CYMBALTA Reviews (DULOXETINE)

Average Rating: 2.7 (2745 Ratings)

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 ANTIDEPRESSANTS

 Type: Rx Drug

  

CYMBALTA  (DULOXETINE):  Duloxetine is used to treat depression and anxiety. In addition, duloxetine is used to help relieve nerve pain (peripheral neuropathy) in people with diabetes or ongoing pain due to medical conditions such as arthritis, chronic back pain, or fibromyalgia (a condition that causes widespread pain). Duloxetine may improve your mood, sleep, appetite, and energy level, and decrease nervousness. It can also decrease pain due to certain medical conditions. Duloxetine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). This medication works by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in the brain.   FDA Approval Date: 2004-08-03 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on CYMBALTA: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR CYMBALTACOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 3  Fibromyalgia/Depression Nausea, diarrhea, upset stomach, dry mouth, sleepiness I have only been on 30mg for 4 days and have the extreme runs. Upset stomach and no appetite. Pain in minimal though and I feel less anxious and depressed. F 38 4 days
10/5/2009
 3  Depression, fibromyalisia Mid day sleepiness. The worst was the excessive sweating, I would soak through layers of clothes and would have to change every hour even with the mildest movement such as grocery shopping. If it hadn't been for the cold sweats I loved the results. It took six years to figure out it was the cymbalta wasn't worth having the cold sweats which agrivated the fibromyalsia. I would rather be suicidal. F 46 6 years
10/16/2009
 3  anxiety, mild depression vivid nightmares, insomnia, very low sex drive, delayed orgasm I started taking Cymbalta because I had adverse reactions to Wellbutrin. I feel like my eratic emotions are more in check but I am concerned about my low sex drive and nightmares. I had night terrors on Wellbutrin too which is one reason I made the switch to Cymbalta. I am becoming increasingly concerned about taking this medication after reading other peoples comments. F 27 18 days
10/11/2009
 3  Depression, Anger, SAD I did not experience side effects, other than maybe a lower libido. Until.....weaning! I have never been on any medication that is worse to wean from than this one. The buzzing in my head, for about 6 months now. I went to 4 doctors to find out why I was suddenly having buzzing (also called tinnitus) but no one could come up with any reasons. Finally a psychiatrist resident told me that it was a result of weaning off some anti-depressants. OMG, I am so glad to know that I will not have this horrible constant buzzing for ever. I also experienced an elevated liver function, again my doctor did not know why, but I have since read it is due to long term Cymbalta, in fact that is one of the reasons I eventually stopped taking it. Actually, I have been on it for 4 years and I am still trying to wean off, it's been 6 months, slowly tapering. I am dizzy, very depressed and at time agitated and mean. F 50 4 years
8/26/2009
 3  Depression Strange thoughts, Nightmares I have been on 60 mg for the last year and I tried to wean myself off once and it just did not work. I am 28 now and was dignosed with depression when I was 14 and took Zoloft and Prozac for 4 years. Those meds were nothing compared to Cymbalta. I can say that it has helped with depression but the nightmares and insomia are starting to really drag me down. I can of panic when I know I need to go to bed. It helps alot when I read beofre bed if not I have extreme nightmares that I feel like are too real. F 28 1 years
8/31/2009
 3  Depression and anxiety extreme dry mouth at first - could not drink enough water. Hypersomnia - could sleep in excess of 12 hrs per day. Stomach discomfort - started as constipation, then switched to diarrhea when dose was upped from 30mg to 60mg. have seen some improvement in mood, but still lack interest in things I use to love; lack motivation; still isolate/withdraw. F 40 2 months
9/22/2009
 3  depression with fibromyalgia Weight gain (30+ pounds without changing eating habits), uninterested in sex, have days where I cry for no reason, especially right before my period. F 44 8 months
9/22/2009
 3   initial nausea which went away after 1 week. moodiness and agitation at 30mg, stabalized mood at 60mg, but much fatigue and 20 lbs weight gain, back to 30 mg, agitation and moodiness, brain fog, back to 60 mg, better mood, but much fatigue and weight gained back that lost at 30 mg. Taking Cymbalta for peripheral nueropathy and body aches due to a spinal arthritis and possible fybromyalgia. Amazingly, Cymbalta cured? my virtigo and insomnia. First time in years I was able to sleep through the night and dream, incredibly detailed dreams btw. Pain deminished, but then returned after two years on drug. Back to where I started w/ pain and numbness, but still sleeping well and no vertigo/dizziness. Some blurry vision off and on. Prior to Cymbalta I was always very cold, excruciatingly cold when temp was under 50 degrees F. Would like to go off Cymbalta because of fatigue and return of pain and stiffness, but can not risk return of insomnia and vertigo. Sweat alot, but feels good not to be soooooo cold. Reduced to 30 mg, but even though there was no return of vertigo or insomnia, I could not handle the irratic mood swings and brain fog. Now back at 60 mg, I am always so tired and sleep hours dueing the day, lack of motivation, can no longer multi-task and often can not finish what I started. F 47 2 years
9/29/2009
 3  Depression & nerve pain (MS) Drastic drop in libido, profuse sweating, decreased appetite I really don't know what to do. I was switched to Cymbalta from Pristiq for cost reasons because I have no insurance. I have MS and all my meds are very expensive, so my MD signed me up for an assistance plan and Cymbalta is on it. The decreased libido is a major problem because I truly love my husband of 14 years, but I have a VERY difficult time being interested on an intimate level. I also cannot deal with the sweating. I sweat so profusely that it has become embarrassing. I have taken Lexapro successfully in the past and I am thinking about trying that again, regardless of the cost. F 33 2 months
9/29/2009
 3  bi-polar/depression dry mouth, constipation, irritable..more than usual, and sometimes mean, cramping in feet or legs, almost no sex drive (really bad), some nightmares. I have been on cymbalta for a few months now. I am only on 30mg, and have recently noticed I have been very irritable, and short with my husband and kids. Of course they helped point it out. I would say my depression is better, but I am just not very nice right now. As of today my dr. told me not to take it for about 4-5 days and then let him know how I feel. From reading other entries I am assuming I will be experiencing some terrible side effects by doing that...i'll have to call tomorrow and see if I should expect to feel bad. IE: headaches, and etc. F 40 5 months
9/29/2009
 3  Depression and Anxiety Insomnia. Mentally alert (no more need for caffeine in the a.m.). Short term memory is crap. My sweat smells differently (someone else mentioned this too). Better mood in general, like a mild cocaine buzz, but no euphoria - just good mood and awake. Not helping with anxiety yet. Really hard for me to sleep. Conscience about my body odor now. Waiting for the anit-anxiety effect to kick in. Appetite decreased. I read lots of reviews mentioning hair loss. the second I see any hairloss, I'm OFF Cymbalta and on to next antidepressant. This is my first one. F 32 5 days
7/24/2009
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 3  Fibromyalgia Numbness in the head, like brain was in a vise grip (30 mg), numbness in face and traveling numbness through the body (20mg) I was really bummed because the cymbalta acutally helped my fibromyalgia pain from day 1. And unlike other people, it cut my appetite, which was a blessing because of weight gain from taking meds for pain. But I oould not put up with the numbness in my head. At the lower dosage and the numbness in the head was lessened but then I developed numbness in the face and then it started traveling throughout the body like the fibromyalgia pain did. If it weren't for the numbness, cymbalta would have been an answer to my fibromyalgia pain. :( F 48 2 weeks
7/24/2009
 3  Manic Depression, Anxiety Constipation, Weight Gain, Severe Fatigue, Body Aches, Dry Mouth. Cymbalta worked quickly for my depression and anxiety. The consipation made me feel horrible, Im finally getting over that. I have gained 30 pounds, I am always hungry. About once a week I have severe Muscle aches, mainly in my back. Cymbalta will help with depression and anxiety....But the weight gain is causing even more sadness. F 17 4 months
8/1/2009
 3  Dysthymia/Fibromyalgia Headaches, severe sugar cravings, increased appetite, gained over 60 lbs. Nausea, light-headed and sweating more than I ever have in my LIFE. Fatigue worse than before going on it. While it has helped somewhat with my depression, I am starting to doubt that I will be able to continue on the medication. It has worked better for me than Zoloft did, but I feel so ill most of the time that my quality of life has gone down, though my depression has leveled out. My doc added Wellbutrin, 300 mg to see if that would help more. I do feel that my mood swings have also leveled out, but I just dont know that I can handle much more of the Cymbalta side effects. Started out on 30 mg, am now on 60 and doc wants to up it to 90. Dont think I will do that. F 38 6 months
8/13/2009
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 3  severe depression complete loss of appetite; nightmares; yawning; diarrhea I feel better emotionally already. I've lost a lot of weight and have a lot of self confidence. But I also have clear vivid nightmares every night at the same time. F 15 2 weeks
7/19/2009
 3  Depression, Anxiety My main side effect is cold chills and just feeling cold all the time unless I am outside in the 90 degree weather we are having. Feeling a little bit sleepier than usual. This is day 5. If the tiredness does not go away, I will have to stop it. I cannot afford to be tired with an 18 month old running around. I was on zoloft for 7 years with no side effects at all and it just completely stopped working. I have been in a depressive state for a year and a half now after having my last baby and have not been able to come out of it. It has gotten progressively worse. I got a 2 weeks supply from my DR and I am gonna take it the whole 2 weeks and see if there is improvement. I have found out over the years you have to at least give meds a 2 week trial. I thought about not taking it after day 2, day 3, day 4 but decided to finsih the 14 days. I sure hope it helps because I can't stand being in the state ive been in for the past year and a half. I have 4 kids to take care of and they keep me very busy. Good luck to everyone F 39 5 days
6/20/2009
 3  Fibromyalgia Increasing nausea, insomnia, blurred vision, headaches It has really helped with the fibro pain, but after a month I can't take the side effects anymore and am awaiting an answer as to how I get off this drug. F 55 1 months
6/23/2009
 3  depression floating/numb feeling on skin and in movement, not wanting to be touched/have anything move against skin, confusion, nausea, uncomfortably dry mouth or thick saliva at back of throat, odd feeling in throat like a knot, loss of appetite, severe nighttime insomnia if med taken after 10am, confusion, trouble thinking and concentrating, excessive yawning, floating feeling increases just after yawning/sneezing, diarrhea (first day), constipation (no movements for 4 days thereafter), loss of libido Only 5 days into it, not having much fun so far. Started on 60mg. Would really recommend taking it right after waking up, as the sleeplessness is really weird. F 25 4 days
6/24/2009
 3  depression On cymbalta I had no side effects, it's getting off of it which is TERRIBLE. Just trying to get off of it I've gained 7lbs, have massive head aches, crying spells etc. It's been so bad I've had to go back on 20mg just so I can go about my day normally, and also so I don't gain more weight! It works well for depression, but you have to decide if its worth it because the side effects getting off of it are VERY painful. F 25 6 months
7/15/2009
 3  Major depressive disorder/anxiety Hypotension?, night sweats, excessive yawning, spontaneous orgasms, vivid dreams At 30mg, I was yawning about twice every minute, these were "big yawns" and on top of that I would occassionaly experience an orgasm from the yawns. However I felt no difference in my depression and was increased to 60mg. At 60mg I still had excessive yawning and when I'd wake up in the morning, I'd feel floaty and tingly, I assume this was hypotension. At this dose my anxiety was better but no change in severe depression. I was increased to 90mg and still had hypotension in the morning but the yawning went away. Still no significant change in my depression or suicidal ideation. My doctor increased me to 120mg even though there's no evidence to indicate this dosage works. I finaly felt better but started having hypotension everyday, more vivid dreams and would wake up drenched in sweat. I just went to my doctor today and he's switching to me to Pristiq with no withdrawal time. I'm supposed to take the first dose tomorrow. F 29 6 months
6/9/2009
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