CYMBALTA Reviews (DULOXETINE)

Average Rating: 2.7 (2745 Ratings)

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 ANTIDEPRESSANTS

 Type: Rx Drug

  

CYMBALTA  (DULOXETINE):  Duloxetine is used to treat depression and anxiety. In addition, duloxetine is used to help relieve nerve pain (peripheral neuropathy) in people with diabetes or ongoing pain due to medical conditions such as arthritis, chronic back pain, or fibromyalgia (a condition that causes widespread pain). Duloxetine may improve your mood, sleep, appetite, and energy level, and decrease nervousness. It can also decrease pain due to certain medical conditions. Duloxetine is known as a serotonin-norepinephrine reuptake inhibitor (SNRI). This medication works by helping to restore the balance of certain natural substances (serotonin and norepinephrine) in the brain.   FDA Approval Date: 2004-08-03 (Sources: U.S. Centers for Medicare Services, FDA)

  

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Key to Ratings: 1=LOW (I would not recommend taking this medicine.)
5=HIGH (this medicine cured me or helped me a great deal.)

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More on CYMBALTA: Reviews Summary  |  Drug Safety Information

RATING  REASONSIDE EFFECTS FOR CYMBALTACOMMENTSSEXAGEDURATION/
DOSAGE
DATE ADDED
 
 1  Fibromyalgia/ Major Depression Nausia in the beginning. I had to come off of it because it didn't ever help for pain and I had a sudden major depression on it. After upping it I went back on Effexor. Cymbalta is a weak antidepressant for major depression. I was actually debilitated when Cymbalta just stopped working. I was crying and a mess. It was the longest 2 weeks until I got back on Effexor. I'm glad I wasn't suicidal!!! F 45 12 months
3/7/2008
 1  IBS Syndrome brain zaps, tired,moody,numb face,on it a year trying to withdrwawl like going to hell every hour. I think its posion to our brain F 42 15 months
10/16/2007
 1  Depression Insomnia, confusion, itchy skin, digestive problems, worse depression, etc. Upon discontinuing med, TERRIBLE WITHDRAWAL SYMPTOMS (anger, sadness, confusion, brain zaps, dizziness, more). WARNING!! Withdrawal from this med was HELL--DO NOT TAKE IT! My Mom took this med for depression for several months with NO improvement. She tried to come off from it and just could not handle the withdrawal; she acted "out in a fog" for several days before unexpectedly COMMITTING SUICIDE with one of my Dad's guns. BEWARE, this stuff is POISON!! F 44 1 months
9/7/2007
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 1  foot neuropathy after foot surgery Extreme nausea, tiredness, dizziness, flat mood, headache, dry mouth, abdominal pain, loss of libido and ability to orgasm I am trying to taper off the medication, and am experiencing a constant headache. F 53 2 months
9/15/2007
 1  Anxiety; Mild Depression Difficulty Urinating; Very Tired and Listless All Day After Taking Dose; Nausea; No Taste For Food; General Apathy I was on this pill at 30mg a day for 7 days before the Dr. told me to take 60mg a day. I could hardly eat, and just sat on the couch everyday staring at the tv. It made my anxiety worse and I was quicker to anger than usual. I found that I just did not care about anyone or anything anymore. I would not reccommend this drug to anyone with anxiety issues, as it was not a very big help. F 30 11 days
7/18/2007
 1  depression/anxiety/fibromyalgia Works great at first. BUT DON'T DO IT!!!! EVER!!!! Eventually, I was no longer myself. Agressive, angry outburts, worse depression than before, worse anxiety, worse insomnia. Withdrawal is hell. Tapering may not help. If your psychiatrist or prescriber is not helpful with withdrawal symptoms, seek help from someone immediately DON'T DO IT! F 27 2 years
9/13/2007
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 1  Depression/Anxiety N/A I am reading everyone's comments here on askapatient.com about their experiences with Cymbalta and now I am almost scared to take it. I went to the doctor today for the first time to discuss my on going anxiety issue and depression, mostly about the anxiety though. I was nervous as a hen and I tried to explain that it has gotten to the point where I can't even carry on a discussion without someone feeling like I am "attacking" them. I always have that feeling in my chest like right before you are going on a roller coaster like just scared it is constant. I sweat, I turn red in the face, my heart races. So he gave me some cymbalta samples 30mg for 1 week then 60 mg for another week. I have never been on this type of medication before and I already suffer from nausea. I play piano and I am left handed. I also smoke pot but I don't drink alcohol. F 20 0 days
7/16/2007
 1  chronic headache Low sex drive. Severe and persistent withdrawal syndrome. No big side effects from taking the drug(30 mg/day) other than zero sex drive. The problem is getting off this drug. I had severe confusion and "brain zaps" when stopping the drug, and I was on a low dose. Consequently I'm now trying to taper off it (I'm in my 5th week) and and just can't seem to stop it w/o getting brain zaps. I'm down to 5 mg/every other day and if I try to stop taking it for longer than that the severity of the brain zaps increase. I would not recommend this drug unless all other options have failed. F 44 2 months
11/3/2008
 1  Mild Depression/anxiety Shaky, jittery, total loss of appetite, dull nausea, depression. Absolutely impossible to sleep. Like I did 3 rails of cocaine right before bed. Anyone who has ever taken Ecstasy, it felt identical to that eaten up feeling of coming down. There is just no other way to describe it. Sort of like taking WAY too much pseudo ephedrine cold medicine, the daytime kind. I'm also really sensitive to meds, I have heard other people have had great experiences. Just figured I'd share. Within hours of my first dose, 30 mg, I started shaking, and I couldn't eat anything. I took it at 12:30 in the afternoon, and by 7:00PM I was shaky and jittery and all of my muscles, including my jaw, were tensing up. I tried to sleep, but I was completely wired, like I was on speed. I didn't sleep a wink, even after I got up and took 2 Unisom capsules. The next day I felt like I had the flu, hot and cold and still shaky and unable to eat. I was depressed and just stayed in bed all day. I won't be repeating that anytime soon. The side effects were ten times worse than being depressed and anxious. They say it goes away with time, but I don't think I'd survive even another night like last night. F 25 1 days
10/3/2007
 1  Depression Dizziness, nausea, headache, buzzing noise in head. DO NOT TAKE THIS DRUG. IT IS POISON. After taking 30 mg a day for 3 weeks, I stopped. I HAVE NEVER felt so awful as I do today. Started cying and laughing hysterically. Head is so mucked up I can barely move or think. Called doc and he said it's withdrawal. WTF, is this heroine or something? Withdrawal? I've stopped other SSRI's in the past and never experienced anything. This is bullshit. Do not take this poison. F 57 3 weeks
9/17/2007
 1  anxiety It was great at first. Then when I tried to get off the drug I was out of my head crazy for the first 6 days. Now I am on day 8 and still shaking. i cannot get in to see the dr. because we have a balance at the clinic. This is horrible. F 39 12 months
10/4/2007
 1  depression anxiety feel wired, feel homicidal/suicidal, agitated, no appetite, confused took my first dose this A.M. Will struggle through to see if benefits outweigh this horrible feeling. I am a recovering meth addict and feel exactly as if I am coming off of meth!! Slamming beers( which I have not done for years) to counteract total feelings of rage and despair! F 45 1 days
11/1/2008
 1  fibromyagia / depression Sleeplessness, night sweats (more than I ever had during meno- pause), heart pounding, shortness of breath, blurred vission, mood swings, disconnected thought prosseses, fatique, and more I can,t even think of. I have been taking cymbalta for about 4 years. I was on 60-90mgs. I was still very depressed and was increased to 120mgs.2 years ago. I did not toerate it so the docs lowered the dose again. I stayed at 60mgs then back to 90 a few more months. Oct. 23rd 08 I was increased to 120mgs. again, even though I had not tolerated it before. Nov. 1,08 I, per a phone call to doc, went to the E.R. The docter on call had never heard of side effects like this from cymbalta and stated I could be having a stroke. Immediately after telling the E.R. doc of the drug and symptons,she stated they had several cases of the same type. After blood work and no sign of stroke I was sent home, told to start decreasing the cymbalta and call the doctors office on monday for an apt. F 57 4 years
11/2/2008
 1  anxiety/depression nausea (at first), constipation, dizziness, NEVER sleep, always yawning and tired, very mean, hostile and aggressive when upset about something, very very bad night sweats I have been on Cymbalta for about 2 months now and I feel like I am losing my mind. I went on it to calm me down a bit, I am very anxious, and it has done the opposite. While being on this medication I have no control over my emotions or my actions when I get emotional. I have never been a physical person and I do not think twice to hit someone if I am really hurt. I am pushing the people who I am closest to away. After I have an episode I feel like I was drunk and have NO IDEA why I did it! I need off! F 25 6 weeks
11/2/2008
 1  Fibromyalgia It tore my stomach up. The pains were terrible and for 6 weeks you would most likely find me in the bathroom! F 59 4 weeks
11/7/2007
 1  Anxiety 1st 2 nights I slept and didnt get up for only about an hour, vivid dreams of falling, dry mouth, constipation, trouble urinating, sweats, tremors of body and eyes and now that I stopped taking it I have a massive headache... Dont take this medication! Horrible. I wouldnt recommend it to anyone. Ive tried paxil, lexapro and now this and nothing is helping me. I am also on xanax its the only thing that keeps me sane... F 35 3 days
11/5/2007
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 1  Fibromyalgia Incredible yawning nonstop. Tongue, throat swelling. Weird.....Constant yawning with my throat closing at the end of the yawn. VERY SCARY! Also, noted that when trying to talk or "sing" my tongue felt very thick and my spouse said that I didn't "sound" right. Finally, took benedryl after the third dose and woke up with all those bad symptoms gone. Only took three doses and NO MORE for me. Doctor said, Yes, that is from cymbalta. Stop taking it! F 40 3 days
11/5/2007
 1  Depression Weight Gain - 60 pounds in two years; loss of interest in sex; no desire to particpate in life; stronger feelings of worthlessness I've been weening off Cymbalta for a month now. I'm doing my own taper program to reduce the withdrawl effects, especially the brain zaps. Been a little bit*hy, but only when I get over tired. I don't crave seratonin producing foods as much any more and weight gain has stopped! I'm starting to get interested in my life again... I think doctors need to research this drug more than just relying on what the pharama companies tell them in order to sell it. F 44 2 years
11/17/2007
 1  Major Depression/ Bi Polar Uncontrolable crying, dark thoughts, exploded at anyone who looked at me wrong, gained 40+ pounds within 4 months.. shall I continue?? I never knew in a million years that I would be afraid of myself. What I mean is that during the 4 months I was taking Cymbalta, I almost took my life. I was on a different AD before this and the doctor switched it to this. After being hospitalized, my new doctor put me back on the previous AD which I can honestly say saved my life. F 31 4 months
10/22/2007
 1  depression I turned into a raging maniac, i had nausea, cold/hot flashes. I felt out of control, & disorientated. Also, headache,crying, insomnia, and I can't tell you all the side effects. I would never ever take this drug again, nor would I recommend this to ANYONE!! This is a BAD drug, they should have better warnings about the side effects. F 52 10 days
10/24/2007

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