CYMBALTA Reviews (DULOXETINE)

Average Rating: 2.7 (2745 Ratings)

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 ANTIDEPRESSANTS

 Type: Rx Drug

  

CYMBALTA  (DULOXETINE):  Duloxetine is used to treat depression and anxiety. In addition, duloxetine is used to help relieve nerve pain (peripheral neuropathy) in people with diabetes or ongoing pain due to medical conditions such as arthritis, chronic back pain, or fibromyalgia (a condition that causes widespread pain). Duloxetine may improve your mood, sleep, appetite, and energy level, and decrease nervousness. It can also decrease pain due to certain medical conditions. Duloxetine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). This medication works by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in the brain.   FDA Approval Date: 2004-08-03 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on CYMBALTA: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR CYMBALTACOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 4  Depression, Suicidal Thoughts, Anxi heart palpitations, decreased libido, dizziness, tremors I was originally taking 20mg Celexa for depression due to my Divorce and other life issues, and that didn't seem to be doing much. I used to take Lexapro (10mg), and I grew an tolerance to it. So my doctor switched me to Cymbalta (30mg) with an order to continue to take the Celexa for a week then start taking the 60mg capsules of Cymbalta. After only three days of taking the drug, my mood instantly improved. It's worth the side effects, but I don't feel anxious or depressed as often. A good thing for me, especially after just being left behind and accused of so many things. F 21 3 days
12/30/2009
 4  Depession/constant pain in thigh First day i felt a little nauseated but not since, dry mouth, some headaches for a couple weeks, now after 3 mo I'm getting a bad pain in my neck. My pain is gone! My depression is much better, woo hoo! I am concerned about my neck pain because I might have to stop taking the drug, going to make an appointment with doc, we'll see. P.S. The symptoms I had were worse when I felt dehydrated, and improved much when I drank more water. F 44 91 days
12/11/2009
 4  CFS/Fibro pain, anxiety, depression No neg. side effects so far. I switched from Zoloft to Cymbalta and also continue to take 300mg. of Wellbutrin, and 5mg. of Dexedrine. I feel that it works better than Zoloft and I feel more 'naturally relaxed', if you will. I am on 60mg. and I am hoping that it will really help me cope with my pain. F 37 3 days
12/5/2009
 4  Mild depression/Generalized Anxiety I'm now almost 3 weeks in and have still only experienced positive side effects...more energy, more focus, less moody, etc. Only negative was in the first couple of days...feeling a bit foggy and some tension through my neck and shoulders. I follow-up with my doctor this week to determine if we need to add or take away anything and I pretty sure we'll keep things just as they are. I feel human again and I can only hope this feeling will last. F 28 3 weeks
12/9/2009
 4  fibromyalgia/CFS/depression weight gain, sweating, tiredness, lack of emotion. At first I was amazed about the feeling of quality of life once again. It was wonderful with my worst pain and depression. But I was still having issues with so tired and falling asleep even driving. I hated the zombie feeling it gave me. I wouldn't even cry hardly at all with the saddest situations. I was taking it along with other meds: flexeril at night for sleep, tramadol for a kick in the mornings and for pain, lyrica for fibro and nerve pain. I'm trying to get off of all my medicines. It's not easy. I've taken some of them for 6 or 7 years. F 47 14 months
12/27/2009
 4  Fibromyalgia/Chronic Fatigue Dry mouth, sleepiness 1-2 hours after taking. I would like to commment that everyone is effected differently, by different medications. It doesn't mean they should be taken off the market. I started out taking Amitriptyline, which has been on the market since the 1950's and is used to treat a multitude of different diagnoses. I had a terrible time with it- morose, deep depression, etc. I started Cymbalta 15 days ago and have noticied an increase in energy, better sleep at night, and so far minimal help with my fibrolyalgia. I am only on 30mg at bedtime and would like to increase eventually because I have noticied a slight increase in my mood, energy level, and sleep. No terrible side effects so far. Some meds will not work for you, period, just have to find the right one, or combination. Cymbalta has helped me so far, looking forward to being on it longer and getting better. F 28 15 days
12/22/2009
 4  MAJOR depression, suicide attempt. Constipation (1200 mg calcium gel caps is a remedy), the first day I experience,d 1 or 2 hrs of nausea first day only, dizziness has been eliminated by taking the 60 mgs at night !! 1 brain zapper after 10 months during a migraine headache which was a very sharp pain that radiated from my head and downmy back that was shocking and lasted a total of maybe 1 second. I have relief from major depression, anxiety, suicidal thoughts are becoming fewer, I also take 200 mg of zoloft which I find to be less affective compared to cymbalta. Yesterday, Christmas day began with a crying episode that I could NOT shake for several hours that included hopelessness in a major way. I was Determined NOT to remain depressed so I first tried 1/2mg ativan followed by an additional dose of 60 mg of cymbalta. Gradually over 3 hrs the heavy dark shroud of miserable depression began to fall away. It has been over 24 hrs. NO DEPRESSION. This was my miracle on Christmas day. Uncertain about night and day sweats as that has been around for a decade due to menopause and a total hysterectomy. I sleep at night, no nightmares and my dreams are , REALLY VIVID as I am a VISUAL ARTIST. I do wake up refreshed. A few times I have experienced theo peripheral shadows, 1 second, then gone but I now realize what they are and they no longer scare the hell out of me. I will accept the annoying side affects if cymbalta continues to keep the grim reaper, depression and anxiety, OUT of lifejourney. I look forward to each step where scientists take one further towards a better life for those who suffer. Hopefully this forum of exchange will be a step forward in reaching the cure all miracle drug. In the mean time take advantage of the progress that have been made. Blessings to all of you who still suffer. Oh, sex life; try a roller coaster ride to work you up to it . F 60 300 days
12/27/2009
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 4  Depression/Anxiety nausea when first started. Fatigue after 3-4 months F 31 120 days
12/3/2009
 4  Mild depression/Generalized Anxiety Foggy, tension through jaw neck and shoulders, sweating I just started taking 30 mg of Cymbalta 3 days ago and almost stopped immediately because of the comments left on this forum. I continued however because I realize that people are less likely to leave positive feedback in any situation. So, I'm here to say that if you've just started stick with it...my worst side effects only lasted a day. And already I feel better, have more energy and in general feel like a wait has been lifted off my shoulders. I know from experience that you must try several different meds before you find the one that works for you, so if Cymbalta's not working for you talk to your doctor right away and try something new. Thankfully, after several different types and combinations of meds I have finally found something that works for me. F 28 3 days
11/22/2009
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 4  fibromyalgia inability to have an orgasm I've been taking 60 mg for 1-1/2 years. Cymbalta dramatically improved my bodily pain levels from the fibromyalgia. I also have arthritis, but that is not reduced at all. The orgasm issue is frustrating. Sex is still enjoyable, however. I've recently added Wellbutrin to try to counteract that part of it. F 54 1.5 years
11/18/2009
Email
 4  Depression, Anxiety Nausea, Diarrhea, constipation- stomach issues. The first few months, I experienced headaches and fatigue. When I began Cymbalta, I had to take naps frequently. Also, I felt like I was in a fog most of the time. Later, I experienced constipation. Now, it's nausea everyday and diarrhea a couple days a week. Overall, it has definitely helped with anxiety. F 24 11 months
11/15/2009
 4  Depression No side effects that I'm aware of. F 58 12 years
60 MG 1X day
8/23/2014
 4  Depression. Weight loss. A little memory zap. F 49 1 days
60mg
3/12/2014
 4  chronic pain At first I experienced a sensation of periodic brain shocks which were a little unsettling but after the first couple days these symptoms subsided. My physical pain level has been on average anywhere from 5-7 on a scale of 1-10 every day for the last 12+ years. It has now become much less (2-3) and depressive feelings/mood much better as well. I don't understand why there are so many who have had adverse reactions to Cymbalta, I have had great results so far. F 54 1 years
60 mg 2xda
3/16/2015
Email
 4  Fibromyalgia, Depression Decreased libido. F 52 2 years
60mg
2/3/2015
 4  Fibromtalga, cfs,pain, depression I have been taken cymbalta for yrs. Tried to change to a different med, could not it got put back on cymbalta. Then I was changed duloxetine the gentic brand of cymbalta and I just dont feel right. I can NOT fond if there is a differents between them, but my insurance did the same saying there is no different. Can anyone help me on this? Ty F 57 10 years
120mgs
1/19/2015
Email
 4  Depression Anxiety Neropathy The incessive body jerking! It works so well for my Depression and Panic disorder and Neuropathy pain. But the body jerking makes me want to jump out of a window. I fear staying on it but what else can I do.... F 45 2 years
60
2/17/2015
Email
 4  Pelvic pain,anxiety Raised by blood pressure 10 points, but nothing major Really stopped my pelvic pain and helped the anxiety . It is a hard drup to get off of though...must do it very gradually to not have bad feeling symptoms. I was off for a while but after my pelvic nerve troubles I went back on it because a specialist recommended cymbalta again to me. I have no long term affects from this drug that I know of, this time over 5 years, last time, maybe 1 year F 64 5 years
30 mg 1X day
6/6/2015
 4  bipolar major depressive episode weight gain, sluggishness, sleepiness, restless legs, rashes, slow healing wounds. What a strange drug. I just say at the outset that it definitely helped the depression and seeing as that was making me suicidal I can offset the multiple side effects against that. But it's after the depression passed that I realised how it had wrecked my physical bod somewhat. Weight gain was appalling and by the time came when I realised it had done all it could for the depression I was feeling very "zonked", a sign with me that it's time to reduce meds because the episode is gone. The thing is, nobody should be just placed on an anti depressant forever. You are not ALWAYS depressed, it is a reaction to something happening in your life where your mind cannot handle it. My psych was great, we reduced it quite quickly with a few, not many, initial anxiety days where my biochemistry got used to being without and now, six months down the line I feel a lot better, am losing weight and feeling like my old self. Would I take it again? Maybe. If the depression was threatening my life once more. F 42 2.5 years
60mg to 20 1X day
7/8/2015
Email
 4  fibermyaliga i had been taking cymbalta since 2007 for depression at 30mg then 60mg. have been living with the fibermyaliga pain for over 10 years. went to see rheumatoloist, after going to all pressure points of my body, which just about brought me off the table, he increased my dosage to 120mg to be taken in the morning. took about 3weeks, but i do not hurt. the pain is gone. this has really worked for me. i have had some weight gain, i can handle that, but the pain was getting too much for me. so i am one that would say that cymbalta is a good drug. F 70
120mg 1X day
2/11/2015

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