 and within 2 weeks it did start to help with the pain of fibro. I was taking 60 mg up until 2 weeks ago, but it stopped working. I have had to gradually come off of it because the pain is intense while moving away from it, for me. I am now completely off and was worried the pain would increase. There has been pain weaning back and I am hoping to start something else, but the weight gain is getting out of hand. I have lost a pound and 1/2 over the past two weeks coming off. For the time I did take it, it did work very well for the pain and than slowly stopped. The problem is, over 60mg does not make a difference. F 48 7 months
6/4/2005
 4   Was on Paxil for 4 years and the past 3 months it hasn't helped the depression at all. My sister went from Zoloft to Cymbalta and told me to speak to my doctor. I went in for an appointment 2 days ago. I see the doc every 6 weeks for medication mgmt. We spoke about the Cymbalta. He is weaning me off the Paxil while on 30mg of the Cymbalta. After I am totally off the Paxil, I will take 60mg a day. I am looking forward to seeing how this medicine will help the depression, my irritable bowel syndrome, fibromyalgia and anxiety. As far as side effects- I already sweat and dry mouth all the time anyway. Any one of my 10 medications could be the cause. I am hoping the Cymbalta will work and the idea of losing weight, is an answer to my prayers. Once I start the 60mg, I will update my comments. F 54 3 days
8/30/2007
 4  anxiety/depression/lack of patience Helped with my mood and patience TREMENDOUSLY, 30mg a day for about 3 mos, but some of the side effects are bumming me out. Really tired alot of the time, real vivid crazy dreams, and I have a REALLY hard time waking up in the morning no matter how much sleep I get. Sweat alot while sleeping too. Am going to try 30mg every other day and see if that helps. F 40 3 months
8/30/2007
 4  Major Depression Some sleepiness, but not as bad as before the pill. Some lowered sex drive. Slight constipation. Night sweats...tending to occur 3-4 times a week with more vivid dreams. I have gained about 30 lbs. Started on 30 and went to 60 mg. Dropped back to 30 mg, because of side effects. Just went back to 60mg/day (30mg in morn, 30 mg after dinner). Decided the benefits out weighed the side effects. For myself, there is a 2 week "crazy time" (named by my husband) whenever I changed dosages and when I started. If you can get past those 2 weeks, you will notice a fantastic change. I actually get up and go out of the house. I will do laundry and wash the dishes again. My husband did notice that I tend to twitch for the first hour or so that I sleep. After reading all of this, the drug sounds horrific, but it has done wonders for me as well. F 31 18 months
8/30/2007
 4  Depression and Anxiety I have been taking Cymbalta for about a year. Any side effects I have had have eventually gone away except for occasional excessive sweating of my scalp. Cymbalta is the only thing that has ever helped me. F 64 12 months
8/30/2007
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 4  Fibromyalgia & Severe Depression SEVERE, SEVERE SWEATING, hand tremors, bloated stomach, weight gain, gas, thoughts of suicide, I sleep 12 to 17 hours at a time and still am sleepy and lethargic, loss of interest in doing anything, tired all the time, can't get motivated to do anything except go to work and come home, no energy, constipation, some stomach cramps, still depressed, lack of concentration, can't keep focused, short term memory, increased urinaation, some headaches, dry mouth, increased dreams, feelings of worthlessness, anti-social, nothing really seems to matter Cymbalta helped me in the beginning. Started at 30 then to 60, and now 90 mg daily with Wellbutrin SR. Doctor says the Wellbutrin (150 mg) is suppose to help with my loss of energy and lethargy. I am seriously wanting to discuss with my Doctor, & considering coming off Cymbalta because of the SEVERE SWEATING (my face, head, hair, under garmets) all stay wet about 90% of the time, day, and night, and with summer here, I am scared the severe sweating will even increase with the heat. I am not able to play and enjoy my granddaughters because of the sweating and being tired and wanting to sleep all the time! I am afraid to stop though because I don't know what other meds. are out there that can help me with the combination of fibromyalgia and depression. Surely there is something that can address these issues without the severe sweating and other major side effects. I have A-Fib and am on some heart meds. & other meds too, so I might be limited! Anyone know of anything that mig F 60 2 years
5/23/2007
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 4  anxiety eating disorder (bulemia) felt very jittery with major headaches and dizziness for 1st few days then side effects wore off. Feel less anxious- no more mood swings. Negative side effects wore off within a few days. Feel a little more in control of eating disorder. In a much better mood- much more stable. Sex drive did not decrease which is great. Still makes me kind of jittery and go to the bathroom often so I take it in the morning. Only annoying side effect is the night sweats- typically about 3 nights out of the week have to get up and change clothes i get so sweaty. Vivid dreams but don't consider it a negative side effect. OK so far. (30mg-- staying at 30) My sister is on 30- working great for her after 8 months-- doc at first got her up to 60mg- she said side effects unbearable so went back down- 30 working fantastic. F 25 1 months
5/18/2007
 4  Depression/anxiety nausea at first, which subsided after a couple of weeks. Still a bit sleepy during the day (I take it in the morning), but then frequent waking at night, with very vivid, weird dreams! I do feel more relaxed and able to handle life's ups and downs, as well as some serious family issues. I've gotten used to the side effects, and am sticking with it. Tough it out - things do get better, and your body will adjust!!! F 35 2 months
6/23/2007
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 4  severe headache menopause, anxiety Only bad thing is muscle spasms in my back...My doc started me out with 30 mg for first week and then 60 mg after. During this time I was going off Remeron. At 2.5 weeks got horrible cramps in back that kept me from sleeping. They have gradually decreased to random times mostly when awake. I take a very low dose os Seroquel to sleep at night 50-75 mg. Great as far as relieving headache and returning attention and focus. I love the meds except for spasms. I do not have the crazy hunger like I did with Remeron. F 53 5 weeks
9/12/2007
 4  Depression; aches due to Lupus I had been terribly tired for months. My doctor suggested I try taking the Cymbalta at night instead of the morning because he thought that was what may be making me tired. Since then, I have had moderate insomnia. I will go back to taking it in the morning and see if it helps. My doctor increased my dosage from 60mg to 120mg. She had just went to a seminar on the study of cymbalta. The study showed that by doulbling the dose it helps to control the appetite in some people. Since then, I have felt so much better. I don't feel as tired and I have not had all of the food cravings that I usually have. So, I will stick with it and see how it works out. F 38 6 months
7/11/2007

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