CYMBALTA Reviews (DULOXETINE)

Average Rating: 2.7 (2745 Ratings)

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 ANTIDEPRESSANTS

 Type: Rx Drug

  

CYMBALTA  (DULOXETINE):  Duloxetine is used to treat depression and anxiety. In addition, duloxetine is used to help relieve nerve pain (peripheral neuropathy) in people with diabetes or ongoing pain due to medical conditions such as arthritis, chronic back pain, or fibromyalgia (a condition that causes widespread pain). Duloxetine may improve your mood, sleep, appetite, and energy level, and decrease nervousness. It can also decrease pain due to certain medical conditions. Duloxetine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). This medication works by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in the brain.   FDA Approval Date: 2004-08-03 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on CYMBALTA: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR CYMBALTACOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 1  fibromyalgia Terrible side effects! Debilitating leg pain close to needing walker or wheelchair. Bouts of panic. Insomnia. Anti-social behavior. Vivid dreams. Initially nearly bit my tongue off during my sleep on several occasions. It's dangerous stuff. You can't tell me otherwise. I took myself off after my doctor brushed off my rremarks regarding side effects I was experiencing. I never asked for this stuff. She simply put me on it because she notice that "fibromyalgia" was noted on my chart some years prior to seeing her. This drug robbed me of quality life for nearly two years. The leg pain was both muscle and ligament related. At times I would nearly fall down when my muscles would give out unexpectedly. At other times one leg would become rigid and I was unable to straighten it out. At times I could not turn over in bed. Eventually my entire spine became sore and stiff and I had to sleep on ice packs. My doctor blamed this on arthritis. I took myself off the drug and found a new doctor. After 8 days I am pain free! F 61 20 months
10/4/2009
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 1  Depression I couldn't really tell it was making any difference in my depression, so the dr continued to up my dosage. Now, trying to taper myself off this crazy stuff after years of taking it daily, I am experiencing the following: Dizziness, Nausea (now I know what projectile vomiting is!), vomiting, light-headedness... and this has been going on (only when I don't take any) for three months now. It has gotten to where I count the tiny balls that make up the capsule and reduce the amount of tiny balls by 5 every few days and make new dosages by putting "new dosage" in emptied vitamin capsules. Absolute HELL trying to get off this stuff! F 45 3 years
10/3/2009
 1  neuropathic pain post-chemo/depress nausea, headache, excess sweating, insomnia This SNRI is not for everyone, certainly not for me. Side effects are too marked to continue this. F 56 1 days
10/11/2009
 1  depression/anxiety med helped for a while, but I gained about 30lbs in the midsection. I was always thin and fit before. was taking it for multiple failed fertility treatment's and devastating experience with failed IVF. became pregnant surprisingly (by natural means). my md stopped the 60mg cymbalta cold turkey and switched me to lexapro. I had to be hospitalized within a day for severe vomiting, & electrolyte imbalances. I felt terribly anxious and had heart palpitations I didn't understand. I had waited 7 years for a baby. At 12 1/2 weeks pregnant....after all that suffering, the baby died. DO Not stop this medication cold turkey. They make a 20mg capsule. then you can open it and remove some beads. my life will never be the same again. F 38 2 days
10/9/2009
 1  Depression After several 3or 4 weeks I had bad dreams and pain in my legs. On day I took 30 mg thenthe nest day 60mg with 30 I had pain in one or the other legs always moved and then the next day on 60 it was often in both lgs. I had to buy a cane and I fell from spasams in both legs at the same time. I realized it was related to the pill and a side effect that got worse with a higher dose. The leg pain stopped when I stopped the pills. The withdrawl was awful major waves in my head like dizzy can't drive or walk. I now have to restart after 3 days and take 30mg and get off very slowly or I won't be able to work. The doctor had no knowlefdge of expected side effects the pharmacist helped. I hate this pill. Hard to get off and awfull side effects pain , bad dreams and pain in my legs. F 59 3 months
9/6/2009
 1  Bi-Polar headache lasted for a month, insomnia, brain zaps for 2 weeks when discontinued the medication The brain zaps were weird. Just standing in a store and little prickles of electricity floating in my head...I will never take this medication again. Switched to Lexapro. F 46 1 months
8/29/2009
 1  FM Huge weight gain, bloating, could not fall asleep for 1-2hrs every night,increased sweating. Never go on this medication...aside from the side effects while taking it tapering off is worse. F 44 7 months
8/29/2009
 1  back pain depression Insomnia headaches nightmares I started taking cymbalta 2 months ago. I have had nightmares about my car wrecking, drowning, not being able to move, my husband having an affair with my best friend, and a lot more. The nightmares make me not want to sleep. I have actually woke up and wanted to cry. And also sometimes I just can't sleep, I don't feel tired at bedtime (even though I was tired an hour before). I also have the worst headaches and while I have the headaches my right eye is blurry. And it hasn't helped my back pain at all F 22 2 months
8/30/2009
 1  Depression Severe fatigue, problems staying asleep, slight nausea I have been on Cymbalta for almost a week and have been in bed the entire time. It has caused me to be severely fatigued with flu-like symptoms that came on about 24 hours after beginning this drug. The depression was not as bad as I feel on this medication. I am supposed to go to 60mg in two days but after reading the reports of the great difficulty in getting off Cymbalta - I am going to stop taking it before it gets even worse. F 62 5 days
8/28/2009
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 1  Depression Nausea, diarrhea, anxiety, agitation, bad dry mouth, difficulty urinating. My physician prescribed me Cymbalta because Lexapro was at highest dose (20 mg) and not working. I was put on 60 mg. and have been in my own hell ever since. I am now 3 weeks into trying to get off it. Went down to 30 mg. for two weeks and am now off it completely. I have been having terrible side effects ever since. Constant rining in my ears,vertigo,"brain zaps" that I can only explain as a shock to my brain, agitation, sudden crying, terrible taste in my mouth, headache, sweats, foot cramps, diarrhea and stomache pain, nausea. I feel worse than I ever have in my life! I can hardly get my work done, I freak out when driving because my brain is zapping so often. Those who are trying to come off Cymbalta should be very careful. Better yet never start it in the first place. F 47 4 months
9/19/2009
 1  depression, fibromyalgia unable to have orgasm, loss of all emotion, insomnia, forgetfulness, loss of appetite which I don't need. not worth the loss of sex drive or ability to have an orgasm, ever! Did nothing for my fibromyalgia- Lyrica works so much better. F 39 4 days
9/20/2009
 1  Depression, anxiety, fibromyalgia, Heightened anxiety, increased depression, listlessness, apathy, emotional numbing, increased physical pain! My pdoc and I decided to switch to 60mg cymbalta from years of being on Effexor XR 300mg(which recently seemed to "poop out" on me). After 4 weeks on 60, began a steep slide back into a state of depression I haven't experienced for many years, so was upped to 120 mg in mid July. I just began 100mg Pristiq today, since Cymbalta clealy did absolutely nothing for me other than put me in a dangerously depressed and pain filled state. I feel like a total zombie, can't do much but get in and out of bed to go to the bathroom. A constant feeling of background dread - a shadow of my former vibrant self. I feel totally disconnected and struggling to get through each day holding on to the hope that I will wake up feeling better and able to function normally again. F 42 3 months
9/12/2009
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 1  depression/pain brain freezes, brain shivers i took it for about 4 months and at first it was WONDERFUL, then the brain shivers started to happen, i was grateful that i read a lot about the drug before taking it so when they started i knew it was the cymbalta and i wasnt loosing my mind. i would suggest that anyone considering taking this drug to be really sure they read about it, Ive been in several different meds for depression and pain and this one was a HORROR to get off of. I didnt think I would ever be normal again, but after about a month it finally let up and I started to feel normal again (depressed still but at least no brain freezes) i am not on wellbutrin and tolerate that just fine, cymbalta to me is junk F 34 4 months
7/23/2009
 1  neuralgia/chronic pain sweating at first, then tapering off. Strange dreams(but not nightmares). Good control of pain. After 1 year began depression never had before, confusion, lost concentration, and thought I was going to have to check into a mental hospital and leave work. When saw doctor, she immediately switched me off Cymbalta to Effexor to stabilize the depression. Dr. mentioned had 5 patients had to do the same thing for. Long term use was not studied enough, in her opinion. Once again I'm looking for relief for control chronic pain. F 43 1.5 years
7/22/2009
 1  generalized anxiety Terrible nausea, Tremors, extreme dry mouth, felt like I have the flu alternating with chills, hot flashes, sore throat, blurred vision, ear ringing, tachycardia, inability to sleep past 3 am, Took two days but agree with the comment, I wonder if this is what chemotherapy is like. F 49 2 days
8/13/2009
 1  Depression and anxiety So tired I felt like I had the flu, foggy, severe pain in one eye, horrible stomach ache, hedache I only took this for two days and was unable to continue due to the side effects. I felt so ill I had to call in sick to work and I never do that. I hear it does help some people though, it is just how it reacts within your particular system. F 35 2 days
7/24/2009
 1  anxiety today is only day 1 and will probably be the last. i feel very sick to my stomach. i feel like i drank NyQuil and am forcing my self to stay awake. HUGE lack of concentration, dizzy, headache this is not fun at all!! i would rather deal with the panic attacks for a while longer then see if this gets any better. i sure hope i wouldn't get wore.. good luck all F 25 1 days
6/18/2009
 1  Fibromyalgia Confusion,impaired short-term memory,decreased sex drive,insomnia,night sweats,increased pain,severe headaches,irritable bowel,constipation,unable to focus,unable to multi-task,depression,weight gain,vertigo,stiff joints,etc... The public needs to be made aware that this drug is a poison. If you are not taking this drug, do not begin to take it. Please research discontinuation symptoms the drug manufacturer does not disclose, as well as the "common side effects" that the drug company so nonchalantly lists. BEWARE OF THIS DRUG!! F 48 4 years
6/18/2009
 1  Pain I only took only 30 mg of Cymbalta for one day (prescribed for pain from a hip and lower back dislocation), but I will never take it again due to the horrible side effects. I felt like a zombie on this drug, and my family was really concerned about me. I was "out of it," extremely sleepy, took accidental naps during the day, experienced horrible diarrhea, embarrassing stomach gurgling and flatulence, moderate nausea, loss of appetite, slight loss of coordination, occasional blurred vision, and generally felt numb both in body and in spirit. My pain is terrible and Cymbalta dulled it significantly, but it's side effects are not worth it. There is no way I could live a functional life on this drug. I'm a 30 year old graduate student who was prescribed this medication for serious pain combined with a little anxiety about my situation: I dislocated my lower back and hip in a sports accident and had multiple surgeries for my injury over a year ago, but I'm still in terrible pain and have trouble sitting for long periods of time. As a result, I'm extremely worried about finishing my PhD program with these limitations. I was hoping that Cymbalta would help. No way. This stuff reduced my pain from an objective standpoint, but the whole reason I want so desperately to get rid of my pain is to be a functional human being. Cymbalta made me feel like a numbed up zombie, in addition to making me extremely sick. I know they tell you to stick with the medication because it doesn't work for at least a week, but why on earth would I want to force my body to get habituated to something that effects me like poison? It's not worth it. Rather than targeting my pain alone, it was like trying to kill a flea with a jackhammer. If it works for you that's great (obviously stick with it), but after my experience I would caution others who are prescribed this drug for pain. I'm writing this the morning after I took Cymbalta for the first time, and I still feel a bit queasy and "out of it," like I'm slightly hung over. There is no way taking it again today! F 30 1 days
7/6/2009
 1  Generalized Anxiety Disorder Dizziness both the spinning kind and the getting up to quick/low blood pressure kind. Blurred Vision. Overwhelming tiredness. Periods of depression probably due to the tiredness. Loss of appetite. Mild Weight Loss. Dry Mouth. Feeling Hot. Sweating. My psych nurse switched me to Cymbalta from Lexapro about a month ago because I was a little tired on the Lexapro. The Cymbalta was horrible for me. The first side effects noticed were mild dizziness upon standing - the kind you get if you have low blood pressure and get up too quickly from a seated or lying down position. I thought I could stick it out because many times the side effects will disappear as your body adjusts to the new medication. That didn't happen. After about two and a half weeks on Cymbalta, the side effects began getting worse. The extreme "crashing" fatigue was awful. Then the spinning type of dizziness began. And when I began feeling depressed and hopeless, I said that's it. But, of course that was on a Saturday and I had to wait until Monday to get ahold of my nurse practitioner. Well, I was very close to going to the ER on Saturday night because of the depressed mood. Fortunately, I was able to "stick it out" until Monday when my psych. nurse practitioner took me off of it completely and switched me back to Lexapro. That was four days ago and I still feel horrid. The dizziness is bad - withdrawal? - worse than before and now I feel anxious and jittery. Ugh. Tomorrow I am going to pick up a prescription for a medication to help with the dizziness. Hopefully it will help. Luckily I have a "stand by" prescription of Xanax for the anxiety. F 41 24 days
6/26/2009

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